Doxorubicin (Adriamycin) HCl

Pfizer辉瑞授权 目录号:S1208 别名: NSC 123127

Doxorubicin (Adriamycin) HCl Chemical Structure

Molecular Weight(MW): 579.98

Doxorubicin (Adriamycin) HCl是一种抗生素类试剂,在肿瘤细胞中抑制DNA topoisomerase II,并诱导DNA损伤和凋亡。

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RMB 960.91 现货
RMB 736.03 现货
RMB 1712.71 现货
RMB 5473.95 现货
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客户购买Selleck的此次产品后发表的文献33篇:

客户使用该产品的9个实验数据:

  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (F) Kaplan-Meier curves are shown for all groups described: no hydrogel, a hydrogel loaded with paclitaxel, or a hydrogel loaded with doxorubicin. The number of mice per group (n) and median survival (ms) are listed. The experiment was performed at least three times.

    Science, 2018, 10(433), doi: 10.1126/scitranslmed.aar1916. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017, 16(5):468-476. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) HCl purchased from Selleck.

     

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) HCl purchased from Selleck.

产品安全说明书

Topoisomerase抑制剂选择性比较

生物活性

产品描述 Doxorubicin (Adriamycin) HCl是一种抗生素类试剂,在肿瘤细胞中抑制DNA topoisomerase II,并诱导DNA损伤和凋亡。
靶点
Topo II [1]
(Tumor cells)
体外研究

Adriamycin是抗菌的蒽环霉素,通常在两种水平发挥其抗肿瘤活性,改变DNA,和产生自由基,通过DNA损伤,触发癌细胞凋亡。Adriamycin 通过插入到 DNA链中而阻断DNA合成,且抑制DNA拓扑异构酶 II(TOP2)。Adriamycin 作用于快速增值和表达高水平TOP2的细胞最有效。此外, Adriamycin通过产生神经酰胺(通过激活p53 或其他下游通路如JNK而促进凋亡)而触发凋亡,通过丝苏氨酸蛋白酶而降解,线粒体中释放细胞色素 c,提高 FasL(死亡受体Fas/CD95 配体)mRNA产量, 且产生更多的自由基。[2] 使用GSNO(亚硝基谷胱甘肽)预处理,抑制抗Doxorubicin的乳腺癌细胞系MCF7/Dx,伴随着增强蛋白谷胱甘肽和核中Doxorubicin 的积累。[3] 在共济失调毛细血管扩张症突变(ATM),及ATM 和 Rad3相关的(ATR)信号通路中,提高的 cyclin G2(CycG2)表达和蛋白磷酸化修饰导致Adriamycin诱导的G2/M 检查点停滞。[5] Adriamycin作用于小鼠胚胎成纤维细胞(MEFs)和心肌细胞,抑制AMP活化蛋白激酶(AMPK),导致SIRT1 功能障碍,p53 累积, 且促进细胞死亡。[6] Adriamycin产生明显的热休克反应,抑制热休克蛋白或使热休克蛋白沉默增强,Adriamycin增强促进神经母细胞瘤细胞凋亡的效果。在不可测量蛋白酶抑制的条件下,纳摩尔Adriamycin处理神经母细胞瘤细胞,使特定的一系列蛋白过泛素化,这种作用存在剂量依赖性,且引起泛素化酶,如乳酸脱氢酶和α-烯醇酶的缺失,α-enolase, 蛋白泛素化模式与蛋白酶抑制剂Bortezomib相似,说明Adriamycin也可通过损伤蛋白而发挥作用。[8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 MWTGeY5kfGmxbjDBd5NigQ>? NU\SUWZwUW6qaXLpeIlwdiCxZjDSUmEhe3mwdHjld4l{KHerdHigSWQ2OCCxZjCwMlU5KM7:TR?= NXHWb2dSPDlyNUO2
Yoshida sarcoma MU\GeY5kfGmxbjDBd5NigQ>? NXL5XGFqUW6qaXLpeIlwdiCxZjDbN2heXGSUIHnuZ49zeG:{YYTpc44hf2m2aDDJR|UxKG:oIECuNFIh|ryP MVKxN|IzQTh4
CHO NUXnO4pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\GR5B6UUN3ME2wMlA3KM7:TR?= NUK4dJB5OTN3NEe1NC=>
8226 NXTvU4tYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfWOHhKSzVyPUCuNFM{KM7:TR?= NEC2bIUyPDR5N{Ow
8226/ADR MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfSR|V4UUN3ME2wMlU3KM7:TR?= NVH4TY1WOTR2N{ezNC=>
MCF7/ADR MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjyXVdzUUN3ME2zMlEh|ryP MXKxOFQ4PzNy
H69 MmfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T3eWlEPTB;MD64O{DPxE1? MlewNVQ4QTV6NR?=
N417 M4PW[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMkOg{txO NXnyU5h4OTR5OUW4OS=>
H9 NInWNpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLFNnJjUW6qaXLpeIlwdiCxZjDIPUBk\WyuczDjbJJwdmmlYXzsfUBqdm[nY4Tl[EB4cXSqIITo[UBJUVZvMTCoTFkwUUmLQjmge4l1cCCLREWwJI9nKDBwMEGg{txO MkO1NVU1QDZ6MR?=
T-C8166 MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkOzTWQ2OD1yLkCxJO69VQ>? NUTWeYp{OTV2OE[4NS=>
T-H9 MmXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELRZVVKTDVyPUCuNFEh|ryP NYXaU2wxOTV2OE[4NS=>
T-MT4 NFrsUFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULafYl{UUR3ME2wMlAyKM7:TR?= NFz0[HIyPTR6Nkix
SKMEL-5 NF7MblhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW3SWQ2OD1|LkKg{txO NF;McZEyPjF|N{Wz
MLM MV\DfZRwfG:6aXOgRZN{[Xl? MmHUSWQ2OD1yLkGzJO69VQ>? MYexPFc2OzVy
KBM-3 NEiwfXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXq[Yw4UUN3ME2wMlAzPiEQvF2= NIK1epUyQTl3OEe3
HT-29 NICyTVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzvNE4xOSEQvHe= NGnhcFQ1QCCq NVvNZ21JSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJk> M4PJT|I4Pzh2NEm=
EMT6 Mom4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDETlZqOC53IN88US=> MVmxJIg> MVvJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gZpkhdWWjc4XybY5oKG[xcjDzeZJ3cX[rbneg[pJi[3Srb37zJJdqfGhiRVS1NEBw\iByLkCwNFEh|ryP MUe3OFUzPjd2
H2981 Ml7NR5l1d3SxeHnjJGF{e2G7 MmHjTWM2OD1yLkWg{txO M3fqV|c4OzFyMkO=
LOX M1TsdWN6fG:2b4jpZ{BCe3OjeR?= NV\Od2xTUUN3ME2wMlA1OiEQvF2= NF3SRmE4QDV|M{Ox
C38 MVHDfZRwfG:6aXOgRZN{[Xl? NVXUS5NpUUN3ME2wMlAyKM7:TR?= NF3RRXo5ODV5Mkmx
EAC MYDDfZRwfG:6aXOgRZN{[Xl? NXXlbW4yPzJiaB?= NIO1Sm9KSzVyPUCuN|Uh|ryP NHG0OGY5OzVyMEi3
SKVLB MmDZR5l1d3SxeHnjJGF{e2G7 M3zUb2lEPTB;NT62JO69VQ>? MWG4OVc3QTF2
AUC375 NYntTGpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXi5Nm57UUN3ME2wMlEyOiEQvF2= NXizN|drQDZ2OE[wNC=>
A2780-C25 MYfDfZRwfG:6aXOgRZN{[Xl? MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBwgGGuaYDsZZRqdi2{ZYPpd5RidnRiQUK3PFAuSzJ3IIfpeIghUUN3MDDv[kAxNjB4MzFOwG0> M2Pxflg5OzF5NUW=
A2780-CP3 NIXOZ4lEgXSxdH;4bYMhSXO|YYm= NEHwRpREgXSxdH;4bYNqfHliYXfhbY5{fCClaYPwcIF1cW5vcnXzbZN1[W62IFGyO|gxNUOSMzD3bZRpKEmFNUCgc4YhOC5yNU[g{txO NUDLcZU2QDh|MUe1OS=>
A2780-DX5 MVzDfZRwfG:6aXOgRZN{[Xl? MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiQUK3PFAuTFh3IIfpeIghUUN3MDDv[kAxNjN3NzFOwG0> NV:1VG5yQDh|MUe1OS=>
MXF7 NX3nUJJnS3m2b4TvfIlkKEG|c3H5 NU\1XIpbSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5Qhe2Wwc3n0bZZmKE2[Rkege4l1cCCLQ{WwJI9nKDBwMEK4JO69VQ>? M2XCXVg6PjB3NUi=
MXF7 NXO5bm1OS3m2b4TvfIlkKEG|c3H5 NVyzVYNVSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhdWm2b4jhcpRzd26nLYLld4l{fGGwdDDNXGY4KHerdHigTWM2OCCxZjCwMlAzQCEQvF2= NFrO[Yg5QTZyNUW4
MXF7 MVvDfZRwfG:6aXOgRZN{[Xl? MoTpRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4Sg[I95d3K3YnnjbY4uemW|aYP0ZY51KE2[Rkege4l1cCCLQ{WwJI9nKDFwMUeyJO69VQ>? MoPSPFk3ODV3OB?=
WiDr NGLoT|FEgXSxdH;4bYMhSXO|YYm= NYm5XnRZSWO2aY\peJkh[WejaX7zeEB{\W6|aYTpeoUhX2mGcjDj[YxtKHerdHigTWM2OCCxZjCwMlA2OyEQvF2= M3nMXFg6PjB3NUi=
MCF NWizZpZDTnWwY4Tpc44hSXO|YYm= M3XodnJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4Uh[XO|ZYPz[YQh[XNiZX7oZY5k\W2nboSgbY4h[3m2b4TvfIlkcXS7IH;mJIFlemmjbYnjbY4> NV7ZdlJ2QDl6NEG1NS=>
C6 NEnSVY5EgXSxdH;4bYMhSXO|YYm= MXOyMlUhdWdxbVy= NVnUb5ZmPzJiaB?= M3zacGROW09? MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBz[XRiQ{[gZ4VtdHNiYYSgOVAhfWdxbVygeI8hOi53IH3nM41N NFj2R2E5QTh6NkC0
C6 MlftSpVv[3Srb36gRZN{[Xl? NETRbWMzNjVibXevcWw> NGj5OW81KGh? MkjmSG1UVw>? NH7mc|RKdmirYnn0bY9vKG:oIIT1ZpVtcW5icH;sfY1memm8YYTpc44> NXqyXnk4QDl6OE[wOC=>
C6 M{nNeGN6fG:2b4jpZ{BCe3OjeR?= MkXLNk42KG2pL33M NHrO[lA2KGh? MV3EUXNQ MVTDfZRwfG:6aXPpeJkh[XO|ZYPz[YQh[XNiY3XscEBz\WynYYPl NF\wVmU5QTh6NkC0
SKVLB MonGR5l1d3SxeHnjJGF{e2G7 NWqzZoNwPzJiaB?= MlXwTWM2OD14LkW0JO69VQ>? M37yTFkxODN3MkC=
MCF7/VP16 M4K5TGN6fG:2b4jpZ{BCe3OjeR?= MmGyOVAh|rypL33M MXq3NkBp Mo\6TWM2OD1zND6yJO69VQ>? MkjoPVAzOjd7Mh?=
CA755 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\MNVAh|ryP NYmzR|dHPiCm M1O4UmlEPTB;MD6wNVQh|ryP NXfSbYJMQTV{NkW3NC=>
CHO MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknlNVAh|ryP NFTTNGg3KGR? Mo\2TWM2OD1yLkC2JO69VQ>? M1rwSVk2OjZ3N{C=
Panc02 M4DMdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTONVAh|ryP NEnjRVg3KGR? NXzndlNqUUN3ME2wMlA3PSEQvF2= NX;MXVRXQTV{NkW3NC=>
PC14 NHzQ[mNEgXSxdH;4bYMhSXO|YYm= M2TmT|Qh\A>? Mn\RSG1UVw>? NH7YTm5KSzVyPUCuNlkh|ryP NYHIVJcxQTh{MkW0Ni=>
HOP62 M4XWW2N6fG:2b4jpZ{BCe3OjeR?= NF3PN2c4OiCq NHP4Z3ZKSzVyPUCuNFA1KM7:TR?= NULxU5pGQTh5M{[2NS=>
SF-295 M2TNVWN6fG:2b4jpZ{BCe3OjeR?= NX3WUWJVPzJiaB?= MknqTWM2OD1yLkCzOUDPxE1? NFL2N5E6QDd|Nk[x
MDA-MB-361 NWTGRYI1S3m2b4TvfIlkKEG|c3H5 M3zaOlEhcA>? NX;R[ZFCTE2VTx?= Ml3ZR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSDLV3CMVM3OSCneIDy[ZN{cW6pIFzhZ3ohf2m2aDDJR|UxKG:oIECuNFEzKM7:TR?= MkHxNVA{QTV2OUC=
MDA-MB-361 M4HNPWN6fG:2b4jpZ{BCe3OjeR?= NEDBZZQyKGh? M3q0[mROW09? MnnBR5l1d3SxeHnjbZR6KGGpYXnud5QhVUSDIF3CJFM3OSCneIDy[ZN{cW6pIHPhdoJwgHmyZYD0bYRie2Vic4TDVGczKHerdHigTWM2OCCxZjCwMlAyQCEQvF2= NXT4[GZwOTB|OUW0PVA>
CCRF-SB M2fGZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXm0JIQ> NF7YZXNFVVOR NEH3dohKSzVyPUCuNFEh|ryP M2rweVExPDFzNEe2
CHO-K1 NF20S41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK2R2Q1KGR? NHjxd2tFVVOR M3ryXmlEPTB;MD60JO69VQ>? NV3oWJpuOTB2MUG0O|Y>
KB NYOy[nExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFuxR4g1KGR? NXXvWIY{TE2VTx?= MnjXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQkfEJJdqfGhiSVO1NEBw\iByLk[1JO69VQ>? NX3XW3NlOTB2MUG0O|Y>
KB M3PSOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi3OEBl M2rwTmROW09? M1PaWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\y2{ZYPpd5RidnRiS1LDZY1xf2m2aDDJR|UxKG:oIECuNFYh|ryP M1LiTVExPDFzNEe2
KB MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYe0JIQ> MkLsSG1UVw>? MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHTyeYcuemW|aYP0ZY51KEuETVTSJJdqfGhiSVO1NEBw\iByLkWg{txO MnnVNVA1OTF2N{[=
KB M4DZZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfSOEBl Mn7XSG1UVw>? MnLKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQm[yNGMhf2m2aDDJR|UxKG:oIECuOEDPxE1? NFr1c5QyODRzMUS3Oi=>
HTB-54 NY\pOohlS3m2b4TvfIlkKEG|c3H5 MmPjNVAxKM7:TR?= M2fZ[mlEPTB;MT6xJO69VQ>? NHT2WHIyODR5Nki2NS=>
MEL-AC NF\0RWNEgXSxdH;4bYMhSXO|YYm= Mkf3NVAxKM7:TR?= MmK3TWM2OD1zLkKg{txO NIG4PHMyODR5Nki2NS=>
DU145 M2DGNGN6fG:2b4jpZ{BCe3OjeR?= MmTkO|IhcA>? NWPmcnBxUUN3ME2wMlA2OjhizszN M3y2dlExPDd7Mkiy
K562R MlniR5l1d3SxeHnjJGF{e2G7 M2LtfFczKGh? NULlfZhRUUN3ME2wMlAyPTZizszN MX[xNFQ4QTJ6Mh?=
PACA-2 M4roPWN6fG:2b4jpZ{BCe3OjeR?= Mnm1OkBl MlHrSWQ2OD1yLkCwOlMh|ryP MorhNVA1QTh{MUS=
3Y1 NG\tfGhEgXSxdH;4bYMhSXO|YYm= M4PRT|czKGh? MX7HTVUxRTBwMECzPEDPxE1? MnXiNVA3QTF5MUC=
P388 MXzDfZRwfG:6aXOgRZN{[Xl? MUi3NkBp M{PzZWdKPTB;MD6wNVIh|ryP NHzK[pgyODZ7MUexNC=>
HMV-1 M1jqcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMkig{txO MUGxNFY6QDR|Nh?=
MKN-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwNkSg{txO MUKxNFY6QDR|Nh?=
PC14 M4DNSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TXNmlEPTB;MT65JO69VQ>? MXWxNFY6QDR|Nh?=
T24 NFLXfI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWKzbIxPUUN3ME2wMlY1KM7:TR?= NWnTOFhQOTB4OUi0N|Y>
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NCI-H748 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfEeGtKSzVyPUG0O{4{OSCwTR?= NEP1UJNUSU6JRWK=
SK-MEL-3 Ml;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzXTWM2OD1zNEeuOlEhdk1? M175[XNCVkeHUh?=
SNB75 NVSxNmN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fLW2lEPTB;MUS4MlY2KG6P NXXMZ4g{W0GQR1XS
BB65-RCC NXHmbFFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHEeIFKSzVyPUG0PU4{OSCwTR?= MlfiV2FPT0WU
NCI-H1355 NVXCe|ZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIe0fHFKSzVyPUG1Nk4zPCCwTR?= NYO3OlRYW0GQR1XS
SCC-25 NGnWb4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LQcGlEPTB;MUWzMlc{KG6P NV;5XmVLW0GQR1XS
OAW-42 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT4TWM2OD1zNUOuPFQhdk1? M{\WenNCVkeHUh?=
MONO-MAC-6 NFPp[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3B[YZ[UUN3ME2xOVQvOzZibl2= NFzh[olUSU6JRWK=
WSU-NHL M1TVSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1mwXmlEPTB;MUW0MlU5KG6P MVfTRW5ITVJ?
SNU-423 M2joSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DIT2lEPTB;MUW1MlM1KG6P MnrKV2FPT0WU
SBC-1 NWXKZVN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHVWIV7UUN3ME2xOVYvPCCwTR?= M13MTnNCVkeHUh?=
OVCAR-4 NWTNZ4Z[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlviTWM2OD1zNU[uO|ghdk1? MV7TRW5ITVJ?
NCI-H2347 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jyc2lEPTB;MUW4MlM1KG6P NIPlbI1USU6JRWK=
CAMA-1 NYjxbZVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DlPGlEPTB;MUW5MlM{KG6P NETrZohUSU6JRWK=
GDM-1 MnjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vV[GlEPTB;MUW5Mlchdk1? NIXtXW1USU6JRWK=
KNS-81-FD NYDMSm9lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTF4MD6zNkBvVQ>? MmW2V2FPT0WU
no-10 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTQeFA1UUN3ME2xOlAvOzhibl2= MWrTRW5ITVJ?
NCI-H2052 NHT5[ldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHQNnlEUUN3ME2xOlAvPDdibl2= NYDRcG03W0GQR1XS
DB MoTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnGXFdiUUN3ME2xOlEvPzFibl2= MlvxV2FPT0WU
A4-Fuk MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfTOJI4UUN3ME2xOlIvPDhibl2= Mk\DV2FPT0WU
HCE-T MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPZXJRKSzVyPUG2OE45PyCwTR?= MUTTRW5ITVJ?
HuP-T3 NIjUb3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jy[mlEPTB;MU[1MlU2KG6P MWTTRW5ITVJ?
BC-3 NE\pOXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDpWJVKSzVyPUG2OU45PiCwTR?= MkGyV2FPT0WU
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COLO-800 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jXbmlEPTB;MUexMlghdk1? MYHTRW5ITVJ?
OMC-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PacmlEPTB;MUeyMlE4KG6P M2f5bnNCVkeHUh?=
SJRH30 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[zSHZbUUN3ME2xO|IvQTRibl2= MYrTRW5ITVJ?
HEL NGjtU5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPYTWM2OD1zN{WuNVUhdk1? Ml7IV2FPT0WU
KLE MnvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLSWY9YUUN3ME2xO|UvPDdibl2= M{n6OnNCVkeHUh?=
MEG-01 M3XKTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTLTWM2OD1zN{[uOkBvVQ>? MVHTRW5ITVJ?
OAW-28 NH3RTJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjiOGtoUUN3ME2xO|gvQDRibl2= NX3TWZNwW0GQR1XS
RD MnjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTF6MD6xJI5O Ml:yV2FPT0WU
HCC2218 NHq1TGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjWb2ZyUUN3ME2xPFEvPjZibl2= NGr1SoZUSU6JRWK=
OS-RC-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF6Mj60PUBvVQ>? MkmxV2FPT0WU
HEC-1 NF7IcmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\zV2dKSzVyPUG4Nk45OyCwTR?= M2TofXNCVkeHUh?=
SCC-4 NU[xO2pOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXuPIJKSzVyPUG4N{44OSCwTR?= MWjTRW5ITVJ?
ME-180 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInObFBKSzVyPUG4Ok4xQCCwTR?= M2rJNHNCVkeHUh?=
NB10 Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7JUVBKSzVyPUG4PE4xQSCwTR?= NW[zVpNwW0GQR1XS
SCC-15 MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTF6OD6yOEBvVQ>? M3TPWXNCVkeHUh?=
COR-L105 MkX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7CTWM2OD1zOEiuPVIhdk1? M1zS[nNCVkeHUh?=
HT-1376 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;IV3RQUUN3ME2xPFkvODFibl2= Ml[4V2FPT0WU
RPMI-8866 M1P0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XXWWlEPTB;MUmyMlE{KG6P MWHTRW5ITVJ?
NCI-H2126 M{fKdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF7Mj6yJI5O MU\TRW5ITVJ?
KARPAS-422 NInXR3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TJTmlEPTB;MUmzMlQyKG6P NF7ZRndUSU6JRWK=
COLO-741 NXzFeFI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfsfJdKSzVyPUG5OE42QCCwTR?= M1\kcnNCVkeHUh?=
IPC-298 NV\KUmhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTF7Nj6yNUBvVQ>? NFHicG9USU6JRWK=
OE19 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJyMD6xPEBvVQ>? NU\qXXJVW0GQR1XS
NCI-H1694 MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHyWmluUUN3ME2yNFAvOjZibl2= NFH6fG9USU6JRWK=
SW1990 NFvl[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJyMT65JI5O MlXNV2FPT0WU
LNCaP-Clone-FGC MlPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJyND60O{BvVQ>? M{DYS3NCVkeHUh?=
LB831-BLC NFzmVmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XIS2lEPTB;MkC2MlI2KG6P NV\0[mI{W0GQR1XS
HCT-116 NYeyWVBnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjYbnJ7UUN3ME2yNFcvOzlibl2= MY\TRW5ITVJ?
BxPC-3 MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXmc5FKSzVyPUKxNE46PiCwTR?= MXPTRW5ITVJ?
HT-1197 NYrxfVc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTLTWM2OD1{MUKuOVghdk1? MlHxV2FPT0WU
GB-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjYco01UUN3ME2yNVIvPzNibl2= MlrSV2FPT0WU
RPMI-8226 M1nvS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzRTWM2OD1{MUOuN|chdk1? MUfTRW5ITVJ?
L-540 NWPVNVFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PVdmlEPTB;MkGzMlQ6KG6P MUfTRW5ITVJ?
NCI-H1882 NFrabHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnHTWM2OD1{MUWgcm0> NE\YeVVUSU6JRWK=
A673 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC4S4xKSzVyPUKxOU44QSCwTR?= NFjhboJUSU6JRWK=
NCI-H650 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LYcWlEPTB;MkG3MlYyKG6P MmPKV2FPT0WU
KM12 MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJzOD6xOUBvVQ>? MWXTRW5ITVJ?
KP-N-YS MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHmVHNPUUN3ME2yNVgvPCCwTR?= NXXSO4Y1W0GQR1XS
COLO-684 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjDfoxKSzVyPUKxPU44QSCwTR?= M{T4TnNCVkeHUh?=
MHH-NB-11 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TBe2lEPTB;MkKwMlIzKG6P MnzFV2FPT0WU
HO-1-N-1 NUHISnZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTJ{Mj64N{BvVQ>? MmPLV2FPT0WU
NOMO-1 M1flc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3CTWM2OD1{MkSuOFMhdk1? M{Hwd3NCVkeHUh?=
KYSE-70 NIrIcXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHydml{UUN3ME2yNlQvPjZibl2= NWHL[ZVWW0GQR1XS
NCI-H838 M1rMXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:0W2lEPTB;MkK0Mlc{KG6P NGe0eXNUSU6JRWK=
NY MojvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTJ{OD60PUBvVQ>? M4f6dnNCVkeHUh?=
NCI-H2196 NEW3fJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTJ{OT6xOUBvVQ>? NHO0NnhUSU6JRWK=
FTC-133 MkTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HmTGlEPTB;MkK5MlM4KG6P M3e1bnNCVkeHUh?=
MHH-PREB-1 Mo[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkL2TWM2OD1{MkmuPFIhdk1? M{XSTnNCVkeHUh?=
SK-MEL-2 NF;5PYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHyTpNKUUN3ME2yN|AvOyCwTR?= Moj4V2FPT0WU
Detroit562 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXkfnJKSzVyPUKzNE44OiCwTR?= M33jS3NCVkeHUh?=
NCI-H2405 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4S5WmlEPTB;MkO0MlEhdk1? MXjTRW5ITVJ?
NCI-H2081 NHTRW|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\ERmZKSzVyPUKzOE4zPyCwTR?= MXLTRW5ITVJ?
LB2241-RCC NWT6R5VyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmq1TWM2OD1{M{WuNVEhdk1? NG\uUIxUSU6JRWK=
SNU-387 M1HP[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L4RmlEPTB;MkO2MlA5KG6P Moe5V2FPT0WU
PC-14 M{TKR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnhTWM2OD1{M{[uNVIhdk1? NUHwXnB6W0GQR1XS
CAS-1 NWfNUJFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIriO4lKSzVyPUKzPE4{OSCwTR?= M1PoWXNCVkeHUh?=
TE-11 NGjKU3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTJ2MD64PEBvVQ>? MUnTRW5ITVJ?
LC4-1 NUHFNYpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3K4cGlEPTB;MkSwMlg6KG6P NHH6UIdUSU6JRWK=
HH MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJ2MT60OkBvVQ>? NGO1XlFUSU6JRWK=
JVM-2 NEH5c4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJ2Mj6xO{BvVQ>? MUHTRW5ITVJ?
KNS-42 MmG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\CTWM2OD1{NEKuOlchdk1? MWrTRW5ITVJ?
T-24 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rVSmlEPTB;MkS1MlQ5KG6P NIHuNoRUSU6JRWK=
D-392MG NX6xdY15T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrLUnhDUUN3ME2yOFgvPSCwTR?= Mk\GV2FPT0WU
KOSC-2 M1PFfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjQSo5KSzVyPUK0PE44OSCwTR?= NFT0cIhUSU6JRWK=
D-283MED M3LWXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJ3MD6xN{BvVQ>? NYi4VldCW0GQR1XS
BV-173 MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEC0S|JKSzVyPUK1NE44PyCwTR?= NW\INJZwW0GQR1XS
EW-18 M{nOfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[zbZpKSzVyPUK1NE46KG6P NWHafpVUW0GQR1XS
MS-1 M4LVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\yOpFmUUN3ME2yOVIvPTNibl2= NXq4fIdkW0GQR1XS
Calu-6 M4T5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJ3Mz61OUBvVQ>? NHLtSoNUSU6JRWK=
GR-ST M{KwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXYTWM2OD1{NUWuOFIhdk1? NEn0eY5USU6JRWK=
GAK Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlW0TWM2OD1{NU[uPVEhdk1? NID5VWVUSU6JRWK=
