Ginsenoside Rb1

For research use only. Not for use in humans.

目录号:S3924 别名: Gypenoside Ⅲ 中文名称:人参皂苷 Rb1

Ginsenoside Rb1 Chemical Structure

CAS No. 41753-43-9

Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.

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客户使用Selleck生产的Ginsenoside Rb1发表文献3篇:

产品安全说明书

ATPase抑制剂选择性比较

生物活性

产品描述 Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.
靶点
IRAK-1 [4]
()
NF-κB [4]
()
TLR3 [5]
()
TLR4 [5]
()
TNF-α [5]
()
体外研究

Ginsenoside Rb1 promotes the expressions of Nestin, NSE, GFAP and stimulates the differentiation of NSCs[1]. GRb1 is found to not only inhibit Aβ-induced ROROS overproduction and lipid peroxidation, but also to increase the Bcl-2/Bax ratio and attenuate caspase-3 activation, thereby improving cell survival. GRb1 may therefore act as a ROS scavenger, and such antioxidant properties may play a protective role against Aβ-induced cell injury[2].

体内研究

Ginsenoside Rb1 can increase the ability of spatial learning and neural regeneration. It has an anti-neuroinflammatory effect in a rat model of AD. Oral ginsenoside Rb1 can metabolize ginsenoside compound K through intestinal bacteria, and then play a pharmacological role together with esterification of fatty acids to prevent memory loss and improve spatial learning. Ginsenoside Rb1 increases synaptic density and the expression of brain-derived neurotrophic factors Bcl-2 and antioxidant enzyme in hippocampus of mice, and inhibits apoptosis and calcium overload. Ginsenoside Rb1 can stimulate the release of acetylcholine and enhance the expression of choline acetyltransferase mRNA in rat brain, which contributes to the increase of hippocampal neurogenesis. It significantly increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus[1].

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[2]

- 合并
  • Cell lines: PC12 cells
  • Concentrations: 0.01 mM, 0.1 mM, 1 mM
  • Incubation Time: 24 h
  • Method:

    PC12 cells are grown in RPMI-1640 containing 10% heat-inactivated horse serum and 5% fetal bovine serum at 37˚C in a 5% CO2 atmosphere. The medium is changed every other day and cells are plated at the appropriate density according to each experimental scale. To study the effects of GRb1 on Aβ25-35-induced cell injury, cells are pre-incubated with GRb1 for 24 h, and then Aβ25-35 is added to the medium for an additional 24 h. The experimental groups are: A, control; B, 25 μM Aβ25-35; C, 0.01 mM GRb1 + 25 μM Aβ25-35; D, 0.1 mM GRb1 + 25 μM Aβ25-35; E, 1 mM GRb1 + 25 μM Aβ25-35. Following pre-treatment with GRb1 and treatment with Aβ, the cells are subjected to the MTT assay and flow cytometry analysis, the measurement of ROROS and MDADA, Western blotting and immunocytochemistry.


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: Sprague Dawley (SD) male rats
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (90.14 mM)

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 1109.29
化学式

C54H92O23

CAS号 41753-43-9
储存条件 粉状
溶于溶剂
别名 Gypenoside Ⅲ

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID