Astilbin

For research use only. Not for use in humans.

目录号:S3932 别名: Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside, Taxifolin 3-rhamnoside

Astilbin Chemical Structure

Molecular Weight(MW): 450.39

Astilbin, a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.

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产品安全说明书

Immunology & Inflammation related抑制剂选择性比较

生物活性

产品描述 Astilbin, a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.
体外研究

In vitro, astilbin inhibits Th17 cell differentiation and IL-17 secretion of isolated T cells, and inhibits Jak/Stat3 signaling in Th17 cells, while up-regulating Stat3 inhibitor SCOSE3 expression in psoriatic lesions. Astilbin has been reported to possess multiple clinically relevant bioactivities, including antioxidant, anti-inflammatory, anti-arthritic, and anti-diabetic nephropathy properties. Nevertheless, the molecular mechanisms by which astilbin interacts with inflammatory processes are poorly understood. Astilbin not only inhibits T lymphocyte function in acute heart allograft rejection, but also inhibits migration and antigen presenting of dendritic cells (DCs)[1].

体内研究 Astilbin is reported to reduce activation of both T and B cells in lupus-prone mice. It significantly inhibits inflammatory responses and keratinocyte over-proliferation in a mouse model of imiquimod (IMQ)-induced psoriasis[1]. Astilbin undergoes extensive biotransformation specifically due to enzyme catechol-O-methyl transferase. It gives rise to 3′-O-methylastilbin, a major metabolite of astilbin, which plays important role against the inhibition activated T lymphocytes. The pharmacokinetic parameters of astilbin followed by intragastric administration astilbin (40 mg/kg): Cmax=37.7±14.7 ng/mL, Tmax=25.8±34.3 min, t1/2=161.6±44.1 min[2].

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[1]
- 合并
  • Cell lines: CD4+ T cells
  • Concentrations: 0-100 μg/ml
  • Incubation Time: 3 days
  • Method: Cell viability is assessed using the Cell Counting Kit-8 (CCK8) assay at 3 days after induction of Th17 differentiation. The mean optical density (OD) of the three wells in each group is used to calculate the percentage of cell proliferation.
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: BALB/c mice (male, 18 to 20 g, 8 week-old)
  • Dosages: 25 to 50 mg/kg
  • Administration: orally administered
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (222.02 mM)

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 450.39
化学式

C21H22O11

CAS号 29838-67-3
储存条件 粉状
溶于溶剂
别名 Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside, Taxifolin 3-rhamnoside

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID