D5 receptor 激动剂 | 拮抗剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S0476 SCH-23390 hydrochloride

SCH-23390 hydrochloride is a potent and selective antagonist of dopamine D1-like receptor with Ki of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist of human 5-HT2C receptor with Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.

Pan D5 dopamine receptor, Ki: 0.3 nM
S1771 Chlorprothixene

Chlorprothixene与多巴胺和组织胺受体(如D1, D2, D3, D5, H1, 5-HT2, 5-HT6和5-HT7)具有强结合力, Ki值分别为18nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM和5.6 nM。

Pan D5 receptor, Ki: 9 nM
S5481 Molindone hydrochloride

Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist.

S7993 SKF38393 HCl

SKF38393 HCl是一种选择性dopamine D1/D5 receptor激动剂。