ATPase

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抑制剂选择性比较

特异性亚型抑制剂

ATPase产品

所有产品(48) ATPase抑制剂(43) ATPase激活剂(5)

目录号	产品描述	文献引用	实验数据
S1478	Oligomycin A Oligomycin A (MCH 32)是一种ATP synthase抑制剂，作用于线粒体膜的耦合过程，抑制氧化磷酸化和所有ATP依赖性反应。	Nat Commun, 2021, 12(1):5203 Autophagy, 2021, 1-16 Cell Rep, 2021, 36(3):109430	(F) Detection of expression of SDHA and TOMM20 by immunoblotting in wild-type and Atg7-/- K562 cells with indicated drugs. The expression levels were quantified with number indicated. (G) Quantification analysis of mitochondrial mass in wild-type and Atg7-/- K562 cells when cultured with oligomycin(100 ng/ml), antimycin A(50 μM) and Baf-A1(10 nM).
S7046	Brefeldin A Brefeldin A 作用于HCT 116细胞，抑制内酯抗生素和ATPase，作用于protein transport（蛋白转运），IC50为0.2 μM，诱导癌细胞分化和凋亡。它还能提高同源重组修复效率，是CRISPR-mediated HDR的增强剂。Brefeldin A 也是自噬和线粒体自噬的抑制剂。	Nat Cell Biol, 2021, 10.1038/s41556-021-00704-y Nat Biomed Eng, 2021, 10.1038/s41551-020-00675-9 Cell Rep, 2021, 36(6):109516	Cells were treated with brefeldin A or manumycin A, and the resulting supernatant was collected after 48 h for exosomal preparation (lanes 1 and 2), or exosomes obtained from C81 cells were trypsin-treated or freeze/thawed (F/T) and then trypsin-treated (lanes 3 and 4). Lanes 5 and 6, input exosome controls from C81 or CEM cells, respectively. Resulting exosomes were assayed for the presence of Tax by Western blotting.
S7099	(-)-Blebbistatin (-)-Blebbistatin ((S)-(-)-Blebbistatin)是一种细胞渗透性抑制剂，作用于非肌球蛋白IIATPase，无细胞试验中IC50为~2 μM，不抑制肌球蛋白轻链激酶 (MLCK)，抑制卵裂沟的缢缩，不干扰有丝分裂或收缩环的组装。	Nat Commun, 2021, 12(1):5315 Biomaterials, 2021, 279:121235 Acta Biomater, 2021, S1742-7061(21)00586-9	(C) MyoIIA inhibition by blebbistatin treatment in vivo impairs leukemia cell extravasation into the brain. One hour before B-ALL cell transfer, C57BL/6 CD45.1+ recipient mice were treated with vehicle or blebbistatin (2.5 mg/kg). Twenty-four hours after B-ALL cell transfer, the recipient mice were intravenously injected with CD19-APC antibodies and then euthanized 4 min later.
S1354	Lansoprazole Lansoprazole (A-65006, AG-1749)是一种质子泵抑制剂（PPI）可共价结合壁细胞的 H(+),K(+)-ATPase，防止胃产生胃酸。	Front Cell Dev Biol, 2021, 9:655559 J Virol, 2021, JVI.00190-21 Front Microbiol, 2019, 10:2790
E0054^New	Tegoprazan Tegoprazan (CJ-12420, IN-A001, K-CAB, LXI-15028, RQ-00000004) 是一种新型有效且高度选择性的胃 H+/K+-ATPase 抑制剂，体外对猪、犬和人 H+/K+-ATPase 的 IC50 范围为 0.29 μM 至 0.52 μM。
S5608^New	Pantoprazole sodium hydrate Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) 是一种 H+/K(+)-ATPase 的有效抑制剂，其IC50值为6.8 μM。	J Virol, 2021, JVI.00190-21
S3577^New	Rhodamine 123 Rhodamine 123 (RH-123, R-22420) 是一种荧光阳离子染料，用于标记活细胞中的线粒体。Rhodamine 123 可抑制ADP刺激的线粒体呼吸，其Ki值为12 μM，对倒置的内膜囊泡的 ATPase 活性的Ki值为126 μM，对部分纯化的 F1-ATPase 的Ki值为 177 μM。
S2000	Sodium orthovanadate Sodium orthovanadate是一种碱性磷酸酶和(Na，K)-ATPase抑制剂，IC50为10 μM。	PLoS Pathog, 2021, 17(7):e1009752 Anal Chim Acta, 2021, 1143:144-156 Front Cell Infect Microbiol, 2021, 11:706252
S1389	Omeprazole Omeprazole 是一种可阻滞 H(+)-K(+)-ATPase 的质子泵抑制剂，用于治疗消化不良，消化性溃疡，胃食管逆流，咽喉逆流。	Theranostics, 2021, 11(5):2364-2380 J Virol, 2021, JVI.00190-21 Biosci Rep, 2021, BSR20200842
S1413	Bafilomycin A1 (Baf-A1) Bafilomycin A1 (Baf-A1)是一种液泡H⁺-ATPase抑制剂，IC50为0.44 nM。研究发现 Bafilomycin A1 可以抑制自噬，但是诱导凋亡。	Adv Sci (Weinh), 2021, e2100779 Mol Cell, 2021, S1097-2765(21)00729-2 ACS Nano, 2021, 10.1021/acsnano.1c06452	Mitochondrial depolarization mediated relocation of mitochondrial RC-TPP into lysosomes and the ensuing lysosomal acidity triggered rhodamine fluorescence. RC-TPP-loaded Tom20-GFP+ HeLa cells were treated without or with CCCP (20 μM) in the presence or absence of BFA (200 nM). Colocalization of Tom20-GFP (in green) and mitochondrial RC-TPP (in blue) is shown in cyan. Scale bar: 10 μm.
S2528	Ciclopirox Ciclopirox 是一种合成的抗真菌药物。	Cell Death Dis, 2021, 12(12):1141 Int J Mol Sci, 2021, 22(15)8299 J Transl Med, 2021, 19(1):347
S3019	Ciclopirox ethanolamine Ciclopirox ethanolamine作为一种铁离子螯合剂，具有广谱抗真菌作用。	Front Cell Dev Biol, 2021, 9:719187 ACS Omega, 2021, 6(12):8477-8487 bioRxiv, 2019, 10.1101/748129
S1743	NEXIUM (esomeprazole magnesium) Esomeprazole Magnesium 是一种质子泵 proton pump 抑制剂，在胃壁细胞中通过抑制 H(+)/K(+)-ATPase 减少胃酸分泌。
S2233	Esomeprazole sodium Esomeprazole Sodium 是Esomeprazole的一种钠盐，是有效的质子泵抑制剂，IC50为0.076 mg/kg。	Hum Cell, 2021, 10.1007/s13577-021-00639-4 Hum Cell, 2021, 10.1007/s13577-021-00579-z Cancer Cell Int, 2020, 19;20:58
S4016	Ouabain Ouabain (NSC 25485) 是一种选择性的Na⁺/K⁺-ATPase抑制剂，与α2 /α3亚基结合，K_i为41 nM/15 nM。	Nat Methods, 2021, 18(1):84-91 Mol Oncol, 2020, 10.1002/1878-0261.12853 bioRxiv, 2020, 2020/9/20.4.7.30734	Effect of pharmacological agents capable of increasing intracellular calcium concentration on RSV. HEp-2 cells were infected with RSV strain long at an MOI of 0.1, and treated with a specific Na+/K+-ATPase inhibitor ouabain at indicated concentrations. Supernatants were collected at 48 h postinfection and viral titers were determined by immunoplaque assay. Grey bars represent cytotoxicity of the compounds. The data presented were obtained from two independent experiments. Error bars represent the standard deviations from two independent experiments. Statistical significance between treated and control group were analyzed by t-test (, p < 0.05, *, p < 0.01).
S7266	Golgicide A Golgicide A是一种有效的，快速可逆的GBF1抑制剂。	Autophagy, 2021, 1-13 Front Cell Dev Biol, 2021, 9:706768 Nature, 2019, 567(7747):262-266	CSFV multiplication was inhibited by GCA. (A) The safe concentration of GCA was tested using the MTT assay. The operations and calculations were the same as those used for BFA. (B) Cellular CSFV RNA with or without 400 nM GCA were examined using real-time PCR. (C) The titers of CSFV with or without GCA were tested by IFA. (D) CSFV proliferation in ST cells with or without GCA was observed by IFA at 24, 48 and 72 hpi. Results from the three independent experiments are shown as means ± SD. P<0.05 and *P<0.01 compared with the control group.
S2222	PF-3716556 PF-3716556是一种有效的，选择性的P-CAB钾离子竞争性酸抑制剂，在离子渗透和离子密集检测中，抑制猪H⁺，K⁺-ATPase活性，抑制胃酸分泌，对Na⁺，K⁺-ATPas没有作用活性，用于治疗胃食管返流疾病。
S7460	BTB06584 BTB06584 是IF1依赖性的，选择性的线粒体F1 Fo-ATPase抑制剂.	J Cell Physiol, 2018, 234(1):940-949 Oncotarget, 2017, 8(32):53602-53612	Changes of mitochondrial membrane potential (ΔΨm). (A) Representative micrographs captured by confocal laser scanning microscope were evaluated for ΔΨm by staining with JC-1 at 24h post ionizing radiation. Red dimers indicated normal mitochondrial function and green monomers indicated collapse of ΔΨm with cytoplasmic fluorescence. Scale bar = 50μm. (B) Kinetics of changes of ΔΨm was showed as the ratio of red to green fluorescence in each treatment staining with JC-1 at 0.5, 6, 12, 24, 48, 72 and 96 h after X-ray radiation (IR) with or without 10μM BTB treatment. Data are expressed as means±SD of triplicate measurements. IR compared with IR+BTB, p< 0.05, *p< 0.01, t-test. Control compared with IR+BTB, #p< 0.05, ##p< 0.01, t-test.
S4099	Dexlansoprazole Dexlansoprazole (T 168390, TAK 390)是Lansoprazole的右旋对映体，是质子泵抑制剂（PPI），具有双重缓释性能。Dexlansoprazole 作用于胃壁细胞，通过直接抑制 H(+),K(+)-ATPase 质子泵选择性地抑制胃酸分泌。	J Virol, 2021, JVI.00190-21 Front Microbiol, 2019, 10:2790
S3143	Pyruvic acid Pyruvic acid (Acetylformic acid) 是一种重要的有机化学中间体，在心肌细胞的病理生理和治疗中发挥作用。Pyruvic acid 可显着提高 lactate dehydrogenase (LDH) 和 creatine kinase (CK) 的水平，并降低 Ca²⁺Mg²⁺-ATPase 和 Na⁺K⁺-ATPase 的水平。
S7895	Thapsigargin Thapsigargin 是一种有效的、非竞争性的 the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) 的抑制剂，对carbachol诱导的[Ca2+]i瞬变在存不存在KCl预刺激条件下的IC50值分别为0.353 nM和0.448 nM。Thapsigargin 可诱导细胞凋亡。Thapsigargin 提取自植物Thapsia garganica。	Cell Res, 2021, 10.1038/s41422-021-00565-y Sci Adv, 2021, 7(3)eabc6364 Autophagy, 2021, 1-16
S8101	CB-5083 CB-5083是一种有效的，选择性的，且口服具有生物活性的p97 AAA ATPase抑制剂，IC50为 11 nM。Phase 1。	Nat Commun, 2021, 12(1):713 J Cell Biol, 2021, 220(8)e202009147 EMBO Rep, 2021, 22(3):e52164	LN229 GBM cell lysates were immunoblotted with antibodies recognizing specific focal adhesion proteins. Note the decreased levels of Cas, paxillin, and FAK tyrosine phosphorylation in cells treated with CB-5083. In addition, CB-5083 treatment leads to decreased levels of total PTP-PEST expression, but Vcp protein expression levels are not impacted.
S7821	Bufalin Bufalin (BF)是类固醇受体共激活剂 SRC-3、SRC-1 和 Na+/K+-ATPase 的有效抑制剂。Bufalin 可与Na+/K+-ATPase的亚基α1、α2和α3结合，其Kd值分别为42.5 nM、45 nM和40 nM。Bufalin 是一种从中药蟾酥中分离出来的，具有抗癌活性的，类地高辛免疫反应的主要成分。	Front Oncol, 2021, 11:743824 bioRxiv, 2020, 2020/9/20.4.7.30734
S5502	Ilaprazole sodium Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation.	J Virol, 2021, JVI.00190-21
S4166	Chlorpropamide Chlorpropamide 抑制 Na(+),K(+)-ATPase 并刺激离体肝脏质膜的高亲和力环状AMP-磷酸二酯酶。Chlorpropamide 是一种磺脲类药物，用于治疗2型糖尿病。	Nat Commun, 2017, 8(1):573
S3666	Ilaprazole Ilaprazole (IY-81149)是新型的质子泵 (proton pump)抑制剂，用于治疗消化不良、消化性溃疡、胃食管返流疾病和十二指肠溃疡。它能抑制H+/K+-ATPase，IC50为6 μM。	J Virol, 2021, JVI.00190-21
S0161	ML367 ML367 是一种有效的 ATPase family AAA domain-containing protein 5 (ATAD5) 的微摩尔级抑制剂。ML367 会阻断 DNA repair 途径和一般的 DNA damage 反应，包括紫外线刺激的RPA32磷酸化和CHK1磷酸化。
S4212	Tenatoprazole Tenatoprazole (TU-199)是proton pump 抑制剂类前药, 抑制质子的运输，IC50为3.2 μM。Tenatoprazole 仅标记胃部 H(+),K(+)-ATPase 的α-亚基，约2.6 nM/mg 结合于 H(+),K(+)-ATPase。	J Virol, 2021, JVI.00190-21
S0166	BRITE338733 BRITE-338733 是一种有效的 RecA (一种DNA依赖性ATPase)的抑制剂，IC50值为4.7 µM。
S6918	Oleandrin (PBI-05204) Oleandrin (PBI-05204, Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol) 是 Na+/K+-ATPase 的抑制剂，IC50值为0.62 μM。Oleandrin 可诱导凋亡并减少人胶质瘤细胞的体外迁移。
S2343	Phlorizin Phlorizin (Phloridzin) 是有毒的2'-葡萄糖苷根皮素，属于二氢查尔酮，是一种黄酮类化合物。Phlorizin 是一种非选择性的 SGLT 的抑制剂，对hSGLT1 和 hSGLT2的Ki值分别为300 nM 和 39 nM。Phlorizin 也是 Na+/K+-ATPase 的抑制剂。	Mol Ther Methods Clin Dev, 2022, 24:11-19 Int J Biol Sci, 2019, 15(11):2497-2508 Am J Physiol Renal Physiol, 2019, 316(5):F1078-F1089	PQ increases glucose transport and the translocation of glucose transporters. Cells were treated with PQ for 48 h. The survival of cells treated with PQ in the presence or absence of phlorizin (e) was determined. Bar graph represents percents of viable cells (cell survival).
S3628	BHQ BHQ (2,5-di-t-butyl-1,4-benzohydroquinone) 是有效的、选择性的sarco-endoplasmic reticulum Ca2+-ATPase (SERCA)抑制剂。	Oncogene, 2021, 40(6):1128-1146
S4538	Pantoprazole sodium Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。	J Virol, 2021, JVI.00190-21
S0219	ML241 hydrochloride ML241 hydrochloride 是一种 p97 的有效选择性抑制剂，对 p97 ATPase 和 Ub^G76V–GFP 的IC50值分别为0.11 μM和3.5 μM。
S0856	KM91104 KM 91104 是一种 V-ATPase 的细胞可渗透抑制剂，其特异性靶向V-ATPase亚基a3和亚基B2之间的相互作用。
S8276	FCCP FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)在线粒体中式一种有效的氧化磷酸化的解偶联剂，通过转运质子破坏ATP的合成。	J Dairy Sci, 2022, S0022-0302(21)01120-6 Sci Adv, 2021, 7(49):eabk0490 Sci Adv, 2021, 7(49):eabk0490	The changes in 10-N-nonylacridineorange (NAO) fluorescence indicated the cardiolipin (CL) oxidation. In normal cells, NAO could interact with nonoxidized cardiolipin and produces a characteristic green fluorescence. However, after cardiolipin is oxidized, NAO cannot bind to it. F-H, The changes in MDA, GSH, and SOD levels. I and J, The cytoplasmic [Ca2+] map via confocal microscopy by Fluo-2. Fluorescence intensity of Fluo-2 was measured by excitation wavelengths of 340 nm and emission wavelengths of 500 nm. Data (F/F0) were obtained by dividing fluorescence intensity (F) by (F0) at the resting level (t = 0), which was normalized to normal groups. Data are shown as means ± SEM. *P < .05 vs normal group; #P < .05 vs PA group, @P < .05 vs PA + siRNA-NR4A1 or PA + melatonin groups
S5623	Bedaquiline Bedaquiline (TMC-207, R207910), a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).
S2105	Pantoprazole Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。	J Virol, 2021, JVI.00190-21 Front Microbiol, 2019, 10:2790
S3924	Ginsenoside Rb1 Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.	J Biol Chem, 2021, S0021-9258(21)00790-0 Mol Immunol, 2021, 139:140-152 J Ethnopharmacol, 2021, S0378-8741(21)00169-0
S5058	Revaprazan Hydrochloride Revaprazan Hydrochloride (YH1885) 是一种新型可逆的proton pump抑制剂，具有长效抑酸活性。Revaprazan Hydrochloride 通过结合泵上K+结合位点来可逆性地抑制 H(+)/K(+)-ATPase。	ACS Infect Dis, 2021, 10.1021/acsinfecdis.0c00754
S4290	Digoxin (NSC 95100) Digoxin (NSC 95100)是一种经典的Na,K-ATPase抑制剂，其对α2β3亚型的选择性高于α1β1亚型，用于治疗心房颤动和心脏衰竭。	J Cell Mol Med, 2021, 10.1111/jcmm.16272 J Cell Mol Med, 2021, 25(3):1700-1711 PLoS Pathog, 2020, 16;16(3):e1008341
S8828	Gboxin Gboxin是癌细胞中氧化磷酸化抑制剂。Gboxin 可抑制 F0F1 ATP synthase 的活性。它能特异性地抑制原代小鼠和人源胶质母细胞瘤细胞的生长，而不影响小鼠胚胎成纤维细胞或新生儿星形胶质细胞。
S5454	Saikosaponin D Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities.
S2623	Omecamtiv mecarbil (CK-1827452) Omecamtiv mecarbil (CK-1827452)是一种特异性的心肌肌球蛋白激动剂，是用于左心室收缩性心脏衰竭的临床药物。Phase 2。	Elife, 2021, 10e63691 J Biol Chem, 2021, S0021-9258(21)00245-3 J Pharmacokinet Pharmacodyn, 2021, 10.1007/s10928-021-09787-4	Normal and Mutation human iPSC-CMs Structure when Treated with Omecamtiv Mecarbil. Human iPSC-CMs were plated on 100 kPa flat PDMS and grown for five days and left untreated, treated acutely on day 5, or treated continuously from the time of plating with the myosin activator Omecamtiv Mecarbil. iPSC-CMs were then fixed and stained for actin filaments (phalloidin, red) and nucleus (DAPI, blue). (a, c, e) Normal and (b, d, f) Mutation untreated, acutely treated, and continuously treated iPSC-CMs.
S6815	CDN1163 CDN1163是一种 sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 的小分子变构激活剂，可改善 Ca2+ 稳态。
S4707	Oleic Acid 油酸 Oleic acid (Oleate, 9-Octadecenoic Acid, Elaidoic acid)是一种天然存在于多种动物和植物脂肪和油类中的脂肪酸。它常被用作制作油酸和乳液，并作为一种药物溶剂。	Diabetes Metab Syndr Obes, 2021, 14:4165-4177
S1238	Tamoxifen (ICI 46474) Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) 作用于乳腺组织，是一种雌激素受体estrogen receptor调节剂 (SERM)。Tamoxifen可增强Hsp90分子伴侣ATPase的活性。Tamoxifen可诱导凋亡。	Clin Cancer Res, 2021, 10.1158/1078-0432.CCR-20-3905 Cancers (Basel), 2021, 13(9)2116 Cell Death Dis, 2021, 12(6):619	E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.
S9181	Periplocin Periplocin (Periplocoside)是从传统草药皮质骨膜中提取的，具有心脏和抗癌活性。Periplocin 可以显著地促进成纤维细胞L929细胞的增殖、迁移和刺激胶原蛋白的产生，这取决于 Na/K-ATPase 介导的Src/ERK和PI3K/Akt信号通路的激活，从而促进伤口愈合。

目录号	产品描述	文献引用	实验数据
S1478	Oligomycin A Oligomycin A (MCH 32)是一种ATP synthase抑制剂，作用于线粒体膜的耦合过程，抑制氧化磷酸化和所有ATP依赖性反应。	Nat Commun,2021, 12(1):5203 Autophagy,2021, 1-16 Cell Rep,2021, 36(3):109430	(F) Detection of expression of SDHA and TOMM20 by immunoblotting in wild-type and Atg7-/- K562 cells with indicated drugs. The expression levels were quantified with number indicated. (G) Quantification analysis of mitochondrial mass in wild-type and Atg7-/- K562 cells when cultured with oligomycin(100 ng/ml), antimycin A(50 μM) and Baf-A1(10 nM).
S7046	Brefeldin A Brefeldin A 作用于HCT 116细胞，抑制内酯抗生素和ATPase，作用于protein transport（蛋白转运），IC50为0.2 μM，诱导癌细胞分化和凋亡。它还能提高同源重组修复效率，是CRISPR-mediated HDR的增强剂。Brefeldin A 也是自噬和线粒体自噬的抑制剂。	Nat Cell Biol,2021, 10.1038/s41556-021-00704-y Nat Biomed Eng,2021, 10.1038/s41551-020-00675-9 Cell Rep,2021, 36(6):109516	Cells were treated with brefeldin A or manumycin A, and the resulting supernatant was collected after 48 h for exosomal preparation (lanes 1 and 2), or exosomes obtained from C81 cells were trypsin-treated or freeze/thawed (F/T) and then trypsin-treated (lanes 3 and 4). Lanes 5 and 6, input exosome controls from C81 or CEM cells, respectively. Resulting exosomes were assayed for the presence of Tax by Western blotting.
S7099	(-)-Blebbistatin (-)-Blebbistatin ((S)-(-)-Blebbistatin)是一种细胞渗透性抑制剂，作用于非肌球蛋白IIATPase，无细胞试验中IC50为~2 μM，不抑制肌球蛋白轻链激酶 (MLCK)，抑制卵裂沟的缢缩，不干扰有丝分裂或收缩环的组装。	Nat Commun,2021, 12(1):5315 Biomaterials,2021, 279:121235 Acta Biomater,2021, S1742-7061(21)00586-9	(C) MyoIIA inhibition by blebbistatin treatment in vivo impairs leukemia cell extravasation into the brain. One hour before B-ALL cell transfer, C57BL/6 CD45.1+ recipient mice were treated with vehicle or blebbistatin (2.5 mg/kg). Twenty-four hours after B-ALL cell transfer, the recipient mice were intravenously injected with CD19-APC antibodies and then euthanized 4 min later.
S1354	Lansoprazole Lansoprazole (A-65006, AG-1749)是一种质子泵抑制剂（PPI）可共价结合壁细胞的 H(+),K(+)-ATPase，防止胃产生胃酸。	Front Cell Dev Biol,2021, 9:655559 J Virol,2021, JVI.00190-21 Front Microbiol,2019, 10:2790
E0054^New	Tegoprazan Tegoprazan (CJ-12420, IN-A001, K-CAB, LXI-15028, RQ-00000004) 是一种新型有效且高度选择性的胃 H+/K+-ATPase 抑制剂，体外对猪、犬和人 H+/K+-ATPase 的 IC50 范围为 0.29 μM 至 0.52 μM。
S5608^New	Pantoprazole sodium hydrate Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) 是一种 H+/K(+)-ATPase 的有效抑制剂，其IC50值为6.8 μM。	J Virol,2021, JVI.00190-21
S3577^New	Rhodamine 123 Rhodamine 123 (RH-123, R-22420) 是一种荧光阳离子染料，用于标记活细胞中的线粒体。Rhodamine 123 可抑制ADP刺激的线粒体呼吸，其Ki值为12 μM，对倒置的内膜囊泡的 ATPase 活性的Ki值为126 μM，对部分纯化的 F1-ATPase 的Ki值为 177 μM。
S2000	Sodium orthovanadate Sodium orthovanadate是一种碱性磷酸酶和(Na，K)-ATPase抑制剂，IC50为10 μM。	PLoS Pathog,2021, 17(7):e1009752 Anal Chim Acta,2021, 1143:144-156 Front Cell Infect Microbiol,2021, 11:706252
S1389	Omeprazole Omeprazole 是一种可阻滞 H(+)-K(+)-ATPase 的质子泵抑制剂，用于治疗消化不良，消化性溃疡，胃食管逆流，咽喉逆流。	Theranostics,2021, 11(5):2364-2380 J Virol,2021, JVI.00190-21 Biosci Rep,2021, BSR20200842
S1413	Bafilomycin A1 (Baf-A1) Bafilomycin A1 (Baf-A1)是一种液泡H⁺-ATPase抑制剂，IC50为0.44 nM。研究发现 Bafilomycin A1 可以抑制自噬，但是诱导凋亡。	Adv Sci (Weinh),2021, e2100779 Mol Cell,2021, S1097-2765(21)00729-2 ACS Nano,2021, 10.1021/acsnano.1c06452	Mitochondrial depolarization mediated relocation of mitochondrial RC-TPP into lysosomes and the ensuing lysosomal acidity triggered rhodamine fluorescence. RC-TPP-loaded Tom20-GFP+ HeLa cells were treated without or with CCCP (20 μM) in the presence or absence of BFA (200 nM). Colocalization of Tom20-GFP (in green) and mitochondrial RC-TPP (in blue) is shown in cyan. Scale bar: 10 μm.
S2528	Ciclopirox Ciclopirox 是一种合成的抗真菌药物。	Cell Death Dis,2021, 12(12):1141 Int J Mol Sci,2021, 22(15)8299 J Transl Med,2021, 19(1):347
S3019	Ciclopirox ethanolamine Ciclopirox ethanolamine作为一种铁离子螯合剂，具有广谱抗真菌作用。	Front Cell Dev Biol,2021, 9:719187 ACS Omega,2021, 6(12):8477-8487 bioRxiv,2019, 10.1101/748129
S1743	NEXIUM (esomeprazole magnesium) Esomeprazole Magnesium 是一种质子泵 proton pump 抑制剂，在胃壁细胞中通过抑制 H(+)/K(+)-ATPase 减少胃酸分泌。
S2233	Esomeprazole sodium Esomeprazole Sodium 是Esomeprazole的一种钠盐，是有效的质子泵抑制剂，IC50为0.076 mg/kg。	Hum Cell,2021, 10.1007/s13577-021-00639-4 Hum Cell,2021, 10.1007/s13577-021-00579-z Cancer Cell Int,2020, 19;20:58
S4016	Ouabain Ouabain (NSC 25485) 是一种选择性的Na⁺/K⁺-ATPase抑制剂，与α2 /α3亚基结合，K_i为41 nM/15 nM。	Nat Methods,2021, 18(1):84-91 Mol Oncol,2020, 10.1002/1878-0261.12853 bioRxiv,2020, 2020/9/20.4.7.30734	Effect of pharmacological agents capable of increasing intracellular calcium concentration on RSV. HEp-2 cells were infected with RSV strain long at an MOI of 0.1, and treated with a specific Na+/K+-ATPase inhibitor ouabain at indicated concentrations. Supernatants were collected at 48 h postinfection and viral titers were determined by immunoplaque assay. Grey bars represent cytotoxicity of the compounds. The data presented were obtained from two independent experiments. Error bars represent the standard deviations from two independent experiments. Statistical significance between treated and control group were analyzed by t-test (, p < 0.05, *, p < 0.01).
S7266	Golgicide A Golgicide A是一种有效的，快速可逆的GBF1抑制剂。	Autophagy,2021, 1-13 Front Cell Dev Biol,2021, 9:706768 Nature,2019, 567(7747):262-266	CSFV multiplication was inhibited by GCA. (A) The safe concentration of GCA was tested using the MTT assay. The operations and calculations were the same as those used for BFA. (B) Cellular CSFV RNA with or without 400 nM GCA were examined using real-time PCR. (C) The titers of CSFV with or without GCA were tested by IFA. (D) CSFV proliferation in ST cells with or without GCA was observed by IFA at 24, 48 and 72 hpi. Results from the three independent experiments are shown as means ± SD. P<0.05 and *P<0.01 compared with the control group.
S2222	PF-3716556 PF-3716556是一种有效的，选择性的P-CAB钾离子竞争性酸抑制剂，在离子渗透和离子密集检测中，抑制猪H⁺，K⁺-ATPase活性，抑制胃酸分泌，对Na⁺，K⁺-ATPas没有作用活性，用于治疗胃食管返流疾病。
S7460	BTB06584 BTB06584 是IF1依赖性的，选择性的线粒体F1 Fo-ATPase抑制剂.	J Cell Physiol,2018, 234(1):940-949 Oncotarget,2017, 8(32):53602-53612	Changes of mitochondrial membrane potential (ΔΨm). (A) Representative micrographs captured by confocal laser scanning microscope were evaluated for ΔΨm by staining with JC-1 at 24h post ionizing radiation. Red dimers indicated normal mitochondrial function and green monomers indicated collapse of ΔΨm with cytoplasmic fluorescence. Scale bar = 50μm. (B) Kinetics of changes of ΔΨm was showed as the ratio of red to green fluorescence in each treatment staining with JC-1 at 0.5, 6, 12, 24, 48, 72 and 96 h after X-ray radiation (IR) with or without 10μM BTB treatment. Data are expressed as means±SD of triplicate measurements. IR compared with IR+BTB, p< 0.05, *p< 0.01, t-test. Control compared with IR+BTB, #p< 0.05, ##p< 0.01, t-test.
S4099	Dexlansoprazole Dexlansoprazole (T 168390, TAK 390)是Lansoprazole的右旋对映体，是质子泵抑制剂（PPI），具有双重缓释性能。Dexlansoprazole 作用于胃壁细胞，通过直接抑制 H(+),K(+)-ATPase 质子泵选择性地抑制胃酸分泌。	J Virol,2021, JVI.00190-21 Front Microbiol,2019, 10:2790
S3143	Pyruvic acid Pyruvic acid (Acetylformic acid) 是一种重要的有机化学中间体，在心肌细胞的病理生理和治疗中发挥作用。Pyruvic acid 可显着提高 lactate dehydrogenase (LDH) 和 creatine kinase (CK) 的水平，并降低 Ca²⁺Mg²⁺-ATPase 和 Na⁺K⁺-ATPase 的水平。
S7895	Thapsigargin Thapsigargin 是一种有效的、非竞争性的 the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) 的抑制剂，对carbachol诱导的[Ca2+]i瞬变在存不存在KCl预刺激条件下的IC50值分别为0.353 nM和0.448 nM。Thapsigargin 可诱导细胞凋亡。Thapsigargin 提取自植物Thapsia garganica。	Cell Res,2021, 10.1038/s41422-021-00565-y Sci Adv,2021, 7(3)eabc6364 Autophagy,2021, 1-16
S8101	CB-5083 CB-5083是一种有效的，选择性的，且口服具有生物活性的p97 AAA ATPase抑制剂，IC50为 11 nM。Phase 1。	Nat Commun,2021, 12(1):713 J Cell Biol,2021, 220(8)e202009147 EMBO Rep,2021, 22(3):e52164	LN229 GBM cell lysates were immunoblotted with antibodies recognizing specific focal adhesion proteins. Note the decreased levels of Cas, paxillin, and FAK tyrosine phosphorylation in cells treated with CB-5083. In addition, CB-5083 treatment leads to decreased levels of total PTP-PEST expression, but Vcp protein expression levels are not impacted.
S7821	Bufalin Bufalin (BF)是类固醇受体共激活剂 SRC-3、SRC-1 和 Na+/K+-ATPase 的有效抑制剂。Bufalin 可与Na+/K+-ATPase的亚基α1、α2和α3结合，其Kd值分别为42.5 nM、45 nM和40 nM。Bufalin 是一种从中药蟾酥中分离出来的，具有抗癌活性的，类地高辛免疫反应的主要成分。	Front Oncol,2021, 11:743824 bioRxiv,2020, 2020/9/20.4.7.30734
S5502	Ilaprazole sodium Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation.	J Virol,2021, JVI.00190-21
S4166	Chlorpropamide Chlorpropamide 抑制 Na(+),K(+)-ATPase 并刺激离体肝脏质膜的高亲和力环状AMP-磷酸二酯酶。Chlorpropamide 是一种磺脲类药物，用于治疗2型糖尿病。	Nat Commun,2017, 8(1):573
S3666	Ilaprazole Ilaprazole (IY-81149)是新型的质子泵 (proton pump)抑制剂，用于治疗消化不良、消化性溃疡、胃食管返流疾病和十二指肠溃疡。它能抑制H+/K+-ATPase，IC50为6 μM。	J Virol,2021, JVI.00190-21
S0161	ML367 ML367 是一种有效的 ATPase family AAA domain-containing protein 5 (ATAD5) 的微摩尔级抑制剂。ML367 会阻断 DNA repair 途径和一般的 DNA damage 反应，包括紫外线刺激的RPA32磷酸化和CHK1磷酸化。
S4212	Tenatoprazole Tenatoprazole (TU-199)是proton pump 抑制剂类前药, 抑制质子的运输，IC50为3.2 μM。Tenatoprazole 仅标记胃部 H(+),K(+)-ATPase 的α-亚基，约2.6 nM/mg 结合于 H(+),K(+)-ATPase。	J Virol,2021, JVI.00190-21
S0166	BRITE338733 BRITE-338733 是一种有效的 RecA (一种DNA依赖性ATPase)的抑制剂，IC50值为4.7 µM。
S6918	Oleandrin (PBI-05204) Oleandrin (PBI-05204, Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol) 是 Na+/K+-ATPase 的抑制剂，IC50值为0.62 μM。Oleandrin 可诱导凋亡并减少人胶质瘤细胞的体外迁移。
S2343	Phlorizin Phlorizin (Phloridzin) 是有毒的2'-葡萄糖苷根皮素，属于二氢查尔酮，是一种黄酮类化合物。Phlorizin 是一种非选择性的 SGLT 的抑制剂，对hSGLT1 和 hSGLT2的Ki值分别为300 nM 和 39 nM。Phlorizin 也是 Na+/K+-ATPase 的抑制剂。	Mol Ther Methods Clin Dev,2022, 24:11-19 Int J Biol Sci,2019, 15(11):2497-2508 Am J Physiol Renal Physiol,2019, 316(5):F1078-F1089	PQ increases glucose transport and the translocation of glucose transporters. Cells were treated with PQ for 48 h. The survival of cells treated with PQ in the presence or absence of phlorizin (e) was determined. Bar graph represents percents of viable cells (cell survival).
S3628	BHQ BHQ (2,5-di-t-butyl-1,4-benzohydroquinone) 是有效的、选择性的sarco-endoplasmic reticulum Ca2+-ATPase (SERCA)抑制剂。	Oncogene,2021, 40(6):1128-1146
S4538	Pantoprazole sodium Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。	J Virol,2021, JVI.00190-21
S0219	ML241 hydrochloride ML241 hydrochloride 是一种 p97 的有效选择性抑制剂，对 p97 ATPase 和 Ub^G76V–GFP 的IC50值分别为0.11 μM和3.5 μM。
S0856	KM91104 KM 91104 是一种 V-ATPase 的细胞可渗透抑制剂，其特异性靶向V-ATPase亚基a3和亚基B2之间的相互作用。
S8276	FCCP FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)在线粒体中式一种有效的氧化磷酸化的解偶联剂，通过转运质子破坏ATP的合成。	J Dairy Sci,2022, S0022-0302(21)01120-6 Sci Adv,2021, 7(49):eabk0490 Sci Adv,2021, 7(49):eabk0490	The changes in 10-N-nonylacridineorange (NAO) fluorescence indicated the cardiolipin (CL) oxidation. In normal cells, NAO could interact with nonoxidized cardiolipin and produces a characteristic green fluorescence. However, after cardiolipin is oxidized, NAO cannot bind to it. F-H, The changes in MDA, GSH, and SOD levels. I and J, The cytoplasmic [Ca2+] map via confocal microscopy by Fluo-2. Fluorescence intensity of Fluo-2 was measured by excitation wavelengths of 340 nm and emission wavelengths of 500 nm. Data (F/F0) were obtained by dividing fluorescence intensity (F) by (F0) at the resting level (t = 0), which was normalized to normal groups. Data are shown as means ± SEM. *P < .05 vs normal group; #P < .05 vs PA group, @P < .05 vs PA + siRNA-NR4A1 or PA + melatonin groups
S5623	Bedaquiline Bedaquiline (TMC-207, R207910), a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).
S2105	Pantoprazole Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。	J Virol,2021, JVI.00190-21 Front Microbiol,2019, 10:2790
S3924	Ginsenoside Rb1 Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.	J Biol Chem,2021, S0021-9258(21)00790-0 Mol Immunol,2021, 139:140-152 J Ethnopharmacol,2021, S0378-8741(21)00169-0
S5058	Revaprazan Hydrochloride Revaprazan Hydrochloride (YH1885) 是一种新型可逆的proton pump抑制剂，具有长效抑酸活性。Revaprazan Hydrochloride 通过结合泵上K+结合位点来可逆性地抑制 H(+)/K(+)-ATPase。	ACS Infect Dis,2021, 10.1021/acsinfecdis.0c00754
S4290	Digoxin (NSC 95100) Digoxin (NSC 95100)是一种经典的Na,K-ATPase抑制剂，其对α2β3亚型的选择性高于α1β1亚型，用于治疗心房颤动和心脏衰竭。	J Cell Mol Med,2021, 10.1111/jcmm.16272 J Cell Mol Med,2021, 25(3):1700-1711 PLoS Pathog,2020, 16;16(3):e1008341
S8828	Gboxin Gboxin是癌细胞中氧化磷酸化抑制剂。Gboxin 可抑制 F0F1 ATP synthase 的活性。它能特异性地抑制原代小鼠和人源胶质母细胞瘤细胞的生长，而不影响小鼠胚胎成纤维细胞或新生儿星形胶质细胞。
S5454	Saikosaponin D Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities.

目录号	产品描述	文献引用	实验数据
S2623	Omecamtiv mecarbil (CK-1827452) Omecamtiv mecarbil (CK-1827452)是一种特异性的心肌肌球蛋白激动剂，是用于左心室收缩性心脏衰竭的临床药物。Phase 2。	Elife, 2021, 10e63691 J Biol Chem, 2021, S0021-9258(21)00245-3 J Pharmacokinet Pharmacodyn, 2021, 10.1007/s10928-021-09787-4	Normal and Mutation human iPSC-CMs Structure when Treated with Omecamtiv Mecarbil. Human iPSC-CMs were plated on 100 kPa flat PDMS and grown for five days and left untreated, treated acutely on day 5, or treated continuously from the time of plating with the myosin activator Omecamtiv Mecarbil. iPSC-CMs were then fixed and stained for actin filaments (phalloidin, red) and nucleus (DAPI, blue). (a, c, e) Normal and (b, d, f) Mutation untreated, acutely treated, and continuously treated iPSC-CMs.
S6815	CDN1163 CDN1163是一种 sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 的小分子变构激活剂，可改善 Ca2+ 稳态。
S4707	Oleic Acid 油酸 Oleic acid (Oleate, 9-Octadecenoic Acid, Elaidoic acid)是一种天然存在于多种动物和植物脂肪和油类中的脂肪酸。它常被用作制作油酸和乳液，并作为一种药物溶剂。	Diabetes Metab Syndr Obes, 2021, 14:4165-4177
S1238	Tamoxifen (ICI 46474) Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) 作用于乳腺组织，是一种雌激素受体estrogen receptor调节剂 (SERM)。Tamoxifen可增强Hsp90分子伴侣ATPase的活性。Tamoxifen可诱导凋亡。	Clin Cancer Res, 2021, 10.1158/1078-0432.CCR-20-3905 Cancers (Basel), 2021, 13(9)2116 Cell Death Dis, 2021, 12(6):619	E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.
S9181	Periplocin Periplocin (Periplocoside)是从传统草药皮质骨膜中提取的，具有心脏和抗癌活性。Periplocin 可以显著地促进成纤维细胞L929细胞的增殖、迁移和刺激胶原蛋白的产生，这取决于 Na/K-ATPase 介导的Src/ERK和PI3K/Akt信号通路的激活，从而促进伤口愈合。

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