Doxorubicin (Adriamycin) HCl

Pfizer辉瑞授权 目录号:S1208 别名: NSC 123127

Doxorubicin (Adriamycin) HCl Chemical Structure

Molecular Weight(MW): 579.98

Doxorubicin (Adriamycin) HCl是一种抗生素类试剂,在肿瘤细胞中抑制DNA topoisomerase II,并诱导DNA损伤和凋亡。

规格 价格 库存 购买数量  
RMB 960.91 现货
RMB 736.03 现货
RMB 1712.71 现货
RMB 5473.95 现货
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客户使用Selleck该产品发表文献36篇:

客户使用该产品的10个实验数据:

  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (F) Kaplan-Meier curves are shown for all groups described: no hydrogel, a hydrogel loaded with paclitaxel, or a hydrogel loaded with doxorubicin. The number of mice per group (n) and median survival (ms) are listed. The experiment was performed at least three times.

    Science, 2018, 10(433), doi: 10.1126/scitranslmed.aar1916. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • MM.1S cells inducibly expressing shRNA targeting SIRT6 were grown with or without doxycycline, and then treated with vehicle, doxorubicin (Doxo; 1 μM) or melphalan (mel; 100 μM) for 1 hour prior to the preparation of lysates and analyzed by western blotting. Representative immunoblots (n = 3) for the indicated proteins in MM cells are shown.

    Blood, 2016, 127(9):1138-50. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017, 16(5):468-476. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  •  

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) HCl purchased from Selleck.

产品安全说明书

Topoisomerase抑制剂选择性比较

生物活性

产品描述 Doxorubicin (Adriamycin) HCl是一种抗生素类试剂,在肿瘤细胞中抑制DNA topoisomerase II,并诱导DNA损伤和凋亡。
靶点
Topo II [1]
(Tumor cells)
体外研究

Adriamycin是抗菌的蒽环霉素,通常在两种水平发挥其抗肿瘤活性,改变DNA,和产生自由基,通过DNA损伤,触发癌细胞凋亡。Adriamycin 通过插入到 DNA链中而阻断DNA合成,且抑制DNA拓扑异构酶 II(TOP2)。Adriamycin 作用于快速增值和表达高水平TOP2的细胞最有效。此外, Adriamycin通过产生神经酰胺(通过激活p53 或其他下游通路如JNK而促进凋亡)而触发凋亡,通过丝苏氨酸蛋白酶而降解,线粒体中释放细胞色素 c,提高 FasL(死亡受体Fas/CD95 配体)mRNA产量, 且产生更多的自由基。[2] 使用GSNO(亚硝基谷胱甘肽)预处理,抑制抗Doxorubicin的乳腺癌细胞系MCF7/Dx,伴随着增强蛋白谷胱甘肽和核中Doxorubicin 的积累。[3] 在共济失调毛细血管扩张症突变(ATM),及ATM 和 Rad3相关的(ATR)信号通路中,提高的 cyclin G2(CycG2)表达和蛋白磷酸化修饰导致Adriamycin诱导的G2/M 检查点停滞。[5] Adriamycin作用于小鼠胚胎成纤维细胞(MEFs)和心肌细胞,抑制AMP活化蛋白激酶(AMPK),导致SIRT1 功能障碍,p53 累积, 且促进细胞死亡。[6] Adriamycin产生明显的热休克反应,抑制热休克蛋白或使热休克蛋白沉默增强,Adriamycin增强促进神经母细胞瘤细胞凋亡的效果。在不可测量蛋白酶抑制的条件下,纳摩尔Adriamycin处理神经母细胞瘤细胞,使特定的一系列蛋白过泛素化,这种作用存在剂量依赖性,且引起泛素化酶,如乳酸脱氢酶和α-烯醇酶的缺失,α-enolase, 蛋白泛素化模式与蛋白酶抑制剂Bortezomib相似,说明Adriamycin也可通过损伤蛋白而发挥作用。[8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 MWXGeY5kfGmxbjDBd5NigQ>? MWDJcohq[mm2aX;uJI9nKFKQQTDzfY51cGW|aYOge4l1cCCHREWwJI9nKDBwNUig{txO NFfaSJo1QTB3M{[=
Yoshida sarcoma NXfKTFVDTnWwY4Tpc44hSXO|YYm= NVfvOYlGUW6qaXLpeIlwdiCxZjDbN2heXGSUIHnuZ49zeG:{YYTpc44hf2m2aDDJR|UxKG:oIECuNFIh|ryP Mn[0NVMzOjl6Nh?=
CHO NFHoSJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwME[g{txO M2Oxe|E{PTR5NUC=
8226 MnniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7JTWM2OD1yLkCzN{DPxE1? MYexOFQ4PzNy
8226/ADR M2nN[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{iwPWlEPTB;MD61OkDPxE1? MVqxOFQ4PzNy
MCF7/ADR MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInOdFdKSzVyPUOuNUDPxE1? M1jXbFE1PDd5M{C=
H69 NFjCfpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jBeGlEPTB;MD64O{DPxE1? NEjIUm8yPDd7NUi1
N417 MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMkOg{txO MlSzNVQ4QTV6NR?=
H9 M3HaWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrTPJdvUW6qaXLpeIlwdiCxZjDIPUBk\WyuczDjbJJwdmmlYXzsfUBqdm[nY4Tl[EB4cXSqIITo[UBJUVZvMTCoTFkwUUmLQjmge4l1cCCLREWwJI9nKDBwMEGg{txO NUHEdFExOTV2OE[4NS=>
T-C8166 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fDWGlFPTB;MD6wNUDPxE1? MljDNVU1QDZ6MR?=
T-H9 NUnCWJc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPJTWQ2OD1yLkCxJO69VQ>? NIL4eHAyPTR6Nkix
T-MT4 M4XvWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D5TmlFPTB;MD6wNUDPxE1? NEfBe5AyPTR6Nkix
SKMEL-5 NUC5Um1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDFSFUxRTNwMjFOwG0> MYSxOlE{PzV|
MLM M2PMOmN6fG:2b4jpZ{BCe3OjeR?= MnT2SWQ2OD1yLkGzJO69VQ>? M2PhVVE5PzV|NUC=
KBM-3 NWrtc4hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXuyO|NKUUN3ME2wMlAzPiEQvF2= NXS4fWVMOTl7NUi3Oy=>
HT-29 NF76dY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HiflAvODFizszn Mk\UOFghcA>? NFL3WpdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fS=> MoHINlc4QDR2OR?=
EMT6 NI\qcYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITxfHExNjVizszN M3XUelEhcA>? MYLJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gZpkhdWWjc4XybY5oKG[xcjDzeZJ3cX[rbneg[pJi[3Srb37zJJdqfGhiRVS1NEBw\iByLkCwNFEh|ryP NHq5Uok4PDV{Nke0
H2981 MUHDfZRwfG:6aXOgRZN{[Xl? MmfTTWM2OD1yLkWg{txO NE\XUow4PzNzMEKz
LOX M3vEeWN6fG:2b4jpZ{BCe3OjeR?= M2XabGlEPTB;MD6wOFIh|ryP Mm\jO|g2OzN|MR?=
C38 NVXlVFd4S3m2b4TvfIlkKEG|c3H5 M2[5cmlEPTB;MD6wNUDPxE1? NH;2d3U5ODV5Mkmx
EAC NE[zZ2NEgXSxdH;4bYMhSXO|YYm= MlG4O|IhcA>? NYfV[2UxUUN3ME2wMlM2KM7:TR?= NYXLUFdPQDN3MEC4Oy=>
SKVLB M{LwR2N6fG:2b4jpZ{BCe3OjeR?= MW\JR|UxRTVwNjFOwG0> MX24OVc3QTF2
AUC375 M2TBeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LkNGlEPTB;MD6xNVIh|ryP NGmwNJg5PjR6NkCw
A2780-C25 M4rTT2N6fG:2b4jpZ{BCe3OjeR?= NY\iUHBoS3m2b4TvfIlkcXS7IHHnZYlve3Rib4jhcIlxdGG2aX6tdoV{cXO2YX70JGEzPzhyLVOyOUB4cXSqIFnDOVAhd2ZiMD6wOlMh|ryP NGPSVGw5QDNzN{W1
A2780-CP3 M2nGRmN6fG:2b4jpZ{BCe3OjeR?= MmPrR5l1d3SxeHnjbZR6KGGpYXnud5Qh[2m|cHzheIlvNXKnc3nzeIFvfCCDMke4NE1EWDNid3n0bEBKSzVyIH;mJFAvODV4IN88US=> NEnOTIY5QDNzN{W1
A2780-DX5 M{LGZWN6fG:2b4jpZ{BCe3OjeR?= MlK5R5l1d3SxeHnjbZR6KGGpYXnud5Qh\G:6b4L1ZolkcW5vcnXzbZN1[W62IFGyO|gxNUS[NTD3bZRpKEmFNUCgc4YhOC5|NUeg{txO NHLXXpc5QDNzN{W1
MXF7 NEWyTpFEgXSxdH;4bYMhSXO|YYm= M3rXNWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JJNmdnOrdHn2[UBOYEZ5IIfpeIghUUN3MDDv[kAxNjB{ODFOwG0> M4nBbVg6PjB3NUi=
MXF7 MUfDfZRwfG:6aXOgRZN{[Xl? NXq2V4VtSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhdWm2b4jhcpRzd26nLYLld4l{fGGwdDDNXGY4KHerdHigTWM2OCCxZjCwMlAzQCEQvF2= NGDQWmU5QTZyNUW4
MXF7 M13LVGN6fG:2b4jpZ{BCe3OjeR?= NX\tfWpSSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5Qh\G:6b4L1ZolkcW5vcnXzbZN1[W62IF3YSlchf2m2aDDJR|UxKG:oIEGuNVczKM7:TR?= Mk\SPFk3ODV3OB?=
WiDr MnTJR5l1d3SxeHnjJGF{e2G7 MUPBZ5Rqfmm2eTDh[4FqdnO2IIPlcpNqfGm4ZTDXbWRzKGOnbHyge4l1cCCLQ{WwJI9nKDBwMEWzJO69VQ>? MkjWPFk3ODV3OB?=
MCF NYDEOIpITnWwY4Tpc44hSXO|YYm= NFrMVpVT\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKGG|c3Xzd4VlKGG|IHXubIFv[2WvZX70JIlvKGO7dH;0c5hq[2m2eTDv[kBi\HKrYX35Z4lv M2izXlg6QDRzNUG=
C6 MmH6R5l1d3SxeHnjJGF{e2G7 NUiyd|NsOi53IH3nM41N MXy3NkBp M2HLZ2ROW09? MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBz[XRiQ{[gZ4VtdHNiYYSgOVAhfWdxbVygeI8hOi53IH3nM41N NXnBb4NHQDl6OE[wOC=>
C6 MWXGeY5kfGmxbjDBd5NigQ>? M3TSe|IvPSCvZz;tUC=> MX[0JIg> NVXIPXBCTE2VTx?= M1LU[2lvcGmkaYTpc44hd2ZidIXieYxqdiCyb3z5cYVzcXqjdHnvci=> NHTQTHA5QTh6NkC0
C6 NIrqTpNEgXSxdH;4bYMhSXO|YYm= NY[3NIdQOi53IH3nM41N NELHRmc2KGh? NGT6TmlFVVOR MVvDfZRwfG:6aXPpeJkh[XO|ZYPz[YQh[XNiY3XscEBz\WynYYPl M1\PVlg6QDh4MES=
SKVLB NVjscoM2S3m2b4TvfIlkKEG|c3H5 M{PvdFczKGh? Mn20TWM2OD14LkW0JO69VQ>? NYjxOXZxQTByM{WyNC=>
MCF7/VP16 NFfl[JhEgXSxdH;4bYMhSXO|YYm= NF:1SVg2OCEQvHevcWw> M{XPXlczKGh? M2W2WmlEPTB;MUSuNkDPxE1? NGD0Wlg6ODJ{N{my
CA755 NHT3dXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LuelExKM7:TR?= NWPmc5R1PiCm NHHveWdKSzVyPUCuNFE1KM7:TR?= MYS5OVI3PTdy
CHO NEXx[GpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TBZ|ExKM7:TR?= NHXO[Ww3KGR? MX\JR|UxRTBwME[g{txO MVu5OVI3PTdy
Panc02 NEnwc5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX1WmlROTBizszN MVm2JIQ> MlTQTWM2OD1yLkC2OUDPxE1? Mn\0PVUzPjV5MB?=
PC14 NHe1SHBEgXSxdH;4bYMhSXO|YYm= NXvzVVZRPCCm M1fGd2ROW09? Mm\uTWM2OD1yLkK5JO69VQ>? NHToWVI6QDJ{NUSy
HOP62 NIHnZ3lEgXSxdH;4bYMhSXO|YYm= MYS3NkBp MYfJR|UxRTBwMEC0JO69VQ>? NEXKe3A6QDd|Nk[x
SF-295 M2nIemN6fG:2b4jpZ{BCe3OjeR?= M1jDSlczKGh? M4nKVmlEPTB;MD6wN|Uh|ryP M3Xz[lk5PzN4NkG=
MDA-MB-361 NWKzcItbS3m2b4TvfIlkKEG|c3H5 MnyzNUBp M136SGROW09? M1W5V2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQT3NRk0{PjFiZYjwdoV{e2mwZzDMZYNbKHerdHigTWM2OCCxZjCwMlAyOiEQvF2= MX6xNFM6PTR7MB?=
MDA-MB-361 NFTMT|FEgXSxdH;4bYMhSXO|YYm= NFnIVWYyKGh? MlT5SG1UVw>? M4PRcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQTDNRkA{PjFiZYjwdoV{e2mwZzDjZZJjd3i7cHXweIll[XOnIIP0R3BIOiC5aYToJGlEPTBib3[gNE4xOThizszN MmrnNVA{QTV2OUC=
CCRF-SB M1rUfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnHSVE1KGR? Mm\0SG1UVw>? NXX5fodTUUN3ME2wMlAyKM7:TR?= NH7sO4UyODRzMUS3Oi=>
CHO-K1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrxOEBl MnPYSG1UVw>? MYrJR|UxRTBwNDFOwG0> M4OyTVExPDFzNEe2
KB NUDVWHlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7xOEBl M2\DfmROW09? MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuEN1Sge4l1cCCLQ{WwJI9nKDBwNkWg{txO NXvo[op4OTB2MUG0O|Y>
KB NGDVR2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1THVlQh\A>? NFLKeGFFVVOR NHXCdmpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCR4FueHerdHigTWM2OCCxZjCwMlA3KM7:TR?= MX:xNFQyOTR5Nh?=
KB NFy1XGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXO0JIQ> NH\rUI5FVVOR NELrfJVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCUWRTKHerdHigTWM2OCCxZjCwMlUh|ryP NWDBSHNCOTB2MUG0O|Y>
KB MmfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljBOEBl NHvpVY1FVVOR NIPoT5hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCWlIxSyC5aYToJGlEPTBib3[gNE41KM7:TR?= NFrXZ40yODRzMUS3Oi=>
HTB-54 M{DNZWN6fG:2b4jpZ{BCe3OjeR?= NYHQboJEOTByIN88US=> NI\rZYtKSzVyPUGuNUDPxE1? NEjYeoYyODR5Nki2NS=>
MEL-AC NVW0Z5VrS3m2b4TvfIlkKEG|c3H5 MW[xNFAh|ryP MlnETWM2OD1zLkKg{txO MkHPNVA1PzZ6NkG=
DU145 NInFN3BEgXSxdH;4bYMhSXO|YYm= MoW1O|IhcA>? M4fZWWlEPTB;MD6wOVI5KM7:TR?= M{O1d|ExPDd7Mkiy
K562R M1PUZ2N6fG:2b4jpZ{BCe3OjeR?= NYLmVnp{PzJiaB?= NH3LWo9KSzVyPUCuNFE2PiEQvF2= M2TqTFExPDd7Mkiy
PACA-2 M3vLbWN6fG:2b4jpZ{BCe3OjeR?= NH3OfGM3KGR? MXXFSFUxRTBwMEC2N{DPxE1? MUSxNFQ6QDJzNB?=
3Y1 M4DJZmN6fG:2b4jpZ{BCe3OjeR?= MUK3NkBp MW\HTVUxRTBwMECzPEDPxE1? NXj2fohoOTB4OUG3NVA>
P388 NIPMNWhEgXSxdH;4bYMhSXO|YYm= NHvFRVA4OiCq NYfEXZg1T0l3ME2wMlAyOiEQvF2= MVWxNFY6OTdzMB?=
HMV-1 NGXsbohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWexSnd[UUN3ME2wMlI5KM7:TR?= NYD2eoVNOTB4OUi0N|Y>
MKN-1 NIDpeZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwNkSg{txO MX6xNFY6QDR|Nh?=
PC14 MnXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWSyOG12UUN3ME2xMlkh|ryP NYnldWh1OTB4OUi0N|Y>
T24 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET4XHNKSzVyPUCuOlQh|ryP MV2xNFY6QDR|Nh?=
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BT474 NUTKVWg3S3m2b4TvfIlkKEG|c3H5 MnnJO|IhcA>? Mn\mTWM2OD1yLkC3JO69VQ>? MYOyNVc1OTh|Mx?=
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NCI-H187 M2\mSGN6fG:2b4jpZ{BCe3OjeR?= NVz2[oM{PzJiaB?= Ml2wTWM2OD1yLkCzJO69VQ>? NVvWUVZUOjF5NEG4N|M>
A2780 MVrDfZRwfG:6aXOgRZN{[Xl? NFSzTmVKSzVyPUCuNFAyOiEQvF2= NV3aepBmOjF5N{S0PVk>
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RPMI-7951 M17C[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTF|MD6xOEBvVQ>? Mm\JV2FPT0WU
NCI-H1648 Ml\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVqybJFCUUN3ME2xN|EvQTRibl2= MoH0V2FPT0WU
NCI-H64 MkixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HvPGlEPTB;MUOyMlY2KG6P NWnI[YI4W0GQR1XS
HT-3 MknFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTF|Mz6wOEBvVQ>? MX3TRW5ITVJ?
NCI-H1770 NH\hU5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXBTWM2OD1zM{OuNlEhdk1? Mki2V2FPT0WU
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U-698-M MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fHfGlEPTB;MUO5MlUhdk1? M2PQOnNCVkeHUh?=
LU-99A NV;LNXFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrlTWM2OD1zNE[uOVUhdk1? MWnTRW5ITVJ?
NCI-H748 MmLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH4UXlKSzVyPUG0O{4{OSCwTR?= NH3OSFlUSU6JRWK=
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SNB75 Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3TTWM2OD1zNEiuOlUhdk1? Mnf3V2FPT0WU
BB65-RCC M4DYdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LkdGlEPTB;MUS5MlMyKG6P MmPlV2FPT0WU
NCI-H1355 NYn6RlF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjVXYxRUUN3ME2xOVIvOjRibl2= MmTyV2FPT0WU
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NCI-H2347 MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnJ[4RKSzVyPUG1PE4{PCCwTR?= M3;6cHNCVkeHUh?=
CAMA-1 NVWxZpBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTHTWM2OD1zNUmuN|Mhdk1? M1jtXnNCVkeHUh?=
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no-10 NITjUoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT6dVM6UUN3ME2xOlAvOzhibl2= NH3BbXdUSU6JRWK=
NCI-H2052 M{DxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\iTWM2OD1zNkCuOFchdk1? NEH2bo5USU6JRWK=
DB MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDxTWM2OD1zNkGuO|Ehdk1? M1\2O3NCVkeHUh?=
A4-Fuk MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fDOmlEPTB;MU[yMlQ5KG6P MVzTRW5ITVJ?
HCE-T MkXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n3bGlEPTB;MU[0Mlg4KG6P MkTuV2FPT0WU
HuP-T3 NHHPdpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf2[21KSzVyPUG2OU42PSCwTR?= MlnEV2FPT0WU
BC-3 MnPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkD2TWM2OD1zNkWuPFYhdk1? Mnn2V2FPT0WU
RVH-421 NYDJRVYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jib2lEPTB;MU[5MlE{KG6P NWjJbZRsW0GQR1XS
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HEL MkSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF5NT6xOUBvVQ>? MoTkV2FPT0WU
KLE NHrtdXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TpbmlEPTB;MUe1MlQ4KG6P NFjVXJFUSU6JRWK=
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ME-180 M{LNU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LuRmlEPTB;MUi2MlA5KG6P MUfTRW5ITVJ?
NB10 Ml;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjxW5dIUUN3ME2xPFgvODlibl2= NH3McI5USU6JRWK=
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COR-L105 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojrTWM2OD1zOEiuPVIhdk1? M{S5NHNCVkeHUh?=
HT-1376 MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PuN2lEPTB;MUi5MlAyKG6P MXnTRW5ITVJ?
RPMI-8866 NIi5bVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTF7Mj6xN{BvVQ>? M2m5RnNCVkeHUh?=
NCI-H2126 NGfqcHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLmPGk3UUN3ME2xPVIvOiCwTR?= NUnSeHFjW0GQR1XS
KARPAS-422 MnjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfoN5pKSzVyPUG5N{41OSCwTR?= M3vKWXNCVkeHUh?=
COLO-741 Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\se2lEPTB;MUm0MlU5KG6P NGC3RW9USU6JRWK=
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OE19 NHnCUHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmruTWM2OD1{MECuNVghdk1? NWP4bYJwW0GQR1XS
NCI-H1694 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjjTWM2OD1{MECuNlYhdk1? MWnTRW5ITVJ?
SW1990 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnnTWM2OD1{MEGuPUBvVQ>? NHnu[GJUSU6JRWK=
LNCaP-Clone-FGC MlvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TRPGlEPTB;MkC0MlQ4KG6P MW\TRW5ITVJ?
LB831-BLC NUnGd2VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTrWnlwUUN3ME2yNFYvOjVibl2= M1PFenNCVkeHUh?=
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BxPC-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJzMD65OkBvVQ>? M4jxWHNCVkeHUh?=
HT-1197 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml2xTWM2OD1{MUKuOVghdk1? MlnaV2FPT0WU
GB-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLRTWM2OD1{MUKuO|Mhdk1? MmLhV2FPT0WU
RPMI-8226 NXfiWWZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7ITWM2OD1{MUOuN|chdk1? Mn\ZV2FPT0WU
L-540 Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJzMz60PUBvVQ>? NWK1SHNyW0GQR1XS
NCI-H1882 M1nBbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrudFdKSzVyPUKxOUBvVQ>? Mor6V2FPT0WU
A673 MkOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfCTWM2OD1{MUWuO|khdk1? M{T2eHNCVkeHUh?=
NCI-H650 MoKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vxVGlEPTB;MkG3MlYyKG6P M4\GfHNCVkeHUh?=
KM12 NVHQPItIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi1dohKSzVyPUKxPE4yPSCwTR?= NXfQU3pUW0GQR1XS
KP-N-YS M2rOdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJzOD60JI5O M3j1dnNCVkeHUh?=
COLO-684 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e4NGlEPTB;MkG5Mlc6KG6P MoHpV2FPT0WU
MHH-NB-11 M4K5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;mTWM2OD1{MkCuNlIhdk1? MX\TRW5ITVJ?
HO-1-N-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[0d|ZZUUN3ME2yNlIvQDNibl2= M{\CTXNCVkeHUh?=
NOMO-1 NUTC[ZBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4L3TGlEPTB;MkK0MlQ{KG6P NHXSVZZUSU6JRWK=
KYSE-70 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJ{ND62OkBvVQ>? MWHTRW5ITVJ?
NCI-H838 NHPDe3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2naTmlEPTB;MkK0Mlc{KG6P NXLBfnI4W0GQR1XS
NY NG\Fb3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLP[nBKSzVyPUKyPE41QSCwTR?= M2\UUHNCVkeHUh?=
NCI-H2196 NET2WXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\GVndKSzVyPUKyPU4yPSCwTR?= MYPTRW5ITVJ?
FTC-133 NWrRVZRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJ{OT6zO{BvVQ>? M1rCUnNCVkeHUh?=
MHH-PREB-1 NH3zTHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJ{OT64NkBvVQ>? MXLTRW5ITVJ?
SK-MEL-2 NYHzNHU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJ|MD6zJI5O NXL6PXdUW0GQR1XS
Detroit562 M2PWS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XYbmlEPTB;MkOwMlczKG6P MVPTRW5ITVJ?
NCI-H2405 NHX2XY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\Bc5RKSzVyPUKzOE4yKG6P MYHTRW5ITVJ?
NCI-H2081 NXTjfopsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjZfZNiUUN3ME2yN|QvOjdibl2= NVfGSGVLW0GQR1XS
LB2241-RCC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DQWWlEPTB;MkO1MlEyKG6P NWi3WGdiW0GQR1XS
SNU-387 M4jyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn0SHdKSzVyPUKzOk4xQCCwTR?= M3nkO3NCVkeHUh?=
PC-14 MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJ|Nj6xNkBvVQ>? NHzpSotUSU6JRWK=
CAS-1 Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJ|OD6zNUBvVQ>? NIXXOFVUSU6JRWK=
TE-11 Mn\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\xSW1KSzVyPUK0NE45QCCwTR?= MlzpV2FPT0WU
LC4-1 NUTDTZZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrvPGZKSzVyPUK0NE45QSCwTR?= NYX2fYlsW0GQR1XS
HH NX7XemJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDMVFlKSzVyPUK0NU41PiCwTR?= M3q4eXNCVkeHUh?=
JVM-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\wSI1KUUN3ME2yOFIvOTdibl2= MlnrV2FPT0WU
KNS-42 NYf3dWlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVe3NmpNUUN3ME2yOFIvPjdibl2= MULTRW5ITVJ?
T-24 M3jGfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT5cpJLUUN3ME2yOFUvPDhibl2= MkTxV2FPT0WU
D-392MG NEXObW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvHTWM2OD1{NEiuOUBvVQ>? NIixO2JUSU6JRWK=
KOSC-2 MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jaVmlEPTB;MkS4MlcyKG6P MlW1V2FPT0WU
D-283MED M2DDc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XmNWlEPTB;MkWwMlE{KG6P MXvTRW5ITVJ?
BV-173 MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzmTWM2OD1{NUCuO|chdk1? M{\lRXNCVkeHUh?=
EW-18 MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jWXmlEPTB;MkWwMlkhdk1? NG[5N2lUSU6JRWK=
MS-1 M2nsNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr5b3ZMUUN3ME2yOVIvPTNibl2= MmrjV2FPT0WU
Calu-6 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fBfmlEPTB;MkWzMlU2KG6P MXjTRW5ITVJ?
GR-ST NGPhXWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrXdZgyUUN3ME2yOVUvPDJibl2= MYrTRW5ITVJ?
GAK MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7vdIhKSzVyPUK1Ok46OSCwTR?= MoX2V2FPT0WU
TE-9 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rBU2lEPTB;MkW3MlQ4KG6P Mn\4V2FPT0WU
HuH-7 NW\GXXVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\MWGNKSzVyPUK1PE41PCCwTR?= MWXTRW5ITVJ?
KYSE-520 MmG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVS4NZVKUUN3ME2yOlAvPzdibl2= NH:0OY9USU6JRWK=
NCI-H520 NH3DVVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nMO2lEPTB;Mk[2MlYyKG6P MX\TRW5ITVJ?
HD-MY-Z NV[4cJUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3P1SWlEPTB;MkeyMlc6KG6P NULaPVdPW0GQR1XS
SW756 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LEWGlEPTB;Mke0Mlc5KG6P Mk\ZV2FPT0WU
NB12 NGLiXG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHuTXo4UUN3ME2yO|cvOTJibl2= M3n0W3NCVkeHUh?=
EW-3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJ5OT64PUBvVQ>? Ml\yV2FPT0WU
AM-38 MoD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHXdlBKSzVyPUK4NU42OiCwTR?= MmDhV2FPT0WU
NCI-H23 NIPCcVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PwNWlEPTB;MkizMlkzKG6P M2DOOHNCVkeHUh?=
GOTO M3G1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PvdWlEPTB;Mki1MlU3KG6P M{PE[3NCVkeHUh?=
NCI-H1693 M3TrdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWL3fYJSUUN3ME2yPVAvOzJibl2= Mkn6V2FPT0WU
MOLT-16 M{H2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJ7MD61JI5O NGmyV|hUSU6JRWK=
HOP-92 NI\XUpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzv[ldiUUN3ME2yPVAvPyCwTR?= M4PhO3NCVkeHUh?=
MDA-MB-361 NVPBdHNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGThVnNKSzVyPUK5Nk43PSCwTR?= MVrTRW5ITVJ?
Ramos-2G6-4C10 NFLxe3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjxPHRUUUN3ME2yPVQvPTVibl2= M1vSe3NCVkeHUh?=
CAL-54 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTUUVBWUUN3ME2zNFAvPzNibl2= NUDZNoY2W0GQR1XS
D-263MG MknhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH6ze3hKSzVyPUOwOU42OiCwTR?= NHLhcI1USU6JRWK=
SKG-IIIa Mk\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvxWVZ[UUN3ME2zNVEvOTRibl2= MVzTRW5ITVJ?
HAL-01 NHS0b2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17FRWlEPTB;M{GzMlQ1KG6P NUficlUyW0GQR1XS
LAN-6 Ml;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTNzNT6xNUBvVQ>? M3rTbnNCVkeHUh?=
NCI-H1304 NEXqeopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTN{MT6xO{BvVQ>? MnjtV2FPT0WU
no-11 MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTN{MT62OEBvVQ>? MlqwV2FPT0WU
IST-MES1 NWHtfFVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTN{Mz6zOUBvVQ>? MnHKV2FPT0WU
L-363 MnvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTuTWM2OD1|MkSuOFMhdk1? MYHTRW5ITVJ?
EM-2 M1HCSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkD0TWM2OD1|MkWuOFEhdk1? MXrTRW5ITVJ?
DV-90 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTN{OT60OUBvVQ>? MoXFV2FPT0WU
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