Lipoxygenase

  • 抑制剂选择性比较
  • 溶解性比较
目录号 产品目录 溶解度(25°C)
DMSO 酒精
S1443 Zileuton <1 mg/mL 47 mg/mL 47 mg/mL
S3984 Nordihydroguaiaretic acid (NDGA) <1 mg/mL 60 mg/mL 60 mg/mL
S8236 MK-886 (L-663,536) <1 mg/mL 94 mg/mL <1 mg/mL
S5122 Abietic Acid -1 mg/mL 60 mg/mL -1 mg/mL
S5520 Phenidone -1 mg/mL 32 mg/mL -1 mg/mL
S9024 3-O-Acetyl-11-keto-β-boswellic acid (AKBA) -1 mg/mL 100 mg/mL -1 mg/mL
S4711 Esculetin <1 mg/mL 35 mg/mL <1 mg/mL
产品目录 产品描述 文献引用 实验数据
S1443

Zileuton

Zileuton 是一种口服有效的5-脂氧合酶抑制剂,从而抑制白三烯(LTB 4,LTC 4,LTD 4和LTE 4)的形成,用来缓解哮喘的症状。

S3984New

Nordihydroguaiaretic acid (NDGA)

Nordihydroguaiaretic acid (NDGA)是一种天然存在的酚类防老剂。它是公认的脂肪氧合酶 lipoxygenase抑制剂,具有抗氧化、清除自由基的活性。

S8236

MK-886 (L-663,536)

MK-886是白三烯生物合成的抑制剂,抑制5-脂氧合酶激活蛋白(FLAP)。它同时还是PPARα拮抗剂。

S5122New

Abietic Acid

Abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.

S5520New

Phenidone

Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.

S9024New

3-O-Acetyl-11-keto-β-boswellic acid (AKBA)

3-O-Acetyl-11-keto-β-boswellic acid (AKBA), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase.

S4711

Esculetin

Esculetin是在很多种天然植物产物中发现的香豆素衍生物,具有抗水肿、抗炎、抗肿瘤的生物和药理学特性,能抑制脂肪氧合酶。