Doxycycline

别名: Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum 中文名称:强力霉素

Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum)是一种抗生素,用于治疗由细菌和原生动物引起的多种感染。Doxycycline 也是一种非特异性的 matrix metalloproteinase (MMP) 抑制剂。

Doxycycline Chemical Structure

Doxycycline Chemical Structure

CAS: 564-25-0

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 1040.13 现货
25mg RMB 795.18 现货
1g RMB 3031.08 现货
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客户使用Selleck的Doxycycline发表文献35

产品质控

批次: 纯度: >97%
97

Doxycycline相关产品

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
vascular endothelial cells Antibacterial assay 25 ug/ml 72 hrs Antibacterial activity against Rickettsia prowazekii str. Breinl infected in CD rat primary pulmonary vascular endothelial cells assessed as bacterial shape change at 25 ug/ml measured 72 hrs post infection by Hoechst 33258/phalloidin staining based fluor 28089350
Hep2 Anti-Chlamydial assay 1 ug/ml 8 hrs Anti-Chlamydial activity against Chlamydia trachomatis Serovar LGV-L2 infected in Hep2 cells assessed as reduction in size and number of chlamydial inclusion at 1 ug/ml treated at 8 hrs post-infection and 24 hrs later re-infecting fresh Hep2 cells monolay 32227948
SW1353 Function assay 50 uM Inhibition of IL-1-beta-induced MMP13 production in human SW1353 cells at 50 uM 17267227
Neuro2a Function assay 1 uM Decrease in 7-DHC levels in Dhcr7-deficient mouse Neuro2a cells at 1 uM by LC-MS/GC-MS analysis 26789657
Staphylococcus aureus 2 planktonic cells Bactericidal assay 24 hrs Bactericidal activity against methicillin-resistant Staphylococcus aureus 2 planktonic cells after 24 hrs by calgary biofilm device method, MBC=2μM. 29638121
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by flow cytometry, IC50=15μM. 19482476
K562 Cytotoxicity assay 72 hrs Cytotoxicity against human K562 cells after 72 hrs by flow cytometry, IC50=15μM. 19926173
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50=20μM. 19482476
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50=20μM. 19926173
THP1 Cytotoxicity assay 72 hrs Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide staining-based flow cytometry, IC50=20μM. 19748781
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, CC50=20μM. 21741131
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, CC50=20μM. 22889559
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, CC50=20μM. 21852132
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, CC50=20μM. 24946216
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay, CC50=20μM. 25791675
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay, CC50=20μM. 25282267
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay, CC50=20μM. 27155463
HepG2 Cytotoxicity assay 72 hrs Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay, CC50=20μM. 27654395
K-12 BW25113 Bactericidal assay 24 hrs Bactericidal activity against yafQ gene-deficient Escherichia coli K-12 BW25113 biofilm assessed as log reduction of viable cells after 24 hrs 19307375
K-12 BW25113 Bactericidal assay 24 hrs Bactericidal activity against Escherichia coli K-12 BW25113 biofilm harboring pCA24N ptac::yafQ plasmid assessed as log reduction of viable cells after 24 hrs pretreated with 5 uM of IPTG for 4 hrs 19307375
THP1 Function assay Selectivity index, ratio of IC50 for human THP1 cells to IC50 for Plasmodium falciparum, IC50=3.1μM. 19748781
A673 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells 29435139
BT-12 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells 29435139
skeletal myoblast cells Cytotoxicity assay DNDI: Cytotoxicity in Vitro, 72 hour, in rat skeletal myoblast cells, IC50=14.49μM. ChEMBL
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生物活性

产品描述 Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum)是一种抗生素,用于治疗由细菌和原生动物引起的多种感染。Doxycycline 也是一种非特异性的 matrix metalloproteinase (MMP) 抑制剂。
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05972772 Not yet recruiting
Infectious Disease|Therapeutics
Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit|Mahidol Oxford Tropical Medicine Research Unit
February 1 2024 Phase 2|Phase 3
NCT06007534 Not yet recruiting
Post-exposure Prophylaxis|Sexually Transmitted Diseases|Doxycycline
Assistance Publique - Hôpitaux de Paris
September 2023 Not Applicable
NCT04762134 Recruiting
Bacterial Sexually Transmitted Diseases
Jonathan Troy Grennan|Canadian Institutes of Health Research (CIHR)|British Columbia Centre for Disease Control
June 2 2023 Phase 4
NCT05853120 Recruiting
Sexually Transmitted Diseases
Emory University|Centers for Disease Control and Prevention
May 31 2023 Phase 4
NCT05382208 Recruiting
Emphysema|HIV
Weill Medical College of Cornell University|National Heart Lung and Blood Institute (NHLBI)|University of California Los Angeles|University of Iowa|University of Michigan
August 22 2022 Phase 2
NCT05492019 Recruiting
Parkinson Disease
Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh
July 1 2022 Phase 2

化学信息&溶解度

分子量 444.43 分子式

C22H24N2O8

CAS号 564-25-0 SDF Download Doxycycline SDF
Smiles CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
储存条件(自收到货起)

体外溶解度
批次:

DMSO : 89 mg/mL ( 200.25 mM; DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

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