Doxorubicin (Adriamycin) HCl

Pfizer辉瑞授权 目录号:S1208 别名: NSC 123127, DOX, Doxorubicin hydrochloride, Hydroxydaunorubicin HCl 中文名称:盐酸多柔比星,盐酸阿霉素

仅限科研使用

Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl是一种抗生素类试剂,可抑制DNA topoisomerase II,并在肿瘤细胞中诱导DNA损伤、线粒体自噬和凋亡。Doxorubicin 可降低 AMPK的基础磷酸化。Doxorubicin 可应用于HIV感染病人的联合治疗,但是在免疫治疗中有将HBV重活化的风险。

Doxorubicin (Adriamycin) HCl Chemical Structure

CAS: 25316-40-9

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 960.91 现货
RMB 736.03 现货
RMB 1712.71 现货
RMB 5473.95 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Doxorubicin (Adriamycin) HCl发表文献850篇:

产品安全说明书

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

生物活性

产品描述 Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl是一种抗生素类试剂,可抑制DNA topoisomerase II,并在肿瘤细胞中诱导DNA损伤、线粒体自噬和凋亡。Doxorubicin 可降低 AMPK的基础磷酸化。Doxorubicin 可应用于HIV感染病人的联合治疗,但是在免疫治疗中有将HBV重活化的风险。
靶点
AMPK [6] Topo II [1]
(Tumor cells)
体外研究

Adriamycin是抗菌的蒽环霉素,通常在两种水平发挥其抗肿瘤活性,改变DNA,和产生自由基,通过DNA损伤,触发癌细胞凋亡。Adriamycin 通过插入到 DNA链中而阻断DNA合成,且抑制DNA拓扑异构酶 II(TOP2)。Adriamycin 作用于快速增值和表达高水平TOP2的细胞最有效。此外, Adriamycin通过产生神经酰胺(通过激活p53 或其他下游通路如JNK而促进凋亡)而触发凋亡,通过丝苏氨酸蛋白酶而降解,线粒体中释放细胞色素 c,提高 FasL(死亡受体Fas/CD95 配体)mRNA产量, 且产生更多的自由基。[2] 使用GSNO(亚硝基谷胱甘肽)预处理,抑制抗Doxorubicin的乳腺癌细胞系MCF7/Dx,伴随着增强蛋白谷胱甘肽和核中Doxorubicin 的积累。[3] 在共济失调毛细血管扩张症突变(ATM),及ATM 和 Rad3相关的(ATR)信号通路中,提高的 cyclin G2(CycG2)表达和蛋白磷酸化修饰导致Adriamycin诱导的G2/M 检查点停滞。[5] Adriamycin作用于小鼠胚胎成纤维细胞(MEFs)和心肌细胞,抑制AMP活化蛋白激酶(AMPK),导致SIRT1 功能障碍,p53 累积, 且促进细胞死亡。[6] Adriamycin产生明显的热休克反应,抑制热休克蛋白或使热休克蛋白沉默增强,Adriamycin增强促进神经母细胞瘤细胞凋亡的效果。在不可测量蛋白酶抑制的条件下,纳摩尔Adriamycin处理神经母细胞瘤细胞,使特定的一系列蛋白过泛素化,这种作用存在剂量依赖性,且引起泛素化酶,如乳酸脱氢酶和α-烯醇酶的缺失,α-enolase, 蛋白泛素化模式与蛋白酶抑制剂Bortezomib相似,说明Adriamycin也可通过损伤蛋白而发挥作用。[8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 NW[3cGM3TnWwY4Tpc44hSXO|YYm= MUXJcohq[mm2aX;uJI9nKFKQQTDzfY51cGW|aYOge4l1cCCHREWwJI9nKDBwNUig{txO M{Xn[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzR7MEWzOkc,PDlyNUO2QE9iRg>?
Yoshida sarcoma MVjGeY5kfGmxbjDBd5NigQ>? MlflTY5pcWKrdHnvckBw\iCdM1jdWIRTKGmwY3;ydI9z[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEKg{txO MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOzJ{OUi2K|4yOzJ{OUi2QE9iRg>?
CHO NHSxc|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwME[g{txO MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOzV2N{WwK|4yOzV2N{WwQE9iRg>?
8226 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPNR|RKSzVyPUCuNFM{KM7:TR?= NFe2Z5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNES3O|MxLz5zNES3O|MxRC:jPh?=
8226/ADR NXe1dmx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoC0TWM2OD1yLkW2JO69VQ>? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDR5N{OwK|4yPDR5N{OwQE9iRg>?
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KBM-3 MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ruVGlEPTB;MD6wNlYh|ryP NX\ESmJERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5OVg4Pyd-MUm5OVg4PzxxYU6=
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NCI-H1155 Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTV5OT64O{BvVQ>? NHn2bGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzR4Mz:nQnNCVkeHUkyvZV4>
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NCI-H1623 NFzTfmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HibWlEPTB;NkC0MlYhdk1? M1LqUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PDZ|Lze+V2FPT0WUPD;hQi=>
MN-60 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfEdpN7UUN3ME22NFUvOzdibl2= NFrifHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzR4Mz:nQnNCVkeHUkyvZV4>
JAR NX;NfnRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTZ{NT65OUBvVQ>? NUDudoxLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTN2NkOvK|5USU6JRWK8M4E,
HCC1419 NF\GXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrqXFJKSzVyPU[zNU44PCCwTR?= M3Pk[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PDZ|Lze+V2FPT0WUPD;hQi=>
LU-165 NVrDOJV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\od3k2UUN3ME22N|kvPCCwTR?= Ml;SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVM1PjNxJ{7TRW5ITVJ:L3G+
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DG-75 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUS3OlY1UUN3ME22OlUvQDNibl2= M4nTbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU{PDZ|Lze+V2FPT0WUPD;hQi=>
PFSK-1 NHuyV3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn5O2JKSzVyPU[3PE4xQCCwTR?= NHv4bG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OzR4Mz:nQnNCVkeHUkyvZV4>
MK