For research use only. Not for use in humans.
目录号：S2303 别名： Gossypol Acetic acid, Pogosin, AT101 中文名称：棉酚，棉籽酚，棉子酚
CAS No. 12542-36-8
Gossypol Acetate (Gossypol Acetic acid, Pogosin, AT101) 是多酚醛，可渗透细胞，是一些脱氢酶（如乳酸脱氢酶、NAD-linked enzymes）的抑制剂。
16h after seeding HMLE RAS cells were exposed to 5 uM or 10 uM Gossypol in the presence or absence of Cisplatin for 16h. Afterwards, cells were harvested and lysates were analyzed for apoptosis by western blotting. Actin staining was used as loading control, while LC3a/b staining was used as indicator for autophagy. Accumulation of LC3a/b II indicates autophagy. Non-treated and DMSO-treated cells were used as control. Arrows are indicating the intended staining. For Bcl-xL: * indicates deamidated protein, # indicates unmodified protein. n=1.
Georg August University Gottingen 2014 Western blotting. Gossypol Acetate purchased from Selleck.
Weight gain of Spodoptera littoralis larvae on combined Cry proteins and gossypol. Weight gain (mg ± SE) of 2nd instar S. littoralis after feeding for one week on diet containing different concentrations of Cry proteins, gossypol, or a combination of both. Control = diet with added PBST; C1 = Cry1Ac 0.05 + Cry2Ab2 1.6 pmol/g; C3 = Cry1Ac 0.52 + Cry2Ab2 16.4 pmol/g; C4 = Cry1Ac 1.7 + Cry2Ab2 54.5 pmol/g; G3 = 1.3 μmol/g gossypol. Asterisks indicate significant difference to the control diet using a GLM with gamma distribution followed by Dunnett`s Test (n = 53-60). *** p ≤ 0.001.
Pest Manag Sci, 2016, 73(8):1670-1678. Gossypol Acetate purchased from Selleck.
H9c2 cells were incubated with indicated bioactive compounds for 2 hours prior to protein harvest. Cells were lysed and acetyl-lysine (Ac-Lysine), acetyl-histone 3 (Ac-H3 K9/14) and total histone 3 (Total-H3) were assessed via immunoblot. Acetylation of lysine and Ac-H3 (K9/14) increased for gossypol. Acetyl proteins were normalized to total H3 and quantitation performed via Image J software.
Mol Nutr Food Res, 2017, 61(4). Gossypol Acetate purchased from Selleck.
Effect of AT-101 (AT) on MM cell lines survival. The survival of human (MM-B1, H-Meso-1, and MM-F1) and mouse (#40a) MM cell lines were assessed by the SRB assay after 24, 48, and 72 h of treatment with DMSO or AT-101. The percentage of surviving cells treated with the compound was calculated by normalizing the OD value to that of the control cultures (DMSO). The results are expressed as the means ± SD of three independent experiments performed in triplicate (xp ≤ 0.05, ∗p ≤ 0.01, #p ≤ 0.001 compared with the cultures treated with DMSO).
Front Pharmacol, 2018, 9:1269. Gossypol Acetate purchased from Selleck.
|产品描述||Gossypol Acetate (Gossypol Acetic acid, Pogosin, AT101) 是多酚醛，可渗透细胞，是一些脱氢酶（如乳酸脱氢酶、NAD-linked enzymes）的抑制剂。|
Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro.
|体内研究||Gossypol acetate is able to inhibit tumor growth in Wus1-bearing mice, but the survival of mice is not prolonged, and tumor grows rapidly after short inhibition. Gossypol has now been found to have inhibitory effects on proliferation or to induce apoptosis in ovarian cancer, endometrial cancer, adrenal cortical tumor, thyroid cancer, lung cancer, colon carcinoma, leukemia, pancreatic cancer, melanoma and lymphoma. In addition, gossypol can increase the sensitivity of drug-resistant tumor cells to chemotherapy and radiotherapy. Some clinical trials showed gossypol is well-tolerated, and partial responses are observed in some patients.|
|体外||DMSO||100 mg/mL (172.82 mM)|
|Ethanol||10 mg/mL (17.28 mM)|
|别名||Gossypol Acetic acid, Pogosin, AT101|
|% DMSO % % Tween 80 % ddH2O|
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH2O，混匀澄清。
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )
在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.
S2812 and S2303 share same structures. However, S2812 is described as ‘R’ enantiomer. What’s the difference between S2812 and S2303?
S2303 is the mixture of S2812 and its enantiomer.