Cathepsin B

Cathepsin B产品

目录号	产品描述	文献引用	实验数据
S1013	Bortezomib (PS-341) Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239)是有效的蛋白酶抑制剂，Ki为0.6 nM。它对肿瘤细胞表现出良好的选择性。Bortezomib (PS-341) 可抑制 NF-κB 并诱导 ERK 的磷酸化从而抑制cathepsin B并在卵巢癌和其他固体肿瘤中抑制自噬的催化过程。	Nature, 2021, 10.1038/s41586-020-03118-2 Sci Adv, 2021, 7(23)eabg2697 Sci Adv, 2021, 7(3)eabc6364	Effect of different proteasome inhibitors on dysferlin expression and on membrane resealing in cultured primary myoblasts. Primary myoblasts from patient 2 harboring a homozygous Arg555Trp DYSF mutation that were treated with the indicated amounts of bortezomib for 24 hours. Western blots of protein extracts were stained with anti-dysferlin antibodies and with anti–a-tubulin antibody as loading control.
S7379	E-64 E-64是一种非可逆的、选择性的半胱氨酸蛋白酶抑制剂，同样也抑制木瓜蛋白酶、钙蛋白酶和cathepsins B、H，但不抑制丝氨酸蛋白酶或天冬氨酸蛋白酶。抑制木瓜蛋白酶的IC50为9nM。E-64 可在丝虫的寄生虫中诱导氧化应激和凋亡。	Sci Adv, 2021, 7(3)eabc6364 Cell Chem Biol, 2021, S2451-9456(21)00213-0 Epigenetics Chromatin, 2021, 14(1):23
S7420	CA-074 methyl ester (CA-074 Me) CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) 是可透过膜的CA-074的衍生物，是一种不可逆的cathepsin B抑制剂。	Autophagy, 2021, 1-20 J Hazard Mater, 2021, 411:125134 Free Radic Biol Med, 2021, 163:234-242
S2847	Cathepsin Inhibitor 1 Cathepsin Inhibitor 1抑制剂1 是一种Cathepsin (L, L2, S, K, B)的抑制剂， pIC50 分别为7.9, 6.7, 6.0, 5.5, 5.2。	EMBO J, 2020, 39(1):e102030 Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120315151 bioRxiv, 2019, 10.1101/537753
S4591	Nitroxoline Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline)是对尿道感染中常见的易感革兰氏阳性和革兰氏阴性生物具有活性的尿液抗菌剂。Nitroxoline 可通过抑制 cathepsin B 活性而在体内外实验中发挥抵抗肿瘤的作用。	mBio, 2018, 9(5)
S7380	Leupeptin Hemisulfate Leupeptin Hemisulfate是溶酶体丝氨酸蛋白酶和半胱氨酸蛋白酶可逆的抑制剂。抑制cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM)和kallikrein (Ki=19 μM)，对chymotrypsin, elastase, renin,或pepsin没有作用。	Protein Cell, 2021, 10.1007/s13238-021-00858-3 Front Cell Dev Biol, 2021, 9:670145 Biochem Pharmacol, 2021, 188:114562
S3012	Pazopanib Pazopanib (GW786034) 是一种新型多靶点的VEGFR1，VEGFR2，VEGFR3，PDGFR，FGFR，c-Kit 和 c-Fms/CSF1R抑制剂，无细胞试验中IC50分别为10 nM，30 nM，47 nM，84 nM，74 nM，140 nM 和 146 nM。Pazopanib 可诱导 cathepsin B 的活化和自噬。	Cancers (Basel), 2021, 13(14)3635 Radiother Oncol, 2021, 157:175-181 Int J Mol Sci, 2021, 22(9)4884	Three RCC cell lines treated with different concentrations of TKI and HDIL-2 and incubated for 48 h. Microscopic images show apoptotic materials 48 h following treatment (arrows show the apoptotic materials in the pazopanib-treated cells).

目录号	产品描述	文献引用	实验数据
S1013	Bortezomib (PS-341) Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239)是有效的蛋白酶抑制剂，Ki为0.6 nM。它对肿瘤细胞表现出良好的选择性。Bortezomib (PS-341) 可抑制 NF-κB 并诱导 ERK 的磷酸化从而抑制cathepsin B并在卵巢癌和其他固体肿瘤中抑制自噬的催化过程。	Nature,2021, 10.1038/s41586-020-03118-2 Sci Adv,2021, 7(23)eabg2697 Sci Adv,2021, 7(3)eabc6364	Effect of different proteasome inhibitors on dysferlin expression and on membrane resealing in cultured primary myoblasts. Primary myoblasts from patient 2 harboring a homozygous Arg555Trp DYSF mutation that were treated with the indicated amounts of bortezomib for 24 hours. Western blots of protein extracts were stained with anti-dysferlin antibodies and with anti–a-tubulin antibody as loading control.
S7379	E-64 E-64是一种非可逆的、选择性的半胱氨酸蛋白酶抑制剂，同样也抑制木瓜蛋白酶、钙蛋白酶和cathepsins B、H，但不抑制丝氨酸蛋白酶或天冬氨酸蛋白酶。抑制木瓜蛋白酶的IC50为9nM。E-64 可在丝虫的寄生虫中诱导氧化应激和凋亡。	Sci Adv,2021, 7(3)eabc6364 Cell Chem Biol,2021, S2451-9456(21)00213-0 Epigenetics Chromatin,2021, 14(1):23
S7420	CA-074 methyl ester (CA-074 Me) CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) 是可透过膜的CA-074的衍生物，是一种不可逆的cathepsin B抑制剂。	Autophagy,2021, 1-20 J Hazard Mater,2021, 411:125134 Free Radic Biol Med,2021, 163:234-242
S2847	Cathepsin Inhibitor 1 Cathepsin Inhibitor 1抑制剂1 是一种Cathepsin (L, L2, S, K, B)的抑制剂， pIC50 分别为7.9, 6.7, 6.0, 5.5, 5.2。	EMBO J,2020, 39(1):e102030 Arterioscler Thromb Vasc Biol,2020, ATVBAHA120315151 bioRxiv,2019, 10.1101/537753
S4591	Nitroxoline Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline)是对尿道感染中常见的易感革兰氏阳性和革兰氏阴性生物具有活性的尿液抗菌剂。Nitroxoline 可通过抑制 cathepsin B 活性而在体内外实验中发挥抵抗肿瘤的作用。	mBio,2018, 9(5)
S7380	Leupeptin Hemisulfate Leupeptin Hemisulfate是溶酶体丝氨酸蛋白酶和半胱氨酸蛋白酶可逆的抑制剂。抑制cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM)和kallikrein (Ki=19 μM)，对chymotrypsin, elastase, renin,或pepsin没有作用。	Protein Cell,2021, 10.1007/s13238-021-00858-3 Front Cell Dev Biol,2021, 9:670145 Biochem Pharmacol,2021, 188:114562

目录号	产品描述	文献引用	实验数据
S3012	Pazopanib Pazopanib (GW786034) 是一种新型多靶点的VEGFR1，VEGFR2，VEGFR3，PDGFR，FGFR，c-Kit 和 c-Fms/CSF1R抑制剂，无细胞试验中IC50分别为10 nM，30 nM，47 nM，84 nM，74 nM，140 nM 和 146 nM。Pazopanib 可诱导 cathepsin B 的活化和自噬。	Cancers (Basel), 2021, 13(14)3635 Radiother Oncol, 2021, 157:175-181 Int J Mol Sci, 2021, 22(9)4884	Three RCC cell lines treated with different concentrations of TKI and HDIL-2 and incubated for 48 h. Microscopic images show apoptotic materials 48 h following treatment (arrows show the apoptotic materials in the pazopanib-treated cells).