Chlorpromazine HCl

For research use only. Not for use in humans.

目录号:S2456 别名: Sonazine 中文名称:盐酸氯丙嗪

Chlorpromazine HCl Chemical Structure

CAS No. 69-09-0

Chlorpromazine HCl (Sonazine)是一种多巴胺和钾离子通道抑制剂,对内向整流钾电流和与时间无关的外向电流IC50分别为6.1和16 μM。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1060.43 现货
RMB 787.05 现货
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客户使用Selleck生产的Chlorpromazine HCl发表文献18篇:

客户使用该产品的5个实验数据:

  • Low-micromolar amounts of chlorpromazine inhibit SARS-CoV-induced cytopathology. Vero E6 cells in 96-well plates were infected with SARS-CoV isolate Frankfurt-1 (MOI, 0.005) in the presence of 0 to 16  μM CPZ (B), given at t of +1 h p.i. Cells were incubated for 3 days, and viability was monitored using an MTS assay. In parallel, potential compound cytotoxicity was monitored in mock-infected Vero E6 cells. Graphs show the results (averages and SD) of a representative experiment that was performed in quadruplicate. All experiments were repeated at least twice. For each compound, the EC50, CC50, and SI values are given.

    Antimicrob Agents Chemother, 2014, 58:4875-4884.. Chlorpromazine HCl purchased from Selleck.

  • Prussian blue staining for cells co-cultured with IOPs (25 mg/mL) and different inhibitors, (C1) control, (C2) LY294002 (100 μM, Selleck), (C3) genistein (10 μM, Selleck), (C4) chlorpromazine (10 μM, Selleck) for 24 h, arrows indicate the stained cells;

    Acta Biomater, 2018, 71:49-60. Chlorpromazine HCl purchased from Selleck.

  • Vero and H1299 cells were pretreated with increasing concentrations of CPZ (CME inhibitor), Amiloride (macropinocytosis inhibitor), or Nystatin (CavME inhibitor) for 30 min and infected with IBV at MOI= 1. H2O or DMSO pretreatment in parallel experiments was set as control. The incoming virus level was determined by quantification of viral gRNA at 2 h.p.i.; the expression level of IBV N protein was analyzed at 8 h.p.i.

    Virology, 2018, 528:118-136. Chlorpromazine HCl purchased from Selleck.

  • RT-PCR assay of virus yield in the supernatants (infection group) and CIK cells (entry group). (unpaired t-test, * P < 0.05 and ** P < 0.01). Western blot analysis to monitor viral replication level in CIK cells.

    Virol J, 2018, 15(1):92. Chlorpromazine HCl purchased from Selleck.

  • Effects of inhibitors on GCRV infection. a Virus yield in CIK cells pretreated with vehicle, 10 mM NH4Cl, 20 μM CQ, 50 μM CPZ, or 100 μM of dynasore. b Western blotting analysis to monitor viral replication level. Cells were treated with various inhibitors as described above. After 12 h of incubation, cells were lysed and processed for Western blot analysis of GCRV-VP5 protein expression with polyclonal mouse serum. GAPDH was included as an internal loading control for the Western blots. NC denotes the negative control treated with vehicle. c Virus yield in CIK cells pretreated with vehicle, 5 μg/mL Filipin III, 50 μM LY294002, or 25 μg/mL nystatin. d Western blotting analysis to monitor the viral replication level. Cells were treated with inhibitors as described above. After 12 h of incubation, cells were lysed and processed for Western blot analysis of GCRV-VP5 protein expression with polyclonal mouse serum. GAPDH was included as an internal loading control for the Western blots. NC denotes the negative control treated with vehicle. Each experimental point is the sum of triplicate experiments with two titer assays. Error bars represent the standard errors of the mean. Asterisks represent a significant difference from the control (un-paired t-test)

    Virol J, 2016, 13:25.. Chlorpromazine HCl purchased from Selleck.

产品安全说明书

Dopamine Receptor抑制剂选择性比较

生物活性

产品描述 Chlorpromazine HCl (Sonazine)是一种多巴胺和钾离子通道抑制剂,对内向整流钾电流和与时间无关的外向电流IC50分别为6.1和16 μM。
靶点
Dopamine receptor [6] Potassium channel [6]
体外研究

Chlorpromazine通过降低结合(Kon)和增加GABAARs的结合解除(Koff)来影响微型IPSC(mIPSCs)。[1] Chlorpromazine以电位依赖性方式调控激活TRPA1电流,导致在正电位阻断和负电位的开放概率的增加。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO cells NUH3cHFbTnWwY4Tpc44h[XO|YYm= MlvPR49ueG:3bnSge4F{KGW4YXz1ZZRm\CCob4KgeIhmKGKrbnTpcoch[W[oaX7peJkh[WejaX7zeEBcO0ifOD3PTE1FWEGWLXzhZoVt\WRiNT3ofYRzd3i7dIL5dJRidWmwZTCxRUBz\WOncITvdkB{cXSnczDpckBkdG:wZXSgR2hQKGOnbHzzMEBMcT1yLk[3N{DPxE1? M2HrdlgxQTd3M{i=
CHO cells MYXGeY5kfGmxbjDhd5NigQ>? M{nUbmNwdXCxdX7kJJdieyCndnHseYF1\WRiZn;yJJRp\SCkaX7kbY5oKGGoZnnubZR6KGGpYXnud5QhYzOKXWWtPFYtOTdyLXzhZoVt\WRiREKgd4l1\XNiaX6gZ4xwdmWmIFPIU{Bk\WyuczygT4k:OC5yMEOg{txO MVi4NFk4PTN6

... Click to View More Cell Line Experimental Data

体内研究 Chlorpromazine独立地下调T细胞来源的淋巴因子中各种(IL-2,IFN-γ,IL-4,肿瘤坏死因子,和GM-CSF)的产生和一个急性超抗原驱动的免疫激活的体内模型IL-10分泌的上调。Chlorpromazine介导SEB驱动Chlorpromazin分泌,伴随着一个增强的IL-10 mRNA的积累。[3] Chlorpromazine保护小鼠,正常或肾上腺和豚鼠抗LPS的致死性,并抑制肿瘤坏死因子的血清水平。当LPS诱导的30分钟前,同时,或PS诱导后10分钟给药,Chlorpromazine防止脂多糖致死性,在LPS诱导的30分钟后给药是无效的。在放线菌素D诱导致敏的LPS小鼠中,Chlorpromazine显著抑制LPS的杀伤力和肝毒性。[4] Chlorpromazine保护脑组织从突触传递的大鼠缺氧诱导的不可逆的损失。在)大鼠中,Chlorpromazine也显著延迟缺氧诱导的扩散性抑郁的发生。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 71 mg/mL (199.81 mM)
Water 71 mg/mL (199.81 mM)
Ethanol 71 mg/mL (199.81 mM)

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 355.33
化学式

C17H19ClN2S.HCl

CAS号 69-09-0
储存条件 粉状
溶于溶剂
别名 Sonazine

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03548714 Completed Drug: PT150|Other: Beverage Alcohol Dependence|Alcohol Interaction Pop Test Oncology LLC|Pharmacotherapies for Alcohol and Substance Abuse Consortium|Congressionally Directed Medical Research Programs|Michael Debakey Veterans Affairs Medical Center|Baylor College of Medicine|University of California San Diego September 1 2018 Phase 1
NCT02943213 Completed Drug: Chlorpromazine Hydrochloride Anti-Psychotic|Management of Manifestations of Psychotic Disorders|Treatment of Schizophrenia|Control Nausea and Vomiting|Relief of Restlessness and Apprehension Before Surgery|Acute Intermittent Porphyria|Adjunct in the Treatment of Tetanus|Control Manifestations of the Manic Type of Mani-depressive Illness|Relief of Intractable Hiccups Cycle Pharmaceuticals Ltd.|Parexel November 2016 Phase 1
NCT02295462 Completed Other: Person-centered Care|Other: Optimised Treatment Dementia Martin-Luther-Universität Halle-Wittenberg|University of Luebeck|University of Witten/Herdecke December 2014 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID