Doxorubicin (Adriamycin) HCl

Pfizer辉瑞授权 目录号:S1208 别名: NSC 123127

Doxorubicin (Adriamycin) HCl Chemical Structure

Molecular Weight(MW): 579.98

Doxorubicin (Adriamycin) HCl是一种抗生素类试剂,在肿瘤细胞中抑制DNA topoisomerase II,并诱导DNA损伤和凋亡。

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RMB 960.91 现货
RMB 736.03 现货
RMB 1712.71 现货
RMB 5473.95 现货
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客户购买Selleck的此次产品后发表的文献36篇:

客户使用该产品的9个实验数据:

  • Enhancement of apoptotic response by addition of targeted agents lapatinib and sunitinib to doxorubicin in the same device reservoir at 24 hours. P values were determined using Student’s t test for all graphs.

    Sci Transl Med, 2015, 7(284): 284ra57 . Doxorubicin (Adriamycin) HCl purchased from Selleck.

    (F) Kaplan-Meier curves are shown for all groups described: no hydrogel, a hydrogel loaded with paclitaxel, or a hydrogel loaded with doxorubicin. The number of mice per group (n) and median survival (ms) are listed. The experiment was performed at least three times.

    Science, 2018, 10(433), doi: 10.1126/scitranslmed.aar1916. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.

    Cancer Res 2014 74, 298-308. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    Cleavage of caspase-3, -9 and the expression of PARP were measured by western blot using b-actin as a loading control.

    Cell Cycle, 2017, 16(5):468-476. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • (C) & (D) Treatments with doxorubicin, cisplatin or AZD6244 further decreased the cell viability in RH30 cloned cells in which STAT3 or GP130 was knockdown by shRNA. (*P<.05, ** P <.01, *** P <.001).

    Curr Cancer Drug Targets, 2016, 16(7):631-8. Doxorubicin (Adriamycin) HCl purchased from Selleck.

     

    Doxorubicin release of P(MAA-g-EG) and P(MAA-g-EG) containing nanoparticles in two-step pH conditions. Doxorubicinloaded P(MAA-g-EG) ,P(MAA-g-EG)-1.0NP ,P(MAA-g-EG)-2.5NP, and P(MAA-g-EG)-5.0NP crushed particles (75–150 um) were released in 1 PBS (pH 2.0) for 90 min. Then the pH was increased to 7.0 by adding 5N NaOH and release continued for 6 h.

    J Biomed Mater Res Part A 2012 10.1002/jbm.a.34064. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • Temporal uptake of free DOX or DOX-PCL63-b-PNVP90 micelles into K-562 (I) and DL (J) cells were studied by incubating in 24-well plates at a concentration of 50,000 cells per well. Representative images shown were obtained using a fluorescence microscope Eclipse 80i (Nikon, Japan) (Plan Fluor, 40X, NA 0.75 objective) equipped with blue and red filters for, Hoechst and Doxorubicin respectively (n = 3).

    PLoS One 2014 9, e94309. Doxorubicin (Adriamycin) HCl purchased from Selleck.

    PLoS One 2013 8(1), e54595. Doxorubicin (Adriamycin) HCl purchased from Selleck.

  • CON+ -positive control (with FBS as chemoattractant); CON- - negative control (without chemoattractant); DOX -doxorubicin; WZ -WZ811; PF- PF-573228; * -significant difference compared to positive control: p<0.05; ** -significant difference compared to positive control: p<0.01; # -significant difference between combination and inhibitor only: p<0.05. Cancer cell invasion was analyzed using Transwell membranes assembled in 24-well plates and covered with a layer of Matrigel. COR-L23 cells were treated for 24 h with 50 nM DOX, 10 uM WZ811, 5 uM PF-573228 and combinations of inhibitors with 50 nM DOX. Similarly, RH460 cells were treated for 24 h with 1 uM DOX, 10 uM WZ811, 2.5 uM PF-573228 and combinations of inhibitors with 1 uM DOX. Applied doses were the ones that exerted the most pronounced synergistic effect on cytotoxicity level. After the incubation period, cells that invaded through matrigel and membranes were fixed in 4% paraformaldehyde-PBS and stained with Hoechst 33342 nuclear stain. Cells were visualized and counted under a fluorescent microscope at 10x magnification.

    2014 Dr Milica Pesic from Institute for Biological Research. Doxorubicin (Adriamycin) HCl purchased from Selleck.

产品安全说明书

Topoisomerase抑制剂选择性比较

生物活性

产品描述 Doxorubicin (Adriamycin) HCl是一种抗生素类试剂,在肿瘤细胞中抑制DNA topoisomerase II,并诱导DNA损伤和凋亡。
靶点
Topo II [1]
(Tumor cells)
体外研究

Adriamycin是抗菌的蒽环霉素,通常在两种水平发挥其抗肿瘤活性,改变DNA,和产生自由基,通过DNA损伤,触发癌细胞凋亡。Adriamycin 通过插入到 DNA链中而阻断DNA合成,且抑制DNA拓扑异构酶 II(TOP2)。Adriamycin 作用于快速增值和表达高水平TOP2的细胞最有效。此外, Adriamycin通过产生神经酰胺(通过激活p53 或其他下游通路如JNK而促进凋亡)而触发凋亡,通过丝苏氨酸蛋白酶而降解,线粒体中释放细胞色素 c,提高 FasL(死亡受体Fas/CD95 配体)mRNA产量, 且产生更多的自由基。[2] 使用GSNO(亚硝基谷胱甘肽)预处理,抑制抗Doxorubicin的乳腺癌细胞系MCF7/Dx,伴随着增强蛋白谷胱甘肽和核中Doxorubicin 的积累。[3] 在共济失调毛细血管扩张症突变(ATM),及ATM 和 Rad3相关的(ATR)信号通路中,提高的 cyclin G2(CycG2)表达和蛋白磷酸化修饰导致Adriamycin诱导的G2/M 检查点停滞。[5] Adriamycin作用于小鼠胚胎成纤维细胞(MEFs)和心肌细胞,抑制AMP活化蛋白激酶(AMPK),导致SIRT1 功能障碍,p53 累积, 且促进细胞死亡。[6] Adriamycin产生明显的热休克反应,抑制热休克蛋白或使热休克蛋白沉默增强,Adriamycin增强促进神经母细胞瘤细胞凋亡的效果。在不可测量蛋白酶抑制的条件下,纳摩尔Adriamycin处理神经母细胞瘤细胞,使特定的一系列蛋白过泛素化,这种作用存在剂量依赖性,且引起泛素化酶,如乳酸脱氢酶和α-烯醇酶的缺失,α-enolase, 蛋白泛素化模式与蛋白酶抑制剂Bortezomib相似,说明Adriamycin也可通过损伤蛋白而发挥作用。[8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 MVXGeY5kfGmxbjDBd5NigQ>? M1H2fGlvcGmkaYTpc44hd2ZiUl7BJJN6dnSqZYPpd{B4cXSqIFXEOVAhd2ZiMD61PEDPxE1? M32zUlQ6ODV|Nh?=
Yoshida sarcoma NFnYeIJHfW6ldHnvckBCe3OjeR?= NGDhcotKdmirYnn0bY9vKG:oIGuzTH1V\FJiaX7jc5Jxd3KjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNkDPxE1? MXmxN|IzQTh4
CHO NV;USGtUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnMWnl1UUN3ME2wMlA3KM7:TR?= NYHHcmloOTN3NEe1NC=>
8226 M4LVOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3r2WGlEPTB;MD6wN|Mh|ryP NVO4bWZbOTR2N{ezNC=>
8226/ADR MojES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K1d2lEPTB;MD61OkDPxE1? MmXONVQ1Pzd|MB?=
MCF7/ADR NWrjfZBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF23WIdKSzVyPUOuNUDPxE1? MYKxOFQ4PzNy
H69 NH3NZ2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwOEeg{txO MWOxOFc6PTh3
N417 NEHZOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnu0TWM2OD1yLkKzJO69VQ>? NFLVZZkyPDd7NUi1
H9 NETmSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXz5PGFYUW6qaXLpeIlwdiCxZjDIPUBk\WyuczDjbJJwdmmlYXzsfUBqdm[nY4Tl[EB4cXSqIITo[UBJUVZvMTCoTFkwUUmLQjmge4l1cCCLREWwJI9nKDBwMEGg{txO NXnncJd2OTV2OE[4NS=>
T-C8166 NHLtOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r4RmlFPTB;MD6wNUDPxE1? Mmm2NVU1QDZ6MR?=
T-H9 NGq5UJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnKUWdKTDVyPUCuNFEh|ryP MkjJNVU1QDZ6MR?=
T-MT4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkWwTWQ2OD1yLkCxJO69VQ>? MXuxOVQ5Pjhz
SKMEL-5 MkXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4qzRWVFPTB;Mz6yJO69VQ>? M1ezTlE3OTN5NUO=
MLM NWDMW|BiS3m2b4TvfIlkKEG|c3H5 NYXhOHlwTUR3ME2wMlE{KM7:TR?= NXPNT5RsOTh5NUO1NC=>
KBM-3 NFHMN4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX1UpFKSzVyPUCuNFI3KM7:TR?= MmGxNVk6PTh5Nx?=
HT-29 NHzPXnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3m[FcxNjBzIN88[y=> NVXlUZUzPDhiaB?= M{myVGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5 MmHDNlc4QDR2OR?=
EMT6 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjh[2ZSOC53IN88US=> NUDUU3ZVOSCq MnG3TY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJIJ6KG2nYYP1dolv\yCob4Kgd5Vzfmm4aX7nJIZz[WO2aX;ud{B4cXSqIFXEOVAhd2ZiMD6wNFAyKM7:TR?= MkXuO|Q2OjZ5NB?=
H2981 M2TJdWN6fG:2b4jpZ{BCe3OjeR?= M1n4UmlEPTB;MD61JO69VQ>? MV23O|MyODJ|
LOX MXTDfZRwfG:6aXOgRZN{[Xl? MXrJR|UxRTBwMESyJO69VQ>? MX[3PFU{OzNz
C38 MkTXR5l1d3SxeHnjJGF{e2G7 MYDJR|UxRTBwMEGg{txO MV:4NFU4Ojlz
EAC NVjiVnc3S3m2b4TvfIlkKEG|c3H5 MU[3NkBp NEfTc4ZKSzVyPUCuN|Uh|ryP NX\wXoFbQDN3MEC4Oy=>
SKVLB Ml[wR5l1d3SxeHnjJGF{e2G7 NH3mU4JKSzVyPUWuOkDPxE1? NYrKS2J{QDV5NkmxOC=>
AUC375 MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nJZ2lEPTB;MD6xNVIh|ryP NEPPOmc5PjR6NkCw
A2780-C25 MXrDfZRwfG:6aXOgRZN{[Xl? Ml\5R5l1d3SxeHnjbZR6KGGpYXnud5Qhd3ijbHnwcIF1cW5vcnXzbZN1[W62IFGyO|gxNUN{NTD3bZRpKEmFNUCgc4YhOC5yNkOg{txO MWK4PFMyPzV3
A2780-CP3 MnHWR5l1d3SxeHnjJGF{e2G7 NH\BcphEgXSxdH;4bYNqfHliYXfhbY5{fCClaYPwcIF1cW5vcnXzbZN1[W62IFGyO|gxNUOSMzD3bZRpKEmFNUCgc4YhOC5yNU[g{txO NFnC[HI5QDNzN{W1
A2780-DX5 M3zPSGN6fG:2b4jpZ{BCe3OjeR?= NE\HSpFEgXSxdH;4bYNqfHliYXfhbY5{fCCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgRVI4QDBvRGi1JJdqfGhiSVO1NEBw\iByLkO1O{DPxE1? MYq4PFMyPzV3
MXF7 MYfDfZRwfG:6aXOgRZN{[Xl? NHXadZZCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEB{\W6|aYTpeoUhVViINzD3bZRpKEmFNUCgc4YhOC5yMkig{txO NH;hSms5QTZyNUW4
MXF7 NUPJZZdjS3m2b4TvfIlkKEG|c3H5 M1HQUWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1qfG:6YX70do9v\S2{ZYPpd5RidnRiTWjGO{B4cXSqIFnDOVAhd2ZiMD6wNlgh|ryP NGXjcGE5QTZyNUW4
MXF7 MnXOR5l1d3SxeHnjJGF{e2G7 NYXLUFhJSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5Qh\G:6b4L1ZolkcW5vcnXzbZN