Doxorubicin (Adriamycin) HCl

For research use only. Not for use in humans.

Pfizer辉瑞授权 目录号:S1208 别名: NSC 123127, DOX 中文名称:盐酸多柔比星,盐酸阿霉素

Doxorubicin (Adriamycin) HCl Chemical Structure

CAS No. 25316-40-9

Doxorubicin (Adriamycin, NSC 123127, DOX) HCl是一种抗生素类试剂,可抑制DNA topoisomerase II,并在肿瘤细胞中诱导DNA损伤、线粒体自噬和凋亡。Doxorubicin 可降低 AMPK的基础磷酸化。Doxorubicin 可应用于HIV感染病人的联合治疗,但是在免疫治疗中有将HBV重活化的风险。

规格 价格 库存 购买数量  
RMB 736.03 现货
RMB 1712.71 现货
RMB 5473.95 现货
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客户使用Selleck生产的Doxorubicin (Adriamycin) HCl发表文献684篇:

产品安全说明书

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

生物活性

产品描述 Doxorubicin (Adriamycin, NSC 123127, DOX) HCl是一种抗生素类试剂,可抑制DNA topoisomerase II,并在肿瘤细胞中诱导DNA损伤、线粒体自噬和凋亡。Doxorubicin 可降低 AMPK的基础磷酸化。Doxorubicin 可应用于HIV感染病人的联合治疗,但是在免疫治疗中有将HBV重活化的风险。
靶点
AMPK [6]
()
Topo II [1]
(Tumor cells)
体外研究

Adriamycin是抗菌的蒽环霉素,通常在两种水平发挥其抗肿瘤活性,改变DNA,和产生自由基,通过DNA损伤,触发癌细胞凋亡。Adriamycin 通过插入到 DNA链中而阻断DNA合成,且抑制DNA拓扑异构酶 II(TOP2)。Adriamycin 作用于快速增值和表达高水平TOP2的细胞最有效。此外, Adriamycin通过产生神经酰胺(通过激活p53 或其他下游通路如JNK而促进凋亡)而触发凋亡,通过丝苏氨酸蛋白酶而降解,线粒体中释放细胞色素 c,提高 FasL(死亡受体Fas/CD95 配体)mRNA产量, 且产生更多的自由基。[2] 使用GSNO(亚硝基谷胱甘肽)预处理,抑制抗Doxorubicin的乳腺癌细胞系MCF7/Dx,伴随着增强蛋白谷胱甘肽和核中Doxorubicin 的积累。[3] 在共济失调毛细血管扩张症突变(ATM),及ATM 和 Rad3相关的(ATR)信号通路中,提高的 cyclin G2(CycG2)表达和蛋白磷酸化修饰导致Adriamycin诱导的G2/M 检查点停滞。[5] Adriamycin作用于小鼠胚胎成纤维细胞(MEFs)和心肌细胞,抑制AMP活化蛋白激酶(AMPK),导致SIRT1 功能障碍,p53 累积, 且促进细胞死亡。[6] Adriamycin产生明显的热休克反应,抑制热休克蛋白或使热休克蛋白沉默增强,Adriamycin增强促进神经母细胞瘤细胞凋亡的效果。在不可测量蛋白酶抑制的条件下,纳摩尔Adriamycin处理神经母细胞瘤细胞,使特定的一系列蛋白过泛素化,这种作用存在剂量依赖性,且引起泛素化酶,如乳酸脱氢酶和α-烯醇酶的缺失,α-enolase, 蛋白泛素化模式与蛋白酶抑制剂Bortezomib相似,说明Adriamycin也可通过损伤蛋白而发挥作用。[8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 NHzqWmVHfW6ldHnvckBCe3OjeR?= NFftbnFKdmirYnn0bY9vKG:oIGLORUB{gW62aHXzbZMhf2m2aDDFSFUxKG:oIECuOVgh|ryP MnPNOFkxPTN4
Yoshida sarcoma MlTQSpVv[3Srb36gRZN{[Xl? NGnBepdKdmirYnn0bY9vKG:oIGuzTH1V\FJiaX7jc5Jxd3KjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNkDPxE1? MkG2NVMzOjl6Nh?=
CHO MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrWRXhKSzVyPUCuNFYh|ryP NUjWTXpCOTN3NEe1NC=>
8226 NWX1emt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\WU3hpUUN3ME2wMlA{OyEQvF2= MVKxOFQ4PzNy
8226/ADR NEL5Xo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwNU[g{txO MWKxOFQ4PzNy
MCF7/ADR NWL1[npKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTNwMTFOwG0> NX7ifZRWOTR2N{ezNC=>
H69 M{LT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwOEeg{txO NWXOdHFLOTR5OUW4OS=>
N417 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH4TWM2OD1yLkKzJO69VQ>? MYGxOFc6PTh3
H9 MoLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\TdI1KdmirYnn0bY9vKG:oIFi5JINmdGy|IHPodo9vcWOjbHz5JIlv\mWldHXkJJdqfGhidHjlJGhKXi1zIDjIPU9KUUmEKTD3bZRpKEmGNUCgc4YhOC5yMTFOwG0> MVmxOVQ5Pjhz
T-C8166 NWPSR5B7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrLfFQyUUR3ME2wMlAyKM7:TR?= NUTzcmxuOTV2OE[4NS=>
T-H9 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjvcHdPUUR3ME2wMlAyKM7:TR?= NIHnNY8yPTR6Nkix
T-MT4 MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXj2SYtoUUR3ME2wMlAyKM7:TR?= Mn35NVU1QDZ6MR?=
SKMEL-5 NFq0bo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfFSFUxRTNwMjFOwG0> M2TyPFE3OTN5NUO=
MLM M2XEbmN6fG:2b4jpZ{BCe3OjeR?= NW\U[opDTUR3ME2wMlE{KM7:TR?= MXmxPFc2OzVy
KBM-3 NELZenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\hWWlEPTB;MD6wNlYh|ryP NFPjdFYyQTl3OEe3
HT-29 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrPcFlJOC5yMTFOwIc> NFnxcVQ1QCCq MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eR?= M3LUVVI4Pzh2NEm=
EMT6 M1jPZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGzNE42KM7:TR?= M1:4cVEhcA>? NWPmTIxCUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKGK7IH3lZZN2emmwZzDmc5Ihe3W{dnn2bY5oKG[{YXP0bY9veyC5aYToJGVFPTBib3[gNE4xODBzIN88US=> MofYO|Q2OjZ5NB?=
H2981 NIrrVHREgXSxdH;4bYMhSXO|YYm= MlTVTWM2OD1yLkWg{txO MY[3O|MyODJ|
LOX NXq0W5B2S3m2b4TvfIlkKEG|c3H5 MVzJR|UxRTBwMESyJO69VQ>? NXH2UlJwPzh3M{OzNS=>
C38 M1rPU2N6fG:2b4jpZ{BCe3OjeR?= NYqyPFczUUN3ME2wMlAyKM7:TR?= MYi4NFU4Ojlz
EAC NWG0eZZXS3m2b4TvfIlkKEG|c3H5 M1zveVczKGh? MljJTWM2OD1yLkO1JO69VQ>? NHz1TmI5OzVyMEi3
SKVLB Mlj2R5l1d3SxeHnjJGF{e2G7 NVr4S3BEUUN3ME21MlYh|ryP NVXaO4pDQDV5NkmxOC=>
AUC375 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm0TWM2OD1yLkGxNkDPxE1? MojVPFY1QDZyMB?=
A2780-C25 MVvDfZRwfG:6aXOgRZN{[Xl? NUHDeXN{S3m2b4TvfIlkcXS7IHHnZYlve3Rib4jhcIlxdGG2aX6tdoV{cXO2YX70JGEzPzhyLVOyOUB4cXSqIFnDOVAhd2ZiMD6wOlMh|ryP NUe5eWxFQDh|MUe1OS=>
A2780-CP3 M1jKTWN6fG:2b4jpZ{BCe3OjeR?= Mn3rR5l1d3SxeHnjbZR6KGGpYXnud5Qh[2m|cHzheIlvNXKnc3nzeIFvfCCDMke4NE1EWDNid3n0bEBKSzVyIH;mJFAvODV4IN88US=> NX\Lb4p1QDh|MUe1OS=>
A2780-DX5 MWfDfZRwfG:6aXOgRZN{[Xl? NGizUpJEgXSxdH;4bYNqfHliYXfhbY5{fCCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgRVI4QDBvRGi1JJdqfGhiSVO1NEBw\iByLkO1O{DPxE1? NF3wTnM5QDNzN{W1
MXF7 Mnu4R5l1d3SxeHnjJGF{e2G7 MU\BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDz[Y5{cXSrdnWgUXhHPyC5aYToJGlEPTBib3[gNE4xOjhizszN NG\yWJU5QTZyNUW4
MXF7 NFPu[pFEgXSxdH;4bYMhSXO|YYm= M4LITWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1qfG:6YX70do9v\S2{ZYPpd5RidnRiTWjGO{B4cXSqIFnDOVAhd2ZiMD6wNlgh|ryP MlrDPFk3ODV3OB?=
MXF7 M{nQTGN6fG:2b4jpZ{BCe3OjeR?= M{LRTWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIRwgG:{dXLpZ4lvNXKnc3nzeIFvfCCPWF[3JJdqfGhiSVO1NEBw\iBzLkG3NkDPxE1? MV:4PVYxPTV6
WiDr M{PjUGN6fG:2b4jpZ{BCe3OjeR?= MWrBZ5Rqfmm2eTDh[4FqdnO2IIPlcpNqfGm4ZTDXbWRzKGOnbHyge4l1cCCLQ{WwJI9nKDBwMEWzJO69VQ>? MY[4PVYxPTV6
MCF Mo\vSpVv[3Srb36gRZN{[Xl? MoDTVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDteYx1cWS{dXegdoV{cXO2YX7j[UBie3Onc4Pl[EBieyCnbnjhcoNmdWWwdDDpckBkgXSxdH;4bYNqfHlib3[gZYRzcWGveXPpci=> MmeyPFk5PDF3MR?=
C6 Mn\RR5l1d3SxeHnjJGF{e2G7 NXH2XIZ{Oi53IH3nM41N M{O0flczKGh? MX;EUXNQ NWjab4llS3m2b4TvfIlkcXS7IHHnZYlve3RicnH0JGM3KGOnbHzzJIF1KDVyIIXnM41NKHSxIEKuOUBu\y:vTB?= NX64[WFlQDl6OE[wOC=>
C6 M3WwUmZ2dmO2aX;uJGF{e2G7 NWf3bXBxOi53IH3nM41N MWm0JIg> M1LKbmROW09? MnrCTY5pcWKrdHnvckBw\iC2dXL1cIlvKHCxbInt[ZJqgmG2aX;u MYe4PVg5PjB2
C6 MYXDfZRwfG:6aXOgRZN{[Xl? M{DaW|IvPSCvZz;tUC=> M1rpV|UhcA>? NG[5RVhFVVOR NXXiTHVyS3m2b4TvfIlkcXS7IHHzd4V{e2WmIHHzJINmdGxicnXs[YF{\Q>? MXm4PVg5PjB2
SKVLB MojGR5l1d3SxeHnjJGF{e2G7 NXLCXHhJPzJiaB?= NFjyc4pKSzVyPU[uOVQh|ryP NGHVZWM6ODB|NUKw
MCF7/VP16 MYLDfZRwfG:6aXOgRZN{[Xl? MoDWOVAh|rypL33M NYTqXJJDPzJiaB?= NV\aWGZtUUN3ME2xOE4zKM7:TR?= NFjzSWM6ODJ{N{my
CA755 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXFNVAh|ryP MXy2JIQ> NGD3WFVKSzVyPUCuNFE1KM7:TR?= MWG5OVI3PTdy
CHO M4DyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;Xb|gyOCEQvF2= NYDUXFkyPiCm MWnJR|UxRTBwME[g{txO MWe5OVI3PTdy
Panc02 M4Xjb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnueIkyOCEQvF2= NEH0eYg3KGR? NFLuN|VKSzVyPUCuNFY2KM7:TR?= MVq5OVI3PTdy
PC14 MXfDfZRwfG:6aXOgRZN{[Xl? NWDET5c2PCCm M3LWbGROW09? MnfBTWM2OD1yLkK5JO69VQ>? Mlq4PVgzOjV2Mh?=
HOP62 MmLPR5l1d3SxeHnjJGF{e2G7 M1z3WlczKGh? NVK0dJZrUUN3ME2wMlAxPCEQvF2= MlLJPVg4OzZ4MR?=
SF-295 MW\DfZRwfG:6aXOgRZN{[Xl? NHf3WYc4OiCq MW\JR|UxRTBwMEO1JO69VQ>? NFmwe2Q6QDd|Nk[x
MDA-MB-361 NIHWc|dEgXSxdH;4bYMhSXO|YYm=