Geldanamycin (NSC 122750)

For research use only. Not for use in humans.

目录号：S2713 中文名称：格尔德霉素

Geldanamycin (NSC 122750) Chemical Structure

CAS No. 30562-34-6

Geldanamycin (NSC 122750) 是一种天然的HSP90抑制剂，K_d为1.2 μM，特异性干扰糖皮质激素受体(GR)/HSP联合。Geldanamycin 通过减少宿主的炎症反应来减轻病毒感染引起的ALI(急性肺损伤)/ARDS(急性呼吸窘迫综合征)。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 3131.63	现货
5mg	RMB 1407.44	现货
10mg	RMB 2229.39	现货
50mg	RMB 5493.81	现货
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客户使用Selleck生产的Geldanamycin (NSC 122750)发表文献25篇：

Cell Chem Biol, 2021, S2451-9456(21)00221-X

PubMed: 34077750 ( click the link to review the publication )

J Virol, 2021, JVI0059421

PubMed: 34037421 ( click the link to review the publication )

Anal Chem, 2020, 92(1):1363-1371

PubMed: 31794197 ( click the link to review the publication )

Anal Chem, 2020, 10.1021/acs.analchem.0c02756

PubMed: 32933243 ( click the link to review the publication )

Cell Biol Toxicol, 2020,

PubMed: 31773452 ( click the link to review the publication )

Proteomics, 2020, e1900372

PubMed: 32578935 ( click the link to review the publication )

Virology, 2020, 553:70-80

PubMed: 33242760 ( click the link to review the publication )

Nat Commun, 2019, 10(1):2131

PubMed: 31086186 ( click the link to review the publication )

Autophagy, 2019, 15(9):1558-1571

PubMed: 30821613 ( click the link to review the publication )

EBioMedicine, 2019, 47:170-183

PubMed: 31466918 ( click the link to review the publication )

J Biol Chem, 2019, 294(11):4247-4258

PubMed: 30670591 ( click the link to review the publication )

Food Chem Toxicol, 2019, 132:110645

PubMed: 31254591 ( click the link to review the publication )

Autophagy, 2018, 14(6):958-971

PubMed: 29561705 ( click the link to review the publication )

Mol Syst Biol, 2018, 14(7):e8071

PubMed: 29997244 ( click the link to review the publication )

Toxicol Sci, 2018,

PubMed: 30137596 ( click the link to review the publication )

Radiat Res, 2018, 189(5):519-528

PubMed: 29474156 ( click the link to review the publication )

Hum Mol Genet, 2017, 26(22):4465-4480

PubMed: 28973376 ( click the link to review the publication )

Arch Toxicol, 2016, 90(1):159-80

PubMed: 26705709 ( click the link to review the publication )

Medicinal Chemistry Research, 2016, 10.1007/s00044-016-1553-7

PubMed: ( click the link to review the publication )

J Antimicrob Chemother, 2015, 10.1093/jac/dku549

PubMed: 25558076 ( click the link to review the publication )

Antimicrob Agents Chemother, 2015, 59(8):4727-33

PubMed: 26014950 ( click the link to review the publication )

PLoS One, 2015, 10(9):e0138936

PubMed: 26414348 ( click the link to review the publication )

Cell Stress Chaperones, 2015, 20(2):309-19

PubMed: 25576151 ( click the link to review the publication )

J Mol Neurosci, 2015, 57(3):317-24

PubMed: 26208597 ( click the link to review the publication )
Oncotarget, 2014, 5(12):4269-82

PubMed: 24962213 ( click the link to review the publication )

产品安全说明书

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

生物活性

产品描述

靶点

p185 ^[4] (SKBr3 cells)	HSP90 (N-terminal domain) ^[1] (Cell-free assay)	HSP90 ^[1] (Cell-free assay)
70 nM	0.78 μM(Kd)	1.2 μM(Kd)

体外研究

Geldanamycin结合于Hsp90s (残基1-220) N-末端结构域的ATP结合位点。Geldanamycin剂量依赖性抑制Hsp90的ATPase活性。^[1] 在A2780人卵巢细胞系中，Geldanamycin引起剂量依赖性G2期阻滞，并可逆抑制其进入S期。该抑制作用伴随p53的增加，最终证明是p53依赖性的。^[2] Geldanamycin引起p185受体蛋白-酪氨酸激酶的泛素化和蛋白酶体降解，IC50为70 nM。^{[3, 4]} Geldanamycin是典型的抗肿瘤试剂，对一组60个人肿瘤细胞系的平均GI50为0.18 μM。^[5]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
A2780 cells	NHPFZWVRem:uaX\ldoF1cW:wIHHzd4F6			Moq5R49ueG:3bnSge4F{KGW4YXz1ZZRm\CCob4KgZY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCxdnHybYFvKGOjcnPpco9u[SClZXzsJIxqdmViQUK3PFAtKEmFNUC9N{41KM7:TR?=	NWrZWoo4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG1NVQyPDVpPkGxOVE1OTR3PD;hQi=>
SW620 cell	M2fTRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NYnaOZJ6UW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5iY3;sc5Jm[3SjbDDjZZJkcW6xbXGgV3c3OjBiY3XscEBtcW6nczygTWM2OD14LkKgcm0>	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZ3OEi3PUc,OTV4NUi4O\|k9N2F-
MCF-7 cell	M1fxcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NX;xW3c3UW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5iYoLlZZN1KGOjbnPldkBOS0ZvNzDj[YxtKGyrbnXzMEBKSzVyPU[uOUBvVQ>?	NYruO2NDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2OVg5PzlpPkG1OlU5QDd7PD;hQi=>
K562 cell	M4XtZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NUn0XldIUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5ibHX1b4VucWFiS{W2NkBk\WyuIHzpcoV{NCCLQ{WwQVIzNjFibl2=	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZ3OEi3PUc,OTV4NUi4O\|k9N2F-
HT-29 cell	NWXNSlRQT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NVj4SpVyUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5iY3;sc5Jm[3SjbDDjZZJkcW6xbXGgTHQuOjliY3XscEBtcW6nczygTWM2OD1{ND61JI5O	NXv4[mlORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW2OVg5PzlpPkG1OlU5QDd7PD;hQi=>
SK-BR-3	M{jtSWZ2dmO2aX;uJIF{e2G7	MkjBOVAhdWdxa3e=		NEXBUWpKdmirYnn0bY9vKG:oIH;uZ49o\W6nIIDyc4R2[3RicEG4OUBmemKELUKg[pJwdSCqdX3hckBjemWjc4SgZ4Fv[2W{IHPlcIx{MFONLVLSMVMh[2WubIOpJIF1KDVyIH3nM4toKGSxc3WsJGlEPTB;MD6wO:69VQ>?	M3XwRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd3NkK5NVEoRjd3NkK5NVE9N2F-
SK-BR-3	M4Sxc2Z2dmO2aX;uJIF{e2G7			M37jWmlvKH[rdILvJIlvcGmkaYTpc44hd2ZicEG4OUBmemKELUKgc45kd3C{b4TlbY4hcW5iaIXtZY4h[nKnYYP0JINidmOncjDTT{1DWi1\|IHPlcIx{NCCLQ{WwQVAvODgQvF2=	NIS3PWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95NU[yPVEzLz55NU[yPVEzRC:jPh?=
MCF-7	NVm2U4ZsTnWwY4Tpc44h[XO\|YYm=			MUfJcohq[mm2aX;uJI9nKHO2ZXHkfU1{fGG2ZTDlfJBz\XO\|aX;uJI9nKEiHUkKgbY4hVUOILUegZpJm[XO2IHPhcoNmeiClZXzsd{whUUN3ME2wMlA2\|ryP	NV\BOIxwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCzOFA3ODVpPkGwN\|QxPjB3PD;hQi=>
MCF-7	NIjXbW5HfW6ldHnvckBie3OjeR?=			M{\FOGlvcGmkaYTpc44hd2Zic4TlZYR6NXO2YYTlJIV5eHKnc4Ppc44hd2ZiRWKgbY4hVUOILUegZpJm[XO2IHPhcoNmeiClZXzsd{whUUN3ME2wMlA3\|ryP	M4[1T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{SwOlA2Lz5zMEO0NFYxPTxxYU6=
MCF-7	NIDnN5FHfW6ldHnvckBie3OjeR?=			NVzRRodjUW6qaXLpeIlwdiCxZjDzeIVi\Hlvc4TheIUh\XiycnXzd4lwdiCxZjDSZYYuOSCrbjDNR2YuPyCkcnXhd5Qh[2GwY3XyJINmdGy\|LDDJR\|UxRTBwMt88US=>	M{P1VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{SwOlA2Lz5zMEO0NFYxPTxxYU6=
SKBR-3	MoPFSpVv[3Srb36gZZN{[Xl?			MoC1SYZn\WO2aY\lJINwdmOnboTyZZRqd25iZn;yJGhmei1{IHTl[5Ji\GG2aX;uJIlvKFONQmKtN{Bk\WyuczygR49v[2WwdILheIlwdj13zszN	MkO2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5MUO0NVAoRjF3N{GzOFExRC:jPh?=
HEK293	MXzGeY5kfGmxbjDhd5NigQ>?			MWTJcohq[mm2aX;uJI9nKEiVUEmwJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZZN{\XO\|ZXSgZZMh\W[oZXP0JI9vKEGtdEG6dFI4KGmwdHXyZYN1cW:wIHPvcZBt\XinczDifUBGYU[SIHHu[E9weiC\RmCgWoVvfXNiZoLh[41mdnRiYnHz[YQhemWyb4L0[ZIh\2WwZTDhd5NigQ>?	NF\UdZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNk[4NFE2QSd-MU[2PFAyPTl:L3G+
LS174T	NH7HPFNEgXSxdH;4bYNqfHliYYPzZZk>			NGfnN29EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNWzF5NGSgZ4VtdHNiYomgUXRUKGG\|c3H5MEBKSzVyPUCuOFXPxE1?	M{XQZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEO0NVM2Lz5zN{CzOFE{PTxxYU6=
rat neuronal cells	NFzCO\|FEgXSxdH;4bYNqfHliYYPzZZk>	MXmxNEB2VQ>?	MYeyOEBpenN?	MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBz[XRibnX1do9v[WxiY3XscJMh[XRiMUCgeW0h[W[2ZYKgNlQhcHK\|	NFjtXGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{K3OlY4QSd-MUeyO\|Y3Pzl:L3G+
P19	NYXWcYxpS3m2b4TvfIlkcXS7IHHzd4F6		M4XySFE5KGi{cx?=	MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W\|ZTDQNVkh[2WubIOgZYZ1\XJiMUigbJJ{NCCLQ{WwQVAvOc7:TR?=	NFnIc4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S0NlU3PSd-MUe0OFI2PjV:L3G+
MCF7	NV7wUJN{T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M1zSU2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKg[IF6eyCkeTDTVmIh[XO\|YYmsJGdKPTB;M{WuOu69VQ>?	Ml71QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd6NkmwPVgoRjF5OE[5NFk5RC:jPh?=
HCT116	NX3UZoJNT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NXTJNVM5T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy\|LDDHTVUxRTBwMEKx{txO	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ2M{ewN{c,OTh{NEO3NFM9N2F-
DLD1	NH3XTIVIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NWTjd\|ZET3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hTEyGMTDj[YxteyxiR1m1NF0xNjB\|N988US=>	M4nscVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkSzO\|A{Lz5zOEK0N\|cxOzxxYU6=
KPL4	MmTaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NHfs[3BIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBMWEx2IHPlcIx{NCCJSUWwQVAvODV7zszN	NUDWbYxnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyOFM4ODNpPkG4NlQ{PzB\|PD;hQi=>
A549	M1nzfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NETTcFFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCPTR7IHPlcIx{NCCJSUWwQVAvODZ2zszN	NGP1TVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK0N\|cxOyd-MUiyOFM4ODN:L3G+
KPL4	NITQXHJHfW6ldHnvckBie3OjeR?=		NYjBW4Q2PDBiaILz	Mn7jTY5pcWKrdHnvckBw\iCKc4C5NEBqdiCqdX3hckBMWEx2IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTldIxmfGmxbjDv[kBGemKEMjDs[ZZmdCCjZoTldkA1OCCqcoOsJG1GSz1yLkGx{txO	M4LuRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkSzO\|A{Lz5zOEK0N\|cxOzxxYU6=
KPL4	NW[3XIt5TnWwY4Tpc44h[XO\|YYm=		NYrwdINqPDBiaILz	M1LNSGlvcGmkaYTpc44hd2ZiSIPwPVAhcW5iaIXtZY4hU1CONDDj[YxteyCjc4Pld5Nm\CCjczDk[ZBt\XSrb36gc4YhWmGoLUGgcIV3\WxiYX\0[ZIhPDBiaILzMEBOTUN;MD6zN:69VQ>?	NXTSRok2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyOFM4ODNpPkG4NlQ{PzB\|PD;hQi=>
Jurkat	MneySpVv[3Srb36gZZN{[Xl?	MoqzNUB2VQ>?		MVjJcohq[mm2aX;uJI9nKHSxIFjTVFkxKGmwIF\BSGQh\GWoaXPp[Y51KGi3bXHuJGp2emujdDDj[YxteyCjc4Pld5Nm\CCjczDSTXAheHKxdHXpckBl\We{YXTheIlwdiCjdDCxJJVOKGK7IGfld5Rmem5iYnzveC=>	NVHufGl5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NFg4OTNpPkG4OFA5PzF\|PD;hQi=>
HEK293T	NU\1VoxVTnWwY4Tpc44h[XO\|YYm=			NFnOd\|ZKdmirYnn0bY9vKG:oIGTOSk1idHCqYT3pcoR2[2WmIF7GMYtieHCjQjDhZ5RqfmG2aX;uJIV5eHKnc4Pl[EBqdiCKRVuyPVNVKGOnbHzzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?=	NGjjc3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESwPFcyOyd-MUi0NFg4OTN:L3G+
Jurkat	NEO3TFRHfW6ldHnvckBie3OjeR?=			NUX1SnppUW6qaXLpeIlwdiCxZjDUUmYu[WyyaHGtbY5lfWOnZDDOSk1s[XCyYVKgZYN1cX[jdHnvckBmgHC{ZYPz[YQhcW5iRlHESEBl\W[rY3nlcpQhcHWvYX6gTpVzc2G2IHPlcIx{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=>	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRyOEexN{c,OTh2MEi3NVM9N2F-
SKBR3	M1u0bWZ2dmO2aX;uJIF{e2G7		MWmyOEBpenN?	MWrJcohq[mm2aX;uJI9nKEi\|cEmwMY1m\GmjdHXkJGhGWjJiZHXndoFl[XSrb36gbY4hcHWvYX6gV2tDWjNiY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JHdme3Sncn6gZoxwfA>?	M2PXRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OEG2NVEyLz5zOEixOlEyOTxxYU6=
SKBR3	MnXhSpVv[3Srb36gZZN{[Xl?		M{fZVFI1KGi{cx?=	NGDmWYRKdmirYnn0bY9vKG:oIFjzdFkxNW2nZHnheIVlKFKjZjDk[Ydz[WSjdHnvckBqdiCqdX3hckBUU0KUMzDj[YxteyCjZoTldkAzPCCqcoOgZpkhX2W\|dHXyckBjdG:2	NXnoeFN2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4NVYyOTFpPkG4PFE3OTFzPD;hQi=>
HuH7	NWPnPXVmSW62aY\pdoFtKGG\|c3H5		NYnDTmZIOyCmYYnz	MWDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDI[ZBifGm2aYOgR{B3cXK3czDn[Y5wfHmyZTCxZkBEd25zIHnu[oVkfGWmIHnuJIh2dWGwIFj1TFch[2WubIOgZZN{\XO\|ZXSgZZMhT0GSRFigVm5CKG:{IEG4V{BzWk6DIHzleoVtKGGodHXyJFMh\GG7czDifUByWlRvUFPSJIFv[Wy7c3nzMEBGSzVyPUCuNFAxOjYQvF2=	NX\Kb2J6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5N\|YyQTFpPkG4PVM3OTlzPD;hQi=>
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Sf9	MXzGeY5kfGmxbjDhd5NigQ>?		M1\tVFE3KGi{cx?=	NGHTW5dFcXOybHHj[Y1mdnRib3[gS20uSk:GSWDZJIZzd21iaIXtZY4h\nWubDDs[Y5ofGhiSGPQPVAh[WyyaHGg[ZhxemW\|c3XkJIlvKGKjY4Xsc5ZqenW\|LXnu[oVkfGWmIGPmPUBk\WyuczDh[pRmeiBzNjDodpMh[nliZnz1c5Jme2OnbnPlJJBwdGG{aYrheIlwdiCjc4PhfUwhUUN3ME2wMlA4PM7:TR?=	MmW0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5NUG0OFEoRjJ2N{WxOFQyRC:jPh?=
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MCF7	NYqz[ZpDSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MlfLO\|IhcHK\|	MofsRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHMwWE2VIHHzd4F6NCCLQ{WwQVAvODUQvF2=	NXrYb2hWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwO\|U4PjJpPkK1NFc2PzZ{PD;hQi=>
MDA-MB-231	MYLDfZRwfG:6aXPpeJkh[XO\|YYm=		M3jtPVczKGi{cx?=	M{XRfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN\|Eh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkC1{txO	MoD5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzMEW5NlQoRjJ3MUC1PVI1RC:jPh?=
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MDA-MB 231	NXv3coJVTnWwY4Tpc44h[XO\|YYm=	M2fBTFAvPSCjbnSgOUB2VQ>?		M2fOR2lvcGmkaYTpc44hd2ZiSGPQPVAhcW5iaIXtZY4hVUSDLV3CJFI{OSClZXzsd{Bie3Onc4Pl[EBqdmO{ZXHz[UBqdiCKU2C3NEBxem:2ZXnuJIxmfmWuczDheEAxNjViYX7kJFUhfU1iYomgW4V{fGW{bjDicI91KG2ndHjv[C=>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTFyNUmyOEc,OjVzMEW5NlQ9N2F-
HUVEC	NHfRUG5EgXSxdH;4bYNqfHliYYPzZZk>		NH\uWoQ4OiCqcoO=	MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBJXV[HQzDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODF7zszN	M3fNZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mke3NFY4Lz5{NUK3O\|A3PzxxYU6=
A431	NU\rPZBYS3m2b4TvfIlkcXS7IHHzd4F6		M{jRNlczKGi{cx?=	MkXaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUCuNFTPxE1?	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ5N{C2O{c,OjV{N{ewOlc9N2F-
BGC823	MmHLR5l1d3SxeHnjbZR6KGG\|c3H5		M3zCWlczKGi{cx?=	MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCS2M5OjNiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlA1\|ryP	NFXiR3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK3O\|A3Pyd-MkWyO\|cxPjd:L3G+
HepG2	NYnvXHVyS3m2b4TvfIlkcXS7IHHzd4F6		MUe3NkBpenN?	NXP2cIw4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjB2zszN	NXf1XopFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyO\|cxPjdpPkK1Nlc4ODZ5PD;hQi=>
MDA-MB-231	MnG4R5l1d3SxeHnjbZR6KGG\|c3H5		MUC3NkBpenN?	Mn3VR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTBwMEZOwG0>	NXjqZW5yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyO\|cxPjdpPkK1Nlc4ODZ5PD;hQi=>
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HL7702	MlruR5l1d3SxeHnjbZR6KGG\|c3H5		M4fuW\|czKGi{cx?=	MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFc4ODJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlE1Oc7:TR?=	NVXIXFVURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyO\|cxPjdpPkK1Nlc4ODZ5PD;hQi=>
SW480	MXjDfZRwfG:6aXPpeJkh[XO\|YYm=		NV7WcGd3PzJiaILz	NFPaWYtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUXzR6MDDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvOzIQvF2=	M1\NXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mke3NFY4Lz5{NUK3O\|A3PzxxYU6=
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MDA-MB 231	MoD3SpVv[3Srb36gZZN{[Xl?	MUOwMlUhfU1?	NIDKfG8zPCCqcoO=	M17yRmlvcGmkaYTpc44hUHOyOUCgbY4hcHWvYX6gUWRCNU2EIEKzNUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCKU2C3NEBxem:2ZXnuJIxmfmWuIHH0JFAvPSC3TTDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:m	NFi3eZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK3O\|A3Pyd-MkWyO\|cxPjd:L3G+
MCF7	MlnDR5l1d3SxeHnjbZR6KGG\|c3H5		M4LkTFczKGi{cx?=	NYjocHVrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliTWTTM3BOWyCjc4PhfUwhUUN3ME2wMlA1OjgQvF2=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd3NkK5PUc,OjV5NU[yPVk9N2F-
MCF7	M1juUmZ2dmO2aX;uJIF{e2G7		NYLDdHk{OjRiaILz	MkPLTY5pcWKrdHnvckBw\iCKU2C5NEBqdiCqdX3hckBOS0Z5IHPlcIx{KGG\|c3Xzd4VlKGG\|IIDBb5Qh\GWpcnHkZZRqd25iYYSgOUB1cW2nczDJR\|UxKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd3NkK5PUc,OjV5NU[yPVk9N2F-
MCF7	NIXUVVVHfW6ldHnvckBie3OjeR?=		MWKyOEBpenN?	M{DjS2lvcGmkaYTpc44hd2ZiSGPQPVAhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDI[ZIzKGSnZ4Lh[IF1cW:wIHH0JFUhfGmvZYOgTWM2OCCjZoTldkAzPCCqcoOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	NX;Efpp6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OVYzQTlpPkK1O\|U3Ojl7PD;hQi=>
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MCF7	NGqydIZHfW6ldHnvckBie3OjeR?=		NFXs[owzPCCqcoO=	MUPDbIFv\2ViaX6gR4RkOzdiZYjwdoV{e2mxbjDpckBpfW2jbjDNR2Y4KGOnbHzzJIF1KDVidHnt[ZMhUUN3MDDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd3NkK5PUc,OjV5NU[yPVk9N2F-
MCF7	NHTNd3JHfW6ldHnvckBie3OjeR?=		M3\PZ\|I1KGi{cx?=	NEOx[otEcGGwZ3WgbY4heDJ\|IHX4dJJme3Orb36gbY4hcHWvYX6gUWNHPyClZXzsd{BifCB3IITpcYV{KEmFNUCgZYZ1\XJiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	NU\yUWtuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OVYzQTlpPkK1O\|U3Ojl7PD;hQi=>
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MCF7	NGjve2FHfW6ldHnvckBie3OjeR?=		NVXNd4d3OjRiaILz	NIDRVldKdmirYnn0bY9vKG:oIFjTVFkxKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKGinYYSgd4hw[2ticnXzdI9ve2VvbXXkbYF1\WRiSGPQO\|AheHKxZIXjeIlwdiCjdDC1JJRqdWW\|IFnDOVAh[W[2ZYKgNlQhcHK\|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqeyC{ZXzheIl3\SC2bzD2[Yhq[2ynLYTy[YF1\WRiY3;ueJJwdA>?	M{Lnb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{W2Nlk6Lz5{NUe1OlI6QTxxYU6=
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PC12	NXTGe3diTnWwY4Tpc44h[XO\|YYm=	M2fQT\|ExKHWP	NV\IRnp2OyC2bzCxOkBpenN?	MorCTY5pcWKrdHnvckBw\iCGLXHzdIFzfGG2ZTDibY9{gW62aHXzbZMhcW5icnH0JHBEOTJiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJIlvfHKjY3XscJVt[XJiRD3hd5BienSjdHWgZ49vfGWwdDDheEAyOCC3TTDt[YF{fXKnZDDheEA{KHSxIEG2JIhzeyCkeTDPMZBpfGijbHHs[IVpgWSnL16tZYNmfHmuLVytZ5l{fGWrbnWg[IVzcX[jdHn6ZZRqd25idHXjbI5qeXWnLXLhd4VlKEiSTFOgZY5idHm\|aYOgdoVt[XSrdnWgeI8hfmWqaXPs[U11	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ2Mke2PUc,OjZ4NEK3Olk9N2F-
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SKBR3	MU\GeY5kfGmxbjDhd5NigQ>?		MYmyOEBpenN?	MknCTY5pcWKrdHnvckBw\iCKU2C5NEBifCCQLYTldo1qdnW\|IHnuJIh2dWGwIGPLRnI{KGOnbHzzJIF{e2W\|c3XkJIF{KGmwZIXjeIlwdiCxZjDI[ZIzKHC{b4TlbY4h\GWpcnHkZZRqd25iaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV7MUCxOkc,OzF3OUGwNVY9N2F-
SKBR3	M{H2dWZ2dmO2aX;uJIF{e2G7		M{\OcFI1KGi{cx?=	NWO1V5RyUW6qaXLpeIlwdiCxZjDIV3A6OCCjdDDOMZRmem2rboXzJIlvKGi3bXHuJHNMSlJ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnu[JVkfGmxbjDv[kBCU1RicILveIVqdiCmZXfyZYRifGmxbjDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYO=	NXXBWIp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1PVExOTZpPkOxOVkyODF4PD;hQi=>

... Click to View More Cell Line Experimental Data

体内研究

在FRE/erbB-2 小鼠体内，Geldanamycin (50 mg//kg)对pl85-相关的磷酸酪氨酸水平表现出30%的抑制。^[6]

激酶实验： ^[1]	- 合并核苷结合的等温滴定量热法(ITC): 滴定实验使用MSC系统进行。在每个实验中，16等份15 μL geldanamycin (300 μM在1% DMSO中)在25 °C下注射到1.3 mL蛋白质(31 μM在20 mMTris-HCl中, pH 7.5, 1 mMEDTA)，得到的数据减去稀释热后进行拟合。将geldanamycin加入缓冲液和缓冲液加入蛋白质的稀释热在单独实验中测定。在核苷酸结合位点没有观察到DMSO的结合。滴定数据使用非线性最小二乘法曲线拟合算法拟合，该算法有三个不固定变量：化学计量，结合常数(K_b) 1/K_d)，和相互作用焓的变化(ΔH°)。Geldanamycin结合到完整酵母Hsp90和Hsp90 N-末端结构域，估计的解离常数分别为1.22 μM和0.78 μM。结合到C-末端片段时，没有观察到有意义的热量。
细胞实验： ^[2]	- 合并 Cell lines: A2780人卵巢癌细胞系 Concentrations: 0.001-10 μM Incubation Time: 3小时 Method: 指数生长的细胞用Geldanamycin处理，不同时期的DNA合成通过溴脱氧尿苷(BrdUrd)的整合和流式细胞分析术评估。在此期间，处理的和未处理的细胞，总细胞数没有显著的差别。BrdUrd (10 μM)在37 °C下4小时的培育期间进行整合，将细胞采集并固定在70%乙醇中。DNA通过2 N HC1变性后，细胞用抗- BrdUrd小鼠单克隆抗体培育，随后用异硫氰酸荧光素(FITC)-连接的山羊抗-小鼠IgG培育。细胞在室温下用碘化丙啶着色30分钟，使用Coulter EPICS Profile分析器通过流式细胞术分析。 (Only for Reference)
动物实验： ^[6]	- 合并 Animal Models: 负荷FRE/erbB-2肿瘤的nu/nu小鼠 Dosages: 50 mg/kg Administration: 通过腹腔注射给药 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	36 mg/mL warmed (64.21 mM)
	Water	Insoluble
	Ethanol	Insoluble

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Geldanamycin (NSC 122750) SDF

分子量	560.64
化学式	C₂₉H₄₀N₂O₉
CAS号	30562-34-6
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00003969	Completed	Drug: tanespimycin	Unspecified Adult Solid Tumor Protocol Specific	Cancer Research UK\|National Cancer Institute (NCI)	August 1998	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

Antineoplastic and Immunosuppressive Antibiotics Inhibitors with Unique Features

选择性强的HSP90抑制剂

NVP-BEP800 : HSP90β-selective, IC50=58 nM.
活性最高的HSP90抑制剂

KW-2478 : HSP90, IC50=3.8 nM.
用于临床的HSP90抑制剂

17-AAG (Tanespimycin) : Phase III for Gastrointestinal Stromal Tumors.
最新的HSP90抑制剂

XL888 : ATP-competitive inhibitor of HSP90 with IC50 of 24 nM.

研究领域

产品类型

定制您的化合物库

Geldanamycin (NSC 122750)

客户使用Selleck生产的Geldanamycin (NSC 122750)发表文献25篇：

产品安全说明书

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Geldanamycin (NSC 122750) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

技术支持

Antineoplastic and Immunosuppressive Antibiotics Inhibitors with Unique Features