Fungal

抑制剂选择性比较

Fungal产品

所有产品(95) Fungal抑制剂(92)

目录号	产品描述	文献引用	实验数据
S1517	Natamycin Natamycin (Pimaricin) 是一种天然存在的三唑类抗真菌药物。具有极少或无味道干扰。	Expert Opin Drug Deliv, 2020, 17(3):407-421 BMC Microbiol, 2020, 20(1):275
S2476	Itraconazole Itraconazole (R 51211) 是一种三唑类抗真菌药物，是CYP3A4的有效抑制剂，IC50为6.1 nM。Itraconazole 是一个有效的Hedgehog (Hh)信号通路的拮抗剂。Itraconazole 可通过诱导自噬来抑制恶性胶质瘤的生长。	Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4 Antimicrob Agents Chemother, 2020, 6 pii: AAC Front Microbiol, 2020, 11:579362	Resistance to itraconazole in MA cells. The parental SUM149-Luc cell line and MA1 cells were treated in parallel with 1 mM itraconazole for 9 days (which killed most of the cells in the parental cell line) and were allowed to recover and grow in a drug-free medium for 5 days before being stained. Since itraconazole was ineffective in killing MA1 cells, the cells grew into a continuous monolayer rather than colonies.
S1331	Fluconazole Fluconazole (UK 49858)是一种羊毛甾醇14 alpha去甲基化酶抑制剂，抑制了麦角固醇的形成，用于治疗和预防浅表性和全身性真菌感染。	ACS Omega, 2021, 6(12):8477-8487 PLoS Pathog, 2020, 16;16(3):e1008341 Drug Test Anal, 2020, 10.1002/dta.2917
S1606	Clotrimazole Clotrimazole (BAY b 5097, FB 5097)是一种合成的抗真菌药物，是imidazole的广谱衍生物。	Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4 J Cell Physiol, 2020, 10.1002 J Biol Chem, 2018, 293(1):333-344
S3588^New	Hexylene glycol Hexylene glycol (HG, 2-Methyl-2,4-pentanediol, MPD) 是一种衍生自丙酮的氧化溶剂，已广泛用于工业化学品和化妆品中。Hexylene glycol 具有抗菌 antibacterial 和抗真菌 antifungal 的特性。
S3595^New	D-Gluconic acid D-Gluconic acid 是一种抗真菌 antifungal 药。
S3532^New	AN-2718 AN-2718 is an inhibitor of fungal growth that blocks protein synthesis via the oxaborole tRNA trapping (OBORT) mechanism.
S0938^New	Sakuranetin Sakuranetin is a rice flavonoid phytoalexin that shows antifungal activity. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury.
S0832^New	Dimboa Dimboa (2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one) is an antifungal agent used in crops.
S0971^New	Kakuol Kakuol is a natural compound extracted from the rhizomes of Asarum sieboldii with antifungal activity.
S3373^New	Deoxylapachol Deoxylapachol is a major cytotoxic component of New Zealand brown alga, Landsburgia quercifolia with antifungal and anti-cancer activity.
S3307^New	Galangin 3-methyl ether Galangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin) 分离自 Lychnophora markgravii 的地上部分，具有很强的抗细菌和抗真菌作用。
S0917^New	Allosecurinin Allosecurinine (Phyllochrysine) 是一种从 M.indica 和 M.discoidea 分离的具有抗真菌活性的Securinega生物碱。
S7418^New	Cycloheximide Cycloheximide (Actidione, Naramycin A, CHX), an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy. 已取得危险化学品经营许可	Biomaterials, 2021, 271:120720 Theranostics, 2021, 11(2):700-714 Theranostics, 2021, 11(6):2655-2669
S0770^New	Camalexin Camalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities.
S0491^New	Manogepix (E1210) Manogepix (E1210, MGX, APX001A) 是一种广谱的、口服活性的抗真菌剂，可抑制 Gwt1/Gwt1p (GPI锚定壁转移蛋白1)，该蛋白在真菌细胞壁完整性中起重要作用。
S1956	Miconazole Nitrate Miconazole (NSC 169434) Nitrate是一种咪唑类抗真菌剂，外用或静脉输液。	Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4 Biomol Ther (Seoul), 2020, 25 Cell Death Dis, 2019, 10(6):413
S1666	Flucytosine Flucytosine (5-Fluorocytosine, 5-FC, 5-Fluorocytosine, NSC 103805, Ro 2-9915)是氟嘧啶类似物, 是抗菌药，作用于人白色念珠菌（C. albicans）时 IC50 为0.12 μg/mL。
S2557	Terbinafine HCl Terbinafine HCl (KWD 201)通过抑制角鲨烯环氧酶抑制了麦角固醇的合成，用作抗真菌药物。	Hum Mol Genet, 2020, ddaa244 J Cell Mol Med, 2020, 25
S3073	Caspofungin Acetate Caspofungin Acetate (MK-0991, L-743872)是一种脂肽类抗真菌β-1,3-glucan synthase抑制剂。	Antimicrob Agents Chemother, 2020, 64(2) Biotechnol Adv, 2019, 37(6):107352 J Antimicrob Chemother, 2019, 74(10):2950-2958
S2528	Ciclopirox Ciclopirox 是一种合成的抗真菌药物。	bioRxiv, 2019, 10.1101/748129
S3019	Ciclopirox ethanolamine Ciclopirox ethanolamine作为一种铁离子螯合剂，具有广谱抗真菌作用。	ACS Omega, 2021, 6(12):8477-8487 bioRxiv, 2019, 10.1101/748129
S2535	Econazole nitrate Econazole Nitrate (NSC 243115) 是一种咪唑类抗真菌药物。	Biomol Ther (Seoul), 2020, 25
S1854	Bifonazole Bifonazole (Bay h 4502) 是一种抗真菌剂和前列腺芳香化酶抑制剂，IC50为1.6 μM。	Nature, 2018, 560(7718):372-376	Percentage of MBP+ oligodendrocytes generated from OPCs following treatment with azoles (c). n ≥ 4 wells per condition.
S3161	Sertaconazole nitrate Sertaconazole nitrate (FI-7045)是一种外用广谱抗真菌药，是用来治疗表面皮肤和粘膜感染的辅助用药
S2031	Fenticonazole Nitrate Fenticonazole Nitrate 是一种唑类抗真菌药物。
S1676	Amorolfine HCl Amorolfine HCl是一种抗真菌药物。	Nat Commun, 2021, 12(1):652 Cell Chem Biol, 2019, 26(4):593-599 Nature, 2018, 560(7718):372-376	b, GC–MS-based quantification of three metabolite levels in human glioma cells (GBM528) treated for 24 h with the indicated small molecules at the following concentrations: tamoxifen, 100 nM; clemastine, 2 μM; ifenprodil, 2 μM; ketoconazole, 2.5 μM; amorolfine, 100 nM. Left, lanosterol; centre, zymostenol; right, 14-dehydrozymostenol. n = 2 wells per condition.
S4075	Zinc Pyrithione Zinc pyrithione (OM-1563)是一种抗真菌和抗细菌药物，可以通过阻断质子泵破坏膜转运。	Biol Reprod, 2019, 100(2):468-478 Cell Syst, 2017, 4(6-:600-610
S2536	Miconazole Miconazole 是一种咪唑类抗真菌药物。	Drug Test Anal, 2020, 10.1002/dta.2917 Biomol Ther (Seoul), 2020, 25
S1910	Tioconazole Tioconazole (UK-20349) 是一种抗真菌药物，IC50为1.7 μM。	Chem Biol Drug Des, 2016, 10.1111/cbdd.12872
S4120	Sulconazole Nitrate Sulconazole Nitrate 是一种咪唑衍生物，具有广谱抗真菌活性。
S3154	Butenafine HCl Butenafine HCl (KP-363)是一种合成的苄胺类抗真菌药物，通过抑制甾醇合成，通过抑制角鲨烯环氧酶，而发挥作用。
S3156	Naftifine HCl Naftifine HCl是一种烯丙基胺类抗真菌药，外用治疗足癣，股癣，体癣，通过抑制角鲨烯2,3-环氧酶选择性抑制甾醇的生物合成。
S1833	Butoconazole nitrate Butoconazole nitrate (RS-35887)是一种抗真菌剂，抑制PHA刺激下人外周血淋巴细胞中细胞因子（如IL-2, TNFα, IFN 和 GM-CSF）的分泌，IC50分别为7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL 和 7.6 μg/mL。
S4806	Potassium 1-Naphthaleneacetate Potassium 1-Naphthaleneacetate (KANU, α-Naphthaleneacetic Acid Potassium Salt) is being studied as a synthetic growth factor that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viability of certain fungal plant pathogens.
S9200	Pneumocandin B0 Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent.
S6254	Hydrocinnamic acid Hydrocinnamic acid (3-phenylpropionic acid, Benzylacetic acid)是苯丙氨酸代谢途径中氧化还原酶的底物。它是一种抗真菌剂和代谢物。
S4581	Triacetin Triacetin (Glycerol triacetate, Glyceryl triacetate, Glycerin triacetate, 1,2,3-Triacetoxypropane) 是一种甘油三酸酯，具有杀真菌作用。
S5213	Piroctone Olamine Piroctone Olamine (piroctone ethanolamine) is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections.
S5553	Kasugamycin hydrochloride Kasugamycin is an aminoglycosidic antibiotic isolated from Streptomyces kasugaensis, showing broad-spectrum anti-fungal activity against yeast and various fungus species.
S5944	Butenafine Butenafine是合成的苄胺抗真菌剂。
S5359	Butoconazole Ethyl chrysanthemate is an allelochemical compound used as an attractant.	Nature, 2018, 560(7718):372-376	Percentage of MBP+ oligodendrocytes generated from OPCs following treatment with azoles (c). n ≥ 4 wells per condition.
S8095	Tubercidin Tubercidin (7-deaza-adenosine)，腺苷类似物，是一种核苷抗生素。它可掺入到DNA中，抑制聚合酶，因此抑制DNA复制和RNA、蛋白合成。Tubercidin还具有抗真菌和抗病毒活性。	Mol Cell, 2020, 80(6):1104-1122.e9
S3966	Nifuratel Nifuratel is a nitrofuran derivative with local antiprotozoal and antifungal activity and a broad spectrum of antibacterial action.
S4970	Nerol Nerol (Cis-Geraniol, Neryl alcohol)是存在于多种香精油如柠檬草和槐花中的单萜化合物。
S3829	Isoalantolactone Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia.
S2058	Tolnaftate Tolnaftate 是一种合成的硫代氨基甲酸酯，用作抗真菌剂。	Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00420-z Hum Cell, 2020, 10.1007/s13577-020-00425-8
S4584	Butylparaben Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) 是一种常在化妆品中被用作抗菌防腐剂的化合物。	Environ Toxicol, 2018, 33(4):436-445
S6118	Terpinen-4-ol Terpinen-4-ol是一种天然存在的单萜，是茶树油的主要活性成分，具有多种生物活性如抗真菌活性。
S4996	Tavaborole (AN-2690) Tavaborole (AN-2690) is a boron-containing small molecule with broad spectrum antifungal activity.
S5271	Suloctidil Suloctidil, a sulfur-containing aminoalcohol showing to inhibit human platelet aggregation, is a peripheral vasodilator and a potential antifungal agent.
S4755	lanosterol Lanosterol是一种四环三萜，它可由所有的动物、真菌类固醇衍生而来。
S3778	Patchouli alcohol Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.
S4963	Purpurin Purpurin (1,2,4-Trihydroxyanthraquinone, Hydroxylizaric acid, Verantin)是从茜草根和其他茜草科植物家族中分离出的天然色素。它具有抗血管生成、抗菌、抗氧化活性。Purpurin 可有效地抑制CYP1A1、CYP1A2 和 CYP1B1。
S4178	Climbazole Climbazole是一种广谱的咪唑类抗真菌药剂，具有抗头皮屑的效果。
S3646	Thimerosal Thimerosal (Thiomersalate, Mercurothiolate) is a well-established antiseptic and antifungal agent and usually used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks.
S6270	2-Aminoisobutyric acid 2-Aminoisobutyric acid (NSC-16590, 2-Methylalanine, H-Aib-OH)是一种稀有的、非蛋白氨基酸，是嘧啶代谢的终产物，随着尿液排出，在一些真菌来源的抗生素中有发现。
S4187	Salicylanilide Salicylanilides (WR10019)是一组具有广泛的生物活性的化合物，具有抗病毒效力，抗菌（包括抗分枝杆菌），和抗真菌活性。	Hum Mol Genet, 2020, ddaa244
S4258	Luliconazole Luliconazole是一种广谱抗真菌药物。
S9350	Ethyl 4-Methoxycinnamate Ethyl 4-Methoxycinnamate (Ethyl p-methoxycinnamate, 4-Methoxycinnamic Acid Ethyl Ester), a natural product found in K. galanga and C. zedoaria extracts, has anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.
S9057	Sinigrin Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.	J Invest Dermatol, 2018, 138(12):2644-2652
S2534	Isoconazole nitrate Isoconazole nitrate 是一种唑类抗真菌药物。
S3705	Chlorobutanol Chlorobutanol (Chlorbutol, Chloreton, Chloretone, Chlortran\|, trichloro-2-methyl-2-propanol)是一种防腐剂、镇静剂、催眠剂和弱的局部麻醉剂，具有抗菌抑菌作用。
S3860	Allicin Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.
S9072	Sweroside Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.
S2321	Magnolol Magnolol (NSC 293099) 是一种在Houpu magnolia (Magnolia officinalis) 树皮中发现的生物活性化合物。它能抑制TNFα诱导的NF-KB的激活。	Neoplasia, 2020, 22(11):576-589 J Chromatogr A, 2020, 1625:461230 Micromachines, 2018, 9(6)	Magnolol reduces RNV areas and avascular areas in OIR mice. Mice retinas from OIR group (a, b) and OIR + Magnolol (25 mg/kg) group (c, d) were harvested at P17 and subjected to wholemount immunostaining with IB4 (red), showing neovascular areas (green) and avascular areas (yellow).
S6408	Hexetidine Hexetidine是一种抗细菌和抗真菌剂，具有局部麻醉、止血、除臭、预防牙菌斑作用。
S5033	Terconazole Terconazole (Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol)是一种新型的、广谱的、三唑抗真菌试剂，主要用于治疗阴道真菌感染。	bioRxiv, 2020, 2020/9/20.4.7.30734
S5025	Efinaconazole Efinaconazole (KP-103) 是14 alpha-demethylase的抑制剂。14 alpha-demethylase参与ergosterol的生物合成，ergosterol是真菌细胞膜的成分之一。
S9413	Yangonin Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors.
S5829	Monomyristin Monomyristin (Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate)具有抗细菌和抗真菌活性。
S4601	Clioquinol Clioquinol (Iodochlorhydroxyquin, Chinoform) 是一种具有口服活性的、亲油性的、铜离子结合的卤代8-羟基喹啉（8-hydroxyquinoline），具有抗真菌、抗寄生物以及潜在的抗肿瘤活性。	FASEB J, 2019, 10.1096/fj.201802603RR
S6451	Salifungin Salifungin (Multifungin, Bromosalicylchloranilide)是一种抗真菌剂，在某些个体中可能导致过敏性接触性皮炎。
S3722	Isavuconazole Isavuconazole (BAL-4815, RO-0094815) 是新型超广谱三唑类化合物，对酵母、霉菌和双态性真菌具有活性，抑制cytochrome P450 (CYP)依赖性的14α-lanosterol脱甲基作用，以此抑制真菌细胞膜麦角固醇的合成。
S5541	Dimetridazole Dimetridazole is an anti-fungal and anti-protozoal used for the control of infection in pigs, poultry, turkeys, game birds, pigeons and other caged birds.
S3979	Zinc Undecylenate Zinc Undecylenate (Zinc diundec-10-enoate, Zinc 10-undecenoate) is a natural or synthetic fungistatic fatty acid, antifungal Zinc Undecylenate is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.
S5086	p-Anisaldehyde p-Anisaldehyde (4-Methoxybenzaldehyde, Anisaldehyde, Anisic aldehyde, P-Methoxybenzaldehyde, 4-Anisaldehyde)，茴芹种子提取物，具有抗真菌活性，对很多酵母和实验室培养基、果泥和果汁中的霉菌菌株具有活性。
S6467	Fosfluconazole Fosfluconazole是一种水溶性的fluconazole盐酸盐前体药物。Fluconazole是三唑抗真菌药物，用于治疗和组织表面的和系统性真菌感染。
S4525	Ethylparaben Ethylparaben (Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate)是对羟基苯甲酸（p-hydroxybenzoic acid）的乙酯形式，被用作抗真菌防腐剂和食品添加剂。它还是一种化学过敏原，其生理效应是通过增加组胺释放和细胞所介导的免疫反应所实现。
S4878	Neticonazole Hydrochloride Neticonazole是咪唑类抗真菌剂，用于治疗皮肤真菌感染。
S5845	Chalcone Chalcone (benzylideneacetophenone, phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone)是一种芳族酮，是很多重要的生物化合物（chalcones）的中心，具有抗菌、抗肿瘤和消炎活性。
S4793	Cedryl acetate Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.
S5512	Juglone Juglone (Regianin, 5-Hydroxy-1,4-naphthoquinone), a natural naphthoquinone found in the black walnut and other plants, has moderate antifungal activity and growth-stimulating effects to many types of plants. It sometimes can be used as an herbicide, as a dye for cloth and inks, and as a coloring agent for foods and cosmetics.	Nat Commun, 2019, 10(1):4013
S4516	(+)-Camphor Camphor是一种蜡质的、易燃的、白色或透明的固体，有强烈的香味，通常用于缓解疼痛、减少瘙痒以及治疗真菌感染。它能够激活TRPV1和TRPV3。
S5373	Pseudolaric Acid B Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties.	Eur J Pharmacol, 2020, 876:173064
S4843	Potassium acetate Potassium acetate (Diuretic salt, Potassium ethanoate) is the potassium salt of acetic acid, which is a synthetic carboxylic acid with antibacterial and antifungal properties.
S4286	Anidulafungin (LY303366) Anidulafungin (LY303366), 一种echinocandin的衍生物, 抑制glucan synthase的活性, 用作抗真菌药。	Emerg Microbes Infect, 2020, 1-53 Antimicrob Agents Chemother, 2020, 64(2) BMC Infect Dis, 2020, 19;20(1):287	Effect of Anidulafungin on hemolysis. Arithmetic means ± SEM (n = 8) of the percentage of hemolytic erythrocytes following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Anidulafungin (1.5-6 μg/ml). ***(p<0.001) indicates significant difference from the absence of Anidulafungin (ANOVA).
S3910	4',7-Dimethoxyisoflavone 4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro.
S4287	Micafungin Sodium Micafungin Sodium (FK463, Mycamine)是1,3-β-D-葡聚糖合成抑制剂，用作抗真菌的药物。	Antimicrob Agents Chemother, 2020, 64(2) BMC Infect Dis, 2020, 19;20(1):287 Biotechnol Adv, 2019, 37(6):107352	Effect of Micafungin on erythrocyte forward scatter. A. Original histogram of forward scatter of erythrocytes following exposure for 48 hours to Ringer solution without (grey area) and with (black line) presense of 25 µg/ml Micafungin. B. Arithmetic means ± SEM (n = 14) of the erythrocyte forward scatter (FSC) following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Micafungin (10-25 µg/ml). C. Arithmetic means ± SEM (n = 14) of the percentage of erythrocytes with forward scatter(FSC) <200 following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Micafungin (10-25 µg/ml). D. Arithmetic means ± SEM (n = 14) of the percentage of erythrocytes with forward scatter (FSC) >800 following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Micafungin (10-25 µg/ml). ***(p<0.001) indicates significant difference from the absence of Micafungin (ANOVA).
S4559	Cloxiquine Cloxiquine (5-Chloro-8-quinolinol, Dermofungin)是一种抗细菌、抗真菌、抗衰老和抗痨药物。
S3985	Methyl 4-hydroxybenzoate Methyl 4-hydroxybenzoate (Methylparaben, Methyl p-hydroxybenzoate, Nipagin) 是一种抗真菌剂，应用于多种化妆品、个人护理用品和食品防腐剂。
S3990	Trans-Anethole Trans-anethole (4-Propenylanisole)是苯丙烯衍生物，存在于多种香精油、包括茴香油中。它具有神经调节、抗焦虑、抗氧化、抗真菌、抗炎症和免疫调节活性。
S1442	Voriconazole Voriconazole (UK-109496) 是类似于氟康唑和伊曲康唑的新型三唑衍生物，其作用是通过抑制真菌 cytochrome P-450 依赖性的，14-alpha-sterol demethylase 介导的麦角固醇的合成。	Antimicrob Agents Chemother, 2020, 6 pii: AAC Front Microbiol, 2020, 11:579362 Front Cell Infect Microbiol, 2020, 10:576975	Voriconazole increases the osteogenic activity of human osteoblasts in vitro. Osteoblasts were exposed to voriconazole (VCZ) or fluconazole (FCZ) at 15 or 200 μg/ml in osteoinductive medium (OS+) for up to 7 days. As a positive control, cells were also exposed to sodium fluoride (NaF) at 10 μM in nonosteoinductive medium (OS−). Osteoblastic differentiation was evaluated by measuring alkaline phosphatase (ALP) activity (A) and staining for calcium deposition with alazarin red S stain (B and C); calcium deposition was quantified by measuring the absorbance (A415) of extracted alazarin red S (B) and was assessed by the light microscopic appearance (white arrows) of stained osteoblast cultures (C). Values represent the means ± SD. *, P < 0.05, compared to osteoblasts grown under osteogenic conditions without treatment.
S5174	Kojic acid Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.	Int J Mol Sci, 2017, 18(9)
S5083	Lentinan Lentinan (A823605, Bromoduline)，分离纯化自香菇子实体水煮提取物，是一种真菌多糖免疫调制剂，具有抗肿瘤活性。

目录号	产品描述	文献引用	实验数据
S1517	Natamycin Natamycin (Pimaricin) 是一种天然存在的三唑类抗真菌药物。具有极少或无味道干扰。	Expert Opin Drug Deliv,2020, 17(3):407-421 BMC Microbiol,2020, 20(1):275
S2476	Itraconazole Itraconazole (R 51211) 是一种三唑类抗真菌药物，是CYP3A4的有效抑制剂，IC50为6.1 nM。Itraconazole 是一个有效的Hedgehog (Hh)信号通路的拮抗剂。Itraconazole 可通过诱导自噬来抑制恶性胶质瘤的生长。	Nat Biotechnol,2021, 10.1038/s41587-021-00860-4 Antimicrob Agents Chemother,2020, 6 pii: AAC Front Microbiol,2020, 11:579362	Resistance to itraconazole in MA cells. The parental SUM149-Luc cell line and MA1 cells were treated in parallel with 1 mM itraconazole for 9 days (which killed most of the cells in the parental cell line) and were allowed to recover and grow in a drug-free medium for 5 days before being stained. Since itraconazole was ineffective in killing MA1 cells, the cells grew into a continuous monolayer rather than colonies.
S1331	Fluconazole Fluconazole (UK 49858)是一种羊毛甾醇14 alpha去甲基化酶抑制剂，抑制了麦角固醇的形成，用于治疗和预防浅表性和全身性真菌感染。	ACS Omega,2021, 6(12):8477-8487 PLoS Pathog,2020, 16;16(3):e1008341 Drug Test Anal,2020, 10.1002/dta.2917
S1606	Clotrimazole Clotrimazole (BAY b 5097, FB 5097)是一种合成的抗真菌药物，是imidazole的广谱衍生物。	Nat Biotechnol,2021, 10.1038/s41587-021-00860-4 J Cell Physiol,2020, 10.1002 J Biol Chem,2018, 293(1):333-344
S3588^New	Hexylene glycol Hexylene glycol (HG, 2-Methyl-2,4-pentanediol, MPD) 是一种衍生自丙酮的氧化溶剂，已广泛用于工业化学品和化妆品中。Hexylene glycol 具有抗菌 antibacterial 和抗真菌 antifungal 的特性。
S3595^New	D-Gluconic acid D-Gluconic acid 是一种抗真菌 antifungal 药。
S3532^New	AN-2718 AN-2718 is an inhibitor of fungal growth that blocks protein synthesis via the oxaborole tRNA trapping (OBORT) mechanism.
S0938^New	Sakuranetin Sakuranetin is a rice flavonoid phytoalexin that shows antifungal activity. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury.
S0832^New	Dimboa Dimboa (2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one) is an antifungal agent used in crops.
S0971^New	Kakuol Kakuol is a natural compound extracted from the rhizomes of Asarum sieboldii with antifungal activity.
S3373^New	Deoxylapachol Deoxylapachol is a major cytotoxic component of New Zealand brown alga, Landsburgia quercifolia with antifungal and anti-cancer activity.
S3307^New	Galangin 3-methyl ether Galangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin) 分离自 Lychnophora markgravii 的地上部分，具有很强的抗细菌和抗真菌作用。
S0917^New	Allosecurinin Allosecurinine (Phyllochrysine) 是一种从 M.indica 和 M.discoidea 分离的具有抗真菌活性的Securinega生物碱。
S7418^New	Cycloheximide Cycloheximide (Actidione, Naramycin A, CHX), an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy. 已取得危险化学品经营许可	Biomaterials,2021, 271:120720 Theranostics,2021, 11(2):700-714 Theranostics,2021, 11(6):2655-2669
S0770^New	Camalexin Camalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities.
S0491^New	Manogepix (E1210) Manogepix (E1210, MGX, APX001A) 是一种广谱的、口服活性的抗真菌剂，可抑制 Gwt1/Gwt1p (GPI锚定壁转移蛋白1)，该蛋白在真菌细胞壁完整性中起重要作用。
S1956	Miconazole Nitrate Miconazole (NSC 169434) Nitrate是一种咪唑类抗真菌剂，外用或静脉输液。	Nat Biotechnol,2021, 10.1038/s41587-021-00860-4 Biomol Ther (Seoul),2020, 25 Cell Death Dis,2019, 10(6):413
S1666	Flucytosine Flucytosine (5-Fluorocytosine, 5-FC, 5-Fluorocytosine, NSC 103805, Ro 2-9915)是氟嘧啶类似物, 是抗菌药，作用于人白色念珠菌（C. albicans）时 IC50 为0.12 μg/mL。
S2557	Terbinafine HCl Terbinafine HCl (KWD 201)通过抑制角鲨烯环氧酶抑制了麦角固醇的合成，用作抗真菌药物。	Hum Mol Genet,2020, ddaa244 J Cell Mol Med,2020, 25
S3073	Caspofungin Acetate Caspofungin Acetate (MK-0991, L-743872)是一种脂肽类抗真菌β-1,3-glucan synthase抑制剂。	Antimicrob Agents Chemother,2020, 64(2) Biotechnol Adv,2019, 37(6):107352 J Antimicrob Chemother,2019, 74(10):2950-2958
S2528	Ciclopirox Ciclopirox 是一种合成的抗真菌药物。	bioRxiv,2019, 10.1101/748129
S3019	Ciclopirox ethanolamine Ciclopirox ethanolamine作为一种铁离子螯合剂，具有广谱抗真菌作用。	ACS Omega,2021, 6(12):8477-8487 bioRxiv,2019, 10.1101/748129
S2535	Econazole nitrate Econazole Nitrate (NSC 243115) 是一种咪唑类抗真菌药物。	Biomol Ther (Seoul),2020, 25
S1854	Bifonazole Bifonazole (Bay h 4502) 是一种抗真菌剂和前列腺芳香化酶抑制剂，IC50为1.6 μM。	Nature,2018, 560(7718):372-376	Percentage of MBP+ oligodendrocytes generated from OPCs following treatment with azoles (c). n ≥ 4 wells per condition.
S3161	Sertaconazole nitrate Sertaconazole nitrate (FI-7045)是一种外用广谱抗真菌药，是用来治疗表面皮肤和粘膜感染的辅助用药
S2031	Fenticonazole Nitrate Fenticonazole Nitrate 是一种唑类抗真菌药物。
S1676	Amorolfine HCl Amorolfine HCl是一种抗真菌药物。	Nat Commun,2021, 12(1):652 Cell Chem Biol,2019, 26(4):593-599 Nature,2018, 560(7718):372-376	b, GC–MS-based quantification of three metabolite levels in human glioma cells (GBM528) treated for 24 h with the indicated small molecules at the following concentrations: tamoxifen, 100 nM; clemastine, 2 μM; ifenprodil, 2 μM; ketoconazole, 2.5 μM; amorolfine, 100 nM. Left, lanosterol; centre, zymostenol; right, 14-dehydrozymostenol. n = 2 wells per condition.
S4075	Zinc Pyrithione Zinc pyrithione (OM-1563)是一种抗真菌和抗细菌药物，可以通过阻断质子泵破坏膜转运。	Biol Reprod,2019, 100(2):468-478 Cell Syst,2017, 4(6-:600-610
S2536	Miconazole Miconazole 是一种咪唑类抗真菌药物。	Drug Test Anal,2020, 10.1002/dta.2917 Biomol Ther (Seoul),2020, 25
S1910	Tioconazole Tioconazole (UK-20349) 是一种抗真菌药物，IC50为1.7 μM。	Chem Biol Drug Des,2016, 10.1111/cbdd.12872
S4120	Sulconazole Nitrate Sulconazole Nitrate 是一种咪唑衍生物，具有广谱抗真菌活性。
S3154	Butenafine HCl Butenafine HCl (KP-363)是一种合成的苄胺类抗真菌药物，通过抑制甾醇合成，通过抑制角鲨烯环氧酶，而发挥作用。
S3156	Naftifine HCl Naftifine HCl是一种烯丙基胺类抗真菌药，外用治疗足癣，股癣，体癣，通过抑制角鲨烯2,3-环氧酶选择性抑制甾醇的生物合成。
S1833	Butoconazole nitrate Butoconazole nitrate (RS-35887)是一种抗真菌剂，抑制PHA刺激下人外周血淋巴细胞中细胞因子（如IL-2, TNFα, IFN 和 GM-CSF）的分泌，IC50分别为7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL 和 7.6 μg/mL。
S4806	Potassium 1-Naphthaleneacetate Potassium 1-Naphthaleneacetate (KANU, α-Naphthaleneacetic Acid Potassium Salt) is being studied as a synthetic growth factor that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viability of certain fungal plant pathogens.
S9200	Pneumocandin B0 Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent.
S6254	Hydrocinnamic acid Hydrocinnamic acid (3-phenylpropionic acid, Benzylacetic acid)是苯丙氨酸代谢途径中氧化还原酶的底物。它是一种抗真菌剂和代谢物。
S4581	Triacetin Triacetin (Glycerol triacetate, Glyceryl triacetate, Glycerin triacetate, 1,2,3-Triacetoxypropane) 是一种甘油三酸酯，具有杀真菌作用。
S5213	Piroctone Olamine Piroctone Olamine (piroctone ethanolamine) is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections.
S5553	Kasugamycin hydrochloride Kasugamycin is an aminoglycosidic antibiotic isolated from Streptomyces kasugaensis, showing broad-spectrum anti-fungal activity against yeast and various fungus species.
S5944	Butenafine Butenafine是合成的苄胺抗真菌剂。
S5359	Butoconazole Ethyl chrysanthemate is an allelochemical compound used as an attractant.	Nature,2018, 560(7718):372-376	Percentage of MBP+ oligodendrocytes generated from OPCs following treatment with azoles (c). n ≥ 4 wells per condition.
S8095	Tubercidin Tubercidin (7-deaza-adenosine)，腺苷类似物，是一种核苷抗生素。它可掺入到DNA中，抑制聚合酶，因此抑制DNA复制和RNA、蛋白合成。Tubercidin还具有抗真菌和抗病毒活性。	Mol Cell,2020, 80(6):1104-1122.e9
S3966	Nifuratel Nifuratel is a nitrofuran derivative with local antiprotozoal and antifungal activity and a broad spectrum of antibacterial action.
S4970	Nerol Nerol (Cis-Geraniol, Neryl alcohol)是存在于多种香精油如柠檬草和槐花中的单萜化合物。
S3829	Isoalantolactone Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia.
S2058	Tolnaftate Tolnaftate 是一种合成的硫代氨基甲酸酯，用作抗真菌剂。	Cancer Cell Int,2020, 19;20:58 Hum Cell,2020, 10.1007/s13577-020-00420-z Hum Cell,2020, 10.1007/s13577-020-00425-8
S4584	Butylparaben Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) 是一种常在化妆品中被用作抗菌防腐剂的化合物。	Environ Toxicol,2018, 33(4):436-445
S6118	Terpinen-4-ol Terpinen-4-ol是一种天然存在的单萜，是茶树油的主要活性成分，具有多种生物活性如抗真菌活性。
S4996	Tavaborole (AN-2690) Tavaborole (AN-2690) is a boron-containing small molecule with broad spectrum antifungal activity.
S5271	Suloctidil Suloctidil, a sulfur-containing aminoalcohol showing to inhibit human platelet aggregation, is a peripheral vasodilator and a potential antifungal agent.
S4755	lanosterol Lanosterol是一种四环三萜，它可由所有的动物、真菌类固醇衍生而来。
S3778	Patchouli alcohol Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.
S4963	Purpurin Purpurin (1,2,4-Trihydroxyanthraquinone, Hydroxylizaric acid, Verantin)是从茜草根和其他茜草科植物家族中分离出的天然色素。它具有抗血管生成、抗菌、抗氧化活性。Purpurin 可有效地抑制CYP1A1、CYP1A2 和 CYP1B1。
S4178	Climbazole Climbazole是一种广谱的咪唑类抗真菌药剂，具有抗头皮屑的效果。
S3646	Thimerosal Thimerosal (Thiomersalate, Mercurothiolate) is a well-established antiseptic and antifungal agent and usually used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks.
S6270	2-Aminoisobutyric acid 2-Aminoisobutyric acid (NSC-16590, 2-Methylalanine, H-Aib-OH)是一种稀有的、非蛋白氨基酸，是嘧啶代谢的终产物，随着尿液排出，在一些真菌来源的抗生素中有发现。
S4187	Salicylanilide Salicylanilides (WR10019)是一组具有广泛的生物活性的化合物，具有抗病毒效力，抗菌（包括抗分枝杆菌），和抗真菌活性。	Hum Mol Genet,2020, ddaa244
S4258	Luliconazole Luliconazole是一种广谱抗真菌药物。
S9350	Ethyl 4-Methoxycinnamate Ethyl 4-Methoxycinnamate (Ethyl p-methoxycinnamate, 4-Methoxycinnamic Acid Ethyl Ester), a natural product found in K. galanga and C. zedoaria extracts, has anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.
S9057	Sinigrin Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.	J Invest Dermatol,2018, 138(12):2644-2652
S2534	Isoconazole nitrate Isoconazole nitrate 是一种唑类抗真菌药物。
S3705	Chlorobutanol Chlorobutanol (Chlorbutol, Chloreton, Chloretone, Chlortran\|, trichloro-2-methyl-2-propanol)是一种防腐剂、镇静剂、催眠剂和弱的局部麻醉剂，具有抗菌抑菌作用。
S3860	Allicin Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.
S9072	Sweroside Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.
S2321	Magnolol Magnolol (NSC 293099) 是一种在Houpu magnolia (Magnolia officinalis) 树皮中发现的生物活性化合物。它能抑制TNFα诱导的NF-KB的激活。	Neoplasia,2020, 22(11):576-589 J Chromatogr A,2020, 1625:461230 Micromachines,2018, 9(6)	Magnolol reduces RNV areas and avascular areas in OIR mice. Mice retinas from OIR group (a, b) and OIR + Magnolol (25 mg/kg) group (c, d) were harvested at P17 and subjected to wholemount immunostaining with IB4 (red), showing neovascular areas (green) and avascular areas (yellow).
S6408	Hexetidine Hexetidine是一种抗细菌和抗真菌剂，具有局部麻醉、止血、除臭、预防牙菌斑作用。
S5033	Terconazole Terconazole (Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol)是一种新型的、广谱的、三唑抗真菌试剂，主要用于治疗阴道真菌感染。	bioRxiv,2020, 2020/9/20.4.7.30734
S5025	Efinaconazole Efinaconazole (KP-103) 是14 alpha-demethylase的抑制剂。14 alpha-demethylase参与ergosterol的生物合成，ergosterol是真菌细胞膜的成分之一。
S9413	Yangonin Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors.
S5829	Monomyristin Monomyristin (Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate)具有抗细菌和抗真菌活性。
S4601	Clioquinol Clioquinol (Iodochlorhydroxyquin, Chinoform) 是一种具有口服活性的、亲油性的、铜离子结合的卤代8-羟基喹啉（8-hydroxyquinoline），具有抗真菌、抗寄生物以及潜在的抗肿瘤活性。	FASEB J,2019, 10.1096/fj.201802603RR
S6451	Salifungin Salifungin (Multifungin, Bromosalicylchloranilide)是一种抗真菌剂，在某些个体中可能导致过敏性接触性皮炎。
S3722	Isavuconazole Isavuconazole (BAL-4815, RO-0094815) 是新型超广谱三唑类化合物，对酵母、霉菌和双态性真菌具有活性，抑制cytochrome P450 (CYP)依赖性的14α-lanosterol脱甲基作用，以此抑制真菌细胞膜麦角固醇的合成。
S5541	Dimetridazole Dimetridazole is an anti-fungal and anti-protozoal used for the control of infection in pigs, poultry, turkeys, game birds, pigeons and other caged birds.
S3979	Zinc Undecylenate Zinc Undecylenate (Zinc diundec-10-enoate, Zinc 10-undecenoate) is a natural or synthetic fungistatic fatty acid, antifungal Zinc Undecylenate is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.
S5086	p-Anisaldehyde p-Anisaldehyde (4-Methoxybenzaldehyde, Anisaldehyde, Anisic aldehyde, P-Methoxybenzaldehyde, 4-Anisaldehyde)，茴芹种子提取物，具有抗真菌活性，对很多酵母和实验室培养基、果泥和果汁中的霉菌菌株具有活性。
S6467	Fosfluconazole Fosfluconazole是一种水溶性的fluconazole盐酸盐前体药物。Fluconazole是三唑抗真菌药物，用于治疗和组织表面的和系统性真菌感染。
S4525	Ethylparaben Ethylparaben (Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate)是对羟基苯甲酸（p-hydroxybenzoic acid）的乙酯形式，被用作抗真菌防腐剂和食品添加剂。它还是一种化学过敏原，其生理效应是通过增加组胺释放和细胞所介导的免疫反应所实现。
S4878	Neticonazole Hydrochloride Neticonazole是咪唑类抗真菌剂，用于治疗皮肤真菌感染。
S5845	Chalcone Chalcone (benzylideneacetophenone, phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone)是一种芳族酮，是很多重要的生物化合物（chalcones）的中心，具有抗菌、抗肿瘤和消炎活性。
S4793	Cedryl acetate Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.
S5512	Juglone Juglone (Regianin, 5-Hydroxy-1,4-naphthoquinone), a natural naphthoquinone found in the black walnut and other plants, has moderate antifungal activity and growth-stimulating effects to many types of plants. It sometimes can be used as an herbicide, as a dye for cloth and inks, and as a coloring agent for foods and cosmetics.	Nat Commun,2019, 10(1):4013
S4516	(+)-Camphor Camphor是一种蜡质的、易燃的、白色或透明的固体，有强烈的香味，通常用于缓解疼痛、减少瘙痒以及治疗真菌感染。它能够激活TRPV1和TRPV3。
S5373	Pseudolaric Acid B Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties.	Eur J Pharmacol,2020, 876:173064
S4843	Potassium acetate Potassium acetate (Diuretic salt, Potassium ethanoate) is the potassium salt of acetic acid, which is a synthetic carboxylic acid with antibacterial and antifungal properties.
S4286	Anidulafungin (LY303366) Anidulafungin (LY303366), 一种echinocandin的衍生物, 抑制glucan synthase的活性, 用作抗真菌药。	Emerg Microbes Infect,2020, 1-53 Antimicrob Agents Chemother,2020, 64(2) BMC Infect Dis,2020, 19;20(1):287	Effect of Anidulafungin on hemolysis. Arithmetic means ± SEM (n = 8) of the percentage of hemolytic erythrocytes following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Anidulafungin (1.5-6 μg/ml). ***(p<0.001) indicates significant difference from the absence of Anidulafungin (ANOVA).
S3910	4',7-Dimethoxyisoflavone 4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro.
S4287	Micafungin Sodium Micafungin Sodium (FK463, Mycamine)是1,3-β-D-葡聚糖合成抑制剂，用作抗真菌的药物。	Antimicrob Agents Chemother,2020, 64(2) BMC Infect Dis,2020, 19;20(1):287 Biotechnol Adv,2019, 37(6):107352	Effect of Micafungin on erythrocyte forward scatter. A. Original histogram of forward scatter of erythrocytes following exposure for 48 hours to Ringer solution without (grey area) and with (black line) presense of 25 µg/ml Micafungin. B. Arithmetic means ± SEM (n = 14) of the erythrocyte forward scatter (FSC) following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Micafungin (10-25 µg/ml). C. Arithmetic means ± SEM (n = 14) of the percentage of erythrocytes with forward scatter(FSC) <200 following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Micafungin (10-25 µg/ml). D. Arithmetic means ± SEM (n = 14) of the percentage of erythrocytes with forward scatter (FSC) >800 following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Micafungin (10-25 µg/ml). ***(p<0.001) indicates significant difference from the absence of Micafungin (ANOVA).
S4559	Cloxiquine Cloxiquine (5-Chloro-8-quinolinol, Dermofungin)是一种抗细菌、抗真菌、抗衰老和抗痨药物。
S3985	Methyl 4-hydroxybenzoate Methyl 4-hydroxybenzoate (Methylparaben, Methyl p-hydroxybenzoate, Nipagin) 是一种抗真菌剂，应用于多种化妆品、个人护理用品和食品防腐剂。
S3990	Trans-Anethole Trans-anethole (4-Propenylanisole)是苯丙烯衍生物，存在于多种香精油、包括茴香油中。它具有神经调节、抗焦虑、抗氧化、抗真菌、抗炎症和免疫调节活性。

目录号	产品描述	文献引用	实验数据
S1442	Voriconazole Voriconazole (UK-109496) 是类似于氟康唑和伊曲康唑的新型三唑衍生物，其作用是通过抑制真菌 cytochrome P-450 依赖性的，14-alpha-sterol demethylase 介导的麦角固醇的合成。	Antimicrob Agents Chemother, 2020, 6 pii: AAC Front Microbiol, 2020, 11:579362 Front Cell Infect Microbiol, 2020, 10:576975	Voriconazole increases the osteogenic activity of human osteoblasts in vitro. Osteoblasts were exposed to voriconazole (VCZ) or fluconazole (FCZ) at 15 or 200 μg/ml in osteoinductive medium (OS+) for up to 7 days. As a positive control, cells were also exposed to sodium fluoride (NaF) at 10 μM in nonosteoinductive medium (OS−). Osteoblastic differentiation was evaluated by measuring alkaline phosphatase (ALP) activity (A) and staining for calcium deposition with alazarin red S stain (B and C); calcium deposition was quantified by measuring the absorbance (A415) of extracted alazarin red S (B) and was assessed by the light microscopic appearance (white arrows) of stained osteoblast cultures (C). Values represent the means ± SD. *, P < 0.05, compared to osteoblasts grown under osteogenic conditions without treatment.
S5174	Kojic acid Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.	Int J Mol Sci, 2017, 18(9)
S5083	Lentinan Lentinan (A823605, Bromoduline)，分离纯化自香菇子实体水煮提取物，是一种真菌多糖免疫调制剂，具有抗肿瘤活性。

目录号

产品描述

文献引用

实验数据

S1442

Voriconazole

Voriconazole (UK-109496) 是类似于氟康唑和伊曲康唑的新型三唑衍生物，其作用是通过抑制真菌 cytochrome P-450 依赖性的，14-alpha-sterol demethylase 介导的麦角固醇的合成。

Antimicrob Agents Chemother, 2020, 6 pii: AAC

Front Microbiol, 2020, 11:579362

Front Cell Infect Microbiol, 2020, 10:576975

S5174

Kojic acid

Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.

Int J Mol Sci, 2017, 18(9)

S5083

Lentinan

Lentinan (A823605, Bromoduline)，分离纯化自香菇子实体水煮提取物，是一种真菌多糖免疫调制剂，具有抗肿瘤活性。

研究领域

产品类型

定制您的化合物库

Fungal

抑制剂选择性比较

Fungal产品