Mangiferin

For research use only. Not for use in humans.

目录号:S3808 别名: Alpizarin, Chinomin, Hedysarid

Mangiferin Chemical Structure

CAS No. 4773-96-0

Mangiferin is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements.

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产品安全说明书

Nrf2抑制剂选择性比较

生物活性

产品描述 Mangiferin is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements.
体外研究

Mangiferin possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory effects. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, providing a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. Mangiferin exerts a pro-hypoglycemic role by modulating glucose metabolism, ameliorating insulin resistance, lowering cholesterol synthesis, and inhibiting the expression of the tumor necrosis factor α and inducible nitric oxide synthase. It also induces apoptosis and inhibits the progression and promotion of cell proliferation by interfering with cell cycle regulation, the signaling of several cancer transduction pathways in tumor cells[1].

体内研究 Mangiferin can pass through the blood-ocular barrier and has been shown to be effective in curtailing various eye diseases. Administration of mangiferin (100 mg/kg BW) dissolved in corn oil in healthy male Swiss albino mice lowers the activity of lysosomal enzymes such as β-glucuronidase, acidphosphatase, β-galactosidase and N-acetyl glucosaminidase. Oral administration of mangiferin (100 miligram/kilogram BW) through the diet for 18 weeks significantly ameliorates the elevated levels of glycoprotein components, membrane lipid peroxidation, and ATPases in lung carcinoma-induced animals. Mangiferin also ameliorates intestinal inflammation and impairs the gastrointestinal transit postoperative ileus (POI) of rats. It recovers delayed intestinal transit induced by intestinal manipulation. In mice, Mangiferin shows a gastroprotective effect. Administration of mangiferin (3, 10 and 30 mg/kg) decreases ethanol-induced gastric damage by 30, 35 and 63% respectively, and reduced indomethacin-induced gastric damage by 22, 23, and 57% respectively. In pylorus-ligated rats, gastric secretion and total acidity significantly decrease by mangiferin, and it effectively prevents the depletion of the ethanol-related protein from the gastric mucosa of the non-protein sulfhydryl content. Mangiferin exhibits an antidiabetic role in adult C57BL/6 J mice. It has a significant role in the reduction of cholesterol, triglycerides, and free fatty acid (FFA) levels in both serum and heart, and can also enhance heart tissue phospholipid levels in isoproterenol-induced cardiotoxic rats. Mangiferin has a cytotoprotective role against the neurotoxicity and cognitive impairment induced by aluminium chloride in male Swiss albino mice[1].

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[2]

- 合并
  • Cell lines: RAW 264.7 cells
  • Concentrations: 10, 20 and 40 μM
  • Incubation Time: 16 h
  • Method:

    RAW 264.7 cells are seeded in 6 well plates at a density of 2 × 105 cells/well and then pre-incubated with different concentrations of PT-Mangiferin (10, 20 and 40 μM). The cells are stimulated with LPS (1 μg/ml) for 16 h and then treated with 10 μM DCFH-DA (2',7'-dichlorodihydrofluorescein diacetate) and further incubated for 15 min at 37 °C. The cells are collected, washed with PBS and total of 10000 events are analyzed in FL1 channel by Flow cytometry.


    (Only for Reference)

溶解度 (25°C)

体外 DMSO 84 mg/mL (198.89 mM)

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 422.34
化学式

C19H18O11

CAS号 4773-96-0
储存条件 粉状
溶于溶剂
别名 Alpizarin, Chinomin, Hedysarid

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID