Nobiletin (NSC 76751)

For research use only. Not for use in humans.

目录号:S2333 别名: Hexamethoxyflavone 中文名称:蜜橘黄素,川陈皮素

Nobiletin (NSC 76751) Chemical Structure

CAS No. 478-01-3

Nobiletin (NSC 76751, Hexamethoxyflavone)是O-甲基黄酮,是从柑橘果皮如橘子分离的一种黄酮类化合物。具有抗炎和抗肿瘤活性。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2209.96 现货
RMB 1383.06 现货
RMB 7935.29 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Nobiletin (NSC 76751)发表文献10篇:

客户使用该产品的1个实验数据:

  • NOB modulates Cps1 mRNA and protein expression. a Total protein extracts were prepared from liver samples collected from the four diet/treatment groups of wild-type mice at the indicated circadian time points (n = 3). Western blotting analysis was performed using anti-CPS1 antibody. RC regular chow, HFD high-fat diet, Veh vehicle, NOB Nobiletin. The results shown are representative of three independent experiments. See Additional file 1: Figure S1A for quantitative analysis. b Immunohistochemical staining of CPS1 in liver sections from mice with the indicated diet and treatment at ZT2. c Real-time RT-PCR analysis of Cps1 in liver samples collected as in (a). Data are presented as mean ± SEM (n = 3). Two-way ANOVA with Bonferroni post-hoc tests shows significant statistical differences between HFD.Veh and other three groups (p < 0.0001). d Western blotting analysis of protein lysates of liver samples collected at ZT 6 and 18 from mice with the indicated diet and treatment (n = 3). HPD indicates high-protein diet. The images shown to the left are representative of three independent experiments. Quantitation of Western blots was carried out and the results, presented as mean ± SEM, are shown in the lower panel. Two-way ANOVA with Bonferroni post-hoc tests, RC vs. HPD, ***p < 0.001. e Real-time qPCR analysis was carried out using total RNAs extracted from the liver samples described in (d). The results are presented as mean ± SEM. Two-way ANOVA with Bonferroni post-hoc tests, RC vs. HPD, *p < 0.05.

    Nutr Metab (Lond), 2015, 12:23.. Nobiletin (NSC 76751) purchased from Selleck.

产品安全说明书

MMP抑制剂选择性比较

生物活性

产品描述 Nobiletin (NSC 76751, Hexamethoxyflavone)是O-甲基黄酮,是从柑橘果皮如橘子分离的一种黄酮类化合物。具有抗炎和抗肿瘤活性。
靶点
MMP [1]
()
体外研究

Nobiletin,从柑橘果皮,如橘子中分离得到的柑橘黄酮,具有抗炎和抗肿瘤活性。Nobiletin,一个聚甲氧基黄酮,能够抑制NO和O 2-的产生。Nobiletin显著抑制使用双倍TPA引起的皮肤炎症。它也会抑制环氧合酶-2的表达,以及诱导型NO合酶蛋白和前列腺素E2的释放。[1]在人工基底膜模型中,Nobiletin抑制人类纤维肉瘤HT-1080细胞的肿瘤侵袭活性,不仅通过抑制MMPs的表达,也通过妨碍磷脂酰肌醇3-激酶途径(PI3-K)增加TIMP-1的产生来发挥作用。[2] Nobiletin可能也会通过抑制巨噬细胞海绵状细胞的形成而防止血管壁水平的动脉粥样硬化。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF-7 MX M3q3PWZ2dmO2aX;uJIF{e2G7 MmPnTY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EBqdiCPQ1[tO{BOYCClZXzsd{B2e2mwZzDIc4VkcHO2IEOzN|QzKHO2YXnubY5oNCCLQ{WwQVQvPM7:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN3NEiwNEc,OjF|NUS4NFA9N2F-
MDCK MYTGeY5kfGmxbjDhd5NigQ>? M{PDOWlvcGmkaYTpc44hd2ZiQlPSVEBmgHC{ZYPz[YQhcW5iTVTDT{Bk\WyuczD1d4lv\yCKb3XjbJN1KDN|M{SyJJN1[WmwaX7nMEBKSzVyPUSuPe69VQ>? NUHIWmdqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzOVQ5ODBpPkKxN|U1QDByPD;hQi=>
NIH-3T3-G185 NFq4XYpHfW6ldHnvckBie3OjeR?= MYfUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBF[XWwb4L1ZolkcW5iZX\mcJV5KGmwIF7JTE0{XDNvR{G4OUBk\WyuczygTWM2OD1zMT61{txO MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTd2M{e0Nkc,OTF5NEO3OFI9N2F-
SRA 01/04 NVzOOmZqTnWwY4Tpc44h[XO|YYm= MmD0NlQhcHK| NVXEOGVrUW6qaXLpeIlwdiCxZjDUUmYu[WyyaHGtbY5lfWOnZDDwdo9OVVB7IIDyc4R2[3Srb36gbY4hcHWvYX6gV3JCKDBzL{C0JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCVRGOtVGFITSCjbnHsfZNqeyxiSVO1NF0yP87:TR?= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd{M{eyOkc,OjF5MkO3NlY9N2F-
SRA 01/04 MXHGeY5kfGmxbjDhd5NigQ>? NYHHOHU4OjRiaILz M37n[WlvcGmkaYTpc44hd2ZiVF7GZYxxcGFvc4TpcZVt[XSnZDDwdo8hVU2SOTDwdo9lfWO2aX;uJIlvKGi3bXHuJHNTSSByMT:wOEBk\WyuczDh[pRmeiB{NDDodpMh[nliU1TTMXBCT0ViYnHz[YQh\2WuYYTpckB7gW2xZ4LhdIh6KGG|c3H5MEBKSzVyPUG3{txO M3nHbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MES3O|k5Lz5{MkC0O|c6QDxxYU6=
SRA 01/04 MYPGeY5kfGmxbjDhd5NigQ>? MnHpNlQhcHK| NUT4XVIxUW6qaXLpeIlwdiCxZjDQUWEucW6mdXPl[EBxem:PTWC5JJBzd2S3Y4Tpc44hcW5iaIXtZY4hW1KDIECxM|A1KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDTSHMuWEGJRTDhcoFtgXOrczygTWM2OD1{MD65{txO NYDZWmk{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3NlM4OjZpPkKxO|I{PzJ4PD;hQi=>
SRA 01/04 MnjwSpVv[3Srb36gZZN{[Xl? NFG3SnczPCCqcoO= MUjJcohq[mm2aX;uJI9nKFCPQT3zeIlufWyjdHXkJJBzdyCPTWC5JJBzd2S3Y4Tpc44hcW5iaIXtZY4hW1KDIECxM|A1KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDTSHMuWEGJRTDiZZNm\CCpZXzheIlvKHq7bX;ndoFxcHliYYPzZZktKEmFNUC9NlAvQc7:TR?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB2N{e5PEc,OjJyNEe3PVg9N2F-
HT-29 MU\BcpRq[2GwY3XyJIF{e2G7 NVfaSWh4PzJiaILz MlvzRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkVOwG0> NUP4cYJyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwOVQ3PzdpPkG5NFU1Pjd5PD;hQi=>
SHSY5Y M1jjNmZ2dmO2aX;uJIF{e2G7 MXmxNkBpenN? MXfS[YR2[3Srb36gc4YhcHmmcn;n[Y4heGW{b4jp[IUucW6mdXPl[EBieG:ydH;0bYMh[2WubDDk[YF1cCCrbjDoeY1idiCVSGPZOXkh[2WubIOgZZN{\XO|ZXSgZZMhTE6DIHzh[IRmeiCob4LtZZRqd25iYX\0[ZIhOTJiaILz NFn5Tmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK4Nlc2Pyd-MUiyPFI4PTd:L3G+
SHSY5Y M13USGZ2dmO2aX;uJIF{e2G7 NUfpVo9NOzBidV2= MYizJIhzew>? NUjTfIJrTWyndnH0bY9vKG:oIIDoc5NxcG:{eXzheIVlKEWUSzDs[ZZmdCCrbjDofYRzd2enbjDw[ZJwgGmmZT30doVifGWmIHj1cYFvKFOKU2m1XUBk\WyuczDheEA{OCC3TTDh[pRmeiB|IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MoHYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{OEK3OVcoRjF6MkiyO|U4RC:jPh?=
SHSY5Y MVLGeY5kfGmxbjDhd5NigQ>? MWWzNEB2VQ>? M3PMZlMhcHK| MYjFcIV3[XSrb36gc4YheGixc4Doc5J6dGG2ZXSgdFM5KGyndnXsJIlvKGi7ZILv[4VvKHCncn;4bYRmNXS{ZXH0[YQhcHWvYX6gV2hUYTW\IHPlcIx{KGG2IEOwJJVOKGGodHXyJFMhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ6Mke1O{c,OTh{OEK3OVc9N2F-
SHSY5Y NXfuSlYyTnWwY4Tpc44h[XO|YYm= NFS4dng{OCC3TR?= M3;HVlMhcHK| M2PhRmVt\X[jdHnvckBw\iCyaH;zdIhwenmuYYTl[EBLVmtibHX2[YwhcW5iaInkdo9o\W5icHXyc5hq\GVvdILlZZRm\CCqdX3hckBUUFO\NWmgZ4VtdHNiYYSgN|AhfU1iYX\0[ZIhOyCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| NETwT3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK4Nlc2Pyd-MUiyPFI4PTd:L3G+
ST-13 NUDZR3FVTnWwY4Tpc44h[XO|YYm= Ml[2NVAhfU1? Ml:2NVEh\GG7cx?= M36zdGlv\HWldHnvckBw\iCycnXh[Ilxd2O7dHWg[Iln\mW{ZX70bYF1cW:wIHnuJI1wfXOnIGPUMVE{KGOnbHzzJIF{e2W|c3XkJIF{KGyrcHnkJIFk[3WvdXzheIlwdiCjdDCxNEB2VSC5aYTobY4hOTFiZHH5d{BjgSCxaXygdoVlNXO2YXnubY5oKHKnbHH0bZZmKHSxIHPvcpRzd2x? MlTlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Nki1PFcoRjF7Mk[4OVg4RC:jPh?=
ST-13 MWLGeY5kfGmxbjDhd5NigQ>? NFf0T4wxNjFidH:gN|AhfU1? NEX1Ro8yOSCmYYnz MYrJcoR2[3Srb36gc4Yh[WSrcH;jfZRmKGSrZn\ldoVvfGmjdHnvckBqdiCvb4Xz[UBUXC1zMzDj[YxteyCjc4Pld5Nm\CCjczDzeIlufWyjdHnvckBw\iCjZHnwd4lvKG2UTlGg[ZhxemW|c3nvckBifCByLkGgeI8hOzBidV2ge4l1cGmwIEGxJIRigXNiYomgd4VucS2zdXHueIl1[XSrdnWgVnQuWEOU NUXPPJh[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyOlg2QDdpPkG5NlY5PTh5PD;hQi=>
ST-13 M1nYO2Z2dmO2aX;uJIF{e2G7 MUKwMlEhfG9iM{CgeW0> MXqxNUBl[Xm| MoG4TY5lfWO2aX;uJI9nKGGmaYDvZ5l1\SCmaX\m[ZJmdnSrYYTpc44hcW5ibX;1d4UhW1RvMUOgZ4VtdHNiYYPz[ZN{\WRiYYOgd5RqdXWuYYTpc44hd2ZiYXTpdI9kgXSnIGCyJI1TVkFiZYjwdoV{e2mxbjDheEAxNjFidH:gN|AhfU1id3n0bIlvKDFzIHThfZMh[nlic3XtbU1yfWGwdHn0ZZRqfmViUmStVGNT MnPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{Nki1PFcoRjF7Mk[4OVg4RC:jPh?=
ST-13 M{jtdmZ2dmO2aX;uJIF{e2G7 Moq0NVEh\GG7cx?= MXzJcoR2[3Srb36gc4Yh[WSrcH;jfZRmKGSrZn\ldoVvfGmjdHnvckBqdiCvb4Xz[UBUXC1zMzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBRWEGUZ3HtcYEzKG2UTlGgcIV3\WxiYX\0[ZIhOTFiZHH5d{BjgSC|ZX3pMZF2[W62aYTheIl3\SCUVD3QR3IhemWuYYTpeoUhfG9iY3;ueJJwdA>? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ4OEW4O{c,OTl{Nki1PFc9N2F-
SRA 01/04 MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXm2OEB2VQ>? M{TRTVQh\GG7cx?= NGC1TVdIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBUWkFiMEGvNFQh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIGDDUmEh\XiycnXzd4lwdiCjdDC2OEB2VSCjZoTldkA1KGSjeYOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF7OUi4Nkc,OjNzOUm4PFI9N2F-

... Click to View More Cell Line Experimental Data

体内研究 LD50: 780毫克/千克(i.g.). [4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 81 mg/mL (201.29 mM)
Ethanol 3 mg/mL (7.45 mM)
Water Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 402.39
化学式

C21H22O8

CAS号 478-01-3
储存条件 粉状
溶于溶剂
别名 Hexamethoxyflavone

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项
免费分装抑制剂

MMP Signaling Pathway Map

相关MMP产品

Tags: 购买Nobiletin (NSC 76751) | Nobiletin (NSC 76751)供应商 | 采购Nobiletin (NSC 76751) | Nobiletin (NSC 76751)价格 | Nobiletin (NSC 76751)生产 | 订购Nobiletin (NSC 76751) | Nobiletin (NSC 76751)代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID