Nrf2

抑制剂选择性比较

Nrf2产品

所有产品 Nrf2抑制剂(2) Nrf2激活剂(8) 新Nrf2产品

目录号	产品描述	文献引用	实验数据
S8790	ML385 ML385是一种新型的、特异的NRF2抑制剂，IC50为1.9 μM。它能抑制NRF2的下游靶基因的表达。	Oxid Med Cell Longev, 2019, 2019:9719618 Oxid Med Cell Longev, 2019, 2019:2853534 Biomed Pharmacother, 2019, 109:254-261
S7956^New	Brustaol Brustaol，可分离自B. javanica果实，是一种NRF2抑制剂。
S1848	Curcumin Curcumin 是流行的印度香料姜黄的主要姜黄色素，属于姜科（Zingiberaceae）。它是p300 histone acetylatransferase（IC50~25 μM）和Histone deacetylase的抑制剂，能够激活Nrf2 pathway并抑制NF-κB的激活。	Biochim Biophys Acta Gene Regul Mech, 2019, 1862(8):834-845 Int Immunopharmacol, 2019, 69:213-216 Nat Commun, 2018, 9(1):2494
S7864	Oltipraz Oltipraz 是一种有效的 Nrf2 激活剂，也是一种有效的II期解毒酶诱导剂，显著作用于谷胱甘肽-S-转移酶(GST)。Phase 3。	Biomaterials, 2019, 219:119368 Free Radic Biol Med, 2019, 137:1-12 Inflammation, 2018, 41(3):948-958	Effects of p21 depletion and Nrf2 activation on dexamethasone-induced apoptosis in MC3T3-E1 cells. Cells were transfected with control siRNA or p21 siRNA. Subsequently, transfected cells were pre incubated with oltipraz (20 μM) for 1 h, and then co-incubated with 1 μM dexamethasone for 24 h. Apoptosis was measured by flow cytometry, followed by Annexin V-FITC/PI double staining. Effects of p21 depletion and Nrf2 activation on dexamethasone-induced apoptosis in MC3T3-E1 cells. Cells were transfected with control siRNA or p21 siRNA. Subsequently, transfected cells were pre-incubated with oltipraz (20 μM) for 1 h, and then co-incubated with 1 μM dexamethasone for 24 h. Apoptosis was measured by flow cytometry, followed by Annexin V-FITC/PI double staining.
S6647^New	Bardoxolone Bardoxolone通过从KEAP1释放Nrf2起作用，是Nrf2的激活剂，可以诱导癌细胞凋亡。
S5771	sulforaphane Sulforaphane是一种天然存在的异硫氰酸盐，存在于十字花科蔬菜如西兰花、卷心菜、羽衣甘蓝。它是Nrf2的诱导物。
S3784	Obacunone Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.
S4990	TBHQ Tert-butylhydroquinone (TBHQ)是一种抗氧化剂，用于阻止脂质过氧化，具有多种细胞保护作用。同时，它也是Nrf2的激活剂。	Biochim Biophys Acta Mol Basis Dis, 2019, 10.1016/j.bbadis.2018.12.007 Toxicol Lett, 2018, 295:88-98 Biomed Res Int, 2017, 2017:3754942
S5929	4-Octyl Itaconate 4-Octyl Itaconate激活Nrf2信号，在人类巨噬细胞和分离自全身性红斑狼疮患者的PBMC中抑制促炎性因子的产生。
S4712	Diethylmaleate Diethylmaleate是Nrf2的激活剂，是马来酸的二乙酯形式，能消耗谷胱甘肽并抑制NFkB。

目录号

产品描述

文献引用

实验数据

S8790

ML385

ML385是一种新型的、特异的NRF2抑制剂，IC50为1.9 μM。它能抑制NRF2的下游靶基因的表达。

Oxid Med Cell Longev,2019, 2019:9719618

Oxid Med Cell Longev,2019, 2019:2853534

Biomed Pharmacother,2019, 109:254-261

S7956^New

Brustaol

Brustaol，可分离自B. javanica果实，是一种NRF2抑制剂。

目录号	产品描述	文献引用	实验数据
S1848	Curcumin Curcumin 是流行的印度香料姜黄的主要姜黄色素，属于姜科（Zingiberaceae）。它是p300 histone acetylatransferase（IC50~25 μM）和Histone deacetylase的抑制剂，能够激活Nrf2 pathway并抑制NF-κB的激活。	Biochim Biophys Acta Gene Regul Mech, 2019, 1862(8):834-845 Int Immunopharmacol, 2019, 69:213-216 Nat Commun, 2018, 9(1):2494
S7864	Oltipraz Oltipraz 是一种有效的 Nrf2 激活剂，也是一种有效的II期解毒酶诱导剂，显著作用于谷胱甘肽-S-转移酶(GST)。Phase 3。	Biomaterials, 2019, 219:119368 Free Radic Biol Med, 2019, 137:1-12 Inflammation, 2018, 41(3):948-958	Effects of p21 depletion and Nrf2 activation on dexamethasone-induced apoptosis in MC3T3-E1 cells. Cells were transfected with control siRNA or p21 siRNA. Subsequently, transfected cells were pre incubated with oltipraz (20 μM) for 1 h, and then co-incubated with 1 μM dexamethasone for 24 h. Apoptosis was measured by flow cytometry, followed by Annexin V-FITC/PI double staining. Effects of p21 depletion and Nrf2 activation on dexamethasone-induced apoptosis in MC3T3-E1 cells. Cells were transfected with control siRNA or p21 siRNA. Subsequently, transfected cells were pre-incubated with oltipraz (20 μM) for 1 h, and then co-incubated with 1 μM dexamethasone for 24 h. Apoptosis was measured by flow cytometry, followed by Annexin V-FITC/PI double staining.
S6647^New	Bardoxolone Bardoxolone通过从KEAP1释放Nrf2起作用，是Nrf2的激活剂，可以诱导癌细胞凋亡。
S5771	sulforaphane Sulforaphane是一种天然存在的异硫氰酸盐，存在于十字花科蔬菜如西兰花、卷心菜、羽衣甘蓝。它是Nrf2的诱导物。
S3784	Obacunone Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.
S4990	TBHQ Tert-butylhydroquinone (TBHQ)是一种抗氧化剂，用于阻止脂质过氧化，具有多种细胞保护作用。同时，它也是Nrf2的激活剂。	Biochim Biophys Acta Mol Basis Dis, 2019, 10.1016/j.bbadis.2018.12.007 Toxicol Lett, 2018, 295:88-98 Biomed Res Int, 2017, 2017:3754942
S5929	4-Octyl Itaconate 4-Octyl Itaconate激活Nrf2信号，在人类巨噬细胞和分离自全身性红斑狼疮患者的PBMC中抑制促炎性因子的产生。
S4712	Diethylmaleate Diethylmaleate是Nrf2的激活剂，是马来酸的二乙酯形式，能消耗谷胱甘肽并抑制NFkB。