Nobiletin

别名: NSC 76751, Hexamethoxyflavone 中文名称:蜜橘黄素,川陈皮素

Nobiletin是O-甲基黄酮,是从柑橘果皮如橘子分离的一种黄酮类化合物。具有抗炎和抗肿瘤活性。

Nobiletin Chemical Structure

Nobiletin Chemical Structure

CAS: 478-01-3

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 2209.96 现货
5mg RMB 1383.06 现货
50mg RMB 7935.29 现货
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客户使用Selleck的Nobiletin发表文献14

客户使用该产品的1个实验数据

产品质控

批次: 纯度: 99.73%
99.43

Nobiletin相关产品

相关信号通路图

MMP抑制剂选择性比较

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
SHSY5Y Function assay 30 uM 3 hrs Elevation of phosphorylated ERK level in hydrogen peroxide-treated human SHSY5Y cells at 30 uM after 3 hrs by Western blot analysis 18282757
SHSY5Y Function assay 30 uM 3 hrs Elevation of phosphorylated p38 level in hydrogen peroxide-treated human SHSY5Y cells at 30 uM after 3 hrs by Western blot analysis 18282757
SHSY5Y Function assay 30 uM 3 hrs Elevation of phosphorylated JNk level in hydrogen peroxide-treated human SHSY5Y cells at 30 uM after 3 hrs by Western blot analysis 18282757
ST-13 Function assay 10 uM 11 days Induction of preadipocyte differentiation in mouse ST-13 cells assessed as lipid accumulation at 10 uM within 11 days by oil red-staining relative to control 19268587
ST-13 Function assay 0.1 to 30 uM 11 days Induction of adipocyte differentiation in mouse ST-13 cells assessed as stimulation of adipsin mRNA expression at 0.1 to 30 uM within 11 days by semi-quantitative RT-PCR 19268587
ST-13 Function assay 0.1 to 30 uM 11 days Induction of adipocyte differentiation in mouse ST-13 cells assessed as stimulation of adipocyte P2 mRNA expression at 0.1 to 30 uM within 11 days by semi-quantitative RT-PCR 19268587
SRA 01/04 Growth inhibition assay 64 uM 4 days Growth inhibition of human SRA 01/04 cells assessed as reduction in PCNA expression at 64 uM after 4 days by Western blot analysis 23199882
SRA 01/04 Function assay 24 hrs Inhibition of TNF-alpha-induced proMMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE analysis, IC50=17μM 21723726
SRA 01/04 Function assay 24 hrs Inhibition of TNFalpha-stimulated pro MMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE based gelatin zymography assay, IC50=17μM 22047798
SRA 01/04 Function assay 24 hrs Inhibition of PMA-induced proMMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE analysis, IC50=20.9μM 21723726
SRA 01/04 Function assay 24 hrs Inhibition of PMA-stimulated pro MMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE based gelatin zymography assay, IC50=20.9μM 22047798
HT-29 Anticancer assay 72 hrs Anticancer activity against human HT-29 cells after 72 hrs by MTT assay, IC50=24μM 19054677
SHSY5Y Function assay 12 hrs Reduction of hydrogen peroxide-induced apoptotic cell death in human SHSY5Y cells assessed as DNA ladder formation after 12 hrs 18282757
ST-13 Function assay 11 days Induction of adipocyte differentiation in mouse ST-13 cells assessed as increase in PPARgamma2 mRNA level after 11 days by semi-quantitative RT-PCR relative to control 19268587
MCF-7 MX Function assay Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining, IC50=4.4μM 21354800
MDCK Function assay Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining, IC50=4.9μM 21354800
NIH-3T3-G185 Function assay TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells, IC50=11.5μM 11743742
点击查看更多细胞系数据

生物活性

产品描述 Nobiletin是O-甲基黄酮,是从柑橘果皮如橘子分离的一种黄酮类化合物。具有抗炎和抗肿瘤活性。
靶点
MMP [1]
体外研究(In Vitro)
体外研究活性 Nobiletin,从柑橘果皮,如橘子中分离得到的柑橘黄酮,具有抗炎和抗肿瘤活性。Nobiletin,一个聚甲氧基黄酮,能够抑制NO和O 2-的产生。Nobiletin显著抑制使用双倍TPA引起的皮肤炎症。它也会抑制环氧合酶-2的表达,以及诱导型NO合酶蛋白和前列腺素E2的释放。[1]在人工基底膜模型中,Nobiletin抑制人类纤维肉瘤HT-1080细胞的肿瘤侵袭活性,不仅通过抑制MMPs的表达,也通过妨碍磷脂酰肌醇3-激酶途径(PI3-K)增加TIMP-1的产生来发挥作用。[2] Nobiletin可能也会通过抑制巨噬细胞海绵状细胞的形成而防止血管壁水平的动脉粥样硬化。[3]
体内研究(In Vivo)
体内研究活性 LD50: 780毫克/千克(i.g.). [4]

化学信息&溶解度

分子量 402.39 分子式

C21H22O8

CAS号 478-01-3 SDF Download Nobiletin SDF
储存条件(自收到货起)

体外溶解度
批次:

DMSO : 80 mg/mL ( 198.81 mM; DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Ethanol : 3 mg/mL

Water : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

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