OXPHOS

抑制剂选择性比较

OXPHOS产品

所有产品(8) OXPHOS抑制剂(8)

目录号	产品描述	文献引用	实验数据
S2987^New	4-Methyl-2-oxovaleric acid 4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) 是由星形胶质细胞释放至神经元，可以通过氨基转移酶重新形成亮氨酸。4-Methyl-2-oxovaleric acid 可降低骨骼肌中蛋白质的降解速率。4-Methyl-2-oxovaleric acid 可通过抑制 alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) 的活性来发挥 oxidative phosphorylation (OXPHOS) 的解偶联剂和代谢抑制剂的功效。
S8731	IACS-010759 (IACS-10759) IACS-010759 (IACS-10759)是一种有效的、选择性氧化磷酸化 (oxidative phosphorylation) 抑制剂，IC50小于10 nM，它通过抑制complex I阻止细胞呼吸作用。	Cancer Res, 2020, 29 pii: canres Elife, 2020, 9e56749 Cancers (Basel), 2020, 12(9)E2400
S8943^New	VLX600 VLX600 是一种新型的铁螯合的 oxidative phosphorylation (OXPHOS) 的抑制剂，通过协同作用增强对肿瘤球体的放疗作用。VLX600 在营养缺乏的条件下可显示出增强的细胞毒性。 VLX600 可诱导 autophagy 和 mitochondrial inhibition 并具有抗肿瘤活性。
S0096	S-Gboxin S-Gboxin 是一种Gboxin的功能类似物，是 oxidative phosphorylation (OXPHOS) 的抑制剂，可抑制小鼠和人类的 glioblastoma (GBM) 的生长，其IC50值为470 nM。
S9604^New	IM156 IM156 (HL156A)，一种二甲双胍衍生物，也是 AMPK 的有效激活剂，可增强AMPK磷酸化。IM156 可通过抑制 complex I 来阻止 oxidative phosphorylation (OXPHOS)，并增加细胞凋亡。IM156 可改善各种类型的纤维化并抑制肿瘤。
S8276	FCCP FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)在线粒体中式一种有效的氧化磷酸化的解偶联剂，通过转运质子破坏ATP的合成。	Toxicol In Vitro, 2020, 66:104838 Oncol Rep, 2020, 44(1):103-114 Clin Cancer Res, 2020, 10.1158	The changes in 10-N-nonylacridineorange (NAO) fluorescence indicated the cardiolipin (CL) oxidation. In normal cells, NAO could interact with nonoxidized cardiolipin and produces a characteristic green fluorescence. However, after cardiolipin is oxidized, NAO cannot bind to it. F-H, The changes in MDA, GSH, and SOD levels. I and J, The cytoplasmic [Ca2+] map via confocal microscopy by Fluo-2. Fluorescence intensity of Fluo-2 was measured by excitation wavelengths of 340 nm and emission wavelengths of 500 nm. Data (F/F0) were obtained by dividing fluorescence intensity (F) by (F0) at the resting level (t = 0), which was normalized to normal groups. Data are shown as means ± SEM. *P < .05 vs normal group; #P < .05 vs PA group, @P < .05 vs PA + siRNA-NR4A1 or PA + melatonin groups
S5604	Diphenylamine Hydrochloride Diphenylamine (N-Phenylbenzenamine, Anilinobenzene, C.I. 10355)是苯胺的衍生物，被广泛用作工业抗氧化剂、媒染剂，在农业中也被用作杀真菌剂和驱虫药。
S8828	Gboxin Gboxin是癌细胞中氧化磷酸化抑制剂。Gboxin 可抑制 F0F1 ATP synthase 的活性。它能特异性地抑制原代小鼠和人源胶质母细胞瘤细胞的生长，而不影响小鼠胚胎成纤维细胞或新生儿星形胶质细胞。

目录号	产品描述	文献引用	实验数据
S2987^New	4-Methyl-2-oxovaleric acid 4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) 是由星形胶质细胞释放至神经元，可以通过氨基转移酶重新形成亮氨酸。4-Methyl-2-oxovaleric acid 可降低骨骼肌中蛋白质的降解速率。4-Methyl-2-oxovaleric acid 可通过抑制 alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) 的活性来发挥 oxidative phosphorylation (OXPHOS) 的解偶联剂和代谢抑制剂的功效。
S8731	IACS-010759 (IACS-10759) IACS-010759 (IACS-10759)是一种有效的、选择性氧化磷酸化 (oxidative phosphorylation) 抑制剂，IC50小于10 nM，它通过抑制complex I阻止细胞呼吸作用。	Cancer Res,2020, 29 pii: canres Elife,2020, 9e56749 Cancers (Basel),2020, 12(9)E2400
S8943^New	VLX600 VLX600 是一种新型的铁螯合的 oxidative phosphorylation (OXPHOS) 的抑制剂，通过协同作用增强对肿瘤球体的放疗作用。VLX600 在营养缺乏的条件下可显示出增强的细胞毒性。 VLX600 可诱导 autophagy 和 mitochondrial inhibition 并具有抗肿瘤活性。
S0096	S-Gboxin S-Gboxin 是一种Gboxin的功能类似物，是 oxidative phosphorylation (OXPHOS) 的抑制剂，可抑制小鼠和人类的 glioblastoma (GBM) 的生长，其IC50值为470 nM。
S9604^New	IM156 IM156 (HL156A)，一种二甲双胍衍生物，也是 AMPK 的有效激活剂，可增强AMPK磷酸化。IM156 可通过抑制 complex I 来阻止 oxidative phosphorylation (OXPHOS)，并增加细胞凋亡。IM156 可改善各种类型的纤维化并抑制肿瘤。
S8276	FCCP FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)在线粒体中式一种有效的氧化磷酸化的解偶联剂，通过转运质子破坏ATP的合成。	Toxicol In Vitro,2020, 66:104838 Oncol Rep,2020, 44(1):103-114 Clin Cancer Res,2020, 10.1158	The changes in 10-N-nonylacridineorange (NAO) fluorescence indicated the cardiolipin (CL) oxidation. In normal cells, NAO could interact with nonoxidized cardiolipin and produces a characteristic green fluorescence. However, after cardiolipin is oxidized, NAO cannot bind to it. F-H, The changes in MDA, GSH, and SOD levels. I and J, The cytoplasmic [Ca2+] map via confocal microscopy by Fluo-2. Fluorescence intensity of Fluo-2 was measured by excitation wavelengths of 340 nm and emission wavelengths of 500 nm. Data (F/F0) were obtained by dividing fluorescence intensity (F) by (F0) at the resting level (t = 0), which was normalized to normal groups. Data are shown as means ± SEM. *P < .05 vs normal group; #P < .05 vs PA group, @P < .05 vs PA + siRNA-NR4A1 or PA + melatonin groups
S5604	Diphenylamine Hydrochloride Diphenylamine (N-Phenylbenzenamine, Anilinobenzene, C.I. 10355)是苯胺的衍生物，被广泛用作工业抗氧化剂、媒染剂，在农业中也被用作杀真菌剂和驱虫药。
S8828	Gboxin Gboxin是癌细胞中氧化磷酸化抑制剂。Gboxin 可抑制 F0F1 ATP synthase 的活性。它能特异性地抑制原代小鼠和人源胶质母细胞瘤细胞的生长，而不影响小鼠胚胎成纤维细胞或新生儿星形胶质细胞。