ATPase

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研究领域

抑制剂选择性比较

ATPase产品

所有产品 ATPase抑制剂(22) ATPase激活剂(5)

目录号	产品描述	文献引用	实验数据
S1478	Oligomycin A Oligomycin A是一种ATP synthase抑制剂，作用于线粒体膜的耦合过程，抑制氧化磷酸化和所有ATP依赖性反应。	Nature, 2020, 579(7797):118-122 Nature, 2020, 579(7797):118-122 Cell Rep, 2020, 30(6):1835-1847	(F) Detection of expression of SDHA and TOMM20 by immunoblotting in wild-type and Atg7-/- K562 cells with indicated drugs. The expression levels were quantified with number indicated. (G) Quantification analysis of mitochondrial mass in wild-type and Atg7-/- K562 cells when cultured with oligomycin(100 ng/ml), antimycin A(50 μM) and Baf-A1(10 nM).
S7046	Brefeldin A Brefeldin A 作用于HCT 116细胞，抑制内酯抗生素和ATPase，作用于protein transport（蛋白转运），IC50为0.2 μM，诱导癌细胞分化和凋亡。它还能提高同源重组修复效率，是CRISPR-mediated HDR的增强剂。Brefeldin A 也是自噬和线粒体自噬的抑制剂。	Cell Host Microbe, 2020, 11;27(3):476-485 e7 Ann Transl Med, 2020, 8(8):532 Nat Microbiol, 2019, 4(5):813-825	Cells were treated with brefeldin A or manumycin A, and the resulting supernatant was collected after 48 h for exosomal preparation (lanes 1 and 2), or exosomes obtained from C81 cells were trypsin-treated or freeze/thawed (F/T) and then trypsin-treated (lanes 3 and 4). Lanes 5 and 6, input exosome controls from C81 or CEM cells, respectively. Resulting exosomes were assayed for the presence of Tax by Western blotting.
S7099	(-)-Blebbistatin (-)-Blebbistatin是一种细胞渗透性抑制剂，作用于非肌球蛋白IIATPase，无细胞试验中IC50为~2 μM，不抑制肌球蛋白轻链激酶，抑制卵裂沟的缢缩，不干扰有丝分裂或收缩环的组装。	Nat Cell Biol, 2020, 25 Cell Rep, 2020, 30(11):3864-3874 Cell Death Dis, 2020, 8;11(6):428	(C) MyoIIA inhibition by blebbistatin treatment in vivo impairs leukemia cell extravasation into the brain. One hour before B-ALL cell transfer, C57BL/6 CD45.1+ recipient mice were treated with vehicle or blebbistatin (2.5 mg/kg). Twenty-four hours after B-ALL cell transfer, the recipient mice were intravenously injected with CD19-APC antibodies and then euthanized 4 min later.
S2000	Sodium orthovanadate Sodium orthovanadate是一种碱性磷酸酶和(Na，K)-ATPase抑制剂，IC50为10 μM。	Anal Chem, 2019, 91(23):14943-14950 Methods Mol Biol, 2017, 1493:345-361 Int J Mol Med, 2015, 36(2):386-98
S7895^New	Thapsigargin Thapsigargin 是一种有效的、非竞争性的 the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) 的抑制剂，对carbachol诱导的[Ca2+]i瞬变在存不存在KCl预刺激条件下的IC50值分别为0.353 nM和0.448 nM。Thapsigargin 可诱导细胞凋亡。Thapsigargin 提取自植物Thapsia garganica。
S7821^New	Bufalin Bufalin 是类固醇受体共激活剂 SRC-3、SRC-1 和 Na+/K+-ATPase 的有效抑制剂。Bufalin 可与Na+/K+-ATPase的亚基α1、α2和α3结合，其Kd值分别为42.5 nM、45 nM和40 nM。Bufalin 是一种从中药蟾酥中分离出来的，具有抗癌活性的，类地高辛免疫反应的主要成分。	bioRxiv, 2020, 2020/9/20.4.7.30734
S8828^New	Gboxin Gboxin是癌细胞中氧化磷酸化抑制剂，它能特异性地抑制原代小鼠和人源胶质母细胞瘤细胞的生长，而不影响小鼠胚胎成纤维细胞或新生儿星形胶质细胞。
S2528	Ciclopirox Ciclopirox 是一种合成的抗真菌药物。
