Immunology & Inflammation related

  • 抑制剂选择性比较
  • 溶解性比较
目录号 产品目录 溶解度(25°C)
DMSO 酒精
S2286 Cyclosporin A <1 mg/mL 100 mg/mL 100 mg/mL
S5004 Pimecrolimus <1 mg/mL 100 mg/mL 100 mg/mL
S3032 Bindarit <1 mg/mL 64 mg/mL 64 mg/mL
S1591 Bestatin <1 mg/mL 0.4 mg/mL <1 mg/mL
S8660 GI254023X <1 mg/mL 78 mg/mL 78 mg/mL
S5661 Tiaprofenic acid <1 mg/mL 52 mg/mL 52 mg/mL
S5412 Loxoprofen Sodium 53 mg/mL <1 mg/mL <1 mg/mL
S5361 Bendazac <1 mg/mL 56 mg/mL 56 mg/mL
S5360 Diflorasone <1 mg/mL 82 mg/mL 2 mg/mL
S5466 Saikosaponin A <1 mg/mL 100 mg/mL 100 mg/mL
S7732 ISO-1 <1 mg/mL 47 mg/mL 47 mg/mL
S3778 Patchouli alcohol -1 mg/mL 44 mg/mL -1 mg/mL
S3892 Isopsoralen -1 mg/mL 14 mg/mL -1 mg/mL
S3758 Sinomenine hydrochloride -1 mg/mL 73 mg/mL -1 mg/mL
S3827 Royal jelly acid -1 mg/mL 37 mg/mL -1 mg/mL
S3680 NLRP3 Inflammasome Inhibitor I <1 mg/mL 73 mg/mL <1 mg/mL
S3622 Diammonium Glycyrrhizinate 100 mg/mL 100 mg/mL <1 mg/mL
S3608 Demethylzeylasteral (T-96) <1 mg/mL 96 mg/mL 33 mg/mL
S1622 Prednisone <1 mg/mL 71 mg/mL <1 mg/mL
S1514 Cyclosporine <1 mg/mL 100 mg/mL 100 mg/mL
S1576 Sulfasalazine <1 mg/mL 80 mg/mL <1 mg/mL
S1654 Phenylbutazone <1 mg/mL 62 mg/mL 62 mg/mL
S2512 Tenoxicam <1 mg/mL 68 mg/mL <1 mg/mL
S4268 Flufenamic acid <1 mg/mL 56 mg/mL 56 mg/mL
S7809 MCC950(CP-456773) 85 mg/mL <1 mg/mL 40 mg/mL
S8291 Atractylenolide I <1 mg/mL 46 mg/mL 46 mg/mL
S8522 Compstatin 100 mg/mL -1 mg/mL -1 mg/mL
S4753 Ganoderic acid A <1 mg/mL 100 mg/mL 100 mg/mL
S7434 TAPI-1 60 mg/mL 99 mg/mL 99 mg/mL
S1829 Pranlukast <1 mg/mL 11 mg/mL <1 mg/mL
S7211 PF-04418948 <1 mg/mL 81 mg/mL <1 mg/mL
S3726 Selexipag <1 mg/mL 99 mg/mL 49 mg/mL
S1407 Bimatoprost <1 mg/mL 36 mg/mL 83 mg/mL
S1508 Alprostadil <1 mg/mL 71 mg/mL 71 mg/mL
S4529 Idramantone 33 mg/mL 33 mg/mL 33 mg/mL
S2286 Cyclosporin A <1 mg/mL 100 mg/mL 100 mg/mL
S5004 Pimecrolimus <1 mg/mL 100 mg/mL 100 mg/mL
S3032 Bindarit <1 mg/mL 64 mg/mL 64 mg/mL
S1591 Bestatin <1 mg/mL 0.4 mg/mL <1 mg/mL
S8660 GI254023X <1 mg/mL 78 mg/mL 78 mg/mL
S5661 Tiaprofenic acid <1 mg/mL 52 mg/mL 52 mg/mL
S5412 Loxoprofen Sodium 53 mg/mL <1 mg/mL <1 mg/mL
S5361 Bendazac <1 mg/mL 56 mg/mL 56 mg/mL
S5360 Diflorasone <1 mg/mL 82 mg/mL 2 mg/mL
S5466 Saikosaponin A <1 mg/mL 100 mg/mL 100 mg/mL
S7732 ISO-1 <1 mg/mL 47 mg/mL 47 mg/mL
S3778 Patchouli alcohol -1 mg/mL 44 mg/mL -1 mg/mL
S3892 Isopsoralen -1 mg/mL 14 mg/mL -1 mg/mL
S3758 Sinomenine hydrochloride -1 mg/mL 73 mg/mL -1 mg/mL
S3827 Royal jelly acid -1 mg/mL 37 mg/mL -1 mg/mL
S3680 NLRP3 Inflammasome Inhibitor I <1 mg/mL 73 mg/mL <1 mg/mL
S3622 Diammonium Glycyrrhizinate 100 mg/mL 100 mg/mL <1 mg/mL
S3608 Demethylzeylasteral (T-96) <1 mg/mL 96 mg/mL 33 mg/mL
S1622 Prednisone <1 mg/mL 71 mg/mL <1 mg/mL
S1514 Cyclosporine <1 mg/mL 100 mg/mL 100 mg/mL
S1576 Sulfasalazine <1 mg/mL 80 mg/mL <1 mg/mL
S1654 Phenylbutazone <1 mg/mL 62 mg/mL 62 mg/mL
S2512 Tenoxicam <1 mg/mL 68 mg/mL <1 mg/mL
S4268 Flufenamic acid <1 mg/mL 56 mg/mL 56 mg/mL
S7809 MCC950(CP-456773) 85 mg/mL <1 mg/mL 40 mg/mL
S8291 Atractylenolide I <1 mg/mL 46 mg/mL 46 mg/mL
S8522 Compstatin 100 mg/mL -1 mg/mL -1 mg/mL
S4753 Ganoderic acid A <1 mg/mL 100 mg/mL 100 mg/mL
S7434 TAPI-1 60 mg/mL 99 mg/mL 99 mg/mL
S1211 Imiquimod <1 mg/mL 1 mg/mL <1 mg/mL
s9019 Quillaic acid 97 mg/mL
s9022 20S-Ginsenoside Rg3 100 mg/mL
s9023 20S-Ginsenoside Rh2 100 mg/mL
s9025 AtractylenolideI 46 mg/mL
S5737 Diclofenac Epolamine 82 mg/mL 82 mg/mL 82 mg/mL
S5674 Lodoxamide Tromethamine 19 mg/mL <1 mg/mL <1 mg/mL
S5501 Hydrocortisone acetate -1 mg/mL 80 mg/mL -1 mg/mL
S5500 Amodiaquine hydrochloride -1 mg/mL 56 mg/mL -1 mg/mL
S3969 Veratric acid -1 mg/mL 36 mg/mL -1 mg/mL
S5322 Sodium gualenate 18 mg/mL 60 mg/mL 1 mg/mL
S5579 Chelidonic acid -1 mg/mL 4 mg/mL -1 mg/mL
S5451 Ferulic acid methyl ester 41 mg/mL 41 mg/mL 41 mg/mL
S5457 Curculigoside 15 mg/mL 93 mg/mL 93 mg/mL
S5458 Verbascoside 100 mg/mL 100 mg/mL 23 mg/mL
S5459 Aucubin 15 mg/mL 69 mg/mL <1 mg/mL
S5463 Curcurbitacin IIA <1 mg/mL 100 mg/mL 5 mg/mL
S5471 Monotropein 78 mg/mL 78 mg/mL <1 mg/mL
S5517 Fenamic acid -1 mg/mL 42 mg/mL -1 mg/mL
S3776 Sophoricoside <1 mg/mL 86 mg/mL <1 mg/mL
S5043 Benorylate -1 mg/mL 62 mg/mL -1 mg/mL
S5016 Isoprinosine 100 mg/mL 100 mg/mL 2 mg/mL
S5044 Isoxepac <1 mg/mL 53 mg/mL 53 mg/mL
S5046 Clonixin <1 mg/mL 52 mg/mL 15 mg/mL
S4966 4-Methylesculetin -1 mg/mL 38 mg/mL -1 mg/mL
S4832 Tolmetin -1 mg/mL 51 mg/mL -1 mg/mL
S4835 Aceclofenac -1 mg/mL 70 mg/mL -1 mg/mL
S3997 Oxaceprol -1 mg/mL 34 mg/mL -1 mg/mL
S4789 5-Acetylsalicylic acid -1 mg/mL 36 mg/mL -1 mg/mL
S5157 Thymol -1 mg/mL 30 mg/mL -1 mg/mL
S3982 Batyl alcohol -1 mg/mL 68 mg/mL -1 mg/mL
S3906 Astragalus polyphenols -1 mg/mL 81 mg/mL -1 mg/mL
S3877 Lysionotin -1 mg/mL 68 mg/mL -1 mg/mL
S3881 Scopoletin -1 mg/mL 38 mg/mL -1 mg/mL
S3790 Methyl gallate -1 mg/mL 36 mg/mL -1 mg/mL
S3799 Gentisic acid -1 mg/mL 30 mg/mL -1 mg/mL
S3765 Picroside II -1 mg/mL 100 mg/mL -1 mg/mL
S3774 Dehydroandrographolide Succinate Potasium Salt -1 mg/mL 10 mg/mL -1 mg/mL
S3775 Ligustrazine hydrochloride -1 mg/mL 34 mg/mL -1 mg/mL
S3932 Astilbin -1 mg/mL 100 mg/mL -1 mg/mL
S3837 Echinocystic acid -1 mg/mL 94 mg/mL -1 mg/mL
S3824 Quercitrin -1 mg/mL 89 mg/mL -1 mg/mL
S3841 Eleutheroside B -1 mg/mL 74 mg/mL -1 mg/mL
S3956 Tetramethylpyrazine -1 mg/mL 27 mg/mL -1 mg/mL
S3614 Lupeol <1 mg/mL 1 mg/mL <1 mg/mL
S3685 4-Biphenylacetic acid <1 mg/mL 42 mg/mL 42 mg/mL
S3745 Balsalazide disodium 87 mg/mL 87 mg/mL <1 mg/mL
S1439 Tranilast <1 mg/mL 66 mg/mL <1 mg/mL
S4169 Teriflunomide <1 mg/mL 32 mg/mL ,1 mg/mL
S2413 Geniposidic acid <1 mg/mL 16 mg/mL 2 mg/mL
S1939 Levamisole hydrochloride 48 mg/mL <1 mg/mL <1 mg/mL
S1681 Mesalamine <1 mg/mL 31 mg/mL 31 mg/mL
S2910 Tempol 34 mg/mL 34 mg/mL 34 mg/mL
S1679 Flurbiprofen <1 mg/mL 49 mg/mL 49 mg/mL
S3062 Diclofenac Potassium 10 mg/mL 69 mg/mL <1 mg/mL
S4098 Halcinonide <1 mg/mL 90 mg/mL 4 mg/mL
S1823 Fenoprofen Calcium <1 mg/mL 105 mg/mL 10 mg/mL
S4152 Ethamsylate 53 mg/mL 53 mg/mL <1 mg/mL
S2383 Gastrodin <1 mg/mL 50 mg/mL <1 mg/mL
S2387 Lappaconite HBr <1 mg/mL 28 mg/mL <1 mg/mL
S4165 Benzydamine HCl 69 mg/mL 69 mg/mL 69 mg/mL
S4170 Coumarin <1 mg/mL 29 mg/mL 29 mg/mL
S2400 Rheic Acid <1 mg/mL <1 mg/mL <1 mg/mL
S4188 Sasapyrine <1 mg/mL 52 mg/mL 52 mg/mL
S7448 CORM-3 <1 mg/mL 38 mg/mL <1 mg/mL
S4682 Loxoprofen <1 mg/mL 49 mg/mL 49 mg/mL
S8141 Cl-amidine 70 mg/mL 84 mg/mL 84 mg/mL
S3027 Fenoprofen calcium hydrate <1 mg/mL 48 mg/mL 18 mg/mL
S8097 C-DIM12 <1 mg/mL 71 mg/mL 71 mg/mL
S2350 Rutin <1 mg/mL 100 mg/mL 2 mg/mL
S3106 Pidotimod 10 mg/mL 49 mg/mL <1 mg/mL
S4515 Ademetionine disulfate tosylate 79 mg/mL 79 mg/mL <1 mg/mL
S4690 Escin <1 mg/mL 66 mg/mL <1 mg/mL
产品目录 产品描述 文献引用 实验数据
A2009New

Rituximab

Rituximab是嵌合的anti-CD20单克隆抗体,与B细胞上的CD20抗原结合,结合亲和力为5 nM。MW: 143.86 KD。

A2001

Ipilimumab

Ipilimumab是一种免疫调节单克隆抗体,靶向细胞表面抗原CTLA-4;也是一种免疫检查点抑制剂;MW:148 KD。

S2286

Cyclosporin A

Cyclosporin A是一种免疫抑制剂,与亲环素结合,随后抑制calcineurin,无细胞试验中IC50为7 nM,广泛用于预防器官移植反应中的排斥反应。

S5004

Pimecrolimus

Pimecrolimus是一种抑免蛋白配体, 可以特异地与胞质受体macrophilin-12结合;是钙调蛋白抑制剂。

S3032

Bindarit

Bindarit是天然化合物,具有特定抗炎活性,因为选择性抑制炎症趋化因子亚家族,包括单核细胞趋化蛋白MCP-1/CCL2, MCP-3/CCL7, 和 MCP-2/CCL8。

S1591

Bestatin

Bestatin 是竞争性氨肽酶B抑制剂,作用于K562细胞,IC50为100 mg/ml。

S8660New

GI254023X

GI254023X is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.

S5661New

Tiaprofenic acid

Tiaprofenic acid is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.

S5412New

Loxoprofen Sodium

Loxoprofen sodium is a non-steroidal anti-inflammatory drug.

S5361New

Bendazac

Bendazac is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.

S5360New

Diflorasone

Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties.

S5466New

Saikosaponin A

Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inflammatory, immunomodulatory, and anti-bacterial activities.

S7732New

ISO-1

ISO-1 is an inhibitor of MIF (Macrophage migration inhibitory factor D-dopachrome tautomerase activity with an IC50 of ~7 μM.

S3778New

Patchouli alcohol

Patchouli alcohol, an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.

S3892New

Isopsoralen

Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.

S3758New

Sinomenine hydrochloride

Sinomenine (SN), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.

S3827New

Royal jelly acid

Royal jelly acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.

S3680New

NLRP3 Inflammasome Inhibitor I

NLRP3 Inflammasome Inhibitor I是合成格列本脲的中间底物,它是NLRP3 inflammasome的抑制剂。

S3622New

Diammonium Glycyrrhizinate

Diammonium glycyrrhizinate (DG)是一种传统的中草药,从甘草中提取纯化而来。它具有抗炎活性,对生物氧化具有抗性、对膜具有保护性。DG通过抑制NF-κB、TNF-α和细胞间黏附分子1来减少炎症损伤。

S3608New

Demethylzeylasteral (T-96)

Demethylzeylasteral (T-96)是从Tripterygium wilfordii Hook F.中分离出的活性成分,能够抑制UDP-glucuronosyltransferase (UGT)的亚型UGT1A6UGT2B7,具有免疫抑制活性。

S1622

Prednisone

Prednisone 是一种人工合成的皮质类固醇剂,是特别有效的免疫抑制剂的化合物。

S1514

Cyclosporine

Cyclosporine 是一种钙调酶抑制剂,用作免疫抑制剂药物来组织器官移植中的免疫排斥。

S1576

Sulfasalazine

Sulfasalazine 是一种磺胺剂,是Mesalazine的衍生物,主要用作抗炎剂。

S1654

Phenylbutazone

Phenylbutazone 是一种非甾体抗炎剂,用于治疗慢性疼痛,包括关节炎的症状。

S2512

Tenoxicam

Tenoxicam是一种有效的自由基清除剂,IC50为56.7 μM。

S4268

Flufenamic acid

Flufenamic acid 是一种非甾体抗炎药物,离子通道调节剂。

S8559

INF39

INF39是NLRP3的无毒性的、不可逆的抑制剂,通过与NLRP3不可逆地直接相互作用以及部分抑制LPS驱动的促炎性基因表达,阻止NLRP3的激活。

S7809

MCC950(CP-456773)

MCC950(CP-456773)是一种有效的、选择性NLRP3抑制剂,在骨髓来源的巨噬细胞中IC50为7.5 nM。对AIM2, NLRC4或NLRP1炎症体没有作用。

S8291

Atractylenolide I

Atractylenolide I 是A. macrocephala根茎的主要类倍半萜烯类化合物。具有广谱的药理活性,如抗炎、促消化、抗氧化作用。

S8522

Compstatin

Compstatin与complement component C3结合,抑制补体激活,IC50为1.2 μM。

S4753

Ganoderic acid A

Ganoderic acid A (GAA),是Ganoderma lucidum中具有活性的三萜系化合物,具有镇痛、抗氧化、细胞毒性、保护肝脏和抗肿瘤活性。

S7434

TAPI-1

TAPI-1 是一种ADAM17/TACE抑制剂, 其对细胞因子受体有抑制作用。

S1829

Pranlukast

Pranlukast 是一种选择性白三烯受体拮抗剂。

S7211

PF-04418948

PF-04418948 是一种有效的选择性前列腺素 EP₂ receptor 拮抗剂,IC50 为 16 nM。Phase 1.

S3726New

Selexipag

Selexipag is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).

S1407

Bimatoprost

Bimatoprost是一种前列腺素类似物,局部(眼药水)用药,治疗青光眼和高眼压症。

S1508

Alprostadil

Alprostadil 用于治疗勃起功能障碍,具有血管舒张的特性。它是前列腺素的类似物,是Prostaglandin E1的激动剂。

S4529

Idramantone

Idramantone是一种免疫激动剂。

S4709

Latanoprost

Latanoprost是前列腺素F2α的类似物,是前列腺素类选择性FP受体的激动剂。Latanoprost增加葡萄膜巩膜外流,因而减少眼压。

A2009New

Rituximab

Rituximab是嵌合的anti-CD20单克隆抗体,与B细胞上的CD20抗原结合,结合亲和力为5 nM。MW: 143.86 KD。

A2001

Ipilimumab

Ipilimumab是一种免疫调节单克隆抗体,靶向细胞表面抗原CTLA-4;也是一种免疫检查点抑制剂;MW:148 KD。

S2286

Cyclosporin A

Cyclosporin A是一种免疫抑制剂,与亲环素结合,随后抑制calcineurin,无细胞试验中IC50为7 nM,广泛用于预防器官移植反应中的排斥反应。

S5004

Pimecrolimus

Pimecrolimus是一种抑免蛋白配体, 可以特异地与胞质受体macrophilin-12结合;是钙调蛋白抑制剂。

S3032

Bindarit

Bindarit是天然化合物,具有特定抗炎活性,因为选择性抑制炎症趋化因子亚家族,包括单核细胞趋化蛋白MCP-1/CCL2, MCP-3/CCL7, 和 MCP-2/CCL8。

S1591

Bestatin

Bestatin 是竞争性氨肽酶B抑制剂,作用于K562细胞,IC50为100 mg/ml。

S8660New

GI254023X

GI254023X is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.

S5661New

Tiaprofenic acid

Tiaprofenic acid is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.

S5412New

Loxoprofen Sodium

Loxoprofen sodium is a non-steroidal anti-inflammatory drug.

S5361New

Bendazac

Bendazac is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.

S5360New

Diflorasone

Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties.

S5466New

Saikosaponin A

Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inflammatory, immunomodulatory, and anti-bacterial activities.

S7732New

ISO-1

ISO-1 is an inhibitor of MIF (Macrophage migration inhibitory factor D-dopachrome tautomerase activity with an IC50 of ~7 μM.

S3778New

Patchouli alcohol

Patchouli alcohol, an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.

S3892New

Isopsoralen

Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.

S3758New

Sinomenine hydrochloride

Sinomenine (SN), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.

S3827New

Royal jelly acid

Royal jelly acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.

S3680New

NLRP3 Inflammasome Inhibitor I

NLRP3 Inflammasome Inhibitor I是合成格列本脲的中间底物,它是NLRP3 inflammasome的抑制剂。

S3622New

Diammonium Glycyrrhizinate

Diammonium glycyrrhizinate (DG)是一种传统的中草药,从甘草中提取纯化而来。它具有抗炎活性,对生物氧化具有抗性、对膜具有保护性。DG通过抑制NF-κB、TNF-α和细胞间黏附分子1来减少炎症损伤。

S3608New

Demethylzeylasteral (T-96)

Demethylzeylasteral (T-96)是从Tripterygium wilfordii Hook F.中分离出的活性成分,能够抑制UDP-glucuronosyltransferase (UGT)的亚型UGT1A6UGT2B7,具有免疫抑制活性。

S1622

Prednisone

Prednisone 是一种人工合成的皮质类固醇剂,是特别有效的免疫抑制剂的化合物。

S1514

Cyclosporine

Cyclosporine 是一种钙调酶抑制剂,用作免疫抑制剂药物来组织器官移植中的免疫排斥。

S1576

Sulfasalazine

Sulfasalazine 是一种磺胺剂,是Mesalazine的衍生物,主要用作抗炎剂。

S1654

Phenylbutazone

Phenylbutazone 是一种非甾体抗炎剂,用于治疗慢性疼痛,包括关节炎的症状。

S2512

Tenoxicam

Tenoxicam是一种有效的自由基清除剂,IC50为56.7 μM。

S4268

Flufenamic acid

Flufenamic acid 是一种非甾体抗炎药物,离子通道调节剂。

S8559

INF39

INF39是NLRP3的无毒性的、不可逆的抑制剂,通过与NLRP3不可逆地直接相互作用以及部分抑制LPS驱动的促炎性基因表达,阻止NLRP3的激活。

S7809

MCC950(CP-456773)

MCC950(CP-456773)是一种有效的、选择性NLRP3抑制剂,在骨髓来源的巨噬细胞中IC50为7.5 nM。对AIM2, NLRC4或NLRP1炎症体没有作用。

S8291

Atractylenolide I

Atractylenolide I 是A. macrocephala根茎的主要类倍半萜烯类化合物。具有广谱的药理活性,如抗炎、促消化、抗氧化作用。

S8522

Compstatin

Compstatin与complement component C3结合,抑制补体激活,IC50为1.2 μM。

S4753

Ganoderic acid A

Ganoderic acid A (GAA),是Ganoderma lucidum中具有活性的三萜系化合物,具有镇痛、抗氧化、细胞毒性、保护肝脏和抗肿瘤活性。

S7434

TAPI-1

TAPI-1 是一种ADAM17/TACE抑制剂, 其对细胞因子受体有抑制作用。

S1211

Imiquimod

Imiquimod 是新型合成的药剂,具有免疫反应修饰活性。

s9019New

Quillaic acid

Quillaic acid is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol and shows strong anti-inflammatory activity.

s9022New

20S-Ginsenoside Rg3

20S-Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It exihits neuromodulatory, cognition enhancing, anti-inflammatory, antioxidative, anti-angiogenic, and anticancer activities.

s9023New

20S-Ginsenoside Rh2

20S-Ginsenoside Rh2 is a ginsenoside found in Panax species and inhibits cancer development, progression, and metastasis.

s9025New

AtractylenolideI

Atractylenolide I (ATL-I) is a bioactive component of Rhizoma Atractylodis macrocephalae and shows anti-inflammatory effects.

S5737New

Diclofenac Epolamine

Diclofenac Epolamine is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.

S5674New

Lodoxamide Tromethamine

Lodoxamide Tromethamine is the tromethamide salt form of lodoxamide, a synthetic mast cell stabilizing compound with anti-inflammatory activity.

S5648New

Iguratimod

Iguratimod is a small molecule compound with anti-inflammatory and immunomodulatory actions and used for the treatment of rheumatoid arthritis.

S5501New

Hydrocortisone acetate

Hydrocortisone Acetate is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.

S5500New

Amodiaquine hydrochloride

Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.

S3969New

Veratric acid

Veratric acid, a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects.

S5322New

Sodium gualenate

Sodium gualenate (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound, which is gradually decomposed in the solid state at room temperature. It has anti-inflammatory and wound-healing effects.

S5579New

Chelidonic acid

Chelidonic acid is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals.

S5451New

Ferulic acid methyl ester

Methyl ferulate is a lipophilic derivative of ferulic acid, which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer.

S5457New

Curculigoside

Curculigoside, a diterpenoid triepoxide, is one of the main bioactive phenolic compounds isolated from the rhizome of Curculigo orchioides Gaertn. and has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects.

S5458New

Verbascoside

Verbascoside, a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant.

S5459New

Aucubin

S5463New

Curcurbitacin IIA

Cucurbitacin IIa (CuIIa) is the major active component of the Helmseya amabilis root and is known to have antiviral and anti-inflammatory effects.

S5471New

Monotropein

Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity.

S5517New

Fenamic acid

Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid.

S5261New

Ufenamate

Ufenamate is an anthranilic acid derivative with anti-inflammatory activity.

S5318New

Acacetin

S3776New

Sophoricoside

Sophoricoside (SOPH)是一种分离自槐花(豆科)的异黄酮,具有多种药理作用,如消炎、抗癌、抑制免疫力等效应。

S5043New

Benorylate

Benorylate是阿司匹林和扑热息痛经拼合原理制成,具有消炎、止痛和解热活性。

S5016New

Isoprinosine

Isoprinosine是一种免疫药理试剂,具有抗病毒活性。

S5044New

Isoxepac

Isoxepac是一种非类固醇的芳基乙酸衍生物,具有抗炎症、解热镇痛活性。

S5046New

Clonixin

Clonixin是一种非类固醇的消炎药物,具有镇痛、解热和抑制血小板作用。

S4966New

4-Methylesculetin

4-methylesculetin是香豆素衍生物,具有强大的抗氧化和抗炎活性。

S4832New

Tolmetin

Tolmetin是一种非类固醇的抗炎药,属于杂环乙酸衍生物类,具有止痛和退热作用。

S4835New

Aceclofenac

Aceclofenac是一种非类固醇的抗炎药,具有抗炎和止痛作用。

S3997New

Oxaceprol

Oxaceprol是一种抗炎性药物,用于治疗骨关节炎。

S4789New

5-Acetylsalicylic acid

5-Acetylsalicylic acid is a nonsteroidal anti-inflammatory drug.

S5157New

Thymol

Thymol, a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.

S3982New

Batyl alcohol

Batyl alcohol, isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent.

S3906New

Astragalus polyphenols

Astragalus is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions.

S3877New

Lysionotin

Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.

S3881New

Scopoletin

Scopoletin is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.

S3813New

Bakuchiol

Bakuchiol is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.

S3790New

Methyl gallate

Methyl Gallate is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.

S3799New

Gentisic acid

Gentisic acid, an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties.

S3765New

Picroside II

Picroside II is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

S3774New

Dehydroandrographolide Succinate Potasium Salt

Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.

S3775New

Ligustrazine hydrochloride

Tetramethylpyrazine, also known as ligustrazine, is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

S3932New

Astilbin

Astilbin, a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.

S3871New

Muscone

Muscone, a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent.

S3837New

Echinocystic acid

Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.

S3893New

Bornyl acetate

Bornyl acetate, the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.

S3824New

Quercitrin

Quercitrin (3-rhamnosyl quercetin), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.

S3841New

Eleutheroside B

Eleutheroside B (syringin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.

S3761New

Eucalyptol

Eucalyptol is a natural organic compound which controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.

S3956New

Tetramethylpyrazine

Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

S3614New

Lupeol

Lupeol是一种显著的白桦脂酸型三萜烯,存在于植物、真菌和动物中,具有抗癌、抗原生动物、化学预防、消炎作用。

S3685New

4-Biphenylacetic acid

4-Biphenylacetic acid (BPA)是一种潜在的非类固醇消炎试剂,与β-cyclodextrin形成固体包结络合物。它与喹诺酮类抗菌药物相互作用可诱导γ-氨基丁酸受体的功能阻滞。

S3745New

Balsalazide disodium

Balsalazide Disodium是balsalazide的二钠盐形式,balsalazide是一种口服的对氨水杨酸钠前体药物,在结肠中被酶解、产生抗炎性的美沙拉秦(mesalazine)。

S1439

Tranilast

Tranilast是一种抗过敏化合物。

S4169

Teriflunomide

Teriflunomide是Leflunomide的活性代谢物,通过抑制酶二氢乳清酸脱氢酶,从而抑制嘧啶从头合成,作为一种免疫调节剂。

S2413

Geniposidic acid

Geniposidic acid 是一种环烯醚萜类糖苷,用于治疗炎症,黄疸以及肝病。

S1939

Levamisole hydrochloride

Levamisole,也被称作(-)-Tetramisole,是一种驱虫药物,已经尝试用于治疗风湿性疾病通过增加巨噬细胞的趋化性和T-淋巴细胞的功能显著恢复免疫应答。

S1681

Mesalamine

Mesalamine是一种抗炎化合物。

S2910

Tempol

Tempol是一种超氧化物清除剂,具有神经保护,抗炎症和镇痛效果。Phase 2

S1679

Flurbiprofen

Flurbiprofen 是一种苯基烷酸衍生物,是非甾体类抗炎药(NSAIDs)。

S3062

Diclofenac Potassium

Diclofenac Potassium是一种非类固醇消炎药,用于减轻炎症和某些状况下的止痛药。

S4098

Halcinonide

Halcinonide是一种高效的皮质类固醇,用作局部制剂,作为抗炎剂。

S1823

Fenoprofen Calcium

Fenoprofen Calcium是一种非甾体类,抗炎,抗关节炎药剂。

S4152

Ethamsylate

Ethamsylate是一种止血药,抑制前列腺素的生物合成和功能,提高毛细血管内皮阻力和血小板粘附。

S2383

Gastrodin

Gastrodin是一种多元酚,是4-羟基苄醇的葡糖苷。

S2387

Lappaconite HBr

Lappaconite HBr是从Aconitum sinomontanum Nakai 提取的一种生物碱,具有抗炎作用。

S4165

Benzydamine HCl

Benzydamine HCl 是一种外用的非甾体抗炎药(NSAID),具有抗炎,镇痛,解热和局部麻醉剂的活性。

S4170

Coumarin

Coumarin是植物化学成分,具有肝毒性和致癌性。

S2400

Rheic Acid

Rheic Acid 是Rhubarb的组成部分,是从Rheum coreanum Nakai新鲜根茎分离得到的。

S4188

Sasapyrine

Sasapyrine是一种口服的非甾体类抗炎药。

S7448

CORM-3

CORM-3 是水溶性一氧化碳的释放分子,具有抗炎和保护心脏的作用。

S4682

Loxoprofen

Loxoprofen是非类固醇的消炎药,属于丙酸衍生物。

S8141

Cl-amidine

Cl-amidine是一种不可逆地泛peptidylarginine deiminase (PAD)抑制剂,对PAD4、PAD1和PAD3的IC50值分别为5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM。

S3027

Fenoprofen calcium hydrate

Fenoprofen calcium hydrate是一种非甾类抗炎症药物(NSAID)。

S4706

Eugenol

Eugenol是一种自然存在的香味化合物,发现于丁香油和其他植物中。Eugenol通过增加组胺释放和细胞免疫发挥其生理作用。

S8097

C-DIM12

C-DIM12是Nurr1的激活剂,刺激膀胱癌细胞和肿瘤中Nurr1所介导的细胞凋亡、抑制胶质细胞中对NF-κB依赖的基因表达。

S2350

Rutin

Rutin是在许多植物中发现的一种黄酮苷,包括Buckwheat; Tobacco; Forsythia; Hydrangea; Viola, 等。

S3106

Pidotimod

Pidotimod是一种合成的二肽分子,对适应性和先天性免疫反应都有生物学免疫活性。对动物和人的样本进行体外研究发现Pidotimod对适应性和先天性免疫反应都有很好的活性,这一结论也在体内实验中得到了确认。这些活性已经应用到临床,在减轻儿童上呼吸道和尿道感染复发率上效果良好。在成人呼吸道感染复发的抑制上也有同样效果。

S4515

Ademetionine disulfate tosylate

Ademetionine Disulfate Tosylate是腺苷蛋氨酸离子的非对映异构体的硫酸氢盐-甲苯磺酸盐混合盐形式。Ademetionine(腺苷蛋氨酸)具有抗炎活性,被用于治疗慢性肝疾病。

S4690

Escin

Escin是在欧洲七叶树中所发现的皂苷混合物,具有抗炎、血管收缩的、血管保护作用。

S4524

2-Ethoxybenzamide

2-Ethoxybenzamide是一种常见的止痛剂和消炎药,用于缓解发热发烧、头痛和其他的轻微疼痛。