Ribavirin (ICN-1229)

别名: NSC-163039, RTCA, Tribavirin 中文名称:利巴韦林

Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin)是一种抗病毒剂,用于治疗重症RSV感染,丙型肝炎病毒感染和其他病毒感染。

Ribavirin (ICN-1229) Chemical Structure

Ribavirin (ICN-1229) Chemical Structure

CAS: 36791-04-5

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 738.91 现货
100mg RMB 574.27 现货
1g RMB 3030.3 现货
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客户使用Selleck的Ribavirin (ICN-1229)发表文献21

客户使用该产品的3个实验数据

产品质控

批次: 纯度: 99.89%
99.32

Ribavirin (ICN-1229)相关产品

Antiviral抑制剂选择性比较

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
human KB cells Function assay 1-1000 μg/ml 72 h Antiviral activity against Rhinovirus type 13 infected in human KB cells assessed as inhibition of virus-induced cytopathic effect at 1 to 1000 ug/ml after 72 hrs 211234
MDCK cells Function assay 3 days Antiviral activity against Influenza B virus (B/HK/5/72) infected in MDCK cells assessed as virus-induced cytopathic effect after 3 days by microscopic analysis, EC50=0.094 μM 23117173
mouse L1210 cells Function assay 20-60 mins Inhibition of IMPDH in mouse L1210 cells assessed as formation of [2,8-3H]hypoxanthine from [2,8-3H]IMP after 20 to 60 mins, IC50=1 μM 22555152
human CEM cells Function assay 20-60 mins Inhibition of IMPDH in human CEM cells assessed as formation of [2,8-3H]hypoxanthine from [2,8-3H]IMP after 20 to 60 mins, IC50=1 μM 22555152
MDCK cells Function assay 36 h Antiinfluenza activity against influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs, IC50=1.9 μM 22341943
MDBK cells Function assay 2 days Antiviral activity against Bovine viral diarrhea virus 1-NADL ATCC VR534 infected in MDBK cells assessed as reduction of viral cytopathic effect after 2 days bt MTS assay, EC50=4.6 μM 22944333
african green monkey Vero cells Function assay 5 days Antiviral activity against RSV A2 infected in african green monkey Vero cells after 5 days by plaque reduction assay, EC50=7 μM 20359898
HEL cells Function assay 2-3 days Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay, EC50=10 μM 20034711
HEK293 cells Function assay 24 h Inhibition of influenza A virus RNA-dependent RNA polymerase expressed in HEK293 cells after 24 hrs by dual luciferase reporter gene assay, EC50=15 μM 24313730
human BE(2)-C cells Function assay 18-20 h Antiviral activity against Western equine encephalomyelitis virus infected in human BE(2)-C cells assessed as inhibition of viral RNA replication after 18 to 20 hrs by luciferase reporter gene assay, IC50=16 μM 24151954
human MT4 cells Cytotoxic assay 96 h Cytotoxicity against human MT4 cells after 96 hrs by MTT assay, CC50=31 μM 19482481
human HuH7 cells Cytotoxic assay 3 days Cytotoxicity against human HuH7 cells infected with HCV1b after 3 days by MTS assay, CC50=32 μM 22100256
human KB cells Function assay 72 h Antiviral activity against Rhinovirus type 13 infected in human KB cells assessed as inhibition of virus-induced cytopathic effect after 72 hrs relative to control 722730
E6SM cell lines Function assay Effective concentration required to inhibit Herpes simplex virus-1(HSV-1) / thymine kinase deficient (TK-)B2006 / VMW1837 induced cytopathicity by 50% in E6SM cell lines, EC50=0.005 μM 11495586
BHK21 cell line Function assay Inhibition of West Nile virus VLP replicon in BHK21 cell line, EC50=1.1 μM 16539402
HeLa cell Function assay Effective concentration required to inhibit respiratory synaptial(RSV) virus-induced cytopathicity by 50% in HeLa cell lines, EC50=1.5 μM 11495586
human HuH7-J20 cells Function assay Antiviral activity against HCV JFH1 infected in human HuH7-J20 cells assessed as inhibition of viral life cycle by measuring secreted alkaline phosphatase level preincubated with cells for 1 hr followed by viral inoculation for 3 hrs measured at 72 hrs, EC50=30.4 μM 26428870
点击查看更多细胞系数据

生物活性

产品描述 Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin)是一种抗病毒剂,用于治疗重症RSV感染,丙型肝炎病毒感染和其他病毒感染。
体外研究(In Vitro)
体外研究活性 Ribavirin显著降低了亚基因组复制子转染细胞的复制系统的效率,尽管Ribavirin对HCV复制的水平几乎没有影响。Ribavirin增加丙型肝炎病毒的突变频率,NS5A编码区的突变率最高。Ribavirin增强TH1,同时抑制T2细胞因子产生刺激的T细胞。[1] Ribavirin显示了抗病毒活性,抗多种RNA病毒,并结合使用α-干扰素来治疗丙型肝炎病毒感染。Ribavirin减少感染的脊髓灰质炎病毒的产生,少到细胞培养物的0.00001%。 [2] Ribavirin的抗病毒活性是通过病毒的遗传物质的致死突变直接作用。[3] Ribavirin在生理浓度(高达500毫克/毫升)显着降低病毒引起的巨噬细胞的活化。Ribavirin抑制Th2细胞产生IL-4,而这并不会抹杀Th1细胞产生IFN-γ。[4] Ribavirin在体外表现出对DNA和RNA病毒广泛的抗病毒活性。Ribavirin是一种细胞生长抑制剂,导致DNA,RNA和蛋白质合成的的减少。Ribavirin能诱导辅助性T细胞表型从从2型转变为1型。 [5]
实验图片 检测方法 检测指标 实验图片 PMID
Western blot p-AKT / AKT / pBP1 / BP1 Cyclin D1 EZH2 / p-ERK / ERK / p-eIF4E / eIF4E / p21 p53 / p-p53 / p21 / Mdm2 21415224
Growth inhibition assay Cell number 21415224
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05940545 Recruiting
CCHF
Liverpool School of Tropical Medicine
July 12 2023 Phase 1|Phase 2
NCT04283513 Not yet recruiting
Hemorrhagic Fever
U.S. Army Medical Research and Development Command
October 31 2022 Phase 2
NCT04335123 Completed
COVID-19
University of Kansas Medical Center
April 4 2020 Phase 1
NCT04285034 Completed
Lassa Fever
University of Oxford
November 26 2019 --
NCT03889106 Terminated
Lassa Fever
University of Oxford|National Institute for Health Research United Kingdom|Kenema Government Hospital|London School of Hygiene and Tropical Medicine|Public Health England
March 1 2019 --
NCT03585725 Terminated
Follicular Lymphoma|Mantle Cell Lymphoma
Weill Medical College of Cornell University|Memorial Sloan Kettering Cancer Center
September 26 2018 Early Phase 1

化学信息&溶解度

分子量 244.20864 分子式

C8H12N4O5

CAS号 36791-04-5 SDF Download Ribavirin (ICN-1229) SDF
Smiles C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
储存条件(自收到货起)

体外溶解度
批次:

DMSO : 49 mg/mL ( 200.64 mM; DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Water : 49 mg/mL

Ethanol : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

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