Quercitrin

For research use only. Not for use in humans.

目录号:S3824 别名: 3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine

Quercitrin Chemical Structure

Molecular Weight(MW): 448.38

Quercitrin (3-rhamnosyl quercetin), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.

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RMB 1695.65 现货
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产品安全说明书

Immunology & Inflammation related抑制剂选择性比较

生物活性

产品描述 Quercitrin (3-rhamnosyl quercetin), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.
体外研究

Quercitrin ameliorates cytokine-impaired viability of RINm5F cells and improves Glucose-stimulated insulin secretion in cytokine-treated RINm5F cells. It also reduces production of cellular ROS from cytokines and restrains the enhancement of NO production caused by cytokines in RINm5F cells via inhibition of iNOS expression[1].

体内研究 Quercitrin significantly suppresses the elevation of reactive oxygen species (ROS) production and malondialdehyde (MDA) content, reduces tissue plasminogen activator (t-PA) activity, enhances the antioxidant enzyme activities and abrogates cytochrome P450 2E1 (CYP2E1) induction in mouse brains. Quercitrin also prevents CCl4 induced cerebral function disorders associated with its ability to inhibit the activities of monoamine oxidase (MAO), acetylcholine esterase (AChE) and the N-methyl-D-aspartate receptor 2B subunit (NR2B). Quercitrin is known to have biological effects such as anti-oxidative, anti-inflammatory, and anti-apoptosis effects and it might be a more potent antioxidant and a neuroprotective agent than quercetin due to its high bioavailability in the digestive track. Quercitrin significantly reduces acute systemic inflammation in LPS-induced models as well as attenuates inflammation in the livers of mice. Quercitrin could also reduce inflammation and apoptosis in cytokine-induced models. In streptozotocin (STZ)-induced diabetic models, quercitrin displays organ protective properties in the pancreas, liver and kidney by improving the antioxidant status[2].

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[1]
- 合并
  • Cell lines: The insulin-secreting cell line RINm5F
  • Concentrations: 0, 5, 10 and 20 μM
  • Incubation Time: 2 h
  • Method: Cells are cultured in DMEM with 10% FBS, 100 U/ml penicillin, 100 μg/ml streptomycin, 2 mmol/l in a humidified atmosphere (5% CO2, 37°C). After starvation for 24 h, cells are treated with quercetin or quercitrin (0, 5, 10 and 20 μM) for 2 h, then co-incubated with TNF-α (10 ng/ml), IL-1β (5 ng/ml) and IFN-γ (1,000 U/ml) for 24 h.
    (Only for Reference)
动物实验:[2]
- 合并
  • Animal Models: Male ICR mice
  • Dosages: 50 and 100 mg/kg
  • Administration: i.p.
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 89 mg/mL (198.49 mM)

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 448.38
化学式

C21H20O11

CAS号 522-12-3
储存条件 粉状
溶于溶剂
别名 3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID