OXPHOS
抑制剂选择性比较
OXPHOS产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2987 |
4-Methyl-2-oxovaleric acid4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) 是由星形胶质细胞释放至神经元,可以通过氨基转移酶重新形成亮氨酸。4-Methyl-2-oxovaleric acid 可降低骨骼肌中蛋白质的降解速率。4-Methyl-2-oxovaleric acid 可通过抑制 alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) 的活性来发挥 oxidative phosphorylation (OXPHOS) 的解偶联剂和代谢抑制剂的功效。 |
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S8731 |
IACS-010759 (IACS-10759)IACS-010759 (IACS-10759)是一种有效的、选择性氧化磷酸化 (oxidative phosphorylation) 抑制剂,IC50小于10 nM,它通过抑制complex I阻止细胞呼吸作用。 |
||
S8943 |
VLX600VLX600 是一种新型的铁螯合的 oxidative phosphorylation (OXPHOS) 的抑制剂,通过协同作用增强对肿瘤球体的放疗作用。VLX600 在营养缺乏的条件下可显示出增强的细胞毒性。 VLX600 可诱导 autophagy 和 mitochondrial inhibition 并具有抗肿瘤活性。 |
||
S0096 |
S-GboxinS-Gboxin 是一种Gboxin的功能类似物,是 oxidative phosphorylation (OXPHOS) 的抑制剂,可抑制小鼠和人类的 glioblastoma (GBM) 的生长,其IC50值为470 nM。 |
||
S9604 |
IM156IM156 (HL156A),一种二甲双胍衍生物,也是 AMPK 的有效激活剂,可增强AMPK磷酸化。IM156 可通过抑制 complex I 来阻止 oxidative phosphorylation (OXPHOS),并增加细胞凋亡。IM156 可改善各种类型的纤维化并抑制肿瘤。 |
||
S8276 |
FCCPFCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)在线粒体中式一种有效的氧化磷酸化的解偶联剂,通过转运质子破坏ATP的合成。 |
![]() ![]() The changes in 10-N-nonylacridineorange (NAO) fluorescence indicated the cardiolipin (CL) oxidation. In normal cells, NAO could interact with nonoxidized cardiolipin and produces a characteristic green fluorescence. However, after cardiolipin is oxidized, NAO cannot bind to it. F-H, The changes in MDA, GSH, and SOD levels. I and J, The cytoplasmic [Ca2+] map via confocal microscopy by Fluo-2. Fluorescence intensity of Fluo-2 was measured by excitation wavelengths of 340 nm and emission wavelengths of 500 nm. Data (F/F0) were obtained by dividing fluorescence intensity (F) by (F0) at the resting level (t = 0), which was normalized to normal groups. Data are shown as means ± SEM. *P < .05 vs normal group; #P < .05 vs PA group, @P < .05 vs PA + siRNA-NR4A1 or PA + melatonin groups
|
|
S5604 |
Diphenylamine HydrochlorideDiphenylamine (N-Phenylbenzenamine, Anilinobenzene, C.I. 10355)是苯胺的衍生物,被广泛用作工业抗氧化剂、媒染剂,在农业中也被用作杀真菌剂和驱虫药。 |
||
S8828 |
GboxinGboxin是癌细胞中氧化磷酸化抑制剂。Gboxin 可抑制 F0F1 ATP synthase 的活性。它能特异性地抑制原代小鼠和人源胶质母细胞瘤细胞的生长,而不影响小鼠胚胎成纤维细胞或新生儿星形胶质细胞。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2987 |
4-Methyl-2-oxovaleric acid4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) 是由星形胶质细胞释放至神经元,可以通过氨基转移酶重新形成亮氨酸。4-Methyl-2-oxovaleric acid 可降低骨骼肌中蛋白质的降解速率。4-Methyl-2-oxovaleric acid 可通过抑制 alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) 的活性来发挥 oxidative phosphorylation (OXPHOS) 的解偶联剂和代谢抑制剂的功效。 |
||
S8731 |
IACS-010759 (IACS-10759)IACS-010759 (IACS-10759)是一种有效的、选择性氧化磷酸化 (oxidative phosphorylation) 抑制剂,IC50小于10 nM,它通过抑制complex I阻止细胞呼吸作用。 |
||
S8943 |
VLX600VLX600 是一种新型的铁螯合的 oxidative phosphorylation (OXPHOS) 的抑制剂,通过协同作用增强对肿瘤球体的放疗作用。VLX600 在营养缺乏的条件下可显示出增强的细胞毒性。 VLX600 可诱导 autophagy 和 mitochondrial inhibition 并具有抗肿瘤活性。 |
||
S0096 |
S-GboxinS-Gboxin 是一种Gboxin的功能类似物,是 oxidative phosphorylation (OXPHOS) 的抑制剂,可抑制小鼠和人类的 glioblastoma (GBM) 的生长,其IC50值为470 nM。 |
||
S9604 |
IM156IM156 (HL156A),一种二甲双胍衍生物,也是 AMPK 的有效激活剂,可增强AMPK磷酸化。IM156 可通过抑制 complex I 来阻止 oxidative phosphorylation (OXPHOS),并增加细胞凋亡。IM156 可改善各种类型的纤维化并抑制肿瘤。 |
||
S8276 |
FCCPFCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)在线粒体中式一种有效的氧化磷酸化的解偶联剂,通过转运质子破坏ATP的合成。 |
![]() ![]() The changes in 10-N-nonylacridineorange (NAO) fluorescence indicated the cardiolipin (CL) oxidation. In normal cells, NAO could interact with nonoxidized cardiolipin and produces a characteristic green fluorescence. However, after cardiolipin is oxidized, NAO cannot bind to it. F-H, The changes in MDA, GSH, and SOD levels. I and J, The cytoplasmic [Ca2+] map via confocal microscopy by Fluo-2. Fluorescence intensity of Fluo-2 was measured by excitation wavelengths of 340 nm and emission wavelengths of 500 nm. Data (F/F0) were obtained by dividing fluorescence intensity (F) by (F0) at the resting level (t = 0), which was normalized to normal groups. Data are shown as means ± SEM. *P < .05 vs normal group; #P < .05 vs PA group, @P < .05 vs PA + siRNA-NR4A1 or PA + melatonin groups
|
|
S5604 |
Diphenylamine HydrochlorideDiphenylamine (N-Phenylbenzenamine, Anilinobenzene, C.I. 10355)是苯胺的衍生物,被广泛用作工业抗氧化剂、媒染剂,在农业中也被用作杀真菌剂和驱虫药。 |
||
S8828 |
GboxinGboxin是癌细胞中氧化磷酸化抑制剂。Gboxin 可抑制 F0F1 ATP synthase 的活性。它能特异性地抑制原代小鼠和人源胶质母细胞瘤细胞的生长,而不影响小鼠胚胎成纤维细胞或新生儿星形胶质细胞。 |