NF-κB

信号通路图

研究领域

抑制剂选择性比较

NF-κB产品

目录号 产品描述 文献引用 实验数据
S1013

Bortezomib (PS-341)

Bortezomib (PS-341)是有效的蛋白酶抑制剂,Ki为0.6 nM。它对肿瘤细胞表现出良好的选择性。Bortezomib (PS-341) 可抑制 NF-κB 并诱导 ERK 的磷酸化从而抑制cathepsin B并在卵巢癌和其他固体肿瘤中抑制自噬的催化过程。

S4902

QNZ (EVP4593)

QNZ (EVP4593)有效抑制NF-κB激活和TNF-α产生,在Jurkat T细胞中IC50分别为11 nM和7 nM。

S1623

Acetylcysteine(N-acetylcysteine)

Acetylcysteine(N-acetyl-l-cysteine)是ROS抑制剂,拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂,主要用作祛痰剂,可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用

S1848

Curcumin

Curcumin 是流行的印度香料姜黄的主要姜黄色素,属于姜科(Zingiberaceae)。它是p300 histone acetylatransferase(IC50~25 μM)和Histone deacetylase的抑制剂,能够激活Nrf2 pathway并抑制NF-κB的激活。

S4073

Sodium 4-Aminosalicylate

Sodium 4-Aminosalicylate是一种用于治疗肺结核的抗生素,通过NF-κB的抑制和自由基清除起作用。

S6671New

SN50

SN50是一种可渗透细胞的NF-κB抑制肽,由Kaposi成纤维细胞生长因子信号肽组成。SN50抑制NF-κB的活化并减轻呼吸机诱发的肺损伤。

S8941New

NIK SMI1

NIK SMI1是一种高效、高选择性的NF-κB-inducing kinase (NIK)抑制剂,抑制NIK催化ATP水解为ADP的Ki值为0.23 nM。

S6714New

INH14

INH14是TLR2介导的NF-kB激活抑制剂,对IKKα和IKKβ的IC50值分别为8.975 μM和3.598 μM。

S7351

JSH-23

JSH-23是一种NF-κB转录活性抑制剂,在RAW 264.7细胞系中IC50为7.1 μM。

S7414

Caffeic Acid Phenethyl Ester

Caffeic Acid Phenethyl Ester是强效的特异性NF-κB活化抑制剂,也能够表现出抗氧化、免疫调节和抗炎活动。

S3137

Sodium salicylate

Sodium salicylate用来作为镇痛药和退烧药,是一种非甾类消炎药 (NSAID), 在癌细胞中可以诱导细胞凋亡和坏死。在转染的T细胞中,Sodium salicylate可以抑制 NF-kappa B的激活, 也可以抑制依赖NF-kappa B 的转录,包括Ig kappa 增强子 以及 人类免疫缺陷病毒 (HIV) 长末端重复序列(LTR)。

S3939

4'-Methoxyresveratrol

4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum.

S4798

Benfotiamine

Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1) and has been investigated for the treatment and prevention of Diabetic Nephropathy and Diabetes Mellitus, Type 2.

S7672

Omaveloxolone (RTA-408)

Omaveloxolone (RTA-408)是一种合成的三萜类化合物,其激活细胞保护转录因子 Nrf2 并抑制 NF-κB 信号。Phase 2。

S3998

(+)-α-Lipoic acid

R(+)-α-lipoic acid是thioctic acid的生理形式之一,是一种强效的抗氧化剂,可减轻糖尿病神经性症状。它比其外消旋体具有更优越的抗氧化性。

S5144

Neferine

Neferine, a natural component of Nelumbo nucifera, has antitumor efficiency in cancer.

S9208

Ginsenoside Rb3

Ginsenoside Rb3 是从人参中提取的天然产物,在心血管疾病包括心肌的缺血/再灌注(I/R)损伤中起着重要作用。在人肾293T细胞中检测了Ginsenoside Rb3(0.1-10 μM)对肿瘤坏死因子TNF-α诱导的 nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) 荧光素酶报告基因的抑制作用,IC50值为8.2 μM。在用10 ng/mL TNF-α处理后的HepG2细胞中,Ginsenoside Rb3 还以剂量依赖性的方式抑制 cyclooxygenase-2 (COX-2)inducible nitric oxide synthase (iNOS) 信使mRNA的诱导诱导表达。

S3633

Pyrrolidinedithiocarbamate ammonium

Ammonium pyrrolidine dithiocarbamate (PDTC)是NF-κB的有效抑制剂,抑制IκB磷酸化、阻止NF-κB易位入核并减少下游细胞因子的表达。

S3816

Dehydroevodiamine

Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.

S9244

8-O-acetyl shanzhiside methyl ester

8-O-acetyl shanzhiside methyl ester, isolated from the leaves of Lamiophlomis rotata Kudo, promotes angiogenesis, which leads to the improvement of functional outcome after stroke.

S8484

GSK2982772

GSK2982772是receptor-interacting protein-1 (RIP1) kinase (RIPK1)的ATP竞争性抑制剂,IC50为16 nM。它能够抑制多种TNF依赖性的细胞反应,具有良好的激酶特异性和细胞活性。

S8642

GSK'963

GSK'963是RIP1 kinase (RIPK1)的手性小分子抑制剂,在FP结合实验中IC50值为29 nM。它对RIP1的选择性是对其他339种激酶的10,000倍以上。

S8261

GSK583

GSK583是一种高度有效的、选择性的RIP2激酶抑制剂,IC50为5 nM。

S2261

Andrographolide

Andrographolide是一种Labdane类二萜,是药用植物Andrographis paniculata的主要生物活性成分

S2382

Evodiamine

Evodiamine 是Evodiae Fructus中提取的一种生物碱。它能通过抑制IkB kinase活性抑制NF-kB的激活。

S4937

4'-Hydroxychalcone

4'-Hydroxychalcone,存在于草药、香料和茶叶中,是一种刺甘草查尔酮。它具有多种生物活性,能够抑制TNF-α诱导的NF-κB通路激活、并激活BMP信号通路。

S9295

Dauricine

Dauricine, a plant metabolite isolated from the Asian vine Menispermum dauricum, plays a variety of biological roles in the human body, from inhibiting cancer cell growth to blocking cardiac transmembrane Na+, K+, and Ca2+ ion currents.

S5343

Vanillic acid

Vanillic acid is a flavoring agent which is also an intermediate in the production of vanillin from ferulic acid.

S9193

Aristolochic acid A

Aristolochic acid A是一种致癌、致突变和具有肾毒性的试剂,来源于马兜铃科的开花植物。

S2313

Indole-3-carbinol

Indole-3-carbinol是通过降解硫代葡萄糖酸盐芸苔葡萄糖硫苷而来的,广泛存在于十字花科蔬菜中。它能够抑制NF-κBIκBα激酶的激活。

S9040

Maslinic acid

Maslinic Acid, a Natural Triterpene, exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating.

S7273

SC75741

SC75741 是强效的NF-κB抑制剂,其EC50为200 nM。

S3760

Stachydrine hydrochloride

Stachydrine is isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. It has potent anti-metastatic activity and cardioprotective effects.

S3770

Sodium Aescinate

Sodium aescinate (SA) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic.

S3771

Stachydrine

Stachydrine, also known as N,N-dimethylproline or proline betaine, is a quaternary ammonium derivative of proline that occurs widely in Medicago species. It is an osmoprotective compound found in urine.

S3773

Tyrosol

Tyrosol is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives.

S8483

CBL0137 HCl (CBL-0137 HCl)

CBL0137(CBL-0137)激活p53并抑制NF-kB,在细胞实验中,IC50分别为0.37 μM 和 0.47 μM。它还能抑制组蛋白分子伴侣FACT,FACT促进染色质转录复合体的形成。

S9388

(+)-Praeruptorin A

Praeruptorin A is a coumarin compound naturally occurring in the roots of Peucedanum praeruptorum Dunn., a commonly used traditional Chinese medicine for the treatment of certain respiratory diseases and hypertension. (+)-Praeruptorin A is one of enantiomers that shows more potent relaxant effects than (−)-praeruptorin A in rat aorta rings and may be an activator of eNOS.

S2321

Magnolol

Magnolol 是一种在Houpu magnolia (Magnolia officinalis) 树皮中发现的生物活性化合物。它能抑制TNFα诱导的NF-KB的激活。

S3874

Curcumenol

Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.

S1825

Erdosteine

Erdosteine 是一种祛痰剂,用于治疗过多粘稠的粘液。

S3880

Schisantherin A

Schisantherin A,也被称作Gomisin C,是一种五味子红素,具有止咳、镇静、消炎、抗骨质疏松、神经保护、增强认知和心脏保护活性。

S8341

TAK-243 (MLN7243)

TAK-243 (MLN7243)是有效的ubiquitin activating enzyme (UAE)抑制剂,在UBCH10 E2硫代酸酯测定中IC50为1 ± 0.2 nM。在激酶和受体库中的选择性检验中,它对脱靶靶点包括I型和II型人源碳酸酐酶的抑制作用微弱。TAK-243 (MLN7243)可诱导ER stress,抑制NFκB信号通路的激活并促进凋亡。

S4763

4-Hydroxychalcone

4-Hydroxychalcone is a chalcone metabolite with diverse biological activities. It inhibits TNFα-induced NF-κB pathway activation in a dose-dependent manner and also activates BMP signaling.

S9106

Eleutheroside E

Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.

S3808

Mangiferin

Mangiferin is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements.

S2341

(-)-Parthenolide

(-)-Parthenolide, Nuclear Factor-κB抑制剂,可特异性地耗尽HDAC1蛋白,而不影响其他I/II类 HDACs。促进MDM2的泛素化并激活p53的细胞功能。

S3604

Triptolide (PG490)

Triptolide (PG490) 是一种三环氧二萜类化合物,是从中草药雷公藤中提取的免疫抑制剂。它是一种NF-κB抑制剂,抑制NF-κB转录活性,破坏p65/CBP的相互作用,减少p65蛋白。

S3811

Ginsenoside Re

Ginsenoside Re (Ginsenoside B2) 是三七的提取物、人参中的主要人参皂苷,属于20(S)-原人参三醇组 (protopanaxatriol group)。它具有多种体外和体内作用,包括血管舒张作用,抗氧化剂,抗高血脂和血管生成作用。Ginsenoside Re 会降低 β-amyloid protein (Aβ) 并通过抑制 JNKNF-κB 起到抗炎的作用。

S3138

Methylthiouracil

Methylthiouracil 是一种抗甲状腺制剂,可以减少存储甲状腺激素的形成以及甲状腺中的甲状腺球蛋白。Methylthiouracil也与放射性碘联用。

S3899

Hederagenin

Hederagenin is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo.

S5453

Hyperoside

Hyperoside, a naturally occuring flavonoid compound, exerts multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.

S3867

(E)-Cardamonin

Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.

S3872

Guaiacol

Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. It is a precursor to various flavorants, such as eugenoland vanillin.

S4712

Diethylmaleate

Diethylmaleate是Nrf2的激活剂,是马来酸的二乙酯形式,能消耗谷胱甘肽并抑制NFkB。

S9170

Engeletin

Engeletin, a bioactive flavonoid, has multiple biological activities such as anti-diabetic and anti-inflammatory effects.

S3923

Ginsenoside Rg1

Ginsenoside Rg1 是人参的主要活性成分之一,被确定为原人参三醇型,对多种癌症具有药理作用,例如神经保护和抗肿瘤作用。Ginsenoside Rg1 可降低 cerebral Aβ 水平并减少 NF-κB 核转移。

S3924

Ginsenoside Rb1

Ginsenoside Rb1 is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.

S3603

Betulinic acid

Betulinic acid是一种天然的五环三萜类化合物,具有抗病毒,抗疟药,抗发炎和抗肿瘤的特性。Betulinic acid也是 NF-kB 的活化剂。Phase 1/2

S5804

N-Acetylcysteine amide

N-acetylcysteine amide是一种能穿透细胞膜的抗氧化剂,具有消炎活性,能够调节NF-κB的激活、HIF-1α和ROS。

S2371

Vanillylacetone

Vanillylacetone在化学结构上与其他香料,如Vanillin 和 Eugenol类似,用来作为一种香味味添加剂。

目录号 产品描述 文献引用 实验数据
S1013

Bortezomib (PS-341)

Bortezomib (PS-341)是有效的蛋白酶抑制剂,Ki为0.6 nM。它对肿瘤细胞表现出良好的选择性。Bortezomib (PS-341) 可抑制 NF-κB 并诱导 ERK 的磷酸化从而抑制cathepsin B并在卵巢癌和其他固体肿瘤中抑制自噬的催化过程。

S4902

QNZ (EVP4593)

QNZ (EVP4593)有效抑制NF-κB激活和TNF-α产生,在Jurkat T细胞中IC50分别为11 nM和7 nM。

S1623

Acetylcysteine(N-acetylcysteine)

Acetylcysteine(N-acetyl-l-cysteine)是ROS抑制剂,拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂,主要用作祛痰剂,可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用

S1848

Curcumin

Curcumin 是流行的印度香料姜黄的主要姜黄色素,属于姜科(Zingiberaceae)。它是p300 histone acetylatransferase(IC50~25 μM)和Histone deacetylase的抑制剂,能够激活Nrf2 pathway并抑制NF-κB的激活。

S4073

Sodium 4-Aminosalicylate

Sodium 4-Aminosalicylate是一种用于治疗肺结核的抗生素,通过NF-κB的抑制和自由基清除起作用。

S6671New

SN50

SN50是一种可渗透细胞的NF-κB抑制肽,由Kaposi成纤维细胞生长因子信号肽组成。SN50抑制NF-κB的活化并减轻呼吸机诱发的肺损伤。

S8941New

NIK SMI1

NIK SMI1是一种高效、高选择性的NF-κB-inducing kinase (NIK)抑制剂,抑制NIK催化ATP水解为ADP的Ki值为0.23 nM。

S6714New

INH14

INH14是TLR2介导的NF-kB激活抑制剂,对IKKα和IKKβ的IC50值分别为8.975 μM和3.598 μM。

S7351

JSH-23

JSH-23是一种NF-κB转录活性抑制剂,在RAW 264.7细胞系中IC50为7.1 μM。

S7414

Caffeic Acid Phenethyl Ester

Caffeic Acid Phenethyl Ester是强效的特异性NF-κB活化抑制剂,也能够表现出抗氧化、免疫调节和抗炎活动。

S3137

Sodium salicylate

Sodium salicylate用来作为镇痛药和退烧药,是一种非甾类消炎药 (NSAID), 在癌细胞中可以诱导细胞凋亡和坏死。在转染的T细胞中,Sodium salicylate可以抑制 NF-kappa B的激活, 也可以抑制依赖NF-kappa B 的转录,包括Ig kappa 增强子 以及 人类免疫缺陷病毒 (HIV) 长末端重复序列(LTR)。

S3939

4'-Methoxyresveratrol

4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum.

S4798

Benfotiamine

Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1) and has been investigated for the treatment and prevention of Diabetic Nephropathy and Diabetes Mellitus, Type 2.

S7672

Omaveloxolone (RTA-408)

Omaveloxolone (RTA-408)是一种合成的三萜类化合物,其激活细胞保护转录因子 Nrf2 并抑制 NF-κB 信号。Phase 2。

S3998

(+)-α-Lipoic acid

R(+)-α-lipoic acid是thioctic acid的生理形式之一,是一种强效的抗氧化剂,可减轻糖尿病神经性症状。它比其外消旋体具有更优越的抗氧化性。

S5144

Neferine

Neferine, a natural component of Nelumbo nucifera, has antitumor efficiency in cancer.

S9208

Ginsenoside Rb3

Ginsenoside Rb3 是从人参中提取的天然产物,在心血管疾病包括心肌的缺血/再灌注(I/R)损伤中起着重要作用。在人肾293T细胞中检测了Ginsenoside Rb3(0.1-10 μM)对肿瘤坏死因子TNF-α诱导的 nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) 荧光素酶报告基因的抑制作用,IC50值为8.2 μM。在用10 ng/mL TNF-α处理后的HepG2细胞中,Ginsenoside Rb3 还以剂量依赖性的方式抑制 cyclooxygenase-2 (COX-2)inducible nitric oxide synthase (iNOS) 信使mRNA的诱导诱导表达。

S3633

Pyrrolidinedithiocarbamate ammonium

Ammonium pyrrolidine dithiocarbamate (PDTC)是NF-κB的有效抑制剂,抑制IκB磷酸化、阻止NF-κB易位入核并减少下游细胞因子的表达。

S3816

Dehydroevodiamine

Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.

S9244

8-O-acetyl shanzhiside methyl ester

8-O-acetyl shanzhiside methyl ester, isolated from the leaves of Lamiophlomis rotata Kudo, promotes angiogenesis, which leads to the improvement of functional outcome after stroke.

S8484

GSK2982772

GSK2982772是receptor-interacting protein-1 (RIP1) kinase (RIPK1)的ATP竞争性抑制剂,IC50为16 nM。它能够抑制多种TNF依赖性的细胞反应,具有良好的激酶特异性和细胞活性。

S8642

GSK'963

GSK'963是RIP1 kinase (RIPK1)的手性小分子抑制剂,在FP结合实验中IC50值为29 nM。它对RIP1的选择性是对其他339种激酶的10,000倍以上。

S8261

GSK583

GSK583是一种高度有效的、选择性的RIP2激酶抑制剂,IC50为5 nM。

S2261

Andrographolide

Andrographolide是一种Labdane类二萜,是药用植物Andrographis paniculata的主要生物活性成分

S2382

Evodiamine

Evodiamine 是Evodiae Fructus中提取的一种生物碱。它能通过抑制IkB kinase活性抑制NF-kB的激活。

S4937

4'-Hydroxychalcone

4'-Hydroxychalcone,存在于草药、香料和茶叶中,是一种刺甘草查尔酮。它具有多种生物活性,能够抑制TNF-α诱导的NF-κB通路激活、并激活BMP信号通路。

S9295

Dauricine

Dauricine, a plant metabolite isolated from the Asian vine Menispermum dauricum, plays a variety of biological roles in the human body, from inhibiting cancer cell growth to blocking cardiac transmembrane Na+, K+, and Ca2+ ion currents.

S5343

Vanillic acid

Vanillic acid is a flavoring agent which is also an intermediate in the production of vanillin from ferulic acid.

S9193

Aristolochic acid A

Aristolochic acid A是一种致癌、致突变和具有肾毒性的试剂,来源于马兜铃科的开花植物。

S2313

Indole-3-carbinol

Indole-3-carbinol是通过降解硫代葡萄糖酸盐芸苔葡萄糖硫苷而来的,广泛存在于十字花科蔬菜中。它能够抑制NF-κBIκBα激酶的激活。

S9040

Maslinic acid

Maslinic Acid, a Natural Triterpene, exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating.

S7273

SC75741

SC75741 是强效的NF-κB抑制剂,其EC50为200 nM。

S3760

Stachydrine hydrochloride

Stachydrine is isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. It has potent anti-metastatic activity and cardioprotective effects.

S3770

Sodium Aescinate

Sodium aescinate (SA) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic.

S3771

Stachydrine

Stachydrine, also known as N,N-dimethylproline or proline betaine, is a quaternary ammonium derivative of proline that occurs widely in Medicago species. It is an osmoprotective compound found in urine.

S3773

Tyrosol

Tyrosol is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives.

S8483

CBL0137 HCl (CBL-0137 HCl)

CBL0137(CBL-0137)激活p53并抑制NF-kB,在细胞实验中,IC50分别为0.37 μM 和 0.47 μM。它还能抑制组蛋白分子伴侣FACT,FACT促进染色质转录复合体的形成。

S9388

(+)-Praeruptorin A

Praeruptorin A is a coumarin compound naturally occurring in the roots of Peucedanum praeruptorum Dunn., a commonly used traditional Chinese medicine for the treatment of certain respiratory diseases and hypertension. (+)-Praeruptorin A is one of enantiomers that shows more potent relaxant effects than (−)-praeruptorin A in rat aorta rings and may be an activator of eNOS.

S2321

Magnolol

Magnolol 是一种在Houpu magnolia (Magnolia officinalis) 树皮中发现的生物活性化合物。它能抑制TNFα诱导的NF-KB的激活。

S3874

Curcumenol

Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.

S1825

Erdosteine

Erdosteine 是一种祛痰剂,用于治疗过多粘稠的粘液。

S3880

Schisantherin A

Schisantherin A,也被称作Gomisin C,是一种五味子红素,具有止咳、镇静、消炎、抗骨质疏松、神经保护、增强认知和心脏保护活性。

S8341

TAK-243 (MLN7243)

TAK-243 (MLN7243)是有效的ubiquitin activating enzyme (UAE)抑制剂,在UBCH10 E2硫代酸酯测定中IC50为1 ± 0.2 nM。在激酶和受体库中的选择性检验中,它对脱靶靶点包括I型和II型人源碳酸酐酶的抑制作用微弱。TAK-243 (MLN7243)可诱导ER stress,抑制NFκB信号通路的激活并促进凋亡。

S4763

4-Hydroxychalcone

4-Hydroxychalcone is a chalcone metabolite with diverse biological activities. It inhibits TNFα-induced NF-κB pathway activation in a dose-dependent manner and also activates BMP signaling.

S9106

Eleutheroside E

Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.

S3808

Mangiferin

Mangiferin is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements.

S2341

(-)-Parthenolide

(-)-Parthenolide, Nuclear Factor-κB抑制剂,可特异性地耗尽HDAC1蛋白,而不影响其他I/II类 HDACs。促进MDM2的泛素化并激活p53的细胞功能。

S3604

Triptolide (PG490)

Triptolide (PG490) 是一种三环氧二萜类化合物,是从中草药雷公藤中提取的免疫抑制剂。它是一种NF-κB抑制剂,抑制NF-κB转录活性,破坏p65/CBP的相互作用,减少p65蛋白。

S3811

Ginsenoside Re

Ginsenoside Re (Ginsenoside B2) 是三七的提取物、人参中的主要人参皂苷,属于20(S)-原人参三醇组 (protopanaxatriol group)。它具有多种体外和体内作用,包括血管舒张作用,抗氧化剂,抗高血脂和血管生成作用。Ginsenoside Re 会降低 β-amyloid protein (Aβ) 并通过抑制 JNKNF-κB 起到抗炎的作用。

S3138

Methylthiouracil

Methylthiouracil 是一种抗甲状腺制剂,可以减少存储甲状腺激素的形成以及甲状腺中的甲状腺球蛋白。Methylthiouracil也与放射性碘联用。

S3899

Hederagenin

Hederagenin is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo.

S5453

Hyperoside

Hyperoside, a naturally occuring flavonoid compound, exerts multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.

S3867

(E)-Cardamonin

Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.

S3872

Guaiacol

Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. It is a precursor to various flavorants, such as eugenoland vanillin.

S4712

Diethylmaleate

Diethylmaleate是Nrf2的激活剂,是马来酸的二乙酯形式,能消耗谷胱甘肽并抑制NFkB。

S9170

Engeletin

Engeletin, a bioactive flavonoid, has multiple biological activities such as anti-diabetic and anti-inflammatory effects.

S3923

Ginsenoside Rg1

Ginsenoside Rg1 是人参的主要活性成分之一,被确定为原人参三醇型,对多种癌症具有药理作用,例如神经保护和抗肿瘤作用。Ginsenoside Rg1 可降低 cerebral Aβ 水平并减少 NF-κB 核转移。

S3924

Ginsenoside Rb1

Ginsenoside Rb1 is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.

目录号 产品描述 文献引用 实验数据
S3603

Betulinic acid

Betulinic acid是一种天然的五环三萜类化合物,具有抗病毒,抗疟药,抗发炎和抗肿瘤的特性。Betulinic acid也是 NF-kB 的活化剂。Phase 1/2

目录号 产品描述 文献引用 实验数据
S5804

N-Acetylcysteine amide

N-acetylcysteine amide是一种能穿透细胞膜的抗氧化剂,具有消炎活性,能够调节NF-κB的激活、HIF-1α和ROS。

目录号 产品描述 文献引用 实验数据
S2371

Vanillylacetone

Vanillylacetone在化学结构上与其他香料,如Vanillin 和 Eugenol类似,用来作为一种香味味添加剂。