Acyclovir (Aciclovir)

别名: Acycloguanosine, ACV, NSC 645011,BW 248U 中文名称:阿昔洛韦

Acyclovir (Aciclovir)是一种合成的核苷类似物,有效作用于疱疹病毒。Acyclovir 可在Jurkat白血病细胞中诱导细胞周期紊乱和凋亡。

Acyclovir (Aciclovir) Chemical Structure

Acyclovir (Aciclovir) Chemical Structure

CAS: 59277-89-3

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 1058.76 现货
50mg RMB 814.95 现货
1g RMB 5487.3 现货
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客户使用Selleck的Acyclovir (Aciclovir)发表文献16

客户使用该产品的1个实验数据

产品质控

批次: 纯度: 99.93%
99.01

Acyclovir (Aciclovir)相关产品

Antiviral抑制剂选择性比较

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
african green monkey Vero cells Function assay 48 h Antiviral activity against HSV2 strain 333 infected in african green monkey Vero cells assessed as inhibition of cytopathic effect after 48 hrs by plaque reduction assay, EC50=1.87 μM 22704890
HEL cells Function assay 4 days Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathogenicity after 4 days, EC50=0.2 μM 22459876
African green monkey Vero 76 cells Cytotoxicity assay 48-96 h Cytotoxicity against African green monkey Vero 76 cells assessed as cell viability after 48 to 96 hrs by crystal violet staining, CC50=13 μM 26119992
BSC-1 cells Function assay Antiviral activity of the compound was evaluated against the Herpes simplex virus type-1 in BSC-1 cells, IC50=2.6 μM 2913300
P3HR-1 cells Function assay Effective concentration for the inhibition of Epstein-Barr virus EBV-DNA synthesis in human lymphoblastoid P3HR-1 cells, EC50=6.75 μM 12408726
HFF cells Function assay Concentration for HSV-1 plaque reduction (VPR) by 50% in HFF cells, EC50=1.1 μM 14584954
HFF cells Function assay Inhibitory concentration required to reduce HSV-1 induced cytopathogenic effect (CPE) by 50 % in HFF cells, EC50=2.22 μM 14584954
human embryonic lung cells Function assay Antiviral activity was measured as effective concentration required to reduce Varicella Zoster virus (OKA)-induced plaque formation in human embryonic lung cells, EC50=1.1 μM 11549457
HEL cells Function assay Compound was tested for anti-viral activity against HSV-1(G) in HEL cells, EC50=1.3 μM 14643328
HEL cell Function assay Effective concentration required to inhibit Tyrosine kinase (TK+) Varicella-Zoster virus-induced cytopathicity by 50% in OKA strain HEL cell lines, EC50=4.53 μM 11495586
HSV-2 MS Vero cells Function assay Inhibition of viral cytopathic effect in infected human foreskin fibroblast cell monolayers of HSV-2 MS Vero cells by 50%, EC50=6.2 μM 11585457
HSV-1 E-377 Vero cells Function assay Inhibition of plaque formation in monolayers of HSV-1 E-377 Vero cells by 50%, EC50=4.4 μM 11585457
HSV-1 KOS Vero cells Function assay Inhibition of plaque formation in monolayers of HSV-1 KOS Vero cells by 50%, EC50=2.2 μM 11585457
HeLa cell Function assay Ability to inhibit cytopathogenicity of herpes simplex type 1 virus (G) in HeLa cell culture, IC50=0.19 μM 11356110
HEp-2 cells Function assay Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus-1 (K979) in HEp-2 cells 2842506
HeLa cells Function assay Inhibition of HSV-1 DNA synthesis in virus-infected HeLa cells, IC50=1.9 μM 7752206
human HFF cells Function assay Inhibitory concentration of the drug against the cytopathic effect for E-377 strain of herpes simplex virus-1 (HSV-1) in human HFF cells, EC50=0.04 μM 8394933
human HFF cells Function assay Inhibitory concentration of the drug against the cytopathic effect for MS strain of herpes simplex virus-2 (HSV-2) in human HFF cells, EC50=0.09 μM 8394933
MRC-5 cells Function assay Antiviral activity in plaque reduction assay was determined against herpes simplex virus type 2 (HSV-2) in MRC-5 cells, IC50=2.5 μM 2153202
human lung fibroblasts (MRC-5) Function assay Compound was tested for antiviral activity against Herpes Simplex virus Type-1(18189) in human lung fibroblasts (MRC-5) 3040998
Raji cells Function assay Inhibitory concentration of the drug against the antigen production against P3HR-1 strain of epstein barr virus-2 (EBV) in Raji cells, EC50=2.9 μM 8394933
Vero cells Function assay Inhibitory activity against herpes simplex virus type 2 (HSV 2) strain 186 in Vero cells, IC50=1.7 μM 8576922
BSC-1 cells Function assay Effective concentration required to inhibit herpes simplex virus 1 in BSC-1 cells in ELISA, EC50=1.5 μM 15634003
HFF cells Function assay Effective concentration required to inhibit varicella zoster virus replication in HFF cells, EC50=1.6 μM 15634003
HFF cells Function assay Effective concentration required to inhibit herpes simplex virus 1 in HFF cells in cytopathic effect (CPE) assay, EC50=0.9 μM 15634003
Daudi cells Function assay Inhibition of EBV replication in Daudi cells by viral capsid antigen-ELISA, EC50=0.33 μM 17004726
WI-38 cell Function assay Anti viral activity against VZV(pplla strain) in WI-38 cell monolayers, ID50=4 μM 1316966
HEL cells Function assay Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect, EC50=0.14 μM 23099097
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生物活性

产品描述 Acyclovir (Aciclovir)是一种合成的核苷类似物,有效作用于疱疹病毒。Acyclovir 可在Jurkat白血病细胞中诱导细胞周期紊乱和凋亡。
靶点
HSV [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05589688 Not yet recruiting
Obesity
University Hospital Toulouse
January 2024 Phase 1
NCT06058858 Not yet recruiting
Cytomegalovirus Infections|Acute Leukemia|B Cell Lymphoma
Assistance Publique - Hôpitaux de Paris
October 1 2023 --
NCT05468619 Recruiting
Herpes Simplex
National Institute of Allergy and Infectious Diseases (NIAID)
September 23 2022 Phase 1
NCT05198570 Recruiting
Herpesviridae Infections|Herpes Simplex 1|Varicella Zoster Virus Infection|Transplantation Infection|Oncology
University of Pisa|IRCCS Burlo Garofolo
September 15 2021 --

化学信息&溶解度

分子量 225.2 分子式

C8H11N5O3

CAS号 59277-89-3 SDF Download Acyclovir (Aciclovir) SDF
Smiles C1=NC2=C(N1COCCO)N=C(NC2=O)N
储存条件(自收到货起)

体外溶解度
批次:

DMSO : 45 mg/mL ( 199.82 mM; DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

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