S3019	Ciclopirox ethanolamine Ciclopirox ethanolamine作为一种铁离子螯合剂，具有广谱抗真菌作用。
S2233	Esomeprazole sodium Esomeprazole Sodium 是Esomeprazole的一种钠盐，是有效的质子泵抑制剂，IC50为0.076 mg/kg。	Cancer Cell Int, 2020, 19;20:58
S7266	Golgicide A Golgicide A是一种有效的，快速可逆的GBF1抑制剂。	Nature, 2019, 567(7747):262-266 Cells, 2019, 8(3) J Cell Biochem, 2019, 120(9):15604-15615	CSFV multiplication was inhibited by GCA. (A) The safe concentration of GCA was tested using the MTT assay. The operations and calculations were the same as those used for BFA. (B) Cellular CSFV RNA with or without 400 nM GCA were examined using real-time PCR. (C) The titers of CSFV with or without GCA were tested by IFA. (D) CSFV proliferation in ST cells with or without GCA was observed by IFA at 24, 48 and 72 hpi. Results from the three independent experiments are shown as means ± SD. P<0.05 and *P<0.01 compared with the control group.
S2222	PF-3716556 PF-3716556是一种有效的，选择性的P-CAB钾离子竞争性酸抑制剂，在离子渗透和离子密集检测中，抑制猪H⁺，K⁺-ATPase活性，抑制胃酸分泌，对Na⁺，K⁺-ATPas没有作用活性，用于治疗胃食管返流疾病。
S7460	BTB06584 BTB06584 是IF1依赖性的，选择性的线粒体F1 Fo-ATPase抑制剂.	J Cell Physiol, 2018, 234(1):940-949	Changes of mitochondrial membrane potential (ΔΨm). (A) Representative micrographs captured by confocal laser scanning microscope were evaluated for ΔΨm by staining with JC-1 at 24h post ionizing radiation. Red dimers indicated normal mitochondrial function and green monomers indicated collapse of ΔΨm with cytoplasmic fluorescence. Scale bar = 50μm. (B) Kinetics of changes of ΔΨm was showed as the ratio of red to green fluorescence in each treatment staining with JC-1 at 0.5, 6, 12, 24, 48, 72 and 96 h after X-ray radiation (IR) with or without 10μM BTB treatment. Data are expressed as means±SD of triplicate measurements. IR compared with IR+BTB, p< 0.05, *p< 0.01, t-test. Control compared with IR+BTB, #p< 0.05, ##p< 0.01, t-test.
S5554	Lanatoside C Lanatoside C, a cardiac glycoside which belongs to a class of compounds derived from plants called foxglove, possesses the ability to inhibit the interchange of Na+ and K+ across cell membrane and is widely used to treat anti-arrhythmias and heart failure.
S3699	2,3-Butanedione-2-monoxime 2,3-Butanedione monoxime (BDM)是一种低亲和力的、非竞争性的skeletal muscle myosin-II抑制剂，抑制骨骼肌和心肌收缩。
S8101	CB-5083 CB-5083是一种有效的，选择性的，且口服具有生物活性的p97 AAA ATPase抑制剂，IC50为 11 nM。Phase 1。	Cells, 2020, 9(2) Cell Cycle, 2020, 19;1-12 Cell, 2019, 177(3):766-781	LN229 GBM cell lysates were immunoblotted with antibodies recognizing specific focal adhesion proteins. Note the decreased levels of Cas, paxillin, and FAK tyrosine phosphorylation in cells treated with CB-5083. In addition, CB-5083 treatment leads to decreased levels of total PTP-PEST expression, but Vcp protein expression levels are not impacted.
S4166	Chlorpropamide Chlorpropamide是一种磺脲类药物，用于治疗2型糖尿病。	Nat Commun, 2017, 8(1):573
S3628	BHQ BHQ是有效的、选择性的sarco-endoplasmic reticulum Ca2+-ATPase (SERCA)抑制剂。
S8276	FCCP FCCP在线粒体中式一种有效的氧化磷酸化的解偶联剂，通过转运质子破坏ATP的合成。	Toxicol In Vitro, 2020, 66:104838 Clin Cancer Res, 2020, 10.1158 J Recept Signal Transduct Res, 2019, 1-9	The changes in 10-N-nonylacridineorange (NAO) fluorescence indicated the cardiolipin (CL) oxidation. In normal cells, NAO could interact with nonoxidized cardiolipin and produces a characteristic green fluorescence. However, after cardiolipin is oxidized, NAO cannot bind to it. F-H, The changes in MDA, GSH, and SOD levels. I and J, The cytoplasmic [Ca2+] map via confocal microscopy by Fluo-2. Fluorescence intensity of Fluo-2 was measured by excitation wavelengths of 340 nm and emission wavelengths of 500 nm. Data (F/F0) were obtained by dividing fluorescence intensity (F) by (F0) at the resting level (t = 0), which was normalized to normal groups. Data are shown as means ± SEM. *P < .05 vs normal group; #P < .05 vs PA group, @P < .05 vs PA + siRNA-NR4A1 or PA + melatonin groups
S5623	Bedaquiline Bedaquiline, a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).
S3924	Ginsenoside Rb1 Ginsenoside Rb1 is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.
S5454	Saikosaponin D Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities.
S2623	Omecamtiv mecarbil (CK-1827452) Omecamtiv mecarbil (CK-1827452)是一种特异性的心肌肌球蛋白激动剂，是用于左心室收缩性心脏衰竭的临床药物。Phase 2。	Circ Res, 2019, 10.1161/CIRCRESAHA.118.314505 Dev Cell, 2019, 49(6):920-935 Cell Metab, 2018, 27(3):602-615	Normal and Mutation human iPSC-CMs Structure when Treated with Omecamtiv Mecarbil. Human iPSC-CMs were plated on 100 kPa flat PDMS and grown for five days and left untreated, treated acutely on day 5, or treated continuously from the time of plating with the myosin activator Omecamtiv Mecarbil. iPSC-CMs were then fixed and stained for actin filaments (phalloidin, red) and nucleus (DAPI, blue). (a, c, e) Normal and (b, d, f) Mutation untreated, acutely treated, and continuously treated iPSC-CMs.
S6815^New	CDN1163 CDN1163是一种 sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 的小分子变构激活剂，可改善 Ca2+ 稳态。
S4707	Oleic Acid 油酸（Oleic acid）是一种天然存在于多种动物和植物脂肪和油类中的脂肪酸。它常被用作制作油酸和乳液，并作为一种药物溶剂。
S1238	Tamoxifen Tamoxifen作用于乳腺组织，是一种雌激素受体estrogen receptor拮抗剂。Tamoxifen可增强Hsp90分子伴侣ATPase的活性。Tamoxifen可诱导凋亡。	Aging Dis, 2020, 9;11(3):523-535 Bone, 2020, 130:115123 Front Oncol, 2020, 9:1503	E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.
S9181	Periplocin Periplocin 是从传统草药皮质骨膜中提取的，具有心脏和抗癌活性。Periplocin 可以显著地促进成纤维细胞L929细胞的增殖、迁移和刺激胶原蛋白的产生，这取决于 Na/K-ATPase 介导的Src/ERK和PI3K/Akt信号通路的激活，从而促进伤口愈合。

目录号	产品描述	文献引用	实验数据
S1478	Oligomycin A Oligomycin A是一种ATP synthase抑制剂，作用于线粒体膜的耦合过程，抑制氧化磷酸化和所有ATP依赖性反应。	Nature,2020, 579(7797):118-122 Nature,2020, 579(7797):118-122 Cell Rep,2020, 30(6):1835-1847	(F) Detection of expression of SDHA and TOMM20 by immunoblotting in wild-type and Atg7-/- K562 cells with indicated drugs. The expression levels were quantified with number indicated. (G) Quantification analysis of mitochondrial mass in wild-type and Atg7-/- K562 cells when cultured with oligomycin(100 ng/ml), antimycin A(50 μM) and Baf-A1(10 nM).
S7046	Brefeldin A Brefeldin A 作用于HCT 116细胞，抑制内酯抗生素和ATPase，作用于protein transport（蛋白转运），IC50为0.2 μM，诱导癌细胞分化和凋亡。它还能提高同源重组修复效率，是CRISPR-mediated HDR的增强剂。Brefeldin A 也是自噬和线粒体自噬的抑制剂。	Cell Host Microbe,2020, 11;27(3):476-485 e7 Ann Transl Med,2020, 8(8):532 Nat Microbiol,2019, 4(5):813-825	Cells were treated with brefeldin A or manumycin A, and the resulting supernatant was collected after 48 h for exosomal preparation (lanes 1 and 2), or exosomes obtained from C81 cells were trypsin-treated or freeze/thawed (F/T) and then trypsin-treated (lanes 3 and 4). Lanes 5 and 6, input exosome controls from C81 or CEM cells, respectively. Resulting exosomes were assayed for the presence of Tax by Western blotting.
S7099	(-)-Blebbistatin (-)-Blebbistatin是一种细胞渗透性抑制剂，作用于非肌球蛋白IIATPase，无细胞试验中IC50为~2 μM，不抑制肌球蛋白轻链激酶，抑制卵裂沟的缢缩，不干扰有丝分裂或收缩环的组装。	Nat Cell Biol,2020, 25 Cell Rep,2020, 30(11):3864-3874 Cell Death Dis,2020, 8;11(6):428	(C) MyoIIA inhibition by blebbistatin treatment in vivo impairs leukemia cell extravasation into the brain. One hour before B-ALL cell transfer, C57BL/6 CD45.1+ recipient mice were treated with vehicle or blebbistatin (2.5 mg/kg). Twenty-four hours after B-ALL cell transfer, the recipient mice were intravenously injected with CD19-APC antibodies and then euthanized 4 min later.
S2000	Sodium orthovanadate Sodium orthovanadate是一种碱性磷酸酶和(Na，K)-ATPase抑制剂，IC50为10 μM。	Anal Chem,2019, 91(23):14943-14950 Methods Mol Biol,2017, 1493:345-361 Int J Mol Med,2015, 36(2):386-98
S7895^New	Thapsigargin Thapsigargin 是一种有效的、非竞争性的 the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) 的抑制剂，对carbachol诱导的[Ca2+]i瞬变在存不存在KCl预刺激条件下的IC50值分别为0.353 nM和0.448 nM。Thapsigargin 可诱导细胞凋亡。Thapsigargin 提取自植物Thapsia garganica。
S7821^New	Bufalin Bufalin 是类固醇受体共激活剂 SRC-3、SRC-1 和 Na+/K+-ATPase 的有效抑制剂。Bufalin 可与Na+/K+-ATPase的亚基α1、α2和α3结合，其Kd值分别为42.5 nM、45 nM和40 nM。Bufalin 是一种从中药蟾酥中分离出来的，具有抗癌活性的，类地高辛免疫反应的主要成分。	bioRxiv,2020, 2020/9/20.4.7.30734
S8828^New	Gboxin Gboxin是癌细胞中氧化磷酸化抑制剂，它能特异性地抑制原代小鼠和人源胶质母细胞瘤细胞的生长，而不影响小鼠胚胎成纤维细胞或新生儿星形胶质细胞。
S2528	Ciclopirox Ciclopirox 是一种合成的抗真菌药物。
S3019	Ciclopirox ethanolamine Ciclopirox ethanolamine作为一种铁离子螯合剂，具有广谱抗真菌作用。
S2233	Esomeprazole sodium Esomeprazole Sodium 是Esomeprazole的一种钠盐，是有效的质子泵抑制剂，IC50为0.076 mg/kg。	Cancer Cell Int,2020, 19;20:58
S7266	Golgicide A Golgicide A是一种有效的，快速可逆的GBF1抑制剂。	Nature,2019, 567(7747):262-266 Cells,2019, 8(3) J Cell Biochem,2019, 120(9):15604-15615	CSFV multiplication was inhibited by GCA. (A) The safe concentration of GCA was tested using the MTT assay. The operations and calculations were the same as those used for BFA. (B) Cellular CSFV RNA with or without 400 nM GCA were examined using real-time PCR. (C) The titers of CSFV with or without GCA were tested by IFA. (D) CSFV proliferation in ST cells with or without GCA was observed by IFA at 24, 48 and 72 hpi. Results from the three independent experiments are shown as means ± SD. P<0.05 and *P<0.01 compared with the control group.
S2222	PF-3716556 PF-3716556是一种有效的，选择性的P-CAB钾离子竞争性酸抑制剂，在离子渗透和离子密集检测中，抑制猪H⁺，K⁺-ATPase活性，抑制胃酸分泌，对Na⁺，K⁺-ATPas没有作用活性，用于治疗胃食管返流疾病。
S7460	BTB06584 BTB06584 是IF1依赖性的，选择性的线粒体F1 Fo-ATPase抑制剂.	J Cell Physiol,2018, 234(1):940-949	Changes of mitochondrial membrane potential (ΔΨm). (A) Representative micrographs captured by confocal laser scanning microscope were evaluated for ΔΨm by staining with JC-1 at 24h post ionizing radiation. Red dimers indicated normal mitochondrial function and green monomers indicated collapse of ΔΨm with cytoplasmic fluorescence. Scale bar = 50μm. (B) Kinetics of changes of ΔΨm was showed as the ratio of red to green fluorescence in each treatment staining with JC-1 at 0.5, 6, 12, 24, 48, 72 and 96 h after X-ray radiation (IR) with or without 10μM BTB treatment. Data are expressed as means±SD of triplicate measurements. IR compared with IR+BTB, p< 0.05, *p< 0.01, t-test. Control compared with IR+BTB, #p< 0.05, ##p< 0.01, t-test.
S5554	Lanatoside C Lanatoside C, a cardiac glycoside which belongs to a class of compounds derived from plants called foxglove, possesses the ability to inhibit the interchange of Na+ and K+ across cell membrane and is widely used to treat anti-arrhythmias and heart failure.
S3699	2,3-Butanedione-2-monoxime 2,3-Butanedione monoxime (BDM)是一种低亲和力的、非竞争性的skeletal muscle myosin-II抑制剂，抑制骨骼肌和心肌收缩。
S8101	CB-5083 CB-5083是一种有效的，选择性的，且口服具有生物活性的p97 AAA ATPase抑制剂，IC50为 11 nM。Phase 1。	Cells,2020, 9(2) Cell Cycle,2020, 19;1-12 Cell,2019, 177(3):766-781	LN229 GBM cell lysates were immunoblotted with antibodies recognizing specific focal adhesion proteins. Note the decreased levels of Cas, paxillin, and FAK tyrosine phosphorylation in cells treated with CB-5083. In addition, CB-5083 treatment leads to decreased levels of total PTP-PEST expression, but Vcp protein expression levels are not impacted.
S4166	Chlorpropamide Chlorpropamide是一种磺脲类药物，用于治疗2型糖尿病。	Nat Commun,2017, 8(1):573
S3628	BHQ BHQ是有效的、选择性的sarco-endoplasmic reticulum Ca2+-ATPase (SERCA)抑制剂。
S8276	FCCP FCCP在线粒体中式一种有效的氧化磷酸化的解偶联剂，通过转运质子破坏ATP的合成。	Toxicol In Vitro,2020, 66:104838 Clin Cancer Res,2020, 10.1158 J Recept Signal Transduct Res,2019, 1-9	The changes in 10-N-nonylacridineorange (NAO) fluorescence indicated the cardiolipin (CL) oxidation. In normal cells, NAO could interact with nonoxidized cardiolipin and produces a characteristic green fluorescence. However, after cardiolipin is oxidized, NAO cannot bind to it. F-H, The changes in MDA, GSH, and SOD levels. I and J, The cytoplasmic [Ca2+] map via confocal microscopy by Fluo-2. Fluorescence intensity of Fluo-2 was measured by excitation wavelengths of 340 nm and emission wavelengths of 500 nm. Data (F/F0) were obtained by dividing fluorescence intensity (F) by (F0) at the resting level (t = 0), which was normalized to normal groups. Data are shown as means ± SEM. *P < .05 vs normal group; #P < .05 vs PA group, @P < .05 vs PA + siRNA-NR4A1 or PA + melatonin groups
S5623	Bedaquiline Bedaquiline, a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).
S3924	Ginsenoside Rb1 Ginsenoside Rb1 is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions.
S5454	Saikosaponin D Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities.

目录号	产品描述	文献引用	实验数据
S2623	Omecamtiv mecarbil (CK-1827452) Omecamtiv mecarbil (CK-1827452)是一种特异性的心肌肌球蛋白激动剂，是用于左心室收缩性心脏衰竭的临床药物。Phase 2。	Circ Res, 2019, 10.1161/CIRCRESAHA.118.314505 Dev Cell, 2019, 49(6):920-935 Cell Metab, 2018, 27(3):602-615	Normal and Mutation human iPSC-CMs Structure when Treated with Omecamtiv Mecarbil. Human iPSC-CMs were plated on 100 kPa flat PDMS and grown for five days and left untreated, treated acutely on day 5, or treated continuously from the time of plating with the myosin activator Omecamtiv Mecarbil. iPSC-CMs were then fixed and stained for actin filaments (phalloidin, red) and nucleus (DAPI, blue). (a, c, e) Normal and (b, d, f) Mutation untreated, acutely treated, and continuously treated iPSC-CMs.
S6815^New	CDN1163 CDN1163是一种 sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 的小分子变构激活剂，可改善 Ca2+ 稳态。
S4707	Oleic Acid 油酸（Oleic acid）是一种天然存在于多种动物和植物脂肪和油类中的脂肪酸。它常被用作制作油酸和乳液，并作为一种药物溶剂。
S1238	Tamoxifen Tamoxifen作用于乳腺组织，是一种雌激素受体estrogen receptor拮抗剂。Tamoxifen可增强Hsp90分子伴侣ATPase的活性。Tamoxifen可诱导凋亡。	Aging Dis, 2020, 9;11(3):523-535 Bone, 2020, 130:115123 Front Oncol, 2020, 9:1503	E, Analysis of BrCSC viability upon treatment with tamoxifen (tam) and fulvestrant (fulv) at the indicated doses. The experiments were performed in triplicates. ** P<0.01.
S9181	Periplocin Periplocin 是从传统草药皮质骨膜中提取的，具有心脏和抗癌活性。Periplocin 可以显著地促进成纤维细胞L929细胞的增殖、迁移和刺激胶原蛋白的产生，这取决于 Na/K-ATPase 介导的Src/ERK和PI3K/Akt信号通路的激活，从而促进伤口愈合。

研究领域

产品类型

ATPase

信号通路图

研究领域

抑制剂选择性比较

ATPase产品