Geldanamycin (NSC 122750)

For research use only. Not for use in humans.

目录号:S2713 中文名称:格尔德霉素

Geldanamycin (NSC 122750) Chemical Structure

CAS No. 30562-34-6

Geldanamycin (NSC 122750) 是一种天然的HSP90抑制剂,Kd为1.2 μM,特异性干扰糖皮质激素受体(GR)/HSP联合。Geldanamycin 通过减少宿主的炎症反应来减轻病毒感染引起的ALI(急性肺损伤)/ARDS(急性呼吸窘迫综合征)。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 3131.63 现货
RMB 1407.44 现货
RMB 2229.39 现货
RMB 5493.81 现货
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客户使用Selleck生产的Geldanamycin (NSC 122750)发表文献25篇:

产品安全说明书

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

生物活性

产品描述 Geldanamycin (NSC 122750) 是一种天然的HSP90抑制剂,Kd为1.2 μM,特异性干扰糖皮质激素受体(GR)/HSP联合。Geldanamycin 通过减少宿主的炎症反应来减轻病毒感染引起的ALI(急性肺损伤)/ARDS(急性呼吸窘迫综合征)。
靶点
p185 [4]
(SKBr3 cells)
HSP90 (N-terminal domain) [1]
(Cell-free assay)
HSP90 [1]
(Cell-free assay)
70 nM 0.78 μM(Kd) 1.2 μM(Kd)
体外研究

Geldanamycin结合于Hsp90s (残基1-220) N-末端结构域的ATP结合位点。Geldanamycin剂量依赖性抑制Hsp90的ATPase活性。[1] 在A2780人卵巢细胞系中,Geldanamycin引起剂量依赖性G2期阻滞,并可逆抑制其进入S期。该抑制作用伴随p53的增加,最终证明是p53依赖性的。[2] Geldanamycin引起p185受体蛋白-酪氨酸激酶的泛素化和蛋白酶体降解,IC50为70 nM。[3, 4] Geldanamycin是典型的抗肿瘤试剂,对一组60个人肿瘤细胞系的平均GI50为0.18 μM。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A2780 cells NHPFZWVRem:uaX\ldoF1cW:wIHHzd4F6 Moq5R49ueG:3bnSge4F{KGW4YXz1ZZRm\CCob4KgZY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCxdnHybYFvKGOjcnPpco9u[SClZXzsJIxqdmViQUK3PFAtKEmFNUC9N{41KM7:TR?= NWrZWoo4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG1NVQyPDVpPkGxOVE1OTR3PD;hQi=>
SW620 cell M2fTRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYnaOZJ6UW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5iY3;sc5Jm[3SjbDDjZZJkcW6xbXGgV3c3OjBiY3XscEBtcW6nczygTWM2OD14LkKgcm0> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZ3OEi3PUc,OTV4NUi4O|k9N2F-
MCF-7 cell M1fxcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX;xW3c3UW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5iYoLlZZN1KGOjbnPldkBOS0ZvNzDj[YxtKGyrbnXzMEBKSzVyPU[uOUBvVQ>? NYruO2NDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2OVg5PzlpPkG1OlU5QDd7PD;hQi=>
K562 cell M4XtZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUn0XldIUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5ibHX1b4VucWFiS{W2NkBk\WyuIHzpcoV{NCCLQ{WwQVIzNjFibl2= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZ3OEi3PUc,OTV4NUi4O|k9N2F-
HT-29 cell NWXNSlRQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVj4SpVyUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5iY3;sc5Jm[3SjbDDjZZJkcW6xbXGgTHQuOjliY3XscEBtcW6nczygTWM2OD1{ND61JI5O NXv4[mlORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2OVg5PzlpPkG1OlU5QDd7PD;hQi=>
SK-BR-3 M{jtSWZ2dmO2aX;uJIF{e2G7 MkjBOVAhdWdxa3e= NEXBUWpKdmirYnn0bY9vKG:oIH;uZ49o\W6nIIDyc4R2[3RicEG4OUBmemKELUKg[pJwdSCqdX3hckBjemWjc4SgZ4Fv[2W{IHPlcIx{MFONLVLSMVMh[2WubIOpJIF1KDVyIH3nM4toKGSxc3WsJGlEPTB;MD6wO:69VQ>? M3XwRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd3NkK5NVEoRjd3NkK5NVE9N2F-
SK-BR-3 M4Sxc2Z2dmO2aX;uJIF{e2G7 M37jWmlvKH[rdILvJIlvcGmkaYTpc44hd2ZicEG4OUBmemKELUKgc45kd3C{b4TlbY4hcW5iaIXtZY4h[nKnYYP0JINidmOncjDTT{1DWi1|IHPlcIx{NCCLQ{WwQVAvODgQvF2= NIS3PWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95NU[yPVEzLz55NU[yPVEzRC:jPh?=
MCF-7 NVm2U4ZsTnWwY4Tpc44h[XO|YYm= MUfJcohq[mm2aX;uJI9nKHO2ZXHkfU1{fGG2ZTDlfJBz\XO|aX;uJI9nKEiHUkKgbY4hVUOILUegZpJm[XO2IHPhcoNmeiClZXzsd{whUUN3ME2wMlA2|ryP NV\BOIxwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCzOFA3ODVpPkGwN|QxPjB3PD;hQi=>
MCF-7 NIjXbW5HfW6ldHnvckBie3OjeR?= M{\FOGlvcGmkaYTpc44hd2Zic4TlZYR6NXO2YYTlJIV5eHKnc4Ppc44hd2ZiRWKgbY4hVUOILUegZpJm[XO2IHPhcoNmeiClZXzsd{whUUN3ME2wMlA3|ryP M4[1T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{SwOlA2Lz5zMEO0NFYxPTxxYU6=
MCF-7 NIDnN5FHfW6ldHnvckBie3OjeR?= NVzRRodjUW6qaXLpeIlwdiCxZjDzeIVi\Hlvc4TheIUh\XiycnXzd4lwdiCxZjDSZYYuOSCrbjDNR2YuPyCkcnXhd5Qh[2GwY3XyJINmdGy|LDDJR|UxRTBwMt88US=> M{P1VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{SwOlA2Lz5zMEO0NFYxPTxxYU6=
SKBR-3 MoPFSpVv[3Srb36gZZN{[Xl? MoC1SYZn\WO2aY\lJINwdmOnboTyZZRqd25iZn;yJGhmei1{IHTl[5Ji\GG2aX;uJIlvKFONQmKtN{Bk\WyuczygR49v[2WwdILheIlwdj13zszN MkO2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5MUO0NVAoRjF3N{GzOFExRC:jPh?=
HEK293 MXzGeY5kfGmxbjDhd5NigQ>? MWTJcohq[mm2aX;uJI9nKEiVUEmwJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMh\W[oZXP0JI9vKEGtdEG6dFI4KGmwdHXyZYN1cW:wIHPvcZBt\XinczDifUBGYU[SIHHu[E9weiC\RmCgWoVvfXNiZoLh[41mdnRiYnHz[YQhemWyb4L0[ZIh\2WwZTDhd5NigQ>? NF\UdZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNk[4NFE2QSd-MU[2PFAyPTl:L3G+
LS174T NH7HPFNEgXSxdH;4bYNqfHliYYPzZZk> NGfnN29EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNWzF5NGSgZ4VtdHNiYomgUXRUKGG|c3H5MEBKSzVyPUCuOFXPxE1? M{XQZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEO0NVM2Lz5zN{CzOFE{PTxxYU6=
rat neuronal cells NFzCO|FEgXSxdH;4bYNqfHliYYPzZZk> MXmxNEB2VQ>? MYeyOEBpenN? MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBz[XRibnX1do9v[WxiY3XscJMh[XRiMUCgeW0h[W[2ZYKgNlQhcHK| NFjtXGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{K3OlY4QSd-MUeyO|Y3Pzl:L3G+
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MCF7 NV7wUJN{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1zSU2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKg[IF6eyCkeTDTVmIh[XO|YYmsJGdKPTB;M{WuOu69VQ>? Ml71QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd6NkmwPVgoRjF5OE[5NFk5RC:jPh?=
HCT116 NX3UZoJNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXTJNVM5T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|LDDHTVUxRTBwMEKx{txO MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ2M{ewN{c,OTh{NEO3NFM9N2F-
DLD1 NH3XTIVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWTjd|ZET3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hTEyGMTDj[YxteyxiR1m1NF0xNjB|N988US=> M4nscVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkSzO|A{Lz5zOEK0N|cxOzxxYU6=
KPL4 MmTaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHfs[3BIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBMWEx2IHPlcIx{NCCJSUWwQVAvODV7zszN NUDWbYxnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyOFM4ODNpPkG4NlQ{PzB|PD;hQi=>
A549 M1nzfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NETTcFFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCPTR7IHPlcIx{NCCJSUWwQVAvODZ2zszN NGP1TVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK0N|cxOyd-MUiyOFM4ODN:L3G+
KPL4 NITQXHJHfW6ldHnvckBie3OjeR?= NYjBW4Q2PDBiaILz Mn7jTY5pcWKrdHnvckBw\iCKc4C5NEBqdiCqdX3hckBMWEx2IHPlcIx{KGG|c3Xzd4VlKGG|IHTldIxmfGmxbjDv[kBGemKEMjDs[ZZmdCCjZoTldkA1OCCqcoOsJG1GSz1yLkGx{txO M4LuRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkSzO|A{Lz5zOEK0N|cxOzxxYU6=
KPL4 NW[3XIt5TnWwY4Tpc44h[XO|YYm= NYrwdINqPDBiaILz M1LNSGlvcGmkaYTpc44hd2ZiSIPwPVAhcW5iaIXtZY4hU1CONDDj[YxteyCjc4Pld5Nm\CCjczDk[ZBt\XSrb36gc4YhWmGoLUGgcIV3\WxiYX\0[ZIhPDBiaILzMEBOTUN;MD6zN:69VQ>? NXTSRok2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyOFM4ODNpPkG4NlQ{PzB|PD;hQi=>
Jurkat MneySpVv[3Srb36gZZN{[Xl? MoqzNUB2VQ>? MVjJcohq[mm2aX;uJI9nKHSxIFjTVFkxKGmwIF\BSGQh\GWoaXPp[Y51KGi3bXHuJGp2emujdDDj[YxteyCjc4Pld5Nm\CCjczDSTXAheHKxdHXpckBl\We{YXTheIlwdiCjdDCxJJVOKGK7IGfld5Rmem5iYnzveC=> NVHufGl5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NFg4OTNpPkG4OFA5PzF|PD;hQi=>
HEK293T NU\1VoxVTnWwY4Tpc44h[XO|YYm= NFnOd|ZKdmirYnn0bY9vKG:oIGTOSk1idHCqYT3pcoR2[2WmIF7GMYtieHCjQjDhZ5RqfmG2aX;uJIV5eHKnc4Pl[EBqdiCKRVuyPVNVKGOnbHzzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= NGjjc3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESwPFcyOyd-MUi0NFg4OTN:L3G+
Jurkat NEO3TFRHfW6ldHnvckBie3OjeR?= NUX1SnppUW6qaXLpeIlwdiCxZjDUUmYu[WyyaHGtbY5lfWOnZDDOSk1s[XCyYVKgZYN1cX[jdHnvckBmgHC{ZYPz[YQhcW5iRlHESEBl\W[rY3nlcpQhcHWvYX6gTpVzc2G2IHPlcIx{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRyOEexN{c,OTh2MEi3NVM9N2F-
SKBR3 M1u0bWZ2dmO2aX;uJIF{e2G7 MWmyOEBpenN? MWrJcohq[mm2aX;uJI9nKEi|cEmwMY1m\GmjdHXkJGhGWjJiZHXndoFl[XSrb36gbY4hcHWvYX6gV2tDWjNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHdme3Sncn6gZoxwfA>? M2PXRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OEG2NVEyLz5zOEixOlEyOTxxYU6=
SKBR3 MnXhSpVv[3Srb36gZZN{[Xl? M{fZVFI1KGi{cx?= NGDmWYRKdmirYnn0bY9vKG:oIFjzdFkxNW2nZHnheIVlKFKjZjDk[Ydz[WSjdHnvckBqdiCqdX3hckBUU0KUMzDj[YxteyCjZoTldkAzPCCqcoOgZpkhX2W|dHXyckBjdG:2 NXnoeFN2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4NVYyOTFpPkG4PFE3OTFzPD;hQi=>
HuH7 NWPnPXVmSW62aY\pdoFtKGG|c3H5 NYnDTmZIOyCmYYnz MWDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZBifGm2aYOgR{B3cXK3czDn[Y5wfHmyZTCxZkBEd25zIHnu[oVkfGWmIHnuJIh2dWGwIFj1TFch[2WubIOgZZN{\XO|ZXSgZZMhT0GSRFigVm5CKG:{IEG4V{BzWk6DIHzleoVtKGGodHXyJFMh\GG7czDifUByWlRvUFPSJIFv[Wy7c3nzMEBGSzVyPUCuNFAxOjYQvF2= NX\Kb2J6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5N|YyQTFpPkG4PVM3OTlzPD;hQi=>
HuH7 NGr6[3lCdnSrdnnyZYwh[XO|YYm= MVyzJIRigXN? NUDSe5NzSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUGWyYYTpeIl{KENidnnyeZMh\2Wwb4T5dIUhOWJiQ3;uNUBqdm[nY4Tl[EBqdiCqdX3hckBJfUh5IHPlcIx{KGG|c3Xzd4VlKGG|IFfBVGRJKFKQQTDvdkAyQFNicmLORUBt\X[nbDDh[pRmeiB|IHThfZMhe2WuZXP0[YQhf2m2aDC0NEBvVSCKQ2[tO|k3KGGwZDC4NFAhdk1iYn;j[ZBz\X[rcjDifUByWlRvUFPSJIFv[Wy7c3nzMEBGSzVyPUCuNFAyOs7:TR?= NXnBT49KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5N|YyQTFpPkG4PVM3OTlzPD;hQi=>
SH-SY5Y NHTReIlP\XW{b4Dyc5Rm[3Srb36gZZN{[Xl? NYfpd2llVmW3cn;wdo91\WO2aX;uJIFo[Wmwc4SgZoV1[S2jbYnsc4llKHCncITp[IUhOS12Mj3pcoR2[2WmIITvfIlkcXS7IHnuJIh2dWGwIGPIMXN[PVliY3XscJMh[XO|ZYPz[YQh[XNibHHjeIF1\SCmZXj5[JJw\2WwYYPlJJJmdGWjc3WsJGVEPTB;MD6wOFI3Qc7:TR?= NYC3dotMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxN|g5PTlpPkG5NVM5QDV7PD;hQi=>
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... Click to View More Cell Line Experimental Data

体内研究 在FRE/erbB-2 小鼠体内,Geldanamycin (50 mg//kg)对pl85-相关的磷酸酪氨酸水平表现出30%的抑制。[6]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

核苷结合的等温滴定量热法(ITC):

滴定实验使用MSC系统进行。在每个实验中,16等份15 μL geldanamycin (300 μM在1% DMSO中)在25 °C下注射到1.3 mL蛋白质(31 μM在20 mMTris-HCl中, pH 7.5, 1 mMEDTA),得到的数据减去稀释热后进行拟合。将geldanamycin加入缓冲液和缓冲液加入蛋白质的稀释热在单独实验中测定。在核苷酸结合位点没有观察到DMSO的结合。滴定数据使用非线性最小二乘法曲线拟合算法拟合,该算法有三个不固定变量:化学计量,结合常数(Kb) 1/Kd),和相互作用焓的变化(ΔH°)。Geldanamycin结合到完整酵母Hsp90和Hsp90 N-末端结构域,估计的解离常数分别为1.22 μM和0.78 μM。结合到C-末端片段时,没有观察到有意义的热量。
细胞实验:

[2]

- 合并
  • Cell lines: A2780人卵巢癌细胞系
  • Concentrations: 0.001-10 μM
  • Incubation Time: 3小时
  • Method: 指数生长的细胞用Geldanamycin处理,不同时期的DNA合成通过溴脱氧尿苷(BrdUrd)的整合和流式细胞分析术评估。在此期间,处理的和未处理的细胞,总细胞数没有显著的差别。BrdUrd (10 μM)在37 °C下4小时的培育期间进行整合,将细胞采集并固定在70%乙醇中。DNA通过2 N HC1变性后,细胞用抗- BrdUrd小鼠单克隆抗体培育,随后用异硫氰酸荧光素(FITC)-连接的山羊抗-小鼠IgG培育。细胞在室温下用碘化丙啶着色30分钟,使用Coulter EPICS Profile分析器通过流式细胞术分析。
    (Only for Reference)
动物实验:

[6]

- 合并
  • Animal Models: 负荷FRE/erbB-2肿瘤的nu/nu小鼠
  • Dosages: 50 mg/kg
  • Administration: 通过腹腔注射给药
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 36 mg/mL warmed (64.21 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 560.64
化学式

C29H40N2O9

CAS号 30562-34-6
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00003969 Completed Drug: tanespimycin Unspecified Adult Solid Tumor Protocol Specific Cancer Research UK|National Cancer Institute (NCI) August 1998 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID