MMP

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研究领域

抑制剂选择性比较

MMP产品

所有产品 MMP抑制剂(8)

产品目录	产品描述	文献引用	实验数据
S7155	Batimastat (BB-94) Batimastat (BB-94)是一种有效的，广谱matrix metalloprotease (MMP)（基质金属蛋白酶）抑制剂，作用于MMP-1， MMP-2， MMP-9， MMP-7和MMP-3，IC50分别为3 nM， 4 nM， 4 nM， 6 nM和20 nM。	Nature, 2017, 549(7673):533-537 Hum Mol Genet, 2017, 26(20):3946-3959 Biomed Rep, 2016, 4(1):73-78	Proliferation indices of SU-pcGBM2 cells exposed to plain medium (aCSF) or active conditioned medium generated in the presence or absence of pan-MMP inhibitor (BAT).
S8072	NSC 405020 NSC 405020是一种MT1-MMP抑制剂，直接与MT1-MMP的PEX区域相互作用，影响PEX二聚体化，但不影响MT1-MMP的催化活性。	Reproduction, 2018, 155(3):297-306
S4163	Doxycycline Hyclate Doxycycline是四环素抗生素组的一个成员，通常用于治疗各种感染。还是MMP抑制剂。	Sci Rep, 2018, 8(1):7653 Nature, 2017, 548(7665):112-116
S7157	Ilomastat (GM6001, Galardin) Ilomastat (GM6001, Galardin)是一种广谱matrix metalloprotease (MMP)（基质金属蛋白酶）抑制剂，作用于MMP-1， MMP-2， MMP-3， MMP-7， MMP-8， MMP-9， MMP-12， MMP-14，和MMP-26，K_i分别为0.4 nM， 0.5 nM， 27 nM， 3.7 nM， 0.1 nM， 0.2 nM， 3.6 nM， 13.4 nM，和0.36 nM。	Matrix Biol, 2019, 10.1016/j.matbio.2019.07.006 Cell Prolif, 2019, 10.1111/cpr.12633 J Gastroenterol Hepatol, 2018, 33(5):1075-1081	GM6001 inhibits MMP-7 and −10 mRNA expressions in Aurora-A stable cells in HNC. The mRNA expression levels of MMP-7 and −10 were examined by Q-RT-PCR in FaDu/vehicle, and FaDu/Aurora-A transfectants treated with DMSO or GM6001 in a dose-dependent manner. Statistical analysis: p < 0.01, *p < 0.001.
S5543	1, 10-Phenanthroline monohydrate 1,10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry. It is an inhibitor of metallopeptidases.
S7430	SB-3CT SB-3CT 是高效选择性的gelatinase抑制剂，其作用于MMP-2和MMP-9的K_i分别为13.9 nM 和 600 nM。	Biomater Sci, 2019, 7(8):3320-3333 Clin Sci (Lond), 2019, 133(3):515-530 Mol Nutr Food Res, 2018, 10.1002/mnfr.201700969	The matrix metalloproteinase 9(MMP9) inhibitor(SB-3CT) attenuated angiotensin II (Ang II)-induced cardiomyocyte hypertrophy in vitro. (A) Representative immunofluorescent (α-actinin) images of neonatal rat cardiomyocytes (NRCMs) in the presence or absence of MMP9 inhibitor that were administered PBS or Ang II for 48 h. Bar=200 μm. (B) Statistical results for the cell surface area (CSA) of NRCMs. (C-E) The relative mRNA expression levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and β-myosin heavy chain (β-MHC) in NRCMs in the presence or absence of MMP9 inhibitor that were administered PBS or Ang II for 48 h. The intensities were normalized to the levels of GAPDH mRNA with the value in the PBS group defined as 1. * P<0.05 versus the control group, # P<0.05 versus the Ang II group. n=6 samples per experimental group
S7156	Marimastat (BB-2516) Marimastat (BB-2516)是一种广谱的 matrix metalloprotease (MMP) 抑制剂，对 MMP-9，MMP-1，MMP-2，MMP-14 和 MMP-7 的 IC50 分别为 3 nM，5 nM，6 nM，9 nM 和 13 nM。Phase 3。	Cell Signal, 2018, 42:155-164	(E, F) Uev1A mediates negative feedback of NF-κB signaling pathway is dependent on TACE activity. Forty-eight hours after transfection, the cells were pre-treated with BB-2516 (20 μM) for 1 h, followed by TNFα (40 ng/ml) treatment for 2 h. Cell was fixed and stained with antibodies against HA and p65. The same cells were also stained with DAPI to reveal nuclei. White arrows indicate UEV1A-overexpressed cells. (F) Quantitative analysis of the experiments shown in (E). Percentage of cells displaying nuclear p65 is shown for UEV1A- overexpressed or vector-transfected cells. Each sample contains about 1000 cells. The significance of differences was assessed by two-tailed Student's test (***P < 0.001).
S2333	Nobiletin Nobiletin 是O-甲基黄酮，是从柑橘果皮如橘子分离的一种黄酮类化合物。具有抗炎和抗肿瘤活性。	Nutr Metab (Lond), 2015, 12:23 Plant Physiol, 2012, 159(1):81-94	NOB modulates Cps1 mRNA and protein expression. a Total protein extracts were prepared from liver samples collected from the four diet/treatment groups of wild-type mice at the indicated circadian time points (n = 3). Western blotting analysis was performed using anti-CPS1 antibody. RC regular chow, HFD high-fat diet, Veh vehicle, NOB Nobiletin. The results shown are representative of three independent experiments. See Additional file 1: Figure S1A for quantitative analysis. b Immunohistochemical staining of CPS1 in liver sections from mice with the indicated diet and treatment at ZT2. c Real-time RT-PCR analysis of Cps1 in liver samples collected as in (a). Data are presented as mean ± SEM (n = 3). Two-way ANOVA with Bonferroni post-hoc tests shows significant statistical differences between HFD.Veh and other three groups (p < 0.0001). d Western blotting analysis of protein lysates of liver samples collected at ZT 6 and 18 from mice with the indicated diet and treatment (n = 3). HPD indicates high-protein diet. The images shown to the left are representative of three independent experiments. Quantitation of Western blots was carried out and the results, presented as mean ± SEM, are shown in the lower panel. Two-way ANOVA with Bonferroni post-hoc tests, RC vs. HPD, **p < 0.001. e Real-time qPCR analysis was carried out using total RNAs extracted from the liver samples described in (d). The results are presented as mean ± SEM. Two-way ANOVA with Bonferroni post-hoc tests, RC vs. HPD, p < 0.05.

产品目录	产品描述	文献引用	实验数据
S7155	Batimastat (BB-94) Batimastat (BB-94)是一种有效的，广谱matrix metalloprotease (MMP)（基质金属蛋白酶）抑制剂，作用于MMP-1， MMP-2， MMP-9， MMP-7和MMP-3，IC50分别为3 nM， 4 nM， 4 nM， 6 nM和20 nM。	Nature,2017, 549(7673):533-537 Hum Mol Genet,2017, 26(20):3946-3959 Biomed Rep,2016, 4(1):73-78	Proliferation indices of SU-pcGBM2 cells exposed to plain medium (aCSF) or active conditioned medium generated in the presence or absence of pan-MMP inhibitor (BAT).
S8072	NSC 405020 NSC 405020是一种MT1-MMP抑制剂，直接与MT1-MMP的PEX区域相互作用，影响PEX二聚体化，但不影响MT1-MMP的催化活性。	Reproduction,2018, 155(3):297-306
S4163	Doxycycline Hyclate Doxycycline是四环素抗生素组的一个成员，通常用于治疗各种感染。还是MMP抑制剂。	Sci Rep,2018, 8(1):7653 Nature,2017, 548(7665):112-116
S7157	Ilomastat (GM6001, Galardin) Ilomastat (GM6001, Galardin)是一种广谱matrix metalloprotease (MMP)（基质金属蛋白酶）抑制剂，作用于MMP-1， MMP-2， MMP-3， MMP-7， MMP-8， MMP-9， MMP-12， MMP-14，和MMP-26，K_i分别为0.4 nM， 0.5 nM， 27 nM， 3.7 nM， 0.1 nM， 0.2 nM， 3.6 nM， 13.4 nM，和0.36 nM。	Matrix Biol,2019, 10.1016/j.matbio.2019.07.006 Cell Prolif,2019, 10.1111/cpr.12633 J Gastroenterol Hepatol,2018, 33(5):1075-1081	GM6001 inhibits MMP-7 and −10 mRNA expressions in Aurora-A stable cells in HNC. The mRNA expression levels of MMP-7 and −10 were examined by Q-RT-PCR in FaDu/vehicle, and FaDu/Aurora-A transfectants treated with DMSO or GM6001 in a dose-dependent manner. Statistical analysis: p < 0.01, *p < 0.001.
S5543	1, 10-Phenanthroline monohydrate 1,10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry. It is an inhibitor of metallopeptidases.
S7430	SB-3CT SB-3CT 是高效选择性的gelatinase抑制剂，其作用于MMP-2和MMP-9的K_i分别为13.9 nM 和 600 nM。	Biomater Sci,2019, 7(8):3320-3333 Clin Sci (Lond),2019, 133(3):515-530 Mol Nutr Food Res,2018, 10.1002/mnfr.201700969	The matrix metalloproteinase 9(MMP9) inhibitor(SB-3CT) attenuated angiotensin II (Ang II)-induced cardiomyocyte hypertrophy in vitro. (A) Representative immunofluorescent (α-actinin) images of neonatal rat cardiomyocytes (NRCMs) in the presence or absence of MMP9 inhibitor that were administered PBS or Ang II for 48 h. Bar=200 μm. (B) Statistical results for the cell surface area (CSA) of NRCMs. (C-E) The relative mRNA expression levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and β-myosin heavy chain (β-MHC) in NRCMs in the presence or absence of MMP9 inhibitor that were administered PBS or Ang II for 48 h. The intensities were normalized to the levels of GAPDH mRNA with the value in the PBS group defined as 1. * P<0.05 versus the control group, # P<0.05 versus the Ang II group. n=6 samples per experimental group
S7156	Marimastat (BB-2516) Marimastat (BB-2516)是一种广谱的 matrix metalloprotease (MMP) 抑制剂，对 MMP-9，MMP-1，MMP-2，MMP-14 和 MMP-7 的 IC50 分别为 3 nM，5 nM，6 nM，9 nM 和 13 nM。Phase 3。	Cell Signal,2018, 42:155-164	(E, F) Uev1A mediates negative feedback of NF-κB signaling pathway is dependent on TACE activity. Forty-eight hours after transfection, the cells were pre-treated with BB-2516 (20 μM) for 1 h, followed by TNFα (40 ng/ml) treatment for 2 h. Cell was fixed and stained with antibodies against HA and p65. The same cells were also stained with DAPI to reveal nuclei. White arrows indicate UEV1A-overexpressed cells. (F) Quantitative analysis of the experiments shown in (E). Percentage of cells displaying nuclear p65 is shown for UEV1A- overexpressed or vector-transfected cells. Each sample contains about 1000 cells. The significance of differences was assessed by two-tailed Student's test (***P < 0.001).
S2333	Nobiletin Nobiletin 是O-甲基黄酮，是从柑橘果皮如橘子分离的一种黄酮类化合物。具有抗炎和抗肿瘤活性。	Nutr Metab (Lond),2015, 12:23 Plant Physiol,2012, 159(1):81-94	NOB modulates Cps1 mRNA and protein expression. a Total protein extracts were prepared from liver samples collected from the four diet/treatment groups of wild-type mice at the indicated circadian time points (n = 3). Western blotting analysis was performed using anti-CPS1 antibody. RC regular chow, HFD high-fat diet, Veh vehicle, NOB Nobiletin. The results shown are representative of three independent experiments. See Additional file 1: Figure S1A for quantitative analysis. b Immunohistochemical staining of CPS1 in liver sections from mice with the indicated diet and treatment at ZT2. c Real-time RT-PCR analysis of Cps1 in liver samples collected as in (a). Data are presented as mean ± SEM (n = 3). Two-way ANOVA with Bonferroni post-hoc tests shows significant statistical differences between HFD.Veh and other three groups (p < 0.0001). d Western blotting analysis of protein lysates of liver samples collected at ZT 6 and 18 from mice with the indicated diet and treatment (n = 3). HPD indicates high-protein diet. The images shown to the left are representative of three independent experiments. Quantitation of Western blots was carried out and the results, presented as mean ± SEM, are shown in the lower panel. Two-way ANOVA with Bonferroni post-hoc tests, RC vs. HPD, **p < 0.001. e Real-time qPCR analysis was carried out using total RNAs extracted from the liver samples described in (d). The results are presented as mean ± SEM. Two-way ANOVA with Bonferroni post-hoc tests, RC vs. HPD, p < 0.05.