Topo II 选择性抑制剂 | 激活剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S1228 Idarubicin HCl

Idarubicin HCl是蒽环类抗生素Idarubicin的盐酸盐形式,抑制MCF-7细胞中的DNA拓扑异构酶II (topo II),无细胞试验中IC50为3.3 ng/mL。

Selective Topo II (MCF-7 cells), IC50: 3.3 ng/mL
S3181 Flumequine

Flumequine是一种人工合成的化疗用抗生素,抑制拓扑异构酶II, IC50为15 μM。

Selective Topo II, IC50: 15 μM
S1367 Amonafide

Amonafide通过topoisomerase II(拓扑异构酶II)介导导致蛋白相关的DNA链断裂,但不会产生拓扑异构酶I介导的DNA裂解。Phase 3。

Selective
S1393 Pirarubicin (NSC-333054)

Pirarubicin是一种蒽环类抗生素,同时也是一种DNA/RNA合成抑制剂,掺入DNA并与topoisomerase II相互作用,是一种抗肿瘤药物。

Selective
S5627 Amsacrine hydrochloride

Amsacrine hydrochloride (m-AMSA, acridinyl anisidide) is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity.

Selective
S1208 Doxorubicin (Adriamycin) HCl

Doxorubicin (Adriamycin) HCl是一种抗生素类试剂,在肿瘤细胞中抑制DNA topoisomerase II,并诱导DNA损伤和凋亡。

Selective
S1342 Genistein (NPI 031L)

Genistein是一种来源于大豆的植物雌激素,是一种高特异性的蛋白酪氨酸激酶(PTK) 的抑制剂,在NIH-3T3细胞中通过EGF或者胰岛素介导而抑制有丝分裂,IC50分别为12μM和19 μM。

Selective
S6790 Ellipticine hydrochloride

Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.

Selective
S4119 Pefloxacin Mesylate Dihydrate

Pefloxacin Mesylate Dihydrate是第三代氟喹诺酮类抗菌药,可以抑制拓扑异构酶II的活性和DNA复制。

Selective
S5059 Pixantrone Maleate

Pixantrone (BBR-2778) is a novel aza-anthracenedione compound with antitumor activity. It is a weak topoisomerase II inhibitor and forms stable DNA adducts through alkylation with specificity for DNA hypermethylated sites.

Selective
S5008 Ciprofloxacin hydrochloride

Ciprofloxacin (CPX, Cetraxal, Ciloxan, Cipro, Bay-09867) hydrochloride, a fluorinated quinolone, is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases).

Selective
S9634 Phenoxodiol (Haginin E)

Phenoxodiol inhibits XIAP (an apoptosis inhibitor) and DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol activates the mitochondrial caspase system and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol is a synthetic analog of Genestein.

Selective
S1222 Dexrazoxane HCl (ICRF-187)

Dexrazoxane HCl (ICRF-187, ADR-529)是一种胞内铁螯合剂,能够减少氧自由基 的生成,是心脏保护剂。也是topoisomerase II的抑制剂。

Selective
S2064 Balofloxacin

Balofloxacin是一种喹诺酮类抗生素,通过干扰DNA促旋酶,而抑制细菌DNA合成。

Selective
S1225 Etoposide (VP-16)

Etoposide是一种鬼臼毒素的半合成衍生物,通过抑制topoisomerase II 活性而抑制DNA合成。

Selective
S7518 Voreloxin (SNS-595) hydrochloride

Voreloxin 是强效的广谱抗肿瘤活性的Topoisomerase II抑制剂。Phase 2。

Selective
s4604 Levofloxacin hydrate

Levofloxacin是一种广谱的第三代氟喹诺酮抗生素,是氧氟沙星具有光学活性的L型异构体,具有抗菌活性。它通过抑制DNA gyrase(细菌topoisomerase II) 发挥作用。

Selective
S1787 Teniposide

Teniposide 是一种化疗药物,主要用于治疗儿童急性淋巴细胞性白血病(ALL)。

Selective
S2485 Mitoxantrone (NSC-301739) 2HCl

Mitoxantrone 2HCl是Mitoxantrone的盐酸盐形式,是一种合成的抗肿瘤蒽二酮(IC50为0.42 mM)。

Selective
S2492 Novobiocin Sodium (NSC 2382)

Novobiocin Sodium 是一种非常有效的细菌DNA旋转酶和人体有机阴离子转运体,作用于hOAT1,hOAT3和hOAT4,Ki分别为14.87±0.40μM, 4.77±1.12μM 和 90.50±7.50μM。

Pan
S5964 Gatifloxacin hydrochloride

Gatifloxacin (AM-1155, CG5501, BMS-206584, PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases with IC50 of 13.8 μg/ml and 0.109 μg/ml for S. aureus topoisomerase IV and E. coli DNA gyrase, respectively.

Pan
S4006 Clinafloxacin

Clinafloxacin 是一种氟喹诺酮类药物,可以抑制肺炎双球菌中 DNA旋转酶和拓扑异构酶IV。

Pan
S1464 Marbofloxacin

Marbofloxacin是有效的抗生素,抑制细菌DNA复制。

Pan
S1465 Moxifloxacin (BAY12-8039) HCl

Moxifloxacin HCl是一种第四代喹诺酮类抗菌剂。

Pan
S2271 Berberine chloride (NSC 646666)

Berberine chloride是异喹啉类生物碱的季铵盐。

Pan
S1463 Ofloxacin

Ofloxacin是一种合成的广谱抗菌剂。

Pan
S1340 Gatifloxacin

Gatifloxacin是第四代喹诺酮类抗生素。

Pan
S1756 Enoxacin

Enoxacin 是一种口服的广谱喹诺酮类抗菌剂,用于治疗尿路感染和淋病。常见的副作用有失眠。

Pan
S1940 Levofloxacin

Levofloxacin 是一种宽谱的的抗生素类 topoisomerase IItopoisomerase IV抑制剂,用于治疗呼吸道,尿道及消化道感染。

Pan
S1327 Ellagic acid

Ellagic acid具有抗增殖和抗氧化性能。

Pan
S2328 Nalidixic acid

Nalidixic acid 是一种合成的1,8-二氮杂萘类抗菌剂,具有有限的抗菌谱,抑制细菌DNA促旋酶的A亚基。

Pan