Ribavirin (ICN-1229)

For research use only. Not for use in humans.

目录号:S2504 别名: NSC-163039, RTCA, Tribavirin 中文名称:利巴韦林

Ribavirin (ICN-1229) Chemical Structure

CAS No. 36791-04-5

Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin)是一种抗病毒剂,用于治疗重症RSV感染,丙型肝炎病毒感染和其他病毒感染。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 738.91 现货
RMB 574.27 现货
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客户使用Selleck生产的Ribavirin (ICN-1229)发表文献17篇:

客户使用该产品的3个实验数据:

  • (E) Left panel, Western blot showed that 20 μM Ribavirin effectively inhibits elevated Sox2 expression in irradiated SW1990 cells. Right panel, qPCR analysis showed that Sox2 mRNA level in irradiated SW1990 cells at 48 hours was lower than that in non-irradiated SW1990 cells, *p < 0.05. (F) Left panel, Western blot showed 20 μM Ribavirin inhibits elevated Sox2 expression in irradiated BxPc-3 cells. Right panel, qPCR analysis showed that there is no significant fluctuation of Sox2 mRNA in irradiated BxPc-3 cells and Ribavirin did not influence sox2 mRNA level in irradiated BxPc-3 cells.

    Cancer Lett, 2016, 375(1):31-8. . Ribavirin (ICN-1229) purchased from Selleck.

  • Inhibition of viral replication and ensuing myocardial apoptosis ameliorates HDACI-exacerbated viral myocarditis. (A) CVB3-infected cardiac myocytes (MOI, 5) were treated with 1 μM SAHA and the indicated concentrations of ribavirin for 24 h. Cell extracts were analyzed by Western blotting with the indicated antibodies. (B) CVB3-infected cardiac myocytes (MOI, 5) were treated with 1 μM SAHA and 200 μg/ml ribavirin for 24 h. CVB3 titers in cell culture supernatants were determined by TCID50 assay (n = 4). (C) Cardiac myocytes were treated with 200 μg/ml ribavirin for 24 h. Cells morphology was examined by light microscope (scale bar, 100 μm). (D to F) CVB3-infected cardiac myocytes (MOI, 5) were treated with 2 μM SAHA in the presence or absence of 800 μg/ml ribavirin for 24 h. (D) Cell morphology was examined by light microscope (scale bar, 100 μm). (E and F) Cells were collected and stained with 7-AAD and FITC-labeled annexin V, followed by flow cytometric analysis (n = 3). (G and H) BALB/c mice were infected with CVB3 on day 0 and then simultaneously treated with SAHA (50 mg/kg) and ribavirin (100 mg/kg) or vehicle PBS daily from day 0 to day 7 p.i. (G) Survival rate was monitored daily until day 7 p.i. (n = 10). (H) Paraffin sections of heart tissues were prepared on day 7 p.i., and cardiac injury was revealed by H&E (scale bar, 50 μm). *, P < 0.05; ***, P < 0.001.

    J Virol, 2015, 89(20):10512-23.. Ribavirin (ICN-1229) purchased from Selleck.

  • Establishment of Vero-rBoDV-1-Gluc cells to monitor BoDV-1 replication. (A) Dose- and time-dependent inhibitory effects of ribavirin on BoDV-1 replication. Vero-rBoDV-1-Gluc cells were treated with 20 or 40 μM of ribavirin for the indicated periods, and the luciferase activity in the cell supernatant was measured. (B) Quantification of BoDV-1 RNAs in Vero-rBoDV-1-Gluc cells treated with 20 or 40 μM of ribavirin for 72 h. Values are expressed as the mean + S.E. from 3 biological replicates. *, p < 0.05; **, p < 0.01; ****, p < 0.001.

    Antiviral Res, 2017, 143:237-245. Ribavirin (ICN-1229) purchased from Selleck.

产品安全说明书

Antiviral抑制剂选择性比较

生物活性

产品描述 Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin)是一种抗病毒剂,用于治疗重症RSV感染,丙型肝炎病毒感染和其他病毒感染。
体外研究

Ribavirin显著降低了亚基因组复制子转染细胞的复制系统的效率,尽管Ribavirin对HCV复制的水平几乎没有影响。Ribavirin增加丙型肝炎病毒的突变频率,NS5A编码区的突变率最高。Ribavirin增强TH1,同时抑制T2细胞因子产生刺激的T细胞。[1] Ribavirin显示了抗病毒活性,抗多种RNA病毒,并结合使用α-干扰素来治疗丙型肝炎病毒感染。Ribavirin减少感染的脊髓灰质炎病毒的产生,少到细胞培养物的0.00001%。 [2] Ribavirin的抗病毒活性是通过病毒的遗传物质的致死突变直接作用。[3] Ribavirin在生理浓度(高达500毫克/毫升)显着降低病毒引起的巨噬细胞的活化。Ribavirin抑制Th2细胞产生IL-4,而这并不会抹杀Th1细胞产生IFN-γ。[4] Ribavirin在体外表现出对DNA和RNA病毒广泛的抗病毒活性。Ribavirin是一种细胞生长抑制剂,导致DNA,RNA和蛋白质合成的的减少。Ribavirin能诱导辅助性T细胞表型从从2型转变为1型。 [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
E6SM cell lines MUjGeY5kfGmxbjDhd5NigQ>? NGP3cY9G\m[nY4TpeoUh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JGhmenCnczDzbY1xdGW6II\pdpV{NTFqSGPWMVEqKC9idHj5cYlv\SCtaX7hd4Uh\GWoaXPp[Y51KCiWSz2pRlIxODZiLzDWUXcyQDN5IHnu[JVk\WRiY4n0c5BifGirY3n0fUBjgSB3MDWgbY4hTT[VTTDj[YxtKGyrbnXzMEBGSzVyPUCuNFA2KM7:TR?= NH36TZYyOTR7NUW4Oi=>
MDCK cells MXzGeY5kfGmxbjDhd5NigQ>? Mkm3N{Bl[Xm| M1zQSmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGlv\my3ZX76ZUBDKH[rcoXzJEhDN0iNL{WvO|IqKGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB|IHThfZMh[nlibXnjdo9{[2:yaXOgZY5idHm|aYOsJGVEPTB;MD6wPVQh|ryP NVThcFI5OjNzMUexO|M>
mouse L1210 cells M1vKN2Z2dmO2aX;uJIF{e2G7 M2C4b|IxNTZyIH3pcpM> Mn3CTY5pcWKrdHnvckBw\iCLTWDETEBqdiCvb4Xz[UBNOTJzMDDj[YxteyCjc4Pld5Nm\CCjczDmc5Ju[XSrb36gc4YhYzJuOD2zTH1pgXCxeHHueIhqdmViZoLvcUBcOix6LUPIYWlOWCCjZoTldkAzOCC2bzC2NEBucW6|LDDJR|UxRTFizszN NWDlRnp{OjJ3NUWxOVI>
human CEM cells NG\vSZNHfW6ldHnvckBie3OjeR?= NF3EWlMzOC14MDDtbY5{ NWj4TZl3UW6qaXLpeIlwdiCxZjDJUXBFUCCrbjDoeY1idiCFRV2gZ4VtdHNiYYPz[ZN{\WRiYYOg[o9zdWG2aX;uJI9nKFt{LEitN2hecHmyb4jhcpRpcW6nIH\yc40hYzJuOD2zTH1KVVBiYX\0[ZIhOjBidH:gOlAhdWmwczygTWM2OD1zIN88US=> NHXEV|QzOjV3NUG1Ni=>
BHK21 cell line M1rGWmZ2dmO2aX;uJIF{e2G7 M3n3U2lvcGmkaYTpc44hd2ZiV3XzeEBPcWynII\pdpV{KF[OUDDy[ZBtcWOxbjDpckBDUEt{MTDj[YxtKGyrbnWsJGVEPTB;MT6xJO69VQ>? NWL3PWNrOTZ3M{m0NFI>
HeLa cell MnGzSpVv[3Srb36gZZN{[Xl? MnLNSYZn\WO2aY\lJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDy[ZNxcXKjdH;yfUB{gW6jcITpZYwpWlOYKTD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWOrdImgZpkhPTBnIHnuJGhmVGFiY3XscEBtcW6nczygSWM2OD1zLkWg{txO MlWzNVE1QTV3OE[=
MDCK cells NYjOOZZtTnWwY4Tpc44h[XO|YYm= MnGxN|YhcA>? NULKUFVDSW62aXnu[ox2\W68YTDhZ5Rqfmm2eTDh[4FqdnO2IHnu[ox2\W68YTDBJJZqenW|IFixUlEhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgN|YhcHK|LDDJR|UxRTFwOTFOwG0> NWf2eZV{OjJ|NEG5OFM>
MDBK cells MlzOSpVv[3Srb36gZZN{[Xl? MoizNkBl[Xm| NGnpc4NCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBDd3[rbnWgeolz[WxiZHnhdpJp\WFidnnyeZMhOS2QQVTMJGFVS0NiVmK1N|QhcW6oZXP0[YQhcW5iTVTCT{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZidnnyZYwh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgNkBl[Xm|IHL0JG1VWyCjc4PhfUwhTUN3ME20MlYh|ryP MVuyNlk1PDN|Mx?=
african green monkey Vero cells MUDGeY5kfGmxbjDhd5NigQ>? NF;qdms2KGSjeYO= MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDSV3YhSTJiaX7m[YN1\WRiaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjZoTldkA2KGSjeYOgZpkheGyjcYXlJJJm\HWldHnvckBie3OjeTygSWM2OD15IN88US=> MlvTNlA{PTl6OUi=
HEL cells MmDqSpVv[3Srb36gZZN{[Xl? NIPNcGwzNTNiZHH5dy=> MVfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZJx\XNic3ntdIxmgCC4aYL1d{AyKEuRUzDpcoZm[3SnZDDpckBJTUxiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDmdo9uKH[rcoXzMYlv\HWlZXSgZ5l1d3CjdHjv[4VvcWOrdImgZYZ1\XJiMjD0c{A{KGSjeYOgZpkhVVSWIHHzd4F6NCCHQ{WwQVExKM7:TR?= MUCyNFA{PDdzMR?=
HEK293 cells NXPBXGhZTnWwY4Tpc44h[XO|YYm= NVnWc25qOjRiaB?= NI\MVIRKdmirYnn0bY9vKG:oIHnu[ox2\W68YTDBJJZqenW|IGLORU1l\XCnbnTlcpQhWk6DIIDvcJlu\XKjc3Wg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDh[pRmeiB{NDDodpMh[nliZIXhcEBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OTVizszN M2LZ[lI1OzF|N{Ow
human BE(2)-C cells MVTGeY5kfGmxbjDhd5NigQ>? MUSxPE0zOCCq MVLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDX[ZN1\XKwIHXxeYlv\SCnbnPldIhidG:veXXsbZRqeyC4aYL1d{Bqdm[nY4Tl[EBqdiCqdX3hckBDTSh{KT3DJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhWk6DIILldIxq[2G2aX;uJIFnfGW{IEG4JJRwKDJyIHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MU[g{txO NUC2cGlWOjRzNUG5OVQ>
human HuH7-J20 cells MlrwSpVv[3Srb36gZZN{[Xl? MoPuRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGNXKEqISEGgbY5n\WO2ZXSgbY4hcHWvYX6gTJVJPy2MMkCgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBtcW[nIHP5Z4xmKGK7IH3lZZN2emmwZzDz[YNz\XSnZDDhcItidGmwZTDwbI9{eGijdHHz[UBt\X[nbDDwdoVqdmO3YnH0[YQhf2m2aDDj[YxteyCob4KgNUBpeiCob3zsc5dm\CCkeTD2bZJidCCrbn;jeYxifGmxbjDmc5IhOyCqcoOgcYVie3W{ZXSgZZQhPzJiaILzMEBGSzVyPUOwMlQh|ryP NGS3XVQzPjR{OEi3NC=>
human MT4 cells MUPDfZRwfG:6aXRCpIF{e2G7 MofyPVYhcA>? MoTXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUXQ1KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDNWHQh[XO|YYmsJGNEPTB;M{Gg{txO MYCxPVQ5OjR6MR?=
human HuH7 cells NXTuSpFkS3m2b4TvfIlkyqCjc4PhfS=> MVyzJIRigXN? M3n3R2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2UDdiY3XscJMhcW6oZXP0[YQhf2m2aDDIR3Yy[iCjZoTldkA{KGSjeYOgZpkhVVSVIHHzd4F6NCCFQ{WwQVMzKM7:TR?= Mn7CNlIyODB{NU[=
human KB cells NWD3UnB{TnWwY4Tpc44h[XO|YYm= NX74ZW44PzJiaB?= NX[ydphkSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhWmirbn;2bZJ2eyC2eYDlJFE{KGmwZnXjeIVlKGmwIHj1cYFvKEuEIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{dYOtbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDh[pRmeiB5MjDodpMhemWuYYTpeoUhfG9iY3;ueJJwdA>? NWfWe4FMPzJ{N{Ow
human KB cells M{HLSGZ2dmO2aX;uJIF{e2G7 M4nYclEuOTByMDFOwIcwdWx? Ml\jO|IhcA>? NH7UT2NCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBTcGmwb4\pdpV{KHS7cHWgNVMhcW6oZXP0[YQhcW5iaIXtZY4hU0JiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqaXOg[YZn\WO2IHH0JFEhfG9iMUCwNEB2\y:vbDDh[pRmeiB5MjDodpM> Ml\YNlEyOjN2

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p53 / p-p53 / p21 / Mdm2 ; 

PubMed: 22962590     


Dose-dependent expression and phosphorylation of p53 induced by ribavirin. HepG2 cells were treated with the indicated doses of ribavirin (0, 5, 10, 30, 100 µg/ml) for 24 h.

EZH2 / p-ERK / ERK / p-eIF4E / eIF4E / p21 ; 

PubMed: 29487714     


Western blot analyses of EZH2, ERK1/2, eIF4E, and p21 expression in BT12, BT16, and BT37 cells 72 and 96hrs after ribavirin treatment. 

Cyclin D1 ; 

PubMed: 21415224     


Cyclin D1, NBS1 and VEGF protein levels were assessed by western blot in MDA-MB-468 and BT474 cells, treated with the indicated concentrations of ribavirin for 3 days. 

p-AKT / AKT / pBP1 / BP1 ; 

PubMed: 21415224     


AKT activity was assessed as the level of phosphorylation of AKT and its downstream target 4E-BP1 in MDA-MB-468 and BT474 cells treated with the indicated concentrations of ribavirin for 3 days. 

22962590 29487714 21415224
Growth inhibition assay
Cell number ; 

PubMed: 21415224     


Breast cancer cell lines were cultured in the absence or presence of ribavirin at the indicated concentrations for 7 days, and the number of cells was determined.

21415224

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 49 mg/mL (200.64 mM)
Water 49 mg/mL (200.64 mM)
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 244.20864
化学式

C8H12N4O5

CAS号 36791-04-5
储存条件 粉状
溶于溶剂
别名 NSC-163039, RTCA, Tribavirin

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04283513 Not yet recruiting Drug: Virazole Hemorrhagic Fever U.S. Army Medical Research and Development Command June 2021 Phase 2
NCT04335123 Completed Drug: Losartan COVID-19 University of Kansas Medical Center April 4 2020 Phase 1
NCT04285034 Completed -- Lassa Fever University of Oxford November 26 2019 --
NCT03889106 Unknown status Drug: Ribavirin Lassa Fever University of Oxford|National Institute for Health Research United Kingdom|Kenema Government Hospital|London School of Hygiene and Tropical Medicine|Public Health England March 1 2019 --
NCT03585725 Terminated Drug: Ribavirin Follicular Lymphoma|Mantle Cell Lymphoma Weill Medical College of Cornell University|Memorial Sloan Kettering Cancer Center September 26 2018 Early Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID