Camptothecin (NSC-100880)

For research use only. Not for use in humans.

目录号:S1288 别名: CPT, Campathecin, (S)-(+)-Camptothecin 中文名称:喜树碱

Camptothecin (NSC-100880) Chemical Structure

CAS No. 7689-03-4

Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) 是一种特异性的DNA拓扑异构酶I (Topo I)抑制剂,IC50为0.68 μM。Camptothecin 在癌细胞中可通过microRNA-125b介导的线粒体信号通路来诱导凋亡。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1148.32 现货
RMB 630.63 现货
RMB 1409.22 现货
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客户使用Selleck生产的Camptothecin (NSC-100880)发表文献84篇:

产品安全说明书

ADC Cytotoxin抑制剂选择性比较

生物活性

产品描述 Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) 是一种特异性的DNA拓扑异构酶I (Topo I)抑制剂,IC50为0.68 μM。Camptothecin 在癌细胞中可通过microRNA-125b介导的线粒体信号通路来诱导凋亡。Phase 2。
特性 Camptothecin是大量实验证明具有毒性的植物碱,是DNA拓扑异构酶 I (topo I)的特定抑制剂。
靶点
Topo I [2]
(Cell-free assay)
0.68 μM
体外研究

Camptothecin是1966年最先从Camptotheca acuminate独立的植物碱。[1] 有效且特定抑制DNA拓扑异构酶 I (topo I),IC50 为 0.68 μM。Camptothecin 在纳摩尔水平作用于多种人类肿瘤细胞系,包括 HT29, LOX, SKOV3,和 SKVLB,有一定细胞毒性,IC50为37 nM 到48 nM。[2] 与 TNF联用, Camptothecin作用于鼠肝细胞,诱导凋亡,IC50为13 μM。Camptothecin 也废除 TNF诱导的NF-κB激活, 和TNF受体相关因子-2 (TRAF2),X-连锁凋亡蛋白抑制剂(X-IAP), 和FLICE抑制蛋白(FLIP)的表达。[4] 5 μM Camptothecin 作用于HCT116细胞,诱导蛋白酶体调节的混合系白血病5 (MLL5)蛋白降解,导致p53在Ser392位点磷酸化。 [5] 由于Camptothecin的溶解性低,及具有一定副作用,所以已经研发了多种Camptothecin类似物,其中两种如Topotecan和Irinotecan, 已经获得FDA准核,用于癌症化学疗法中。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
P388 MkTVS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NVPW[49rUUN3ME2zNkBvVQ>? MlX0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB|NE[5N|MoRjFyM{S2PVM{RC:jPh?=
P388CPT5 R NIP6SWZIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MlrWTWM2OD1{Lkig{txO M3v5R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{S2PVM{Lz5zMEO0Olk{OzxxYU6=
KBwt M1X2bGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NELjR4pKSzVyPUSwJI5O MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODRzMUS3Okc,OTB2MUG0O|Y9N2F-
KBMDR M4e3cGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MkTkTWM2OD15MDDuUS=> MnvNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB2MUG0O|YoRjFyNEGxOFc3RC:jPh?=
KBV20C M2DNVGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M4\he2lEPTB;M{Cgcm0> NGjG[JQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMESxNVQ4Pid-MUC0NVE1PzZ:L3G+
KB7D M1ewfWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MVTJR|UxRTN3IH7N M3vCO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNEGxOFc3Lz5zMESxNVQ4PjxxYU6=
KBCamp M4XRWWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MYrJR|UxRTFwMESg{txO MoLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB2MUG0O|YoRjFyNEGxOFc3RC:jPh?=
HT29 NEHQTXBkgXSxdH;4bYNqfHliYYPzZZk> NYrDb3loUUN3ME24NEBvVQ>? MlvsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB6NEG4NFgoRjFyOESxPFA5RC:jPh?=
A549 MXTjfZRwfG:6aXPpeJkh[XO|YYm= MWHJR|UxRTZ5IH7N MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh2MUiwPEc,OTB6NEG4NFg9N2F-
T24 MUHjfZRwfG:6aXPpeJkh[XO|YYm= NH\6bW9KSzVyPUi4JI5O NHnDbXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi0NVgxQCd-MUC4OFE5ODh:L3G+
HOP-62 NXTI[VVlT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M{nRe2lEPTB;MUCgcm0> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4N{c,OTFyMkCyPFM9N2F-
HCT-116 MmPHS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M1m5fGlEPTB;M{Cgcm0> NUmzcHY3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGwNlAzQDNpPkGxNFIxOjh|PD;hQi=>
SF-539 MXTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NWLKNlFuUUN3ME2xNEBvVQ>? M4\VeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg{Lz5zMUCyNFI5OzxxYU6=
UACC-62 NGT4N3NIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MX\JR|UxRTFyIH7N M2G0TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg{Lz5zMUCyNFI5OzxxYU6=
OVCAR-3 MXfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MXnJR|UxRTJ{MDDuUS=> NUSxRlVyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGwNlAzQDNpPkGxNFIxOjh|PD;hQi=>
SN12C M3T5d2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 Ml;wTWM2OD1{MDDuUS=> NIrPTXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
DU-145 MoLiS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MULJR|UxRTFyIH7N NEPQN2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
MDA-MB-435 MXvHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NUnMPJM3UUN3ME20NEBvVQ>? M2XlVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg{Lz5zMUCyNFI5OzxxYU6=
WiDr MojqZ5l1d3SxeHnjbZR6KGG|c3H5 M17TZmROW09? NIjwb5VKSzVyPUG3JI5O NEnYem09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUOzOFU3QSd-MUGzN|Q2Pjl:L3G+
A549 NF\nN|NkgXSxdH;4bYNqfHliYYPzZZk> MV\EUXNQ MoKyTWM2OD1zNDDuUS=> MmHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF|M{S1OlkoRjFzM{O0OVY6RC:jPh?=
MKN45 NELHbJNkgXSxdH;4bYNqfHliYYPzZZk> MoHuSG1UVw>? M4iw[2lEPTB;MUegcm0> MlHoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF|M{S1OlkoRjFzM{O0OVY6RC:jPh?=
SK-OV-3 NF3BUlRkgXSxdH;4bYNqfHliYYPzZZk> NEK4d3BFVVOR NVnLXHNZUUN3ME2yNEBvVQ>? NWPHbI9CRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGzN|Q2PjlpPkGxN|M1PTZ7PD;hQi=>
H128 M1Wz[YN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml7CSG1UVw>? NWPwd4k6UUN3ME2xPEBvVQ>? M3ziXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{O0OVY6Lz5zMUOzOFU3QTxxYU6=
SK-BR-3 MmftZ5l1d3SxeHnjbZR6KGG|c3H5 MUDEUXNQ NWjuR45mUUN3ME2yNEBvVQ>? M1HS[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{O0OVY6Lz5zMUOzOFU3QTxxYU6=
LX-1 M4C1OYN6fG:2b4jpZ4l1gSCjc4PhfS=> M2Ow[mROW09? MV7JR|UxRTF{MDDuUS=> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTh3OEezO{c,OTF6NUi3N|c9N2F-
HCT116 MW\jfZRwfG:6aXPpeJkh[XO|YYm= NV7MV3NmTE2VTx?= NEDXfVhKSzVyPUmgcm0> MkjWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF6NUi3N|coRjFzOEW4O|M4RC:jPh?=
A2780 MX3jfZRwfG:6aXPpeJkh[XO|YYm= M1flWWROW09? NGXaclhKSzVyPUSgcm0> MlvFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF6NUi3N|coRjFzOEW4O|M4RC:jPh?=
IMR-32 NI\LUGxkgXSxdH;4bYNqfHliYYPzZZk> NF;vbWF,OTBizszN NGrxZZlFVVOR NX34N2IzUUN3ME2yMlIyKG6P MkjMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4MUe4PVQoRjF{NkG3PFk1RC:jPh?=
P388 MkWzZ5l1d3SxeHnjbZR6KGG|c3H5 NV\v[|ZEUUN3ME2xN{BvVQ>? MnnWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4MkCwPFEoRjF{NkKwNFgyRC:jPh?=
Lewis NHnXN5BkgXSxdH;4bYNqfHliYYPzZZk> NG[we5NKSzVyPUOzJI5O NGfDWWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[yNFA5OSd-MUK2NlAxQDF:L3G+
JLC NGm3eZZkgXSxdH;4bYNqfHliYYPzZZk> NIrz[WRKSzVyPUWuOkBvVQ>? MkfUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4MkCwPFEoRjF{NkKwNFgyRC:jPh?=
HT-29 MWDjfZRwfG:6aXPpeJkh[XO|YYm= NHO3XpNKSzVyPUGuOEDPxE1? NVe4clJHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2N|k2PDFpPkGyOlM6PTRzPD;hQi=>
Caki-2 MXfjfZRwfG:6aXPpeJkh[XO|YYm= MVXJR|UxRTNwOU[g{txO MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ|OUW0NUc,OTJ4M{m1OFE9N2F-
A549 MoDxZ5l1d3SxeHnjbZR6KGG|c3H5 M3XKcGlEPTB;Mj61N{DPxE1? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ|OUW0NUc,OTJ4M{m1OFE9N2F-
HEC-1-B NVuyXIxM[3m2b4TvfIlkcXS7IHHzd4F6 M37CPGlEPTB;OD62OEDPxE1? M{Xrc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkO5OVQyLz5zMk[zPVU1OTxxYU6=
HL-60 MnuzZ5l1d3SxeHnjbZR6KGG|c3H5 NYrCN495UUN3ME22OkBvVQ>? NX;1eI9VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2N|k2PDFpPkGyOlM6PTRzPD;hQi=>
Col2 MmjrZ5l1d3SxeHnjbZR6KGG|c3H5 NEi2RYF,OSEQvF2= NVWxZotqTUR3ME21O{BvVQ>? NXvLb4x6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
HUVEC MnfhZ5l1d3SxeHnjbZR6KGG|c3H5 NVm0XlZEhjFizszN NEnOdoVGTDVyPUK1PEBvVQ>? NH\qZWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
KB NWLW[|c5[3m2b4TvfIlkcXS7IHHzd4F6 MV3+NUDPxE1? NGPWbZRGTDVyPUKyJI5O M3\0[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA4Lz5zNUC0N|QxPzxxYU6=
LCNaP NX6ybng6[3m2b4TvfIlkcXS7IHHzd4F6 NXfC[ppwhjFizszN NVS3VlZWTUR3ME2yPEBvVQ>? NFu0TnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
Lu1 NUDMUnFp[3m2b4TvfIlkcXS7IHHzd4F6 MmjpglEh|ryP NYfzXG5{TUR3ME2yPUBvVQ>? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
RPMI8402 NUf6U2lw[3m2b4TvfIlkcXS7IHHzd4F6 M4DnTp4yOCEQvF2= MYfJR|UxRTZibl2= MmDDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV2OEK5NlkoRjF3NEiyPVI6RC:jPh?=
CPT-K5 MV3jfZRwfG:6aXPpeJkh[XO|YYm= NH7QSlV,OTBizszN NYr1bVdCUUN3ME6xNEDPxE1? MnXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV2OEK5NlkoRjF3NEiyPVI6RC:jPh?=
P388 M1TNN4N6fG:2b4jpZ4l1gSCjc4PhfS=> NUe1WlVVhjFyIN88US=> NWrNU|JbUUN3ME2xOEBvVQ>? NV3GOmI6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
P388/CPT45 M1LPNoN6fG:2b4jpZ4l1gSCjc4PhfS=> NGrERYp,OTBizszN M3fuZ2lEPTB-MUCg{txO MoDRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV2OEK5NlkoRjF3NEiyPVI6RC:jPh?=
KB3-1 MlnFZ5l1d3SxeHnjbZR6KGG|c3H5 MlrHglExKM7:TR?= MXLJR|UxRTRyIH7N NGPwdoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUS4NlkzQSd-MUW0PFI6Ojl:L3G+
KBV-1 + MDR1 NXe0[JM6[3m2b4TvfIlkcXS7IHHzd4F6 MV\+NVAh|ryP MUnJR|UxRTR2MDDuUS=> NVPmPGl4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
KBH MoP3Z5l1d3SxeHnjbZR6KGG|c3H5 M3T4TZ4yOCEQvF2= MYTJR|UxRTR2MDDuUS=> Mn\xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV2OEK5NlkoRjF3NEiyPVI6RC:jPh?=
HOP-62 M1r1eoN6fG:2b4jpZ4l1gSCjc4PhfS=> MX;+NVAh|ryP MnG3S2k2OD1zMDDuUS=> NETnNGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE3PCd-MUW1NFkyPjR:L3G+
HCT-116 NXfkcYky[3m2b4TvfIlkcXS7IHHzd4F6 MkK0glExKM7:TR?= NYfEV|lWT0l3ME2zNEBvVQ>? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG2OEc,OTV3MEmxOlQ9N2F-
F-539 MXrjfZRwfG:6aXPpeJkh[XO|YYm= NFHwN3d,OTBizszN MUjHTVUxRTFyIH7N M1nGclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVY1Lz5zNUWwPVE3PDxxYU6=
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MCF-7 M1\nSYN6fG:2b4jpZ4l1gSCjc4PhfS=> NH3HU4hKSzVyPUSwJI5O NFvwZ2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{K1OFY3QSd-MUeyOVQ3Pjl:L3G+
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SKVLB MkS5Z5l1d3SxeHnjbZR6KGG|c3H5 NFvBfYFKSzVyPUWzJI5O MmrhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTByM{WyNEc,QTByM{WyNFww[T5?
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PC-3 MYDHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NWSySYw1hjFizszN NILDZ|BFVVOR NHjsTmZKSzVyPUW3JI5O NGG0SGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OEe2NVEyLz57OEe2NVEyRC:jPh?=
K562adr MoXES5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MXf+NUDPxE1? MVTEUXNQ MUPJR|UxRTV5IH7N NVLybpJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUi3OlEyOSd-OUi3OlEyOTxxYU6=
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L1210 MX3GeY5kfGmxbjDhd5NigQ>? MXzDc45k\W62cnH0bY9vKHSqYYSgbY5pcWKrdIOgeIhmKHC{b3zp[oVz[XSrb36gc4YhVDF{MUCgZ4VtdHNiYomgOVAmNCCLQ{WwQVAvODF2zszNMi=> M{nPVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{e0NlgoRjJ3M{e0Nlg9N2F-
SK-OV-3 Mk[1R5l1d3SxeHnjbZR6KGG|c3H5 NXvnTGExS3m2b4TvfIlkcXS7IIfhd{Bl\XSncn3pcoVlKGmwII\peJJwKGmwIGPLMW9XNTNiY3XscJMhMG:4YYLpZY4qKG:oIHj1cYFvKHS3bX;yJINmdGxibHnu[ZMh[nlidYPpcochVVSWIHHzd4F6NCCLQ{WwQVAvODN5zszNMi=> Mn;sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzh3M{OzNUc,Pzh3M{OzNVww[T5?
SKVLB MXrDfZRwfG:6aXPpeJkh[XO|YYm= NF7GPGlEgXSxdH;4bYNqfHlid3HzJIRmfGW{bXnu[YQhcW5idnn0do8hcW5iU1vWUGIh[2WubIOoc5ZiemmjbjD3bZRpKHWycnXneYxifGWmIF3EVpAu\2y7Y3;wdo91\WmwKTDv[kBpfW2jbjD0eY1weiClZXzsJIxqdmW|IHL5JJV{cW6pIF3UWEBie3OjeTygTWM2OD1yLkC0Ne69VS5? MlrmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzh3M{OzNUc,Pzh3M{OzNVww[T5?
HT-29 NVPPTmFqS3m2b4TvfIlkcXS7IHHzd4F6 NIOxeY9EgXSxdH;4bYNqfHlid3HzJIRmfGW{bXnu[YQhcW5idnn0do8hcW5iSGStNlkh[2WubIOoZ49td25rIH;mJIh2dWGwIIT1cY9zKGOnbHygcIlv\XNiYomgeZNqdmdiTWTUJIF{e2G7LDDJR|UxRTBwMES2{txONg>? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QDV|M{OxK|44QDV|M{OxQE9iRg>?
LOX M2jOUGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3vqUmN6fG:2b4jpZ4l1gSC5YYOg[IV1\XKvaX7l[EBqdiC4aYTyc{BqdiCOT2igZ4VtdHNiKH3lcIFvd22jKTDv[kBpfW2jbjD0eY1weiClZXzsJIxqdmW|IHL5JJV{cW6pIF3UWEBie3OjeTygTWM2OD1yLkC0PO69VS5? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QDV|M{OxK|44QDV|M{OxQE9iRg>?
T47D M2j4SmN6fG:2b4jpZ4l1gSCjc4PhfS=> MkDIR5l1d3SxeHnjbZR6KHejczDk[ZRmem2rbnXkJIlvKH[rdILvJIlvKFR2N1SgZ4VtdHNqYoLlZZN1MSCxZjDoeY1idiC2dX3vdkBk\WyuIHzpcoV{KGK7IIXzbY5oKE2WVDDhd5NigSxiSVO1NF0xNjJyN988UU4> Mm\1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzh3M{OzNUc,Pzh3M{OzNVww[T5?
L1210 MXfDfZRwfG:6aXPpeJkh[XO|YYm= NGHFcYFEgXSxdH;4bYNqfHlid3HzJI1m[XO3cnXkJI9vKGO3bIT1doVlKG23cnnu[UBtgW2yaH;icIF{fGmlIHzleYtmdWmjIHPlcIx{KCiOMUKxNEktKEmFNUC9NE4xOTYQvF2u M3jDdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh{NE[yN|goRjh{NE[yN|g9N2F-
HL-60 NXG2cXBkTnWwY4Tpc44h[XO|YYm= NFi1[3pKdmirYnn0bY9vKG:oIGTvdI9qe2:vZYLhd4UhUSCkeTDjcIVifmGpZTDjc41xdGW6IH\vdo1ifGmxbjDpckBpfW2jbjDIUE03OCClZXzsd{whUUN3ME2wMlY5|ryPLh?= MljpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDRzMEm4NUc,QDRzMEm4NVww[T5?
KB NVfS[41uT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NELQ[nREd22yb4Xu[EBkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTD0bIUh\Xiyb37lcpRq[WxiZ4Lve5RpKG:oIFvCJINmdGy|IHL5JFUxLSxiQ1O1NF0xNjByNt88UU4> M1nyflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl5Nke2N|IoRjl5Nke2N|I9N2F-
MT-4 NF;MWnJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGrveVhEd22yb4Xu[EBkd26lZX70doF1cW:wIILldZVqemWmIITvJJJm\HWlZTD0bIUh\Xiyb37lcpRq[WxiZ4Lve5RpKG:oIF3UMVQh[2WubIOgZpkhPTBnLDDDR|UxRTBwMEJOwG0v NITFTlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97N{[3OlMzLz57N{[3OlMzRC:jPh?=
COLO 205 MUDDfZRwfG:6aXPpeJkh[XO|YYm= MUfDfZRwfG:6aXPpeJkh\XiycnXzd4VlKGG|IITo[UBkd26lZX70doF1cW:wIIToZZQhcW6qaXLpeIVlKGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKGOnbHz1cIFzKESQQTDv[kBpfW2jbjDjc4xwemWldHHsJINmdGy|IDjDU2xQKDJyNTmsJGlEPTB;MD6wNFU1|ryPLh?= NWLybZc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0O|kzQTNpPkGwOFc6Ojl|PD;hQi=>
HepG2 NUPF[HFHS3m2b4TvfIlkcXS7IHHzd4F6 NEfpVolEgXSxdH;4bYNqfHliZYjwdoV{e2WmIHHzJJRp\SClb37j[Y51emG2aX;uJJRp[XRiaX7obYJqfGWmIHnuZ49zeG:{YYTpc44hd2ZiW{PIYZRpgW2rZHnu[UBqdnSxIHPlcIx2dGG{IFTORUBw\iCqdX3hckBp\XCjdH;j[YxtfWyjcjDj[YxteyBqSHXwS|IqNCCLQ{WwQVAvODB4M988UU4> Mmm5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB2N{myPVMoRjFyNEe5Nlk{RC:jPh?=
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MDA-MB-435 NGnadnFHfW6ldHnvckBie3OjeR?= M2TMXmlvcGmkaYTpc44h[WejaX7zeEBOTEFvTVKtOFM2KGi3bXHuJIJz\WG|dDDjZY5k\XJiY3XscJMhcW5idHjlJIFje2WwY3Wgc4YhUFODLDDJR|UxRTBwMEG1{txONg>? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB3MkiwNkc,OTFyNUK4NFI9N2F-
MDA-MB-435 NXTQOHczTnWwY4Tpc44h[XO|YYm= MV3Jcohq[mm2aX;uJIFo[Wmwc4SgUWRCNU2ELUSzOUBpfW2jbjDidoVie3RiY3HuZ4VzKGOnbHzzJIlvKHSqZTDwdoV{\W6lZTDv[kAyOSCvZz;tUEBJW0FuIFnDOVA:OC5|N{ZOwG0v MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB3MkiwNkc,OTFyNUK4NFI9N2F-
Jurkat NUi1Rm16TnWwY4Tpc44h[XO|YYm= NVzCWoNJUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEq3cnvheEBpfW2jbjDs[ZVs\W2rYTDj[YxteyxiSVO1NF0xNjByNUdOwG0v M1;McVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{i0NlQ2Lz5zMUO4OFI1PTxxYU6=
P388 MlrISpVv[3Srb36gZZN{[Xl? M3jp[mlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBROzh6IH31dolv\SCuZYXr[Y1q[SClZXzsd{whUUN3ME2wMlAyO87:TT6= M4rMeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{i0NlQ2Lz5zMUO4OFI1PTxxYU6=
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DU145 M4jrSGN6fG:2b4jpZ4l1gSCjc4PhfS=> NV\6[5k2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNuIFfJOVA:OC5yMd88UU4> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRyMkeyNkc,OTd2MEK3NlI9N2F-
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HEK293 M1TlWmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3TsXVIh\GG7cx?= NVjvVYQ5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEWNMkmzJINmdGy|IHHmeIVzKDJiZHH5d{BjgSClZXzsJINwfW62aX7nJItqfC16IHHuZYx6e2m|LDDJR|UxRTFwMEJOwG0v MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjVyM{[1Okc,OjJ3MEO2OVY9N2F-
DU145 NXPtVmFvS3m2b4TvfIlkcXS7IHHzd4F6 NIrmZW4zKGSjeYO= NV:4[WNFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYX\0[ZIhOiCmYYnzJIJ6KGOnbHygZ492dnSrbnegb4l1NThiYX7hcJl{cXNuIFnDOVA:OS5yNt88UU4> NELaZlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWwN|Y2Pid-MkK1NFM3PTZ:L3G+
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T47D M3rBcmN6fG:2b4jpZ4l1gSCjc4PhfS=> NWGzZY9CPzJiaILz NELvclVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVPDeGIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9PU4yP87:TT6= MmXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MUm5OFIoRjJ{OEG5PVQzRC:jPh?=
DU145 Mo\uR5l1d3SxeHnjbZR6KGG|c3H5 M3TBdlczKGi{cx?= MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUmuNlnPxE1w MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjhzOUm0Nkc,OjJ6MUm5OFI9N2F-
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