Reductase
Reductase产品
- 所有产品(16)
- Reductase抑制剂 (11)
- Reductase调节剂 (1)
| 目录号 | 产品名 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|---|
| S1202 | Dutasteride | Dutasteride (GI198745, GG-745)是5α-还原酶抑制剂。 | ||
| S2404 | Isoliquiritigenin | Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮，能抑制醛糖还原酶，IC50为320 nM。具有抗肿瘤活性。 |
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| S1197 | Finasteride | Finasteride (MK-906)是一种类固醇II型5α-还原酶抑制剂。 | ||
| S2035 | Epalrestat | Epalrestat是一种醛糖还原酶 aldose reductase抑制剂，IC50为72 nM。 | ||
| S9170 | Engeletin | Engeletin (Dihydrokaempferol 3-rhamnoside), a bioactive flavonoid, has multiple biological activities such as anti-diabetic and anti-inflammatory effects. engeletin againsts LPS-stimulated endometritis in mice via negative regulation of pro-inflammatory mediators via the TLR4-regulated NF-κB pathway. | ||
| S5803 | Alrestatin | Alrestatin是aldose reductase (醛糖还原酶)抑制剂。醛糖还原酶参与了糖尿病并发症，包括糖尿病神经病变的发病机理。 | ||
| S5910 | Alpha-Estradiol | Alpha-Estradiol (α-Estradiol, 17 alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 α-E2) 是一种天然的、非雌性化，是生理上几乎无活性的激素17β-雌二醇（17β- E2）的立体异构体，是雌激素 estrogen 的弱抑制剂。 | ||
| E2457 | Quercetin 3-O-beta-gentiobioside | Quercetin 3-O-beta-gentiobioside is isolated from A. iwayomogi, AR and AGE formation inhibitor, demonstrates biological activities against Aldose reductase (AR) and the formation of advanced glycation endproducts (AGEs). | ||
| S3818 | Tectoridin | Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy. | ||
| S0963 | 2-Acetylacteoside | 2-Acetylacteoside, a phenylethanoid glycoside isolated from Brandisia hancei, inhibits free radical-induced hemolysis of red blood cells and exhibits free radical scavenging activity. | ||
| S1074 | Poliumoside | Poliumoside对于晚期糖基化终产物的形成有显著抑制作用，IC50值为19.69 µM。 在大鼠晶状体醛糖还原酶测定试验中，发现 Poliumoside对rat lens aldose reductase(RLAR)表现出抑制作用，IC50值为8.47 µM。 | ||
| S5446 | 2-Chloro-1-(4-fluorobenzyl)benzimidazole | 2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor which is used for preparation of disubstituted benzimidazole derivative. | ||
| E2578 | 12-O-Methylcarnosic acid | 12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of <i>Salvia microphylla</i>, is an active constituent of 5α-reductase inhibition with an IC<sup>50</sup> value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity. |
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| E0695 | Byakangelicin | Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones. |
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| S9103 | Ginsenoside Ro | Ginsenoside Ro (Chikusetsusaponin V), one of the high-abundance saponins in ginseng, is widely used as a dietary supplement and has many health-promoting effects. | ||
| E5720 | Isocurcumenol | Isocurcumenol 可从 Curcuma zedoaria Rhizomes 中分离得到，是 ERα 的抑制剂。具有抗肿瘤活性。其对 DLA 和 KB 癌细胞的 IC50 分别为 99.1 μg/mL 和 178.2 μg/mL。 | ||
| S1202 | Dutasteride | Dutasteride (GI198745, GG-745)是5α-还原酶抑制剂。 | ||
| S2404 | Isoliquiritigenin | Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮，能抑制醛糖还原酶，IC50为320 nM。具有抗肿瘤活性。 |
|
|
| S1197 | Finasteride | Finasteride (MK-906)是一种类固醇II型5α-还原酶抑制剂。 | ||
| S2035 | Epalrestat | Epalrestat是一种醛糖还原酶 aldose reductase抑制剂，IC50为72 nM。 | ||
| S9170 | Engeletin | Engeletin (Dihydrokaempferol 3-rhamnoside), a bioactive flavonoid, has multiple biological activities such as anti-diabetic and anti-inflammatory effects. engeletin againsts LPS-stimulated endometritis in mice via negative regulation of pro-inflammatory mediators via the TLR4-regulated NF-κB pathway. | ||
| S5803 | Alrestatin | Alrestatin是aldose reductase (醛糖还原酶)抑制剂。醛糖还原酶参与了糖尿病并发症，包括糖尿病神经病变的发病机理。 | ||
| S5910 | Alpha-Estradiol | Alpha-Estradiol (α-Estradiol, 17 alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 α-E2) 是一种天然的、非雌性化，是生理上几乎无活性的激素17β-雌二醇（17β- E2）的立体异构体，是雌激素 estrogen 的弱抑制剂。 | ||
| E2457 | Quercetin 3-O-beta-gentiobioside | Quercetin 3-O-beta-gentiobioside is isolated from A. iwayomogi, AR and AGE formation inhibitor, demonstrates biological activities against Aldose reductase (AR) and the formation of advanced glycation endproducts (AGEs). | ||
| S1074 | Poliumoside | Poliumoside对于晚期糖基化终产物的形成有显著抑制作用，IC50值为19.69 µM。 在大鼠晶状体醛糖还原酶测定试验中，发现 Poliumoside对rat lens aldose reductase(RLAR)表现出抑制作用，IC50值为8.47 µM。 | ||
| S5446 | 2-Chloro-1-(4-fluorobenzyl)benzimidazole | 2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor which is used for preparation of disubstituted benzimidazole derivative. | ||
| E5720 | Isocurcumenol | Isocurcumenol 可从 Curcuma zedoaria Rhizomes 中分离得到，是 ERα 的抑制剂。具有抗肿瘤活性。其对 DLA 和 KB 癌细胞的 IC50 分别为 99.1 μg/mL 和 178.2 μg/mL。 | ||
| E0695 | Byakangelicin | Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones. |
