Isoliquiritigenin

中文名称：异甘草素

目录号：S2404 Purity: 99.26%

Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮，能抑制醛糖还原酶，IC50为320 nM。具有抗肿瘤活性。

Isoliquiritigenin Chemical Structure

CAS: 961-29-5

规格	价格	库存
10mM (1mL in DMSO)	RMB 1812.47	现货
10mg	RMB 1415.93	现货
50mg	RMB 4677.85	现货
1g	RMB 22686.3	现货
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客户使用Selleck的Isoliquiritigenin发表文献9篇

客户使用该产品的1个实验数据

产品质控

批次：纯度： 99.26%

99.26

Isoliquiritigenin相关产品

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Aldose Reductase抑制剂选择性比较

细胞实验数据示例

细胞系	实验类型	给药浓度	孵育时间	活性描述	文献信息
MCF7 cells	Cytotoxicity assay	25-150 μM	72 h	Cytotoxicity against human MCF7 cells at 25 to 150 uM after 72 hrs by MTT assay	18603336
U937 cells	Function assay	5 ug/ml	24 h	Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced CCL5 secretion at 5 ug/ml after 24 hrs by ELISA relative to control	21866899
dog MDCK cells	Function assay	20 ug/mL	1 h	Antiviral activity against Influenza virus A/Puerto Rico/8/34 H1N1 infected in dog MDCK cells assessed as inhibition of viral replication at 20 ug/mL incubated at 1 hr post-infection measured after 24 hrs by hemagglutininating unit assay relative to control	22743086
U937 cells	Function assay	5 ug/ml		Inhibition of LPS-induced AP-1 activation in human U937 cells at 5 ug/ml after 1 hr relative to control	21866899
J774.1 cells	Function assay		24 h	Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay, IC50=29.3 μM	15974608
colon 26-L5 cells	Cytotoxicity assay		72 h	Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50=21.8 μM	18440233
human T47D cells	Function assay		96 h	Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay	19928832
MCF7 cells	Function assay		96 h	Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay	19928832
mouse NIH3T3 cells	Function assay		8 h	Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay, IC50=4.8 μM	21112783
OE21 cells	Cytotoxicity assay		72 h	Cytotoxicity against human OE21 cells after 72 hrs by MTT assay, IC50=48 μM	21696954
dog MDCK cells	Function assay		8 h	Inhibition of PKC/p38MAPK-mediated nuclear-cytoplasmic viral ribonucleoprotein export in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 8 hrs post-infection by inmmunofluorescence	22743086
HUVEC	Cytotoxicity assay		48 h	Toxicity against HUVEC incubated for 48 hrs by MTT assay, IC50=41.17 μM	25590864
K562 cells	Cytotoxicity assay		48 h	Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay, IC50=29.27 μM	25590864
KB cells	Growth inhibition assay			Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50=12 μM	9767632
MT-4 cells	Growth inhibition assay			Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50=7.4 μM	9767632
Hepa lclc7 cells	Cytotoxicity assay			Cytotoxicity against mouse Hepa lclc7 cells, IC50=39 μM	18076142
CHO cells	Cytotoxicity assay			Cytotoxicity against CHO cells by MTT assay, IC50=45.9 μM	19572738
MCF7 cells	Function assay			Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay	19928832
NCI-H292 cells	Function assay			Inhibition of PKC-mediated PKD phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis	22743086
NCI-H292 cells	Function assay			Inhibition of PKC-mediated p38MAPK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis	22743086
NCI-H292 cells	Function assay			Inhibition of PKC-mediated JNK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis	22743086
dog MDCK cells	Function assay			Restoration of GSH level in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 24 hrs post-infection by DTNB-based colometric assay	22743086
RBL-1 cells	Function assay			In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined, IC50=35 μM	8254620
PC3 cells	Cytotoxicity assay			Cytotoxicity against human PC3 cells, IC50=46.4 μM	16441066
Hepa-1c1c7 cells	Function assay			Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity	12762787
Hepa lclc7 cells	Function assay			Induction of mouse quinone reductase in mouse Hepa lclc7 cells assessed as concentration required to double enzyme activity	18076142
点击查看更多细胞系数据

生物活性

产品描述

Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮，能抑制醛糖还原酶，IC50为320 nM。具有抗肿瘤活性。

靶点

Aldose reductase ^[1]
(Cell-free assay)

320 nM

体外研究(In Vitro)
体外研究活性	Isoliquiritigenin通过抑制大鼠晶状体醛糖还原酶可能能够有效预防糖尿病并发症，IC50为320 nM，并且能够预防山梨糖醇在人类红细胞中的积累，IC50为2.0 μM。^[1] Isoliquiritigenin通过抑制单酚酪氨酸酶和二酚酪氨酸酶的活性可以用作美白剂，IC50为8.1 μM。^[2] 在DU145和LNCaP 细胞系中，Isoliquiritigenin诱导细胞周期停滞并抑制细胞生长。^[3]在人类胃癌MGC-803细胞中， Isoliquiritigenin通过增加细胞内游离钙离子浓度，并降低线粒体膜电位(Deltapsi(m))而诱导细胞凋亡。^[4]

体内研究(In Vivo)
体内研究活性	LD50: 小鼠>6克/千克(灌胃) ^[5]

参考文献
[1] Aida K, et al. Planta Med, 1990, 56(3), 254-258. [2] Nerya O, et al. J Agric Food Chem, 2003, 51(5), 1201-1207. [3] Kanazawa M, et al. Eur Urol, 2003, 43(5), 580-586. [4] Ma J, et al. Planta Med, 2001, 67(8), 754-757. [5] Chen G, et al. Phytother Res, 2009, 23(4), 498-506. + 展开

参考文献

+ 展开

化学信息&溶解度

分子量	256.25	分子式	C₁₅H₁₂O₄
CAS号	961-29-5	SDF	Download Isoliquiritigenin SDF
Smiles	C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O
储存条件(自收到货起)	3年-20°C粉状	储备液保存和期限建议分装储备液，避免反复冻融！	1年-80°C溶于溶剂
储存条件(自收到货起)	3年-20°C粉状	储备液保存和期限建议分装储备液，避免反复冻融！	1个月-20°C溶于溶剂

体外溶解度
批次：

Ethanol : 26 mg/mL

DMSO : 12 mg/mL ( (46.82 mM)； DMSO吸湿会降低化合物溶解度，请使用新开封DMSO)

Water : Insoluble

摩尔浓度计算器

体内溶解度
批次：

现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×

稀释计算器分子量计算器

动物体内配方计算器（澄清溶液）

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 μL 动物数量只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

计算结果：

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH₂O，混匀澄清。

体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。

注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

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