NOS

抑制剂选择性比较

NOS产品

目录号 产品描述 文献引用 实验数据
S2877

L-NAME HCl

L-NAME HCl是一种无选择性的一氧化氮合成酶抑制剂,对nNOS (牛源), eNOS (人源)和iNOS (鼠源)的Ki值分别为15nM, 39 nM和4.4 μM。

S9208

Ginsenoside Rb3

Ginsenoside Rb3 是从人参中提取的天然产物,在心血管疾病包括心肌的缺血/再灌注(I/R)损伤中起着重要作用。在人肾293T细胞中检测了Ginsenoside Rb3(0.1-10 μM)对肿瘤坏死因子TNF-α诱导的 nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) 荧光素酶报告基因的抑制作用,IC50值为8.2 μM。在用10 ng/mL TNF-α处理后的HepG2细胞中,Ginsenoside Rb3 还以剂量依赖性的方式抑制 cyclooxygenase-2 (COX-2)inducible nitric oxide synthase (iNOS) 信使mRNA的诱导诱导表达。

S8337

1400W 2HCl

1400W是iNOS的抑制剂,与iNOS缓慢、紧密地结合,具有选择性。

S4962

Agmatine sulfate

Agmatine sulfate是精氨酸的活性代谢产物,能够提高一氧化氮水平、减少血糖水平并提高生长激素水平。

S9029

Prim-o-glucosylcimifugin

Prim-O-glucosylcimifugin 是防风(Radix Saposhnikovia)中的主要成分,长期以来一直应用于传统中医药中治疗发热、风湿和癌症,它表现出潜在的抗癌活性。在LPS激活的 RAW 264.7 巨噬细胞,Prim-O-glucosylcimifugin 可以浓度依赖性的方式下调 NO synthase (iNOS)cyclooxygenase 2 (COX-2) 的mRNA和蛋白质表达。

S3931

Ginsenoside Rd

Ginsenoside Rd, a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity.

S3899

Hederagenin

Hederagenin is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo.

S4548

Aminoguanidine hydrochloride

Aminoguanidine是二胺氧化酶一氧化氮合成酶抑制剂。它通过与3-deoxyglucosone相互作用减少晚期糖基化终末产物(AGEs)水平。

S5542

7-Nitroindazole

7-Nitroindazole, a heterocyclic compound, acts as a selective inhibitor for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.

S5229

Isosorbide dinitrate

Isosorbide Dinitrate(ISDN) 是异山梨醇(isosorbide)的二硝酸盐形式,这是一种具有血管扩张活性的有机硝酸盐。Isosorbide Dinitrate 是一种用于心力衰竭、食道痉挛的药物,用于治疗和预防因没有足够的血液流向心脏而引起的胸痛。Isosorbide Dinitrate 可转化为一氧化氮(NO),一种活性中间化合物,可激活 the enzyme guanylate cyclase (atrial natriuretic peptide receptor A)

S5577

6-Biopterin

6-Biopterin is a natural product that has been considered as a growth factor for some insects.

S3174

L-Arginine HCl (L-Arg)

L-Arginine HCl (L-Arg)是一氧化氮合成的氮供体,是一种有效的血管舒张药,在镰状细胞性贫血时含量不足。

目录号 产品描述 文献引用 实验数据
S2877

L-NAME HCl

L-NAME HCl是一种无选择性的一氧化氮合成酶抑制剂,对nNOS (牛源), eNOS (人源)和iNOS (鼠源)的Ki值分别为15nM, 39 nM和4.4 μM。

S9208

Ginsenoside Rb3

Ginsenoside Rb3 是从人参中提取的天然产物,在心血管疾病包括心肌的缺血/再灌注(I/R)损伤中起着重要作用。在人肾293T细胞中检测了Ginsenoside Rb3(0.1-10 μM)对肿瘤坏死因子TNF-α诱导的 nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) 荧光素酶报告基因的抑制作用,IC50值为8.2 μM。在用10 ng/mL TNF-α处理后的HepG2细胞中,Ginsenoside Rb3 还以剂量依赖性的方式抑制 cyclooxygenase-2 (COX-2)inducible nitric oxide synthase (iNOS) 信使mRNA的诱导诱导表达。

S8337

1400W 2HCl

1400W是iNOS的抑制剂,与iNOS缓慢、紧密地结合,具有选择性。

S4962

Agmatine sulfate

Agmatine sulfate是精氨酸的活性代谢产物,能够提高一氧化氮水平、减少血糖水平并提高生长激素水平。

S9029

Prim-o-glucosylcimifugin

Prim-O-glucosylcimifugin 是防风(Radix Saposhnikovia)中的主要成分,长期以来一直应用于传统中医药中治疗发热、风湿和癌症,它表现出潜在的抗癌活性。在LPS激活的 RAW 264.7 巨噬细胞,Prim-O-glucosylcimifugin 可以浓度依赖性的方式下调 NO synthase (iNOS)cyclooxygenase 2 (COX-2) 的mRNA和蛋白质表达。

S3931

Ginsenoside Rd

Ginsenoside Rd, a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity.

S3899

Hederagenin

Hederagenin is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo.

S4548

Aminoguanidine hydrochloride

Aminoguanidine是二胺氧化酶一氧化氮合成酶抑制剂。它通过与3-deoxyglucosone相互作用减少晚期糖基化终末产物(AGEs)水平。

S5542

7-Nitroindazole

7-Nitroindazole, a heterocyclic compound, acts as a selective inhibitor for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.

目录号 产品描述 文献引用 实验数据
S5229

Isosorbide dinitrate

Isosorbide Dinitrate(ISDN) 是异山梨醇(isosorbide)的二硝酸盐形式,这是一种具有血管扩张活性的有机硝酸盐。Isosorbide Dinitrate 是一种用于心力衰竭、食道痉挛的药物,用于治疗和预防因没有足够的血液流向心脏而引起的胸痛。Isosorbide Dinitrate 可转化为一氧化氮(NO),一种活性中间化合物,可激活 the enzyme guanylate cyclase (atrial natriuretic peptide receptor A)

目录号 产品描述 文献引用 实验数据
S5577

6-Biopterin

6-Biopterin is a natural product that has been considered as a growth factor for some insects.

S3174

L-Arginine HCl (L-Arg)

L-Arginine HCl (L-Arg)是一氧化氮合成的氮供体,是一种有效的血管舒张药,在镰状细胞性贫血时含量不足。