Bortezomib (PS-341)

For research use only. Not for use in humans.

目录号:S1013 别名: LDP-341, MLM341

Bortezomib (PS-341) Chemical Structure

Molecular Weight(MW): 384.24

Bortezomib (PS-341)是有效的蛋白酶抑制剂,Ki为0.6 nM。它对肿瘤细胞表现出良好的选择性。Bortezomib (PS-341) 可抑制 NF-κB 并诱导 ERK 的磷酸化从而抑制cathepsin B并在卵巢癌和其他固体肿瘤中抑制自噬的催化过程。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 749.39 现货
RMB 571.94 现货
RMB 2188.92 现货
RMB 5488.32 现货
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客户使用Selleck生产的Bortezomib (PS-341)发表文献526篇:

产品安全说明书

Proteasome抑制剂选择性比较

生物活性

产品描述 Bortezomib (PS-341)是有效的蛋白酶抑制剂,Ki为0.6 nM。它对肿瘤细胞表现出良好的选择性。Bortezomib (PS-341) 可抑制 NF-κB 并诱导 ERK 的磷酸化从而抑制cathepsin B并在卵巢癌和其他固体肿瘤中抑制自噬的催化过程。
靶点
20S proteasome [1]
(Cell-free assay)
0.6 nM(Ki)
体外研究

Bortezomib,一种硼酸二肽,是一种26S蛋白酶体的高选择性可逆抑制剂,其作用于错误折叠蛋白的降解,并且对细胞周期的调控是必要的。暴露于Bortezomib能够稳定p21,p27,和p53,以及促凋亡Bid和Bax蛋白,微囊蛋白-1,和抑制剂κB-α,这防止了核因子κB诱导的细胞存活途径的激活。Bortezomib也会促进促凋亡c-Jun-NH2末端激酶,以及内质网应激反应的激活。这些细胞蛋白水平的改变导致对增殖,迁移的抑制,和癌细胞凋亡的促进。[2] Bortezomib能够渗透到细胞,并抑制蛋白酶体介导的细胞内长寿蛋白水解,抑制50%蛋白质水解的浓度为∼0.1 μM。Bortezomib对衍生自美国国家癌症研究所(NCI)多重人类肿瘤的一组60个癌细胞系的IC50值为7 nM。PC-3细胞用Bortezomib (100 nM)处理8小时导致细胞积聚在G2-M期,相应的G1期细胞数量减少。Bortezomib在24和48小时杀死PC-3细胞,IC50分别为100和20 nM。Bortezomib治疗16-24小时后诱导细胞核缩合。Bortezomib在低至100 nM浓度下以时间依赖的方式导致PARP裂解,在处理24小时后产生效果。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF-7 NUW4UHk5S3m2b4TvfIlkKEG|c3H5 MnHaOVAh|ryP M1SxbFQ5KGh? NIHmc3dFVVOR NF;jW2NMcWyuczDj[YxteyCkeTDtc5JmKHSqYX6gPVkm MoS3NVA1QTl4NEO=
OVCA 429 NWfKd3R1TnWwY4Tpc44hSXO|YYm= NUDsbI1NOzByIH7N M3vpO|Q5KGh? NXjSc4d3TE2VTx?= NUX5NJczTGm|coXweJMhcW62YXP0JI12dHSrY3XscJVt[XJidIXtc5Ihe3CqZYLvbYR{ NH;jUJUyODl7OUe2Oi=>
RPMI8226 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;2TXZ1OTByIH7N NHvSNW41QCCq NFnab5VFVVOR M3zYZ2lEPTB;M{Cgcm0> M{ToS|EyOzB4NEi5
Dox40 NV3wbph{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr0SXF6OTByIH7N NF[wXnA1QCCq NWTmXWlHTE2VTx?= NHnWbWlKSzVyPUSwJI5O Mnm1NVE{ODZ2OEm=
MR20 NUnJcJVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfoeWZtOTByIH7N NFj6cXo1QCCq M3jLWGROW09? MkjMTWM2OD1{MDDuUS=> M3fRVVEyOzB4NEi5
LR5 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkm3NVAxKG6P M3rTTlQ5KGh? Mn7oSG1UVw>? MWLJR|UxRTJyIH7N NXfD[ItoOTF|ME[0PFk>
U266 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX:xNFAhdk1? M3zkXlQ5KGh? M3rNNmROW09? NVrVSIhGUUN3ME2zJI5O NVTXVYFNOTF|ME[0PFk>
IM-9 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPkbItnOTByIH7N M{\2WFQ5KGh? MXvEUXNQ MYTJR|UxRTZibl2= NE\4dlEyOTNyNkS4PS=>
Hs Sultan M3XMWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTHNVAxKG6P NGHufnE1QCCq NX3QV|dQTE2VTx?= Moq4TWM2OD1{MDDuUS=> NX;xN2NVOTF|ME[0PFk>
PAM-LY2 NH;uV2tHfW6ldHnvckBCe3OjeR?= MnrTNVAxKG6P NYnNR|dLOTJiaB?= NX\wWG1lTE2VTx?= MVvJcohq[mm2czDOSk3PwkJiYXP0bZZifGmxbh?= NXi0b5V2OTF|NUC5NVM>
PAM 212 NET1RotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTNNVAxKG6P M4X4V|czKGh? MVnEUXNQ NF3tfYVKdmirYnn0d{Bk\WyuII\pZYJqdGm2eR?= NVL3[WdOOTF|NUC5NVM>
PAM-LY2 NWrIfW1HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\0NVAxKG6P NUG3b2pOPzJiaB?= MmO4SG1UVw>? MVLJcohq[mm2czDj[YxtKH[rYXLpcIl1gQ>? NEPwN3gyOTN3MEmxNy=>
B4B8 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG0doppOTByIH7N MmHyO|IhcA>? Mn7ISG1UVw>? MVzJcohq[mm2czDj[YxtKH[rYXLpcIl1gQ>? MnX4NVE{PTB7MUO=
B7E3 MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYixNFAhdk1? NH;iWGM4OiCq NVPoXXdxTE2VTx?= MXzJcohq[mm2czDj[YxtKH[rYXLpcIl1gQ>? MYWxNVM2ODlzMx?=
UM-SCC-9 NF3RUo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzSXIMyODBibl2= MkPNO|IhcA>? NYTkfnEzTE2VTx?= MWPJcohq[mm2czDj[YxtKH[rYXLpcIl1gQ>? M4jXNFEyOzVyOUGz
UM-SCC-11B M{\OV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVqxNFAhdk1? MXW3NkBp MkTGSG1UVw>? MnHvTY5pcWKrdIOgZ4VtdCC4aXHibYxqfHl? MoTGNVE{PTB7MUO=
H460 Ml20SpVv[3Srb36gRZN{[Xl? MlfVNVAh|ryP MnTpNlQhcA>? M3q2N2ROW09? NYHxV3JpUW6mdXPld{BD[2xvMjDwbI9{eGixconsZZRqd25iYX7kJINt\WG4YXflJINwenKnbHH0[YQhf2m2aDDHNk1OKHCqYYPlJIFzemW|dB?= NF\zNmUyOjR7MkGxOy=>
U266 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrY[4Z7PTByIH7nM41t NX23eIoyPDhiaB?= MUHEUXNQ MV7Jcohq[mm2czDj[YxtKGe{b4f0bC=> MUGxNlY{OTZzOR?=
ARH77 NG\XOZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jUPVUxOCCwZz;tcC=> MUW0PEBp NFj0d5lFVVOR NWDndI9jUW6qaXLpeJMh[2WubDDndo94fGh? NX3PVFdNOTJ4M{G2NVk>
WAD-1 MoPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jEdFUxOCCwZz;tcC=> NF3pVFc1QCCq M3rUZ2ROW09? MVvJcohq[mm2czDj[YxtKGe{b4f0bC=> M3n0dVEzPjNzNkG5
U266/LR7 Mn7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXK1NFAhdmdxbXy= MkKxOFghcA>? MVjEUXNQ MYXJcohq[mm2czDj[YxtKGe{b4f0bC=> Ml7GNVI3OzF4MUm=
U266/dox4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXyOVAxKG6pL33s M2nDU|Q5KGh? Mn;ZSG1UVw>? M{LNc2lvcGmkaYTzJINmdGxiZ4Lve5Rp NELl[pMyOjZ|MU[xPS=>
RPMI8226/LR5 NYPhWWRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\0OVAxKG6pL33s NEKzOmU1QCCq MoHWSG1UVw>? NFTr[3JKdmirYnn0d{Bk\WyuIHfyc5d1cA>? MkL2NVI3OzF4MUm=
H460 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonKNVAh|ryP NWC0bYoyPzJiaB?= MkXHSG1UVw>? NFzxZpdKSzVyPUGwNEBvVQ>? MVixNlY{OTZ{MB?=
H358 M4q0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYWxNEDPxE1? NUDESFFZPzJiaB?= MmHvSG1UVw>? M2e0cWlEPTB;N{Cgcm0> NYKxToNLOTJ4M{G2NlA>
H322 NI\XNnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYWxNEDPxE1? NIn6NXE4OiCq MXvEUXNQ MnPaTWM2OD14MkCgcm0> Mmn6NVI3OzF4MkC=
H460 M4CyfmZ2dmO2aX;uJGF{e2G7 MoLLNVAxKG6P MWiyOEBp MmHKSG1UVw>? NHHsXGxKdmS3Y3XzJGczNU1vcHjhd4Uh[XK{ZYP0JIFv\CC2dXL1cIlvKGG|c3XtZox6NWSrc3Hzd4Vu[my7 NHHKOVkyOjZ|MU[yNC=>
LNCap-Pro5 MljDSpVv[3Srb36gRZN{[Xl? M3frVFEh|ryP M4PRUVQhcA>? NES1bHZFVVOR MYnTeIFjcWyrenXzJJA2Ow>? NYnqVI1OOTR4MUK1N|I>
T29 NEHoOmNCeG:ydH;zbZMhSXO|YYm= Mo\XOVAhdk1? MXi0PEBpKA>? M2rtdGROW09? NHvTeY5KdmS3Y3XzJINmdGxiYYDvdJRwe2m| MmfNNVY4PzhzN{m=
T29Kt1 MVTBdI9xfG:|aYOgRZN{[Xl? MnfjOVAhdk1? MoK1OFghcCB? NYLvSHRnTE2VTx?= MX\JcoR2[2W|IHPlcIwh[XCxcITvd4l{ MljxNVY4PzhzN{m=
HCT116 MlTVRZBweHSxc3nzJGF{e2G7 M2iwOFUxKG6P NUHteZNpPDhiaDC= NHnHXotFVVOR M2KybWlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? NXXSb4I3OTZ5N{ixO|k>
HKe-3 NWrNdYtGSXCxcITvd4l{KEG|c3H5 NYTJZ3kzPTBibl2= MWq0PEBpKA>? MkixSG1UVw>? MV3JcoR2[2W|IHPlcIwh[XCxcITvd4l{ NHz0XFAyPjd5OEG3PS=>
NB-1691 NITz[nRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn0OWMyKM7:TR?= M3rtT|czKGh? NVHzPFlvUW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9vKHSxIEWl M4DJdVE4Pjh7Nki0
CHLA-255 M2nIXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDDNUDPxE1? MVe3NkBp NH7EfpZKdmirYnn0d{Bk\WyuIIDyc4xq\mW{YYTpc44hfG9iMjW= NUW5d2tmOTd4OEm2PFQ>
SK-N-AS NFnyTnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLGNUDPxE1? NFTUblQ4OiCq MVzJcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36geI8hOTBn MVSxO|Y5QTZ6NB?=
NB-1691 MUTGeY5kfGmxbjDBd5NigQ>? M3y1SFExKG6P MknUNlQhcA>? Mn\MV4lodmmoaXPhcpRtgSC{ZXT1Z4V{KGOnbHzzJIlvKHSqZTDHNE9IOSCyaHHz[S=> NG\xZ4syPzZ6OU[4OC=>
CHLA-255 MnO2SpVv[3Srb36gRZN{[Xl? MXixNEBvVQ>? MX2yOEBp MYPNc4Rme3SueTDy[YR2[2W|IHPlcIx{KGmwIITo[UBIOC:JMTDwbIF{\Q>? NWH6OpkzOTd4OEm2PFQ>
RPMI 8226 NGTGb5JHfW6ldHnvckBCe3OjeR?= NUfMd3FzOjBibl2= NFfCPG85KGh? NIjUS21UcWewaX\pZ4FvfGy7IHXubIFv[2W|IF7GMe67SiCjY4Tpeol1gQ>? NIjiPW8yQTR|NkC1NC=>
MM.1S M{DBbmZ2dmO2aX;uJGF{e2G7 MmPWNlAhdk1? NUnOWW53QCCq M1HN[XNq\26rZnnjZY51dHliZX7oZY5k\XNiTl[t{tpDKGGldHn2bZR6 MXOxPVQ{PjB3MB?=
U266 MYfGeY5kfGmxbjDBd5NigQ>? NUfoWYhVOjBibl2= NIXIdmI5KGh? MlPBV4lodmmoaXPhcpRtgSCnbnjhcoNmeyCQRj5OvmIh[WO2aY\peJk> NFLhXFgyQTR|NkC1NC=>
OPM1 M3XKemZ2dmO2aX;uJGF{e2G7 M1u0flIxKG6P NFPUdY05KGh? NUHPSnE2W2mpbnnmbYNidnSueTDlcohidmOnczDOSk3PwkJiYXP0bZZqfHl? M2\GPVE6PDN4MEWw
INA6 MVLGeY5kfGmxbjDBd5NigQ>? NVK4eWNEOjBibl2= MnnmPEBp MXfTbYdvcW[rY3HueIx6KGWwaHHuZ4V{KE6ILd86RkBi[3Srdnn0fS=> MmXpNVk1OzZyNUC=
OPM2 MVzGeY5kfGmxbjDBd5NigQ>? MnnXNlAhdk1? NGDjc4M5KGh? NHPuepFUcWewaX\pZ4FvfGy7IHXubIFv[2W|IF7GMe67SiCjY4Tpeol1gQ>? MmLmNVk1OzZyNUC=
RPMI 8226 NInGdIxHfW6ldHnvckBCe3OjeR?= NXzVNpRSOjBibl2= NHu2VmY5KGh? M3fsUWlv\HWlZYOgSG5CKHO7boTo[ZNqew>? Mk\ENVk1OzZyNUC=
BaF/3 M2HGdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3UUYFIOTByIH7N M3vhTlQ5KGh? NGnqbW5KSzVyPU[uNkBvVQ>? NXXRVpprOjB|MEW2PVI>
BaF/3-p210 M360[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXFWlUyODBibl2= MX60PEBp MUDJR|UxRTRwNzDuUS=> NHfBVmczODNyNU[5Ni=>
TCC-S MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLmNVAxKG6P MVy0PEBp MnqyTWM2OD1{Lkigcm0> M1fHfFIxOzB3Nkmy
BaF/3 MlziSpVv[3Srb36gRZN{[Xl? NFT5SYg3KG6P M1jhVFQ5KGh? NYrIZ29xUW6mdXPld{BiKGe{ZXH0JGcyKGOnbHytZ5lkdGViYYLy[ZN1 NECwR|IzODNyNU[5Ni=>
BaF/3-p210 M3vncGZ2dmO2aX;uJGF{e2G7 MUm2JI5O MV60PEBp MXXJcoR2[2W|IHGgd4xq\2i2IFexJINmdGxvY4njcIUh[XK{ZYP0 NHy1eHUzODNyNU[5Ni=>
BaF/3-p210 MXTGeY5kfGmxbjDBd5NigQ>? M4KwOFYhdk1? M2X0Z|I1KGh? M1j1WXJm\HWlZYOgeIhmKHCqb4PwbI9zgWyjdHnvckBidmRidHjlJIFkfGm4aYT5JI9nKFKk MWGyNFMxPTZ7Mh?=
Raji MonES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP5NUDPxE1? MY[yOEBp NIK3OHhT\WS3Y3XzJINmdGxidnnhZoltcXS7wrC= Ml3pNlEyPzB7OEi=
LCL-1 MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXexJO69VQ>? NFLweXozPCCq M3u1WnJm\HWlZYOgZ4VtdCC4aXHibYxqfHoEoB?= M4ewTFIyOTdyOUi4
LCL-2 NYHJTm4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[xJO69VQ>? NWrYb4E2OjRiaB?= M2S3PXJm\HWlZYOgZ4VtdCC4aXHibYxqfHoEoB?= NXy0NJJPOjFzN{C5PFg>
BJAB NHT1XGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDMNUDPxE1? MWeyOEBp MXTS[YR2[2W|IHPlcIwhfmmjYnnsbZR6yqB? NH\HWoIzOTF5MEm4PC=>
SNT-13 M37JbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUWxJO69VQ>? MkLUNlQhcA>? NUP2SGx5WmWmdXPld{Bk\WyuII\pZYJqdGm2edMg NXS4OpB6OjFzN{C5PFg>
SNT-16 M1HtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrZbZgyKM7:TR?= NVTBfI54OjRiaB?= NXHuUoZmWmWmdXPld{Bk\WyuII\pZYJqdGm2edMg MorKNlEyPzB7OEi=
Jurkat Ml[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXOxJO69VQ>? NXHJT5BbOjRiaB?= MV7S[YR2[2W|IHPlcIwhfmmjYnnsbZR6yqB? NIHX[FkzOTF5MEm4PC=>
KAI-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmSxNUDPxE1? MlH0NlQhcA>? NWjlTmM1WmWmdXPld{Bk\WyuII\pZYJqdGm2edMg M4f4UVIyOTdyOUi4
SNK-6 NYrFc3o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fSdlEh|ryP MXSyOEBp MnTDVoVlfWOnczDj[YxtKH[rYXLpcIl1gcLi NFOzdG8zOTF5MEm4PC=>
KHYG-1 MkHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUWxSmNwOSEQvF2= MnvoNlQhcA>? NVnXeYZtWmWmdXPld{Bk\WyuII\pZYJqdGm2edMg M33F[VIyOTdyOUi4
SNT-16 MmK0RZBweHSxc3nzJGF{e2G7 NXnqXXltOSEQvF2= M1TrU|YhcA>? M4\QVGlv\HWlZYOgZ4VtdCCjcH;weI9{cXN? MWeyNVE4ODl6OB?=
Jurkat MmPJRZBweHSxc3nzJGF{e2G7 NIDGdZMyKM7:TR?= NInuUWY3KGh? NYK2NWVSUW6mdXPld{Bk\WyuIHHwc5B1d3Orcx?= NIHTd2UzOTF5MEm4PC=>
KAI-3 NYTGWYp3SXCxcITvd4l{KEG|c3H5 M1zab|Eh|ryP Ml7WOkBp MlL5TY5lfWOnczDj[YxtKGGyb4D0c5Nqew>? MYqyNVE4ODl6OB?=
KHYG-1 MlfWRZBweHSxc3nzJGF{e2G7 NFi1c5cyKM7:TR?= MVK2JIg> NGHNN45KdmS3Y3XzJINmdGxiYYDvdJRwe2m| NE\lXVUzOTF5MEm4PC=>
SNT-13 Mm\uRY51cX[rcnHsJGF{e2G7 NYKweoJ1OSEQvF2= M3PvT|I1KGh? M3S5fGlv\HWlZYOgcJl1cWNiaX7m[YN1cW:wIH;mJGVDXg>? M1PUVFIyOTdyOUi4
SNT-16 M2PXU2FvfGm4aYLhcEBCe3OjeR?= NUDTVHR1OSEQvF2= Ml7mNlQhcA>? NYewcWdSUW6mdXPld{BtgXSrYzDpcoZm[3Srb36gc4YhTUKY NFXJN|QzOTF5MEm4PC=>
KAI-3 NUPhNYJQSW62aY\pdoFtKEG|c3H5 MonwNUDPxE1? MorQNlQhcA>? M1;xT2lv\HWlZYOgcJl1cWNiaX7m[YN1cW:wIH;mJGVDXg>? NGnMfY0zOTF5MEm4PC=>
SNK-6 NIG5SIlCdnSrdnnyZYwhSXO|YYm= MUOxJO69VQ>? Ml22NlQhcA>? NGDKfFlKdmS3Y3XzJIx6fGmlIHnu[oVkfGmxbjDv[kBGSlZ? NX[wOpFEOjFzN{C5PFg>
RAW 264.7 NGHZUHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M364elExOCCwTR?= NYHsZ3hTPDhiaB?= Mo\IVoVlfWOnczDj[YxtKH[rYXLpcIl1gcLi NF3UeVkzOjR{N{G1OC=>
A375 M2\NS2Fxd3C2b4Ppd{BCe3OjeR?= M4naOVExKG6P MWqyOEBp M3rDO2lv\HWlZYOgZ4VtdCCjcH;weI9{cXN? MonENlMxPzlyOEO=
BLM MXvBdI9xfG:|aYOgRZN{[Xl? MXGxNEBvVQ>? M2LZT|I1KGh? MWTJcoR2[2W|IHPlcIwh[XCxcITvd4l{ NIm1WogzOzB5OUC4Ny=>
A375 MlOzRZV1d3CqYXf5JGF{e2G7 NXrkSJNSOTBibl2= M1XTflEzKGh? M3u0bmlv\HWlZYOg[o9zdWG2aX;uJI9nKGG3dH;wbIFod3OxbXXz NX\yXoJ1OjNyN{mwPFM>
BLM MojwRZV1d3CqYXf5JGF{e2G7 MlHwNVAhdk1? NU\wc3J7OTJiaB?= M2ewO2lv\HWlZYOg[o9zdWG2aX;uJI9nKGG3dH;wbIFod3OxbXXz MXeyN|A4QTB6Mx?=
H1299 MXLBdI9xfG:|aYOgRZN{[Xl? MnHRPFAhdk1? M1X3PFI1KGh? NF;KNYVFVVOR MnzjV4Vve2m2aYrld{BPW0OOQzDj[YxteyC2bzDNV2Mu\GW{aY\l[EBqSzlvaX7keYNm\CCjcH;weI9{cXN? M3;CfFI2OzJ|Nkmz
Hut-78 M{S4PWZ2dmO2aX;uJGF{e2G7 M3XtT|ExOCCwTR?= M3z0ZlI1KGh? M1ezWGROW09? M1\leGRwf26{ZXf1cIF1\XNiVFfGMe6zOSCjbnSgTWwuOTBiZYjwdoV{e2mxbh?= NYXMNo1VOjV4OEGzN|U>
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HH MUTGeY5kfGmxbjDBd5NigQ>? MVexNFAhdk1? M3jjfFI1KGh? NVvyVZdDTE2VTx?= NYLXfHR{\G:5boLl[5Vt[XSnczDUS2Yu|rJzIHHu[EBKVC1zMjDlfJBz\XO|aX;u NVXtfpFlOjV4OEGzN|U>
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HH NUP1R|BMVWmpcnH0bY9vKEG|c3H5 M2DsUlExOCCwTR?= MWCyOEBp M{j2fGROW09? MlP6VoVlfWOnczDj[YxtKG2rZ4LheIlwdiCkeTC4NQKBmzlzJR?= MkfENlU3QDF|M{W=
U937 NULhO4VoTnWwY4Tpc44hSXO|YYm= NUjnTVdGOTByIH7N M3nGWlYhcA>? MojqTY5lfWOnczDJUE05KGW6cILld5Nqd25iaX6gUHBUNXO2aX31cIF1\WRiVUmzO{Bu[WO{b4DoZYdmew>? M1\OelI2PzlzNEe3
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ES6 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nkPWlEPTB;MD6wNFIyKG6P MmfWV2FPT0WU
SK-UT-1 MljMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jDPWlEPTB;MD6xOlMhdk1? MlrvV2FPT0WU
SH-4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMUezJI5O MkHwV2FPT0WU
TE-9 M4HPRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPuXFlKSzVyPUCuNVgzKG6P NUmwfXJGW0GQR1XS
A253 NWLXbo9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DVOmlEPTB;MD6yNFghdk1? MVPTRW5ITVJ?
no-10 NHLISWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HOU2lEPTB;MD6yNUBvVQ>? M1Ppe3NCVkeHUh?=
MMAC-SF M4GxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr0O|RKSzVyPUCuNlE3KG6P M3PIdnNCVkeHUh?=
A101D MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMkK1JI5O NGK3U4pUSU6JRWK=
NTERA-S-cl-D1 M4PBVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMkSzJI5O MlHYV2FPT0WU
8-MG-BA MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M175WmlEPTB;MD6yOUBvVQ>? MVPTRW5ITVJ?
KNS-42 NWn3V2hVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMkW4JI5O MV;TRW5ITVJ?
LXF-289 NEXRU5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEC0R4lKSzVyPUCuNlY6KG6P NGLIfHRUSU6JRWK=
OVCAR-4 NGfPbGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnLSVNKSzVyPUCuNlg6KG6P NHHkTopUSU6JRWK=
LOUCY NHjBRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofsTWM2OD1yLkK5N{BvVQ>? Mn3wV2FPT0WU
BB65-RCC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjCe|ZkUUN3ME2wMlMxPCCwTR?= NIXRXnRUSU6JRWK=
D-542MG MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwM{K5JI5O NYHYUmJXW0GQR1XS
ONS-76 NHn6dXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LjVWlEPTB;MD6zN{BvVQ>? NGDrSWlUSU6JRWK=
BB30-HNC MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfPOZFuUUN3ME2wMlM{PSCwTR?= MkKwV2FPT0WU
KS-1 NFT1SVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwM{Sgcm0> MVjTRW5ITVJ?
A388 Mn7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\jNWlEPTB;MD6zOVYhdk1? MoXhV2FPT0WU
ES8 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mly2TWM2OD1yLkSgcm0> MULTRW5ITVJ?
MZ2-MEL MlzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLvTWM2OD1yLkSwO{BvVQ>? NGHRWItUSU6JRWK=
HCC2998 MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zjcGlEPTB;MD60NVIhdk1? M1PLcHNCVkeHUh?=
D-247MG MmPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHmVZpKSzVyPUCuOFE{KG6P MmTQV2FPT0WU
ACN NF;nRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\iTWM2OD1yLkSxO{BvVQ>? MXTTRW5ITVJ?
LB2518-MEL MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm3TWM2OD1yLkSyOUBvVQ>? NGXU[XBUSU6JRWK=
ES1 NFLROXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn0fWtKSzVyPUCuOFMhdk1? Ml\qV2FPT0WU
HCE-T Mn7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV71SVJSUUN3ME2wMlQ{QSCwTR?= NGXRVYxUSU6JRWK=
OS-RC-2 M2rL[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3njUmlEPTB;MD60OEBvVQ>? MXjTRW5ITVJ?
MFH-ino Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LWbGlEPTB;MD60OFMhdk1? MXjTRW5ITVJ?
OCUB-M NGTZenpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDCOGhKSzVyPUCuOFQ4KG6P M3\tT3NCVkeHUh?=
CP66-MEL MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjudpJ{UUN3ME2wMlQ4OyCwTR?= NWrqfWRuW0GQR1XS
LB771-HNC NH\LblNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwNEe0JI5O NWLsTZJsW0GQR1XS
DSH1 MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVO4ToxkUUN3ME2wMlQ5KG6P MUDTRW5ITVJ?
HUTU-80 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{H6N2lEPTB;MD61N|Mhdk1? M{XO[HNCVkeHUh?=
CESS MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j0bWlEPTB;MD61N|ghdk1? NWntXnRCW0GQR1XS
NCI-H747 M{HucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rwcWlEPTB;MD61N|khdk1? MWHTRW5ITVJ?
HT-144 M3zpcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\nbmlEPTB;MD61O|Yhdk1? MV7TRW5ITVJ?
COLO-829 NHvRNoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHRVWgzUUN3ME2wMlYyPCCwTR?= NYjKSWtlW0GQR1XS
A4-Fuk NIfCe3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LQT2lEPTB;MD62NlMhdk1? MlfKV2FPT0WU
GI-ME-N MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLB[G9KSzVyPUCuOlM1KG6P M2nCb3NCVkeHUh?=
LB831-BLC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m5emlEPTB;MD62OFEhdk1? M2\ke3NCVkeHUh?=
HOP-62 NX7DPWhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlO0TWM2OD1yLk[0O{BvVQ>? MX3TRW5ITVJ?
BB49-HNC NVvtZoJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH0TWM2OD1yLk[1NkBvVQ>? NIjh[4ZUSU6JRWK=
D-336MG NYrlXXhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwNkW3JI5O NX;zNJlVW0GQR1XS
TK10 MmDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnKcFlKSzVyPUCuOlc6KG6P NFPsN3NUSU6JRWK=
Ramos-2G6-4C10 NUOxSGdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXXZndKSzVyPUCuOlk{KG6P MkixV2FPT0WU
LB373-MEL-D M3PBRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwNzDuUS=> MYLTRW5ITVJ?
SF126 M3PqeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXPfldMUUN3ME2wMlcxOSCwTR?= M4D5e3NCVkeHUh?=
UACC-257 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfhUodKSzVyPUCuO|Ehdk1? NVjl[nVoW0GQR1XS
KINGS-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HWfGlEPTB;MD63NlIhdk1? MX;TRW5ITVJ?
LS-513 NUPBXGlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13veGlEPTB;MD63N|khdk1? M3TDb3NCVkeHUh?=
GI-1 NEL3clJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwN{[0JI5O M2fkS3NCVkeHUh?=
ES7 NUfKT4V4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwN{[2JI5O M3u0SXNCVkeHUh?=
LB2241-RCC MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzJcWVxUUN3ME2wMlgxPCCwTR?= M2PwZXNCVkeHUh?=
D-263MG M37TU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz2TWM2OD1yLkiwO{BvVQ>? M{HFOXNCVkeHUh?=
SW684 NFPsdIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwOEKxJI5O MVXTRW5ITVJ?
ML-2 MnPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwOEKxJI5O MYTTRW5ITVJ?
SK-LMS-1 NHizfmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwOEW0JI5O M2XIUXNCVkeHUh?=
TE-5 MofZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwOE[1JI5O MmHYV2FPT0WU
QIMR-WIL MnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjjbXdKSzVyPUCuPFg6KG6P NFi4XJRUSU6JRWK=
NCI-H1355 NEHm[3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjsXFZRUUN3ME2wMlg6PSCwTR?= NVG2SWRmW0GQR1XS
SNB75 MlLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TrXmlEPTB;MD65NVIhdk1? MVvTRW5ITVJ?
RXF393 M32z[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33xZWlEPTB;MD65NVQhdk1? Mlj6V2FPT0WU
IST-MEL1 NF7tcnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjKOVVKSzVyPUCuPVE4KG6P NGXtSnVUSU6JRWK=
SF268 NX;WPJpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ruOmlEPTB;MD65NlMhdk1? NVvwU|FyW0GQR1XS
KALS-1 NXzTemR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYf1dpRmUUN3ME2wMlkzPSCwTR?= M3f0dnNCVkeHUh?=
HC-1 MmLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWThdVFnUUN3ME2wMlk4PSCwTR?= NU\wdZJRW0GQR1XS
SW872 MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLkSGVMUUN3ME2wMlk6PiCwTR?= NVH3bmRJW0GQR1XS
PSN1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX0cVZKSzVyPUGuNFEhdk1? MV;TRW5ITVJ?
TE-1 NWfre2hMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3GyT2lEPTB;MT6wN{BvVQ>? MX;TRW5ITVJ?
TE-10 MljMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TNc2lEPTB;MT6wN{BvVQ>? MlvCV2FPT0WU
RKO MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fOTmlEPTB;MT6wOkBvVQ>? MoT5V2FPT0WU
LC-2-ad MnW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;YdFFoUUN3ME2xMlA5KG6P MlnkV2FPT0WU
SK-MM-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW0b3FKSzVyPUGuNFkhdk1? NWPDbnBvW0GQR1XS
VA-ES-BJ MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;YeJNFUUN3ME2xMlA6KG6P MXzTRW5ITVJ?
MZ7-mel M4H5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1K2Z2lEPTB;MT6wPUBvVQ>? Mnv4V2FPT0WU
D-392MG NHr0So5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ryS2lEPTB;MT6xJI5O NXu5O2E{W0GQR1XS
CCRF-CEM NILwcHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTpTWM2OD1zLkGzJI5O NFrIVolUSU6JRWK=
EM-2 M{XSb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7aTWM2OD1zLkG2JI5O M3zldnNCVkeHUh?=
HAL-01 NV[ycXI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTDXGdDUUN3ME2xMlE5KG6P Mn7vV2FPT0WU
TE-8 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfkeHJwUUN3ME2xMlE6KG6P MXnTRW5ITVJ?
NCI-H1882 NXTBNnJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfvd41KSzVyPUGuNkBvVQ>? MX\TRW5ITVJ?
Daudi MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XhWWlEPTB;MT6yNkBvVQ>? M4LCSHNCVkeHUh?=
BL-41 M1\md2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTFwMkWgcm0> NHe4ZmhUSU6JRWK=
SR M2W0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTpemV[UUN3ME2xMlI2KG6P NIe3PI9USU6JRWK=
KM12 M1HaTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETGUHVKSzVyPUGuNlchdk1? MoDkV2FPT0WU
K5 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;ETWM2OD1zLkK4JI5O NHXKSY1USU6JRWK=
A3-KAW M{HCUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTFwMkigcm0> NGXC[|hUSU6JRWK=
CMK MoH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3TTWM2OD1zLkK5JI5O MXTTRW5ITVJ?
Calu-6 MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPtTWM2OD1zLkK5JI5O NUfq[5dNW0GQR1XS
IST-SL2 NHnmO4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4D4TmlEPTB;MT6zNUBvVQ>? NXHFc2lUW0GQR1XS
OPM-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTFwM{Ogcm0> MVrTRW5ITVJ?
DU-4475 MkDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HTVGlEPTB;MT6zOkBvVQ>? MYjTRW5ITVJ?
ECC12 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7oTWM2OD1zLkO3JI5O MX3TRW5ITVJ?
L-540 NGLRb4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rXdWlEPTB;MT6zO{BvVQ>? MmPUV2FPT0WU
CAS-1 NGTUeYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHLTWM2OD1zLkO3JI5O NU\YS|RYW0GQR1XS
PF-382 M4e0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jrbWlEPTB;MT60O{BvVQ>? M4fzS3NCVkeHUh?=
LS-411N NV7mSnJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTFwNUOgcm0> NXv3R4FCW0GQR1XS
NCI-H69 MlLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe5bFgzUUN3ME2xMlU1KG6P M4rZPXNCVkeHUh?=
NB12 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\uTWM2OD1zLkW2JI5O MXPTRW5ITVJ?
HEL MnvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13STWlEPTB;MT62NUBvVQ>? NV;zWZV5W0GQR1XS
GCIY M4\YXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fifGlEPTB;MT62NkBvVQ>? Moj1V2FPT0WU
EHEB MmfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTFwNkegcm0> M3e0VXNCVkeHUh?=
TGBC1TKB MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjlU2FKSzVyPUGuO|Ehdk1? NUjWWWF5W0GQR1XS
KURAMOCHI Mo\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXSWZJHUUN3ME2xMlczKG6P M4TmVXNCVkeHUh?=
U-266 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TMeGlEPTB;MT63OkBvVQ>? MWjTRW5ITVJ?
LC4-1 MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFwN{mgcm0> MUTTRW5ITVJ?
NCI-H2126 M4\YWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zYTWlEPTB;MT64JI5O M17kS3NCVkeHUh?=
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