Nucleoside Analog/Antimetabolite

抑制剂选择性比较

Nucleoside Analog/Antimetabolite产品

所有产品 Nucleoside Analog/Antimetabolite抑制剂(6)

目录号	产品描述	文献引用	实验数据
S1149	Gemcitabine HCl Gemcitabine HCl是一种DNA synthesis抑制剂，作用于PANC1，MIAPaCa2，BxPC3和Capan2细胞，IC50分别为50 nM， 40 nM， 18 nM和12 nM。	Nat Commun, 2020, 11(1):3018 Nat Commun, 2020, 24;11(1):1975 Nat Commun, 2020, 10;11(1):2935	RNA incorporating drugs induce SG assembly. HeLa cells were treated with the RNA incorporating agents 5-azacytidine (50 uM) and 6-thioguanine (10 uM), or the DNA incorporating agents trifluorothymidine (10 uM) and gemcitabine (100 nM) for 72 h. Subsequently, the cellular localization of the SG marker protein TIAR (green) and the P-body marker protein DCP1 (red) was analyzed. Nuclei were stained with Hoechst. Scale bars represent 20 um.
S1200	Decitabine Decitabine是DNA甲基转移酶抑制剂，整合进入DNA、导致DNA低甲基化，并使DNA复制停滞在intra-S-phase。Decitabine被用于治疗骨髓增生异常综合征(MDS)。Decitabine可在多种癌细胞系中诱导细胞周期阻滞和凋亡。	Nat Commun, 2020, 6;11(1):740 Oncogene, 2020, 11 J Cancer, 2020, 28;11(10):2874-2886	(A) and (B) SW1116 and LOVO cells were plated, treated for 48 h with decitabine (DAC) and gefitinib (GEF) either alone or in combination, and the expression levels of AKT, mTOR, S6K, and phosphorylation were determined by Western blot analysis as described under Methods. Expression of β-actin served as a loading control. The data are representative of three independent experiments.
S1491	Fludarabine Fludarabine在血管平滑肌细胞中是一种STAT1活化抑制剂，特异性降低STAT1蛋白质水平（和mRNA水平），而对其他STATs无此作用。它还是一种DNA合成抑制剂。Fludarabine可诱导凋亡。	Cell Metab, 2020, 31(3):564-579 Sci Adv, 2020, 29;6(18):eaax7881 Cell Rep, 2020, 31(13):107825	Normal human KC pretreated with STAT1 inhibitor (fludarabine [10 uM]) or STAT3 inhibitor (STA-21 [2 uM]) for 24 h. The mRNA levels of hBD2 and hBD3 were assessed by qRT-PCR.
S1209	Fluorouracil (5-Fluorouracil, 5-FU) Fluorouracil (5-Fluorouracil, 5-FU) 是DNA/RNA合成抑制剂，在肿瘤细胞中通过抑制胸苷酸合成酶（TS）而干扰核苷酸合成。Fluorouracil 可诱导细胞凋亡并可用于治疗HIV。	Cancer Cell, 2020, 37(3):371-386 J Hematol Oncol, 2020, 1;13(1):40 mBio, 2020, 11(3):e01190-20	DNA-PKcs suppression mediated ROS production and GSH content in HepG2 cells exposed to CDDP and 5-Fu. a DNA-PKcs inhibition promoted ROS production in HepG2 cells treated with indicated concentrations of CDDP and 5-Fu. DCFH-DA fluorescent analysis was performed to assess the ROS level. Data presented were mean ?SD of three independent experiments.
S1648	Cytarabine Cytarabine是一种抗代谢药，也是DNA synthesis抑制剂，在野生型CCRF-CEM细胞中IC50为16 nM。Cytarabine 可诱导自噬和细胞凋亡。	Transl Stroke Res, 2020, 10.1007/s12975-019-00771-2 J Cell Mol Med, 2020, 25 J Exp Clin Cancer Res, 2020, 39(1):52	Viability and CI vs Fa after 24-h exposure to cytarabine alone or in combination with ABT-199 in Riva, U2932 and VavP-Bcl2/c-MYC murine tumor cells. Viability shown at 500 nM (500 ng/ml for cytarabine; quadruplicates±s.e.m.).
S1807	Aciclovir Acyclovir 是一种合成的核苷类似物，有效作用于疱疹病毒。Acyclovir 可在Jurkat白血病细胞中诱导细胞周期紊乱和凋亡。	Antimicrob Agents Chemother, 2020, AAC.00245-20 Sci Adv, 2019, 5(8):eaax0780 Nat Immunol, 2019, 20(12):1681-1691	(A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.
S1782	Azacitidine (5-Azacytidine) Azacitidine 是胞苷的核苷类似物，通过捕获DNA甲基转移酶，特异性抑制DNA甲基化。Azacitidine可诱导线粒体凋亡与自噬。	PLoS Pathog, 2020, 16;16(3):e1008341 Neoplasia, 2020, 22(3):142-153 J Cell Mol Med, 2020, 24(9):5260-5273	R-2HG treatment or chemotherapeutic treatment, especially their combinations, decrease MYC levels in leukemic cells (using MONOMAC-6 as a representative). AZA:Azacitidine.
S6854^New	Triazavirin Triazavirin 是一种新型的抗病毒药物，一种核酸的 nucleoside analogue，可抑制 synthesis of viral RNA and DNA 以及基因组片段的复制。Triazavirin 对流感和许多其他病毒具有活性。Triazavirin 在流感传播阶段可作为有效的保护性药剂。
S1714	Gemcitabine Gemcitabine是核酸合成抑制剂，是有效、特异的脱氧胞苷类似物，用于化疗。Gemcitabine可诱导有效的p53依赖的凋亡。	Immunity, 2020, 52(2):357-373 Nat Commun, 2020, 11(1):3018 Nat Commun, 2020, 24;11(1):1975	RNA incorporating drugs induce SG assembly. HeLa cells were treated with the RNA incorporating agents 5-azacytidine (50 uM) and 6-thioguanine (10 uM), or the DNA incorporating agents trifluorothymidine (10 uM) and gemcitabine (100 nM) for 72 h. Subsequently, the cellular localization of the SG marker protein TIAR (green) and the P-body marker protein DCP1 (red) was analyzed. Nuclei were stained with Hoechst. Scale bars represent 20 um.
S1647	Adenosine Adenosine是一种核苷，包含腺嘌呤，通过β-N9-糖苷键，与核糖分子（呋喃核糖的）部分连接。	Front Cell Neurosci, 2018, 12:139 ACS Appl Mater Interfaces, 2016, 8(39):25818-25824 Biogerontology, 2016, 17(5-6):907-920
S2053	Cytidine Cytidine 是一种核苷分子，由胞嘧啶连接到核糖环时形成，胞苷是一种RNA的组成部分。
S2439	Guanosine Guanosine是一种嘌呤核苷。
S3702	Dihydrothymine Dihydrothymine is an intermediate breakdown product of thymine.
S6138	5-Methylcytidine 5-Methylcytidine是由5-methylcytosine衍生而来的修饰核苷。在动物、植物和细菌核糖核酸中均有发现。

目录号	产品描述	文献引用	实验数据
S1149	Gemcitabine HCl Gemcitabine HCl是一种DNA synthesis抑制剂，作用于PANC1，MIAPaCa2，BxPC3和Capan2细胞，IC50分别为50 nM， 40 nM， 18 nM和12 nM。	Nat Commun,2020, 11(1):3018 Nat Commun,2020, 24;11(1):1975 Nat Commun,2020, 10;11(1):2935	RNA incorporating drugs induce SG assembly. HeLa cells were treated with the RNA incorporating agents 5-azacytidine (50 uM) and 6-thioguanine (10 uM), or the DNA incorporating agents trifluorothymidine (10 uM) and gemcitabine (100 nM) for 72 h. Subsequently, the cellular localization of the SG marker protein TIAR (green) and the P-body marker protein DCP1 (red) was analyzed. Nuclei were stained with Hoechst. Scale bars represent 20 um.
S1200	Decitabine Decitabine是DNA甲基转移酶抑制剂，整合进入DNA、导致DNA低甲基化，并使DNA复制停滞在intra-S-phase。Decitabine被用于治疗骨髓增生异常综合征(MDS)。Decitabine可在多种癌细胞系中诱导细胞周期阻滞和凋亡。	Nat Commun,2020, 6;11(1):740 Oncogene,2020, 11 J Cancer,2020, 28;11(10):2874-2886	(A) and (B) SW1116 and LOVO cells were plated, treated for 48 h with decitabine (DAC) and gefitinib (GEF) either alone or in combination, and the expression levels of AKT, mTOR, S6K, and phosphorylation were determined by Western blot analysis as described under Methods. Expression of β-actin served as a loading control. The data are representative of three independent experiments.
S1491	Fludarabine Fludarabine在血管平滑肌细胞中是一种STAT1活化抑制剂，特异性降低STAT1蛋白质水平（和mRNA水平），而对其他STATs无此作用。它还是一种DNA合成抑制剂。Fludarabine可诱导凋亡。	Cell Metab,2020, 31(3):564-579 Sci Adv,2020, 29;6(18):eaax7881 Cell Rep,2020, 31(13):107825	Normal human KC pretreated with STAT1 inhibitor (fludarabine [10 uM]) or STAT3 inhibitor (STA-21 [2 uM]) for 24 h. The mRNA levels of hBD2 and hBD3 were assessed by qRT-PCR.
S1209	Fluorouracil (5-Fluorouracil, 5-FU) Fluorouracil (5-Fluorouracil, 5-FU) 是DNA/RNA合成抑制剂，在肿瘤细胞中通过抑制胸苷酸合成酶（TS）而干扰核苷酸合成。Fluorouracil 可诱导细胞凋亡并可用于治疗HIV。	Cancer Cell,2020, 37(3):371-386 J Hematol Oncol,2020, 1;13(1):40 mBio,2020, 11(3):e01190-20	DNA-PKcs suppression mediated ROS production and GSH content in HepG2 cells exposed to CDDP and 5-Fu. a DNA-PKcs inhibition promoted ROS production in HepG2 cells treated with indicated concentrations of CDDP and 5-Fu. DCFH-DA fluorescent analysis was performed to assess the ROS level. Data presented were mean ?SD of three independent experiments.
S1648	Cytarabine Cytarabine是一种抗代谢药，也是DNA synthesis抑制剂，在野生型CCRF-CEM细胞中IC50为16 nM。Cytarabine 可诱导自噬和细胞凋亡。	Transl Stroke Res,2020, 10.1007/s12975-019-00771-2 J Cell Mol Med,2020, 25 J Exp Clin Cancer Res,2020, 39(1):52	Viability and CI vs Fa after 24-h exposure to cytarabine alone or in combination with ABT-199 in Riva, U2932 and VavP-Bcl2/c-MYC murine tumor cells. Viability shown at 500 nM (500 ng/ml for cytarabine; quadruplicates±s.e.m.).
S1807	Aciclovir Acyclovir 是一种合成的核苷类似物，有效作用于疱疹病毒。Acyclovir 可在Jurkat白血病细胞中诱导细胞周期紊乱和凋亡。	Antimicrob Agents Chemother,2020, AAC.00245-20 Sci Adv,2019, 5(8):eaax0780 Nat Immunol,2019, 20(12):1681-1691	(A) HONE1 and (B) HK1-EBV cells were treated with TPA (40 ng/ml) and SB (3 mM) for EBV induction. After 3 h, uninduced and induced HONE1 and HK1-EBV cells were treated with the vehicle control (0.006% DMSO) or indicated concentrations of berberine for 48 h. Subsequently, the culture medium was harvested for quantitative-PCR analysis with EBNA1 primers. Each sample was normalized to the amount of the GAPDH gene; *p<0.05, compared with the control group.

目录号	产品描述	文献引用	实验数据
S1782	Azacitidine (5-Azacytidine) Azacitidine 是胞苷的核苷类似物，通过捕获DNA甲基转移酶，特异性抑制DNA甲基化。Azacitidine可诱导线粒体凋亡与自噬。	PLoS Pathog, 2020, 16;16(3):e1008341 Neoplasia, 2020, 22(3):142-153 J Cell Mol Med, 2020, 24(9):5260-5273	R-2HG treatment or chemotherapeutic treatment, especially their combinations, decrease MYC levels in leukemic cells (using MONOMAC-6 as a representative). AZA:Azacitidine.
S6854^New	Triazavirin Triazavirin 是一种新型的抗病毒药物，一种核酸的 nucleoside analogue，可抑制 synthesis of viral RNA and DNA 以及基因组片段的复制。Triazavirin 对流感和许多其他病毒具有活性。Triazavirin 在流感传播阶段可作为有效的保护性药剂。
S1714	Gemcitabine Gemcitabine是核酸合成抑制剂，是有效、特异的脱氧胞苷类似物，用于化疗。Gemcitabine可诱导有效的p53依赖的凋亡。	Immunity, 2020, 52(2):357-373 Nat Commun, 2020, 11(1):3018 Nat Commun, 2020, 24;11(1):1975	RNA incorporating drugs induce SG assembly. HeLa cells were treated with the RNA incorporating agents 5-azacytidine (50 uM) and 6-thioguanine (10 uM), or the DNA incorporating agents trifluorothymidine (10 uM) and gemcitabine (100 nM) for 72 h. Subsequently, the cellular localization of the SG marker protein TIAR (green) and the P-body marker protein DCP1 (red) was analyzed. Nuclei were stained with Hoechst. Scale bars represent 20 um.
S1647	Adenosine Adenosine是一种核苷，包含腺嘌呤，通过β-N9-糖苷键，与核糖分子（呋喃核糖的）部分连接。	Front Cell Neurosci, 2018, 12:139 ACS Appl Mater Interfaces, 2016, 8(39):25818-25824 Biogerontology, 2016, 17(5-6):907-920
S2053	Cytidine Cytidine 是一种核苷分子，由胞嘧啶连接到核糖环时形成，胞苷是一种RNA的组成部分。
S2439	Guanosine Guanosine是一种嘌呤核苷。
S3702	Dihydrothymine Dihydrothymine is an intermediate breakdown product of thymine.
S6138	5-Methylcytidine 5-Methylcytidine是由5-methylcytosine衍生而来的修饰核苷。在动物、植物和细菌核糖核酸中均有发现。