IRAK
抑制剂选择性比较
IRAK产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S8562 |
IRAK4-IN-2IRAK4-IN-2 是一种可逆性激酶抑制剂,在TLR和IL-1R信号级联反应中,调节IRAK4的功能。 |
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S0775New |
IRAK4-IN-4IRAK4-IN-4 (compound 15) 是一种 interleukin-1 receptor–associated kinase 4 (IRAK4) 和 cyclic GMP-AMP synthase (cGAS) 的抑制剂,对应的IC50值分别为 2.8 nM和 2.1 nM。 |
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S9701New |
HS-243HS-243 是一种高效的 interleukin-1 receptor-associated kinase (IRAK) 的抑制剂,对于IRAK-1、IRAK-4和TAK1的IC50值分别为24 nM、20 nM和0.5 μM。 |
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S2039New |
IRAK inhibitor 6IRAK inhibitor 6 是一种选择性的Interleukin-1 receptor-associated kinase 4(IRAK4)抑制剂,IC50为 0.16 μM。 |
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S8696 |
2-D082-D08 (2',3',4'-trihydroxy flavone) 是一种具有细胞透性的蛋白类泛素化(protein sumoylation)抑制剂。它还能抑制Axl, IRAK4, ROS1, MLK4, GSK3β, RET (c-RET), KDR和PI3Kα,IC50分别为0.49, 3.9, 5.3, 9.8, 11, 11, 17和35 nM。 |
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S8531 |
PF-06650833PF-06650833是一种有效的IRAK4选择性抑制剂,IC50为0.2 nM。 |
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S3607 |
SarsasapogeninSarsasapogenin (SAR, Parigenin)是一种甾体皂甙元,能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活,在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。 |
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S6598 |
IRAK-1-4 Inhibitor IIRAK-1-4 Inhibitor I是白介素受体相关激酶(IRAK)抑制剂,对IRAK-1和IRAK-4的IC50值分别为0.3 μM和0.2 μM。 |
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S3924 |
Ginsenoside Rb1Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS. |
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S8663 |
TakinibTakinib (EDHS-206)是一种有效的、选择性的TAK1抑制剂,IC50为9.5 nM。对IRAK4和IRAK1的IC50分别为120 nM和390 nM。Takinib 可诱导凋亡。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S8562 |
IRAK4-IN-2IRAK4-IN-2 是一种可逆性激酶抑制剂,在TLR和IL-1R信号级联反应中,调节IRAK4的功能。 |
||
S0775New |
IRAK4-IN-4IRAK4-IN-4 (compound 15) 是一种 interleukin-1 receptor–associated kinase 4 (IRAK4) 和 cyclic GMP-AMP synthase (cGAS) 的抑制剂,对应的IC50值分别为 2.8 nM和 2.1 nM。 |
||
S9701New |
HS-243HS-243 是一种高效的 interleukin-1 receptor-associated kinase (IRAK) 的抑制剂,对于IRAK-1、IRAK-4和TAK1的IC50值分别为24 nM、20 nM和0.5 μM。 |
||
S2039New |
IRAK inhibitor 6IRAK inhibitor 6 是一种选择性的Interleukin-1 receptor-associated kinase 4(IRAK4)抑制剂,IC50为 0.16 μM。 |
||
S8696 |
2-D082-D08 (2',3',4'-trihydroxy flavone) 是一种具有细胞透性的蛋白类泛素化(protein sumoylation)抑制剂。它还能抑制Axl, IRAK4, ROS1, MLK4, GSK3β, RET (c-RET), KDR和PI3Kα,IC50分别为0.49, 3.9, 5.3, 9.8, 11, 11, 17和35 nM。 |
||
S8531 |
PF-06650833PF-06650833是一种有效的IRAK4选择性抑制剂,IC50为0.2 nM。 |
||
S3607 |
SarsasapogeninSarsasapogenin (SAR, Parigenin)是一种甾体皂甙元,能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活,在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。 |
||
S6598 |
IRAK-1-4 Inhibitor IIRAK-1-4 Inhibitor I是白介素受体相关激酶(IRAK)抑制剂,对IRAK-1和IRAK-4的IC50值分别为0.3 μM和0.2 μM。 |
||
S3924 |
Ginsenoside Rb1Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS. |
||
S8663 |
TakinibTakinib (EDHS-206)是一种有效的、选择性的TAK1抑制剂,IC50为9.5 nM。对IRAK4和IRAK1的IC50分别为120 nM和390 nM。Takinib 可诱导凋亡。 |