Allicin

For research use only. Not for use in humans.

目录号:S3860 别名: diallyl thiosulfinate 中文名称:大蒜素

Allicin Chemical Structure

CAS No. 539-86-6

Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.

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质量管理及产品安全说明书

Fungal抑制剂选择性比较

生物活性

产品描述 Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.
体外研究

Allicin is readily permeable through phospholipid membranes aiding its biological activity. It inhibits the growth of cancer cells of murine and human origin. Allicin induces the formation of apoptotic bodies, nuclear condensation and a typical DNA ladder in cancer cells. Furthermore, activation of caspases-3, -8 and -9 and cleavage of poly(ADP-ribose) polymerase are induced by allicin[1]. Allicin is highly reactive with thiol-groups but under certain conditions it also reacts with itself forming further compounds which can also be bioactive, such as vinyl-dithiins, ajoene and polysulfanes. Since allicin is able to oxidize biomolecules such as glutathione or protein cysteine residues under physiological conditions, it fulfils the definition of a Reactive Sulfur Species (RSS). Allicin certainly acts as a “physiological antioxidant” by inducing the cellular “phase II detoxification system”. Allicin activates the redox-dependent mammalian transcription factor Nrf-2 the localization of which depends upon the Keap1 protein (Kelch-like ECH1-associated protein), presumably by oxidizing the regulatory cysteine-residues, as demonstrated for the YAP1-transcription factor which is a functional homologue of the Nrf-2 system in yeast[1]. In vitro studies show that allicin inhibits TNF-α-mediated T cell adhesion to extracellular matrix components and to endothelial cells. Allicin also inhibits TNF-α-mediated intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression on human vascular endothelial cells.

体内研究 Allicin has a protective effect on immune-mediated, Con A-induced hepatitis in mice[2].

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[1]
- 合并
  • Cell lines: L-929, SW480 and HeLa cells
  • Concentrations: 0-100 μM
  • Incubation Time: 24 or 48 h
  • Method: Cell viability assays are carried out as described with slight modifications. Briefly, cells are seeded at a density of 3×104 cells/well into 24-well plates. After 24 h, allicin is added to the medium at various concentrations and incubated for 24 or 48 h as indicated. At the end of the incubation, 50 μl of MTT (2 mg/ml) per well is added, and the formazan crystals formed are solubilized in acidified isopropanol after aspirating the medium. The extent of MTT reduction is measured spectrophotometrically at 570 nm, and the cell survival is expressed as percentage over the untreated control.
    (Only for Reference)
动物实验:[2]
- 合并
  • Animal Models: Balb/c male mice
  • Dosages: 8-20 mg/kg/day
  • Administration: by oral gavage
    (Only for Reference)

溶解度 (25°C)

化学数据

分子量 162.27
密度 1.109 g/mL
化学式

C6H10OS2

CAS号 539-86-6
储存条件 2年 -20°C(避光) 液体
别名 diallyl thiosulfinate

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID