Antiviral

抑制剂选择性比较

Antiviral产品

所有产品(52) Antiviral抑制剂(27) Antiviral调节剂(1)

目录号	产品描述	文献引用	实验数据
S1102	U0126-EtOH U0126-EtOH是一种高度选择性的MEK1/2抑制剂，无细胞试验中IC50为0.07 μM/0.06 μM，作用于ΔN3-S218E/S222D MEK的亲和力比PD098059强100倍。U0126可抑制细胞自噬和线粒体自噬并具有抗病毒的活性。	Adv Sci (Weinh), 2022, 10.1002/advs.202104055 Cell Rep, 2022, 38(11):110522 Oncogene, 2022, 10.1038/s41388-022-02197-x	Cells were stimulated with TPA (10 nM) for 15 min in the presence of the indicated concentrations of U0126. Samples were collected and analyzed by Western blot to detect phosphorylated p42/p44 MAPK.
S1537	Vadimezan (ASA404) Vadimezan (ASA404, NSC 640488, DMXAA)是一种vascular disrupting agents (VDA)，也是一种DT-diaphorase的竞争性抑制剂，无细胞试验中Ki为20 μM ，IC50为62.5 μM。DMXAA (Vadimezan) 也是一种STING 激动剂，具有潜在的抗肿瘤活性。DMXAA (Vadimezan) 在体外可有效诱导 IFN-β 和 TNF-α 的表达，但对 TNF-α 影响相对较低。DMXAA (Vadimezan)具有抗病毒活性。Phase 3。	Cell, 2022, 185(1):169-183.e19 Nat Immunol, 2022, 23(2):287-302 Yonsei Med J, 2022, 63(1):42-55	(B and C) sh-scrambled or sh-ck2a–transducted L929 cells (B) and Raw cells (C) were stimulated by DMXAA (100 μg/ml) for various times. Cytosolic and nuclear extracts were prepared as described in Materials and Methods. Five percent of the cytosolic proteins and 20% of the nuclear proteins were resolved by 10% SDS-PAGE. Subsequently, immunoblotting was conducted by indicated Abs. The amounts of Tubulin and Lamin B1 in cytosol versus nuclei detected by respective Abs were used as internal control for fractionation.
S2713	Geldanamycin (NSC 122750) Geldanamycin (NSC 122750) 是一种天然的HSP90抑制剂，K_d为1.2 μM，特异性干扰糖皮质激素受体(GR)/HSP联合。Geldanamycin 通过减少宿主的炎症反应来减轻病毒感染引起的ALI(急性肺损伤)/ARDS(急性呼吸窘迫综合征)。	ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138 Anal Chem, 2022, 10.1021/acs.analchem.1c05455 Cell Chem Biol, 2021, S2451-9456(21)00221-X	Phenotypic effect of Genetic or Pharmacologic Compromise of the 477 Hsp70-StiA-Hsp90 Complex. The impact of each genetic modification on radial growth, conidiation, and response to various stress conditions was assessed after inoculation of a suspension of 104 conidia on glucose minimal medium (GMM) agar plates and incubation at 37ºC for 5 days.
S1401	Tenofovir Tenofovir (GS-1278) 对reverse transcriptase（逆转录酶）和B型肝炎病毒感染具有抑制作用。	Cancer Discov, 2022, candisc.1117.2021 Antiviral Res, 2021, S0166-3542(21)00068-1 PLoS Pathog, 2020, 16(12):e1009024	The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; ** p<0.0001; * p<0.001 (unpaired t-test).
S5952^New	Baloxavir marboxil Baloxavir marboxil是一种抗病毒药物，是限制内切核酸酶抑制剂。	bioRxiv, 2020, 2020.08.12.246389
E0365^New	Fucoidan Fucoidan是从海洋褐藻中提取的阴离子硫酸化多糖，具有广泛的生物活性，包括抗炎、抗癌、抗病毒、抗氧化、抗凝、抗血栓、抗血管生成和抗幽门螺杆菌等。
E0153^New	Lithium Chloride Lithium Chloride (LiCl)在允许宿主细胞复制的浓度下抑制 1 型和 2 型单纯疱疹病毒的复制。Lithium Chloride还可以防止糖皮质激素诱导的股骨头坏死并增强大鼠的间充质干细胞活性。
E0150^New	Carrageenan Carrageenan (kappa-Carrageenan) 是一种从食用红海藻中提取的天然碳水化合物（多糖）。Carrageenan具有抗凝活性、抗血栓形成活性、抗病毒活性、抗肿瘤活性和免疫调节活性。
S9926^New	ML-SA1 ML-SA1（Mucolipin synthetic agonist 1）是一种选择性 TRPML通道的激动剂。ML-SA1可通过促进溶酶体的酸化和蛋白酶活性，抑制登革病毒2型（DENV2）和寨卡病毒（ZIKV）。ML-SA1 抗 DENV2 RNA 和 ZIKV RNA 的 IC50 值分别为 8.93 μM 和 52.99 μM。ML-SA1 可诱发自噬。ML-SA1也可用于广谱抗病毒研究。
E0110^New	Baloxavir Baloxavir (Baloxavir acid, S-033447) 是一流的、有效的选择性cap-dependent endonuclease (CEN) 抑制剂，IC50 为 2.5 nM。BXA 通过选择性抑制 CEN 活性来抑制病毒 RNA 转录。
E0010^New	Hypocrellin A Hypocrellin A (HA) 是一种从 Shiraia bambusicola 中分离的苝醌，显示出抗病毒、抗菌和抗癌的活性。Hypocrellin A 还是 PKC 的选择性和有效抑制剂。
S1623	Acetylcysteine (N-acetylcysteine) Acetylcysteine (N-acetyl-l-cysteine, NAC)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用。	EMBO Mol Med, 2022, 14(2):e14903 J Exp Clin Cancer Res, 2022, 41(1):41 J Nanobiotechnology, 2022, 20(1):78	(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
S2239	Tubacin Tubacin 是一种高度有效的选择性的，可逆的，细胞渗透性HDAC6抑制剂，无细胞试验中IC50为4 nM，比作用于HDAC1的选择性高350倍。Tubacin 可通过减少病毒RNA合成来抑制乙型脑炎病毒的复制。	Oncogene, 2022, 10.1038/s41388-022-02236-7 Signal Transduct Target Ther, 2021, 6(1):333 STAR Protoc, 2021, 2(3):100674	Verification of Hdac6 deletion in knockout MEFs. Expression of HDAC6 and acetylation of tubulin were analyzed by immunoblotting.
S4879	Tenofovir hydrate Tenofovir (GS-1278) hydrate 可阻止 reverse transcriptase 和乙型肝炎病毒 hepatitis B virus 感染。	Cancer Discov, 2022, candisc.1117.2021 Cells, 2020, 9(4)E1003
S8750	NGI-1 (ML414) NGI-1 (ML414)靶向寡糖转移酶，可能对虫媒病毒发挥抗病毒作用。	J Cell Biochem, 2022, 10.1002/jcb.30204 Cancer Res, 2018, 78(17):5094-5106
S5554	Lanatoside C Lanatoside C 是具有抗病毒和抗肿瘤活性的强心苷。Lanatoside C 通过减弱 MAPK，Wnt，JAK-STAT和PI3K/AKT/mTOR信号通路，诱导G2/M细胞周期停滞并诱导自噬和细胞凋亡。
S3380	Tecovirimat Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) 是一种 antiviral 抗病毒药，通过靶向病毒 p37 protein orthologs 来抑制正痘病毒orthopoxviruses的释放。Tecovirimat 被开发用于治疗天花感染。
S6867	Glyceryl monocaprate (Monocaprin) Monocaprin (Glyceryl caprate)是癸酸的1一甘油酯，对包膜病毒、某些细菌和白色念珠菌具有抗菌的活性。
S9303	Saikosaponin B2 Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.	Phytomedicine, 2019, 67:153163
S2764	DTNB DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure)是一种非荧光探针，可用于定量样品中巯基的数量或浓度。DTNB 还是登革热病毒蛋白酶 protease (NS2B-NS3pro)和链霉菌蛋白酶的变构抑制剂。
S7775	Emricasan (IDN-6556) Emricasan (IDN-6556, PF 03491390, PF-03491390)是有效的、不可逆的泛半胱天冬酶（pan-caspase）抑制剂。Emricasan 也是寨卡病毒感染的抑制剂。	Cancer Res, 2022, canres.2076.2021 Sci Transl Med, 2021, 13(604)eabb1069 Mol Cell, 2021, S1097-2765(21)00458-5
S9063	Harringtonine Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.	Research Square, 2021, 10.21203/rs.3.rs-541829/v1
S3356	Phosphonoacetic acid Phosphonoacetic acid (PAA) 是一种活性内源性代谢产物，具有限制 DNA biosynthesis 的潜力。Phosphonoacetic acid 具有抗病毒的活性。
S8932	Remdesivir (GS-5734) Remdesivir (GS-5734)是腺苷类似物的单磷酰胺酸盐前药，是一种研究性的广谱抗病毒剂，对多种RNA病毒（包括埃博拉病毒和CoV病毒）具有体外活性。	Nature, 2022, 10.1038/s41586-022-04474-x mBio, 2022, 13(2):e0370521 PLoS Pathog, 2022, 18(2):e1010268
S9669	U18666A U18666A (U18) 是一种 intra-cellular cholesterol transport 的抑制剂，可抑制登革热病毒的侵入和复制。
S6801	AKOS B018304 AKOS B018304，是一种对位被极性取代的芳基亚烷基衍生物，一种有效的低微摩尔活性的 chikungunya virus 的抑制剂。
S6814	GS-441524 GS-441524 是一种具有药理活性的三磷酸核苷分子的分子前体，是猫传染性腹膜炎病毒 feline infectious peritonitis virus (FIPV) 的有效抑制剂，其EC50值为0.78 μM。	Int J Pharm, 2022, 620:121739 Front Pharmacol, 2020, 11:606097
S3251	Goitrin Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) 是板蓝根 Radix isatidis 的主要成分之一，广泛用于治疗发烧、清热的传统中药。Goitrin 具有抗病毒和抗内毒素活性。
S2504	Ribavirin (ICN-1229) Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin)是一种抗病毒剂，用于治疗重症RSV感染，丙型肝炎病毒感染和其他病毒感染。	Microbiol Spectr, 2022, e0219321 Antiviral Res, 2021, 196:105209 Antiviral Res, 2021, S0166-3542(21)00068-1	(E) Left panel, Western blot showed that 20 μM Ribavirin effectively inhibits elevated Sox2 expression in irradiated SW1990 cells. Right panel, qPCR analysis showed that Sox2 mRNA level in irradiated SW1990 cells at 48 hours was lower than that in non-irradiated SW1990 cells, *p < 0.05. (F) Left panel, Western blot showed 20 μM Ribavirin inhibits elevated Sox2 expression in irradiated BxPc-3 cells. Right panel, qPCR analysis showed that there is no significant fluctuation of Sox2 mRNA in irradiated BxPc-3 cells and Ribavirin did not influence sox2 mRNA level in irradiated BxPc-3 cells.
S1807	Aciclovir (BW 248U) Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011)是一种合成的核苷类似物，有效作用于疱疹病毒。Acyclovir 可在Jurkat白血病细胞中诱导细胞周期紊乱和凋亡。	Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9 Microbiol Spectr, 2021, 9(3):e0064621 Front Microbiol, 2021, 12:722748	(A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.
S1637	Docosanol Docosanol是一种饱和脂肪酸，在化妆品领域，作为一种润肤剂，乳化剂，和增稠剂，也是营养补充剂，抑制病毒产生，ED50为1.7 mg/ml。
S2420	Aloperine Aloperine是提取自苦参植物，如Sophora alopecuroides L的生物碱，具有抗炎，抗菌，抗病毒,和抗肿瘤的特性。	Cancer Cell Int, 2021, 21(1):662 Tissue Cell, 2021, 74:101706 J Cancer Res Clin Oncol, 2020, 10.1007/s00432-020-03157-2
S2486	Moroxydine HCl Moroxydine HCl 是一种合成的抗病毒化合物，属于杂环双胍系列。	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00639-4 Hum Cell, 2021, 34(6):1911-1918
S2467	Famciclovir Famciclovir (BRL-42810)是一种鸟嘌呤类似物抗病毒药物，用于治疗各种疱疹病毒感染。	Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00639-4
S1883	Idoxuridine Idoxuridine (NSC 39661, SKF 14287) 是一种抗病毒药，作用一猫疱疹病毒1型，IC50为4.3 μM。
S4184	Penciclovir Penciclovir (BRL-39123, VSA 671) 是一种嘌呤的无环核苷类似物，具有强大的抗病毒活性。	Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9 ACS Infect Dis, 2021, 10.1021/acsinfecdis.1c00083 Antiviral Res, 2021, S0166-3542(21)00068-1
S8071	UNC0638 UNC0638 是一种有效的选择性的组蛋白赖氨酸甲基转移酶（HMTase）抑制剂，作用于G9a和GLP，IC50分别为< 15 nM和19 nM，有效且选择性地作用于多种表观遗传和非表观遗传靶点。UNC0638 具有抗病毒的活性。	Adv Sci (Weinh), 2021, e2100779 Sci Adv, 2021, 7(3)eaba8053 Front Oncol, 2021, 11:773186
S9224	Dehydroandrographolide Succinate Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.
S5684	Lapachol Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.
S9278	Saikosaponin C Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.
S4942	4-Hydroxy-3,5-dimethoxybenzyl alcohol 4-Hydroxy-3,5-dimethoxybenzyl alcohol (Syringic alcohol, Syringyl alcohol)是一种酚类，具有抗病毒活性。
S5020	Tilorone dihydrochloride Tilorone dihydrochloride是一种广谱的、具有口服活性的抗病毒试剂，可激活干扰素的生成。它具有抗肿瘤和抗炎活性。
S5016	Isoprinosine Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) 是一种免疫药理试剂，具有抗病毒活性。
S9078	Epigoitrin Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.
S6067	2,4-dichlorobenzyl alcohol 2,4-Dichlorobenzyl alcohol是一种温和的防腐剂，能够杀死口喉感染相关的细菌和病毒。
S2334	Oleanolic Acid Oleanolic Acid (Caryophyllin)是一种天然存在的三萜类，广泛分布于食用和药用植物，与桦木酸相关，具有相对无毒的，抗肿瘤，保肝，及抗病毒的特性。	J Cell Sci, 2021, 134(8)jcs255273 Front Pharmacol, 2021, 12:697483 J Asian Nat Prod Res, 2019, 21(6):522-527
S9099	Orientin Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
S9328	5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.
S9120	Scutellarein Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities.
S4518	Chloroxylenol Chloroxylenol是一种广谱的抗菌类化合物，用来抵抗细菌、藻类、真菌和病毒。
S9136	Neochlorogenic acid Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
S4408	Procodazole Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid)可用作增效剂，对病毒和细菌感染具有非特异性活性免疫保护作用。

目录号	产品描述	文献引用	实验数据
S1102	U0126-EtOH U0126-EtOH是一种高度选择性的MEK1/2抑制剂，无细胞试验中IC50为0.07 μM/0.06 μM，作用于ΔN3-S218E/S222D MEK的亲和力比PD098059强100倍。U0126可抑制细胞自噬和线粒体自噬并具有抗病毒的活性。	Adv Sci (Weinh),2022, 10.1002/advs.202104055 Cell Rep,2022, 38(11):110522 Oncogene,2022, 10.1038/s41388-022-02197-x	Cells were stimulated with TPA (10 nM) for 15 min in the presence of the indicated concentrations of U0126. Samples were collected and analyzed by Western blot to detect phosphorylated p42/p44 MAPK.
S1537	Vadimezan (ASA404) Vadimezan (ASA404, NSC 640488, DMXAA)是一种vascular disrupting agents (VDA)，也是一种DT-diaphorase的竞争性抑制剂，无细胞试验中Ki为20 μM ，IC50为62.5 μM。DMXAA (Vadimezan) 也是一种STING 激动剂，具有潜在的抗肿瘤活性。DMXAA (Vadimezan) 在体外可有效诱导 IFN-β 和 TNF-α 的表达，但对 TNF-α 影响相对较低。DMXAA (Vadimezan)具有抗病毒活性。Phase 3。	Cell,2022, 185(1):169-183.e19 Nat Immunol,2022, 23(2):287-302 Yonsei Med J,2022, 63(1):42-55	(B and C) sh-scrambled or sh-ck2a–transducted L929 cells (B) and Raw cells (C) were stimulated by DMXAA (100 μg/ml) for various times. Cytosolic and nuclear extracts were prepared as described in Materials and Methods. Five percent of the cytosolic proteins and 20% of the nuclear proteins were resolved by 10% SDS-PAGE. Subsequently, immunoblotting was conducted by indicated Abs. The amounts of Tubulin and Lamin B1 in cytosol versus nuclei detected by respective Abs were used as internal control for fractionation.
S2713	Geldanamycin (NSC 122750) Geldanamycin (NSC 122750) 是一种天然的HSP90抑制剂，K_d为1.2 μM，特异性干扰糖皮质激素受体(GR)/HSP联合。Geldanamycin 通过减少宿主的炎症反应来减轻病毒感染引起的ALI(急性肺损伤)/ARDS(急性呼吸窘迫综合征)。	ACS Appl Mater Interfaces,2022, 10.1021/acsami.1c22138 Anal Chem,2022, 10.1021/acs.analchem.1c05455 Cell Chem Biol,2021, S2451-9456(21)00221-X	Phenotypic effect of Genetic or Pharmacologic Compromise of the 477 Hsp70-StiA-Hsp90 Complex. The impact of each genetic modification on radial growth, conidiation, and response to various stress conditions was assessed after inoculation of a suspension of 104 conidia on glucose minimal medium (GMM) agar plates and incubation at 37ºC for 5 days.
S1401	Tenofovir Tenofovir (GS-1278) 对reverse transcriptase（逆转录酶）和B型肝炎病毒感染具有抑制作用。	Cancer Discov,2022, candisc.1117.2021 Antiviral Res,2021, S0166-3542(21)00068-1 PLoS Pathog,2020, 16(12):e1009024	The Nucleotide analog reverse-transcriptase inhibitor Tenofovir disoproxil fumarate was added to TZM-bl cells. Cells were inoculated with 0.05 ng mock-exposed and semen-exposed HIV, and 0.5 ng HIV as infectivity-matched control. Infection rates were measured 3 days post infection by measuring β-galactosidase or or 4 days post infection by measuring luciferase activities. The left panels show the mean enzyme activities ± standard deviation derived from triplicate infections. RLU/s: relative light units per second. Middle panels show normalized infection rates in which reporter enzyme activities obtained from infected cells in the absence of inhibitor were set at 100%. The right panels depict the calculated IC50 values. The number above the bar represents the fold-change in the IC50 derived from 0.05 ng semen-exposed relative to 0.05 or 0.5 ng mock-exposed virus infection. Ns, no statistically significant difference; ** p<0.0001; * p<0.001 (unpaired t-test).
S5952^New	Baloxavir marboxil Baloxavir marboxil是一种抗病毒药物，是限制内切核酸酶抑制剂。	bioRxiv,2020, 2020.08.12.246389
E0365^New	Fucoidan Fucoidan是从海洋褐藻中提取的阴离子硫酸化多糖，具有广泛的生物活性，包括抗炎、抗癌、抗病毒、抗氧化、抗凝、抗血栓、抗血管生成和抗幽门螺杆菌等。
E0153^New	Lithium Chloride Lithium Chloride (LiCl)在允许宿主细胞复制的浓度下抑制 1 型和 2 型单纯疱疹病毒的复制。Lithium Chloride还可以防止糖皮质激素诱导的股骨头坏死并增强大鼠的间充质干细胞活性。
E0150^New	Carrageenan Carrageenan (kappa-Carrageenan) 是一种从食用红海藻中提取的天然碳水化合物（多糖）。Carrageenan具有抗凝活性、抗血栓形成活性、抗病毒活性、抗肿瘤活性和免疫调节活性。
S9926^New	ML-SA1 ML-SA1（Mucolipin synthetic agonist 1）是一种选择性 TRPML通道的激动剂。ML-SA1可通过促进溶酶体的酸化和蛋白酶活性，抑制登革病毒2型（DENV2）和寨卡病毒（ZIKV）。ML-SA1 抗 DENV2 RNA 和 ZIKV RNA 的 IC50 值分别为 8.93 μM 和 52.99 μM。ML-SA1 可诱发自噬。ML-SA1也可用于广谱抗病毒研究。
E0110^New	Baloxavir Baloxavir (Baloxavir acid, S-033447) 是一流的、有效的选择性cap-dependent endonuclease (CEN) 抑制剂，IC50 为 2.5 nM。BXA 通过选择性抑制 CEN 活性来抑制病毒 RNA 转录。
E0010^New	Hypocrellin A Hypocrellin A (HA) 是一种从 Shiraia bambusicola 中分离的苝醌，显示出抗病毒、抗菌和抗癌的活性。Hypocrellin A 还是 PKC 的选择性和有效抑制剂。
S1623	Acetylcysteine (N-acetylcysteine) Acetylcysteine (N-acetyl-l-cysteine, NAC)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用。	EMBO Mol Med,2022, 14(2):e14903 J Exp Clin Cancer Res,2022, 41(1):41 J Nanobiotechnology,2022, 20(1):78	(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
S2239	Tubacin Tubacin 是一种高度有效的选择性的，可逆的，细胞渗透性HDAC6抑制剂，无细胞试验中IC50为4 nM，比作用于HDAC1的选择性高350倍。Tubacin 可通过减少病毒RNA合成来抑制乙型脑炎病毒的复制。	Oncogene,2022, 10.1038/s41388-022-02236-7 Signal Transduct Target Ther,2021, 6(1):333 STAR Protoc,2021, 2(3):100674	Verification of Hdac6 deletion in knockout MEFs. Expression of HDAC6 and acetylation of tubulin were analyzed by immunoblotting.
S4879	Tenofovir hydrate Tenofovir (GS-1278) hydrate 可阻止 reverse transcriptase 和乙型肝炎病毒 hepatitis B virus 感染。	Cancer Discov,2022, candisc.1117.2021 Cells,2020, 9(4)E1003
S8750	NGI-1 (ML414) NGI-1 (ML414)靶向寡糖转移酶，可能对虫媒病毒发挥抗病毒作用。	J Cell Biochem,2022, 10.1002/jcb.30204 Cancer Res,2018, 78(17):5094-5106
S5554	Lanatoside C Lanatoside C 是具有抗病毒和抗肿瘤活性的强心苷。Lanatoside C 通过减弱 MAPK，Wnt，JAK-STAT和PI3K/AKT/mTOR信号通路，诱导G2/M细胞周期停滞并诱导自噬和细胞凋亡。
S3380	Tecovirimat Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) 是一种 antiviral 抗病毒药，通过靶向病毒 p37 protein orthologs 来抑制正痘病毒orthopoxviruses的释放。Tecovirimat 被开发用于治疗天花感染。
S6867	Glyceryl monocaprate (Monocaprin) Monocaprin (Glyceryl caprate)是癸酸的1一甘油酯，对包膜病毒、某些细菌和白色念珠菌具有抗菌的活性。
S9303	Saikosaponin B2 Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.	Phytomedicine,2019, 67:153163
S2764	DTNB DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure)是一种非荧光探针，可用于定量样品中巯基的数量或浓度。DTNB 还是登革热病毒蛋白酶 protease (NS2B-NS3pro)和链霉菌蛋白酶的变构抑制剂。
S7775	Emricasan (IDN-6556) Emricasan (IDN-6556, PF 03491390, PF-03491390)是有效的、不可逆的泛半胱天冬酶（pan-caspase）抑制剂。Emricasan 也是寨卡病毒感染的抑制剂。	Cancer Res,2022, canres.2076.2021 Sci Transl Med,2021, 13(604)eabb1069 Mol Cell,2021, S1097-2765(21)00458-5
S9063	Harringtonine Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.	Research Square,2021, 10.21203/rs.3.rs-541829/v1
S3356	Phosphonoacetic acid Phosphonoacetic acid (PAA) 是一种活性内源性代谢产物，具有限制 DNA biosynthesis 的潜力。Phosphonoacetic acid 具有抗病毒的活性。
S8932	Remdesivir (GS-5734) Remdesivir (GS-5734)是腺苷类似物的单磷酰胺酸盐前药，是一种研究性的广谱抗病毒剂，对多种RNA病毒（包括埃博拉病毒和CoV病毒）具有体外活性。	Nature,2022, 10.1038/s41586-022-04474-x mBio,2022, 13(2):e0370521 PLoS Pathog,2022, 18(2):e1010268
S9669	U18666A U18666A (U18) 是一种 intra-cellular cholesterol transport 的抑制剂，可抑制登革热病毒的侵入和复制。
S6801	AKOS B018304 AKOS B018304，是一种对位被极性取代的芳基亚烷基衍生物，一种有效的低微摩尔活性的 chikungunya virus 的抑制剂。
S6814	GS-441524 GS-441524 是一种具有药理活性的三磷酸核苷分子的分子前体，是猫传染性腹膜炎病毒 feline infectious peritonitis virus (FIPV) 的有效抑制剂，其EC50值为0.78 μM。	Int J Pharm,2022, 620:121739 Front Pharmacol,2020, 11:606097

目录号	产品描述	文献引用	实验数据
S3251	Goitrin Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) 是板蓝根 Radix isatidis 的主要成分之一，广泛用于治疗发烧、清热的传统中药。Goitrin 具有抗病毒和抗内毒素活性。

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S3251

Goitrin

Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) 是板蓝根 Radix isatidis 的主要成分之一，广泛用于治疗发烧、清热的传统中药。Goitrin 具有抗病毒和抗内毒素活性。

目录号	产品描述	文献引用	实验数据
S2504	Ribavirin (ICN-1229) Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin)是一种抗病毒剂，用于治疗重症RSV感染，丙型肝炎病毒感染和其他病毒感染。	Microbiol Spectr, 2022, e0219321 Antiviral Res, 2021, 196:105209 Antiviral Res, 2021, S0166-3542(21)00068-1	(E) Left panel, Western blot showed that 20 μM Ribavirin effectively inhibits elevated Sox2 expression in irradiated SW1990 cells. Right panel, qPCR analysis showed that Sox2 mRNA level in irradiated SW1990 cells at 48 hours was lower than that in non-irradiated SW1990 cells, *p < 0.05. (F) Left panel, Western blot showed 20 μM Ribavirin inhibits elevated Sox2 expression in irradiated BxPc-3 cells. Right panel, qPCR analysis showed that there is no significant fluctuation of Sox2 mRNA in irradiated BxPc-3 cells and Ribavirin did not influence sox2 mRNA level in irradiated BxPc-3 cells.
S1807	Aciclovir (BW 248U) Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011)是一种合成的核苷类似物，有效作用于疱疹病毒。Acyclovir 可在Jurkat白血病细胞中诱导细胞周期紊乱和凋亡。	Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9 Microbiol Spectr, 2021, 9(3):e0064621 Front Microbiol, 2021, 12:722748	(A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.
S1637	Docosanol Docosanol是一种饱和脂肪酸，在化妆品领域，作为一种润肤剂，乳化剂，和增稠剂，也是营养补充剂，抑制病毒产生，ED50为1.7 mg/ml。
S2420	Aloperine Aloperine是提取自苦参植物，如Sophora alopecuroides L的生物碱，具有抗炎，抗菌，抗病毒,和抗肿瘤的特性。	Cancer Cell Int, 2021, 21(1):662 Tissue Cell, 2021, 74:101706 J Cancer Res Clin Oncol, 2020, 10.1007/s00432-020-03157-2
S2486	Moroxydine HCl Moroxydine HCl 是一种合成的抗病毒化合物，属于杂环双胍系列。	Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00639-4 Hum Cell, 2021, 34(6):1911-1918
S2467	Famciclovir Famciclovir (BRL-42810)是一种鸟嘌呤类似物抗病毒药物，用于治疗各种疱疹病毒感染。	Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00639-4
S1883	Idoxuridine Idoxuridine (NSC 39661, SKF 14287) 是一种抗病毒药，作用一猫疱疹病毒1型，IC50为4.3 μM。
S4184	Penciclovir Penciclovir (BRL-39123, VSA 671) 是一种嘌呤的无环核苷类似物，具有强大的抗病毒活性。	Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9 ACS Infect Dis, 2021, 10.1021/acsinfecdis.1c00083 Antiviral Res, 2021, S0166-3542(21)00068-1
S8071	UNC0638 UNC0638 是一种有效的选择性的组蛋白赖氨酸甲基转移酶（HMTase）抑制剂，作用于G9a和GLP，IC50分别为< 15 nM和19 nM，有效且选择性地作用于多种表观遗传和非表观遗传靶点。UNC0638 具有抗病毒的活性。	Adv Sci (Weinh), 2021, e2100779 Sci Adv, 2021, 7(3)eaba8053 Front Oncol, 2021, 11:773186
S9224	Dehydroandrographolide Succinate Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.
S5684	Lapachol Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.
S9278	Saikosaponin C Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.
S4942	4-Hydroxy-3,5-dimethoxybenzyl alcohol 4-Hydroxy-3,5-dimethoxybenzyl alcohol (Syringic alcohol, Syringyl alcohol)是一种酚类，具有抗病毒活性。
S5020	Tilorone dihydrochloride Tilorone dihydrochloride是一种广谱的、具有口服活性的抗病毒试剂，可激活干扰素的生成。它具有抗肿瘤和抗炎活性。
S5016	Isoprinosine Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) 是一种免疫药理试剂，具有抗病毒活性。
S9078	Epigoitrin Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.
S6067	2,4-dichlorobenzyl alcohol 2,4-Dichlorobenzyl alcohol是一种温和的防腐剂，能够杀死口喉感染相关的细菌和病毒。
S2334	Oleanolic Acid Oleanolic Acid (Caryophyllin)是一种天然存在的三萜类，广泛分布于食用和药用植物，与桦木酸相关，具有相对无毒的，抗肿瘤，保肝，及抗病毒的特性。	J Cell Sci, 2021, 134(8)jcs255273 Front Pharmacol, 2021, 12:697483 J Asian Nat Prod Res, 2019, 21(6):522-527
S9099	Orientin Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
S9328	5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.
S9120	Scutellarein Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities.
S4518	Chloroxylenol Chloroxylenol是一种广谱的抗菌类化合物，用来抵抗细菌、藻类、真菌和病毒。
S9136	Neochlorogenic acid Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
S4408	Procodazole Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid)可用作增效剂，对病毒和细菌感染具有非特异性活性免疫保护作用。

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