FCCP

For research use only. Not for use in humans.

目录号:S8276 别名: Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

FCCP Chemical Structure

CAS No. 370-86-5

FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)在线粒体中式一种有效的氧化磷酸化的解偶联剂,通过转运质子破坏ATP的合成。

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客户使用Selleck生产的FCCP发表文献28篇:

产品安全说明书

OXPHOS抑制剂选择性比较

生物活性

产品描述 FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)在线粒体中式一种有效的氧化磷酸化的解偶联剂,通过转运质子破坏ATP的合成。
靶点
OXPHOS [2]
()
ATP synthase [2]
()
体外研究

在体外实验中,FCCP的处理能诱导细胞内Ca2+迅速升至2倍,同时抑制蛋白合成速率。对蛋白翻译速率的抑制作用与eIF2α的磷酸化增加以及依赖双链RNA的蛋白激酶活性增加有关[1]。FCCP还可轻微地减少ATP以及活性氧水平,提高线粒体基因如Tfam和COXIV的表达,诱导老鼠造血干细胞的静态形态特征以及抑制TGF-β的信号转导[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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T47D M{jLbGZ2dmO2aX;uJIF{e2G7 M1\VZWlvcGmkaYTpc44hd2ZiaInwc5hq[S2rbnT1Z4VlKEiLRkGgZYN1cX[jdHnvckBqdiCqdX3hckBVPDeGIHPlcIx{KGK7IFjSSVMuXEtvbIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuOVHPxE1? NIrZS3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmyPVI3OSd-MkC5NlkzPjF:L3G+
T47D NFH5W2ZHfW6ldHnvckBie3OjeR?= NXjrTFlJOSC2bzCxNEB2VQ>? Mkn6TY5pcWKrdHnvckBw\iCKSV[xMY1m\GmjdHXkJIlv\HWldHnvckBw\iC|ZXPy[ZRm\CCYRVfGJIxmfmWuIHnuJFEtKDFyLYDo[Y5idnSqcn;sbY5mNXO2aX31cIF1\WRiaIXtZY4hXDR5RDDj[YxteyCjdDCxJJRwKDFyIIXNJIJ6KEWOSWPB MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl{OUK2NUc,OjB7MkmyOlE9N2F-
T47D Mn21SpVv[3Srb36gZZN{[Xl? NILwfJExNjNidV2= MnXINVUhdWmwcx?= NGrId3lF\WO{ZXHz[UBqdiCvaYTvZ4hwdmS{aXHsJI1mdWK{YX7lJJBwfGWwdHnhcEBqdiCqdX3hckBVPDeGIHPlcIx{KDBwMzD1UUBi\nSncjCxOUBucW6|IHL5JHROWk1iYYPzZZk> NH7KbGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmyPVI3OSd-MkC5NlkzPjF:L3G+
MDA-MB-231 MWjDfZRwfG:6aXPpeJkh[XO|YYm= MYOxJJVO M2\LcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36veoli[mmuaYT5JIF1KDFidV2= MkHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NEW2OVAoRjJ|MkS1OlUxRC:jPh?=
MDA-MB-231 NGThSItEgXSxdH;4bYNqfHliYYPzZZk> MYCwMlEhfG9iMzD1US=> MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wL4\pZYJqdGm2eTDheEAxNjFidH:gN{B2VSCrbjDwdoV{\W6lZTDv[kAxNjFidV2gdo91\W6xbnWgcYl1d2Oqb37kdolidCCnbHXjeJJwdiC2cnHud5BwenRiaX7obYJqfG:{ NVPiRo8{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOFU3PTBpPkKzNlQ2PjVyPD;hQi=>
MDA-MB-231 MmfMSpVv[3Srb36gZZN{[Xl? MoqxNE4{KHWP MoniV5RqdXWuYYTpc44hd2Zib3zp[49ugWOrbj3pcoR2[2WmIIP0ZZRmKDRicnXzdIlz[XSrb36gbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDheEAxNjNidV2= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ2NU[1NEc,OjN{NEW2OVA9N2F-
T47D NIT2T25HfW6ldHnvckBie3OjeR?= NV;o[pBCOC5zIITvJFMhfU1? M3PhbmVn\mWldDDvckBk\WyudXzhdkBz\XOyaYLheIlwdiCrbjDoeY1idiCWNEfEJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKG:6eXflckBkd26|dX3weIlwdiCjdDCwMlEhfG9iMzD1US=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl|OEC5N{c,OjJ7M{iwPVM9N2F-
T47D NID3VHhHfW6ldHnvckBie3OjeR?= NEDYZYgyOCC2bzCzNEB2VQ>? NGjIVVJUfGmvdXzheIlwdiCxZjDzeIF1\SB2IHPlcIx2dGG{IILld5BqemG2aX;uJIlvKGi3bXHuJHQ1P0RiY3XscJMh[XRiMUCgeI8hOzBidV2gbY4heHKnc3XuZ4Uhd2Zib3zp[49ugWOrbh?= NHrkcIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmzPFA6Oyd-MkK5N|gxQTN:L3G+
T47D M2DiZWZ2dmO2aX;uJIF{e2G7 NXTO[3BmOC5|IITvJFEhfU1? NXi2[HBGW3SrbYXsZZRqd25ib3[gd5RifGViNDDj[YxtfWyjcjDy[ZNxcXKjdHnvckBqdiCqdX3hckBVPDeGIHPlcIx{KGG2IECuN{B1dyBzIIXNJIlvKHC{ZYPlcoNmKG:oIH;sbYdwdXmlaX6= M3:ySFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUO4NFk{Lz5{MkmzPFA6OzxxYU6=
Hep3B MlS2SpVv[3Srb36gZZN{[Xl? MlyxNVAhfU1? MmTUV5RqdXWuYYTpc44hd2Zic4TheIUhPCClZXzseYxieiC{ZYPwbZJifGmxbjDpckBpfW2jbjDI[ZA{SiClZXzsd{BifCBzMDD1UUBqdiCycnXz[Y5k\SCxZjDvcIlod227Y3nu MoPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7M{iwPVMoRjJ{OUO4NFk{RC:jPh?=
Hep3B MWfGeY5kfGmxbjDhd5NigQ>? MWixJJVO MkTIV5RqdXWuYYTpc44hd2Zic4TheIUhPCClZXzseYxieiC{ZYPwbZJifGmxbjDpckBpfW2jbjDI[ZA{SiClZXzsd{BifCBzIIXNJIlvKHC{ZYPlcoNmKG:oIH;sbYdwdXmlaX6= MmLXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7M{iwPVMoRjJ{OUO4NFk{RC:jPh?=
T47D M17UPWZ2dmO2aX;uJIF{e2G7 MWKzJJVO NFzoT3EyPSC2bzCyNEBucW6| MYHE[YNz\WG|ZTDpckBucXSxY3jvcoRzcWGuIH3lcYJz[W6nIIDveIVvfGmjbDDpckBpfW2jbjDUOFdFKGOnbHzzJIF1KDNidV2gZYZ1\XJiMUWgeI8hOjBibXnud{BjgSCWTWLNJIF{e2G7 NVfidpBFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5N|gxQTNpPkKyPVM5ODl|PD;hQi=>
TA3/Ha MXjGeY5kfGmxbjDhd5NigQ>? NFzEOm43KHWP M33HfWlv\HWldHnvckBw\iCQQVSoVElJKG:6aXTheIlwdiCrbjDtc5V{\SCWQUOvTIEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIF7BSEhRMUhxTlHELHAqMyC{YYTpc{BifCB4IIXNJIJ6KHOyZXP0do9ndHWxcn;t[ZRmeiCjbnHsfZNqew>? NV:zNoN7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1Olg3OTRpPkK0OVY5PjF2PD;hQi=>
SH-SY5Y M1q3WmZ2dmO2aX;uJIF{e2G7 MUSxNEB2VQ>? MorzOUBucW6| NHfRPFVKdmirYnn0bY9vKG:oIGPPR{BqdiCqdX3hckBUUC2VWUXZJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC2aHHwd4lo[XKpaX6tbY5lfWOnZDDDZVIsKGmwZnz1fEBifCBzMDD1UUBxemVvaX7jeYJifGWmIH\vdkA2KG2rboOge4l1cCByLkKgeW0hS3ODIH\vcIxwf2WmIHL5JINwdXCxdX7kJIFl\Gm2aX;uJIJ6KE[XUlGtNmFOKGS7ZTDiZZNm\CCobIXvdoV{[2WwY3WgZZN{[Xl? MoDFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{NkWwNlQoRjJ3Mk[1NFI1RC:jPh?=
SH-SY5Y M3jEVWZ2dmO2aX;uJIF{e2G7 MXKxNEB2VQ>? NUHQeGZtOTBibXnudy=> M3TCbmlv\HWldHnvckBw\iCvaYTvZ4hwdmS{aXHsJI1mdWK{YX7lJJBwfGWwdHnhcEBtd3O|IHnuJIh2dWGwIGPIMXN[PVliY3XscJMh[XRiMUCgeW0hcW6ldXLheIVlKG[xcjCxNEBucW6|IHnuJJBz\XOnbnPlJI9nKDBwMjD1UUBEe0FiYomgWG1TTSCmeXWgZoF{\WRiYYPzZZk> NXrO[GJKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlUxOjRpPkK1NlY2ODJ2PD;hQi=>
T47D NIHzT21HfW6ldHnvckBie3OjeR?= NVT2N5h7OC5|IIXN MknlN{B1dyBzMjDtbY5{ NGiyU5FKdmO{ZXHz[UBqdiCxeInn[Y4h[2:wc4XtdJRqd25icnH0[UBw\iCvaYTvZ4hwdmS{aXHsJJN1[XSnIESgdoV{eGm{YYTpc44hcW5iaIXtZY4hXDR5RDDj[YxteyCjc4Pld5Nm\CCjczDy[YlvcXSrYYTpc44hd2Zib3zp[49ugWOrbj3zeIFtdGWmIHPlcIx2dGG{IILld5BqemG2aX;uJIF1KDBwMzD1UUBqdmO3YnH0[YQh\m:{IEOgeI8hOTJibXnud{BjgSCFbHHyb{11gXCnIH;4fYdmdiCnbHXjeJJw\GViYYPzZZk> NYfFZ|RXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N|cxPDZpPkK2OlM4ODR4PD;hQi=>
T47D Mor6SpVv[3Srb36gZZN{[Xl? NEXLV5oxNjNidV2= MmfZN|AhdWmwcx?= MWfF[oZm[3Rib36gcYl1d2Oqb37kdolidCCvZX3idoFv\SCyb4TlcpRq[WxiaX6gbJVu[W5iVES3SEBk\WyuczDheEAxNjNidV2gZYZ1\XJiM{CgcYlveyCkeTDUUXJOKGS7ZTDiZZNm\CCobIXvdoV{[2WwY3WgcYlkem:|Y3;wfS=> M2PjNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkO3NFQ3Lz5{Nk[zO|A1PjxxYU6=
T47D NUnUXW5QTnWwY4Tpc44h[XO|YYm= NWDROmhlOC5|IIXN NFvjdlBKdmO{ZXHz[UBqdiCxeInn[Y4h[2:wc4XtdJRqd25icnH0[UBqdiCmaXfpeI9vcW5icHXycYVi[mmuaYrl[EBpfW2jbjDUOFdFKGOnbHzzJIF{e2W|c3XkJIF{KHKnaX7peIlifGmxbjDv[kB{d2SrdX2gZZpq\GVvc4ThcIxm\CClZXzseYxieiC{ZYPwbZJifGmxbjDheEAxNjNidV2gZpkhd3i7dHjldo0hS2yjcnuteJlx\SCnbHXjeJJw\GViYYPzZZkhcW5icILld4Vv[2Vib3[gZZNkd3KkYYTl MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ|N{C0Okc,OjZ4M{ewOFY9N2F-
HCT116 MWLGeY5kfGmxbjDhd5NigQ>? NHHJRpgzKHWP NXzKXXdGOzBibXnudy=> MoOxTY5lfWO2aX;uJI9nKEGPUFugdIhwe3Cqb4L5cIF1cW:wIHH0JHRpei1zN{KgdoV{cWS3ZTDpckBpfW2jbjDIR3QyOTZiY3XscJMh[XRiMjD1UUBi\nSncjCzNEBucW6|IHnuJIdtfWOxc3Wgd5VxeGynbXXueIVlKG2nZHnhJIJ6KGmvbYXuc4Jtd3RibXX0bI9l NHjpcnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKzN|Y5OCd-MkiyN|M3QDB:L3G+
HCT116 M1z0NGZ2dmO2aX;uJIF{e2G7 Mn;KNkB2VQ>? MnXFN|AhdWmwcx?= Moq5TY5lfWO2aX;uJI9nKEGPUFugdIhwe3Cqb4L5cIF1cW:wIHH0JHRpei1zN{KgdoV{cWS3ZTDpckBpfW2jbjDIR3QyOTZiY3XscJMh[XRiMjD1UUBi\nSncjCzNEBucW6|IHnuJIFje2WwY3Wgc4Yh\2y3Y3;z[UBjgSCrbX31co9jdG:2IH3leIhw\A>? Ml\WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{M{O2PFAoRjJ6MkOzOlgxRC:jPh?=
DLD1 NXHZR452TnWwY4Tpc44h[XO|YYm= MYmxJJVO NHHSbmNKdmS3Y4Tpc44hd2ZibXn0c4Npd26mcnnhcEBlgXOodX7jeIlwdiCrbjDoeY1idiCGTFSxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCvaYTvZ4hwdmS{aXHsJGFVWCCycn;keYN1cW:wIHH0JFEhfU1iYomgV4VicG:{c3WgXGYhemWjbD30bY1mKGG|c3H5 M4nNbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzN{e0OlczLz5|MUe3OFY4OjxxYU6=
DLD1 MYPGeY5kfGmxbjDhd5NigQ>? M2rNXVEhfU1? MY\JcoR2[3Srb36gc4YhdWm2b3Poc45lemmjbDDkfZNnfW6ldHnvckBqdiCqdX3hckBFVERzIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIdtgWOxbIn0bYMhSVSSIIDyc4R2[3Srb36gZZQhOSC3TTDifUBU\WGqb4Lz[UBZTiC{ZXHsMZRqdWViYYPzZZk> MnLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF5N{S2O|IoRjNzN{e0OlczRC:jPh?=
LS174T M3LSbWZ2dmO2aX;uJIF{e2G7 NGPi[HQyKHWP NHPmc4ZKdmS3Y4Tpc44hd2ZibXn0c4Npd26mcnnhcEBlgXOodX7jeIlwdiCrbjDoeY1idiCOU{G3OHQh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIH3peI9kcG:wZILpZYwhSVSSIIDyc4R2[3Srb36gZZQhOSC3TTDifUBU\WGqb4Lz[UBZTiC{ZXHsMZRqdWViYYPzZZk> MonJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF5N{S2O|IoRjNzN{e0OlczRC:jPh?=
LS174T Mn\5SpVv[3Srb36gZZN{[Xl? NIfBbGMyKHWP NWLUUGtKUW6mdXP0bY9vKG:oIH3peI9kcG:wZILpZYwh\Hm|ZoXuZ5Rqd25iaX6gbJVu[W5iTGOxO|RVKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHfsfYNwdHm2aXOgRXRRKHC{b3T1Z5Rqd25iYYSgNUB2VSCkeTDT[YFpd3K|ZTDYSkBz\WGuLYTpcYUh[XO|YYm= NVL1Z5ltRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G3O|Q3PzJpPkOxO|c1Pjd{PD;hQi=>
DLD1 Ml7VSpVv[3Srb36gZZN{[Xl? MU[xJJVO MlnKWY5kd3WybHnu[{Bw\iCvaYTvZ4hwdmS{aXHsJI95cWSjdHn2[UBxcG:|cHjvdplt[XSrb36gbY4hcHWvYX6gSGxFOSClZXzsd{BifCBzIIXNJIlvKHC{ZYPlcoNmKG:oIH;sbYdwdXmlaX6gRUBjgSC|ZXHoc5J{\SC[RnW5OkBidmGueYPldkBj[XOnZDDhd5NigQ>? NGfj[Xg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUe3OFY4Oid-M{G3O|Q3PzJ:L3G+
DLD1 M2G5V2Z2dmO2aX;uJIF{e2G7 MUixJJVO MYDVcoNwfXCuaX7nJI9nKG2rdH;jbI9v\HKrYXygc5hq\GG2aY\lJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDEUGQyKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIH;4fYdmdiClb37zeY1xfGmxbjDyZZRmKGG2IEGgeW0hcW5icILld4Vv[2Vib3[gc4xq\2:veXPpckBCKGK7IIPlZYhwenOnIGjG[Vk3KGGwYXz5d4VzKGKjc3XkJIF{e2G7 NWP4TGU1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G3O|Q3PzJpPkOxO|c1Pjd{PD;hQi=>
HEK293 NXn2ZWFrTnWwY4Tpc44h[XO|YYm= MkHUNUB1dyB|IIXN MVjJcohq[mm2aX;uJI9nKEyrQ3ytZYN1cX[jdHXkJHdvfCC|aXfuZYxqdmdiaX6gTGVMOjl|IHPlcIx{KGG2IEGgeI8hOyC3TTDifUBVV1CIbHHzbEBz\XCxcoTldkBo\W6nIHHzd4F6 M4LIXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzN{e0OlczLz5|MUe3OFY4OjxxYU6=
KOPN8 NUDoWpV6TnWwY4Tpc44h[XO|YYm= MoDBNVAhfU1? MVSwMlMhcHK| NEOwcHlKdmS3Y4Tpc44hd2ZibXn0c4Npd26mcnnhcEBu\W2kcnHu[UBxd3SnboTpZYwhdG:|czDpckBpfW2jbjDLU3BPQCClZXzsd{BifCBzMDD1UUBi\nSncjCwMlMhcHK|IHL5JHROWk1ic4ThbY5qdmdiYnHz[YQh\myxdzDjfZRwdWW2cnnjJIFv[Wy7c3nz MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTB6NECyPEc,OzFyOESwNlg9N2F-
HepG2 MlzlSpVv[3Srb36gZZN{[Xl? NVXmTZgyVHWlaX\ldoF{\S:udXPp[oVzcW5vZYjwdoV{e2mwZzDhcpRq\m:uYYTlMZJme2m|dHHueEBx[XKjc3n0[ZMhf2W{ZTD1d4VlKHSxIHnu[oVkfCCjIHP1cJR2emVib3[gTIVxTzJiY3XscJMhfGijdDD3[ZJmKHC{ZT3pcoN2[mG2ZXSge4l1cCClb33wc5Vv\HNwIFnu[oVkfGWmIHjldIF1d2O7dHXzJIVucXRibHnnbJQh\HWnIITvJJRp\SCudXPp[oVz[XOnIILlZYN1cW:wLjDBd5NigSC{ZYP1cJR{KGG{ZTDwdoV{\W62ZXSgZZMhfGinIIDldoNmdnRiLDDJR|UxRTBwMkS1{txO NXXpZYlWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDV5NUC0M{c,S2iHTVLMQE9iRg>?

... Click to View More Cell Line Experimental Data

体内研究 FCCP的处理在8细胞期的小鼠胚胎中可显著降低线粒体膜电位、ATP的生成以及囊胚中细胞内细胞团的数量,对胚泡发育没有影响。在胚胎线粒体功能受到干扰的同时,在胚胎植入后,雌性后代的出生体重下降,抑制持续到断奶阶段。尽管FCCP处理过的雄性小鼠也和雌性小鼠一样,葡萄糖耐受量降低。但是它们的胰岛素敏感度和肥胖度在4-14周内无变化。在预压胚中,线粒体功能降低,然后减少ATP的输出,将影响其后代表型[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[1]

- 合并
  • Cell lines: PC12细胞
  • Concentrations: 30 μM
  • Incubation Time: 30 min, 1h, 2h
  • Method:

    用直径为24-mm的多孔板,加入含0.175 Ci/mmol的[3H]methionine的新鲜培养液,37℃孵育30分钟。在不同的时间段对PC12细胞处理以FCCP,测定蛋白质合成速率。


    (Only for Reference)

溶解度 (25°C)

体外 DMSO 50 mg/mL (196.71 mM)
Water Insoluble
Ethanol '50 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 254.17
化学式

C10H5F3N4O

CAS号 370-86-5
储存条件 粉状
溶于溶剂
别名 Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID