Topo I 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S3898 Hydroxy Camptothecine

Hydroxy Camptothecine (10-Hydroxycamptothecin, Hydroxycamptothecine) is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.

Selective
S0093 Genz-644282

Genz-644282 is a non-camptothecin topoisomerase I (Topo I) inhibitor which can used in cancer research.

Selective Topo I, IC50: 1.2 nM
S1231 Topotecan (NSC609699) HCl

Topotecan HCl是一种拓扑异构酶I抑制剂,作用于MCF-7 Luc细胞和DU-145 Luc细胞,无细胞试验中IC50分别为13 nM和2 nM。

Selective Topo I (MCF-7 Luc cells), IC50: 13 nM; Topo I (DU-145 Luc cells), IC50: 2 nM
S1288 Camptothecin (NSC-100880)

Camptothecin是一种特异性的DNA拓扑异构酶I (Topo I)抑制剂,IC50为0.68 μM。Phase 2。

Selective Topo I, IC50: 0.68 μM
S3603 Betulinic acid

Betulinic acid是一种天然的五环三萜类化合物,具有抗病毒,抗疟药,抗发炎和抗肿瘤的特性。Phase 1/2

Selective Eukaryotic topoisomerase I, IC50: 5 μM
S9321 Topotecan

Topotecan is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.

Selective
S4908 SN-38

SN-38是CPT-11的一种活性代谢物,抑制DNA topoisomerase I,DNA合成,并造成频繁的DNA单链断裂。

Selective
S2423 (S)-10-Hydroxycamptothecin

(S)-10-Hydroxycamptothecin是DNA拓扑异构酶I抑制剂,具有有效的抗肿瘤活性。

Selective
S6631 Belotecan (CKD-602) hydrochloride

Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor.

Selective
S2288 Rubitecan

Rubitecan (9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000) is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.

Selective
S7261 Beta-Lapachone

Beta-Lapachone是一种选择性的DNA topoisomerase I(DNA拓扑异构酶I)抑制剂,对DNA拓扑异构酶II或连接酶无抑制作用。Phase 2。

Selective
S2653 9-amino-CPT (9-Aminocamptothecin)

9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.

Selective
S5026 Irinotecan hydrochloride

Irinotecan (CPT-11, (+)-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

Selective
S1198 Irinotecan (CPT-11)

Irinotecan是一种Topoisomerase I抑制剂,作用于LoVo细胞和HT-29细胞,IC50分别为15.8 μM和5.17 μM。

Selective
S6747 SW-044248

SW-044248 is a non-canonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.

Selective
S5111 7-Ethylcamptothecin

7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.

Selective
S2217 Irinotecan (CPT-11) HCl Trihydrate

Irinotecan HCl Trihydrate通过抑制Topoisomerase 1(拓扑异构酶1)而防止DNA解链。

Selective
S1327 Ellagic acid

Ellagic acid具有抗增殖和抗氧化性能。

Pan
S2271 Berberine chloride (NSC 646666)

Berberine chloride是异喹啉类生物碱的季铵盐。

Pan