TE-9 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXoTWM2OD1{NUeuOFchdk1? NWrCVZpwW0GQR1XS
HuH-7 NIm3XWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHTTWM2OD1{NUiuOFQhdk1? MXrTRW5ITVJ?
KYSE-520 NUXGUYpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDmTWM2OD1{NkCuO|chdk1? M{PtVnNCVkeHUh?=
NCI-H520 M3ewTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfLdYRKSzVyPUK2Ok43OSCwTR?= NXOy[HBiW0GQR1XS
HD-MY-Z NHfxNVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfvTWM2OD1{N{KuO|khdk1? MV\TRW5ITVJ?
SW756 M{Hubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW5TWM2OD1{N{SuO|ghdk1? MXXTRW5ITVJ?
NB12 NFrjOlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;zTWM2OD1{N{euNVIhdk1? NHzxSJFUSU6JRWK=
EW-3 NIDDSoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH5TWM2OD1{N{muPFkhdk1? MnzwV2FPT0WU
AM-38 M{XSOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrMbI5KSzVyPUK4NU42OiCwTR?= MkXhV2FPT0WU
NCI-H23 M{[5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1yy[WlEPTB;MkizMlkzKG6P NIDJXY1USU6JRWK=
GOTO M{e1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\RNGlEPTB;Mki1MlU3KG6P MnXPV2FPT0WU
NCI-H1693 NIGzWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTJ7MD6zNkBvVQ>? NGPjbldUSU6JRWK=
MOLT-16 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[5TWM2OD1{OUCuOUBvVQ>? NESyWGRUSU6JRWK=
HOP-92 NFXmR2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojVTWM2OD1{OUCuO{BvVQ>? M2r6VXNCVkeHUh?=
MDA-MB-361 M1q4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXq1fm9WUUN3ME2yPVIvPjVibl2= M1zvN3NCVkeHUh?=
Ramos-2G6-4C10 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPPfYsyUUN3ME2yPVQvPTVibl2= NIDFepFUSU6JRWK=
CAL-54 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHZTWM2OD1|MECuO|Mhdk1? NXrNcpU1W0GQR1XS
D-263MG NYPSXIk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTMVVF1UUN3ME2zNFUvPTJibl2= NEnOXGdUSU6JRWK=
SKG-IIIa NF34eFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO1ZVlKUUN3ME2zNVEvOTRibl2= NGHpNmxUSU6JRWK=
HAL-01 NVTEcHc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LIVGlEPTB;M{GzMlQ1KG6P NF7ic|dUSU6JRWK=
LAN-6 M4XKbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jUfWlEPTB;M{G1MlEyKG6P MXXTRW5ITVJ?
NCI-H1304 NUTrR|hyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M332TWlEPTB;M{KxMlE4KG6P MnL6V2FPT0WU
no-11 M2PhbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTN{MT62OEBvVQ>? M{L6cXNCVkeHUh?=
IST-MES1 NVyxTnBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF35VYZKSzVyPUOyN{4{PSCwTR?= MnvQV2FPT0WU
L-363 NEGyWHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[3UnhrUUN3ME2zNlQvPDNibl2= NF;uSWZUSU6JRWK=
EM-2 Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTN{NT60NUBvVQ>? MWPTRW5ITVJ?
DV-90 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLkTWM2OD1|MkmuOFUhdk1? MXLTRW5ITVJ?
Saos-2 NV\qe4t5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkOyTWM2OD1|MkmuPVQhdk1? NYS4T5lsW0GQR1XS
UMC-11 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\z[2lEPTB;M{OxMlI5KG6P MorvV2FPT0WU
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