| S1288 |
Camptothecin (CPT)
|
Camptothecin (CPT)是一种特异性的DNA拓扑异构酶I (Topo I)抑制剂，IC50为0.68 μM。Camptothecin 在癌细胞中可通过microRNA-125b介导的线粒体信号通路来诱导凋亡。Phase 2。 |
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Cell Stem Cell, 2025, S1934-5909(25)00256-5
-
Nat Commun, 2025, 16(1):4491
-
EMBO J, 2025, 10.1038/s44318-025-00370-y
|
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| S9665 |
Motixafortide (BL-8040, BKT140)
|
Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) 是一种 CXCR4 的拮抗剂，IC50值约为1 nM。BL-8040 通过改变的miR-15a/16-1的表达，下调 ERK、BCL-2、MCL-1 和 cyclin-D1，诱导AML胚的凋亡。 |
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King's College London, 2023,
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| S3084 |
Guanosine 5'-triphosphate trisodium salt
|
Guanosine 5'-triphosphate (5'-GTP, Guanosine triphosphate, H4GTP) trisodium salt 是鼠细胞中成肌细胞分化的增强剂。Guanosine 5'-triphosphate trisodium salt 可上调miRNA（特别是miR133a和miR133b）和肌原性调节因子，并诱导人肌原性前体细胞在细胞外环境中释放出被鸟苷基分子（主要是鸟苷）填充的外泌体。 |
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| E3687 |
Radix Actinidiae Extract
|
Radix Actinidiae Extract来源于藤梨根Radix Actinidiae，即猕猴桃Actinidia chinensis Planch.的根，可通过调控微小核糖核酸(miRNA)的表达发挥抗癌作用。 |
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| S3309 |
Solasodine
|
Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) 是一种存在于茄科植物中的有毒的生物碱化合物。Solasodine 可降低 matrix metalloproteinase-2 (MMP-2)、MMP-9 和 matrix metalloproteinase (EMMPRIN) 的细胞外诱导剂的mRNA水平，但会增加 reversion-inducing cysteine-rich protein with kazal motifs (RECK)。Solasodine 下调致癌的 microRNA-21 (miR-21)，已知其靶向RECK。Solasodine 还可以减少 PI3K/Akt 信号传导途径并下调miR-21的表达。 |
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| S9067 |
Pseudoprotodioscin
|
Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. |
|
|
| S1288 |
Camptothecin (CPT)
|
Camptothecin (CPT)是一种特异性的DNA拓扑异构酶I (Topo I)抑制剂，IC50为0.68 μM。Camptothecin 在癌细胞中可通过microRNA-125b介导的线粒体信号通路来诱导凋亡。Phase 2。 |
- Cell Stem Cell, 2025, S1934-5909(25)00256-5
- Nat Commun, 2025, 16(1):4491
- EMBO J, 2025, 10.1038/s44318-025-00370-y
|
|
| S3309 |
Solasodine
|
Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) 是一种存在于茄科植物中的有毒的生物碱化合物。Solasodine 可降低 matrix metalloproteinase-2 (MMP-2)、MMP-9 和 matrix metalloproteinase (EMMPRIN) 的细胞外诱导剂的mRNA水平，但会增加 reversion-inducing cysteine-rich protein with kazal motifs (RECK)。Solasodine 下调致癌的 microRNA-21 (miR-21)，已知其靶向RECK。Solasodine 还可以减少 PI3K/Akt 信号传导途径并下调miR-21的表达。 |
|
|
| S9067 |
Pseudoprotodioscin
|
Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. |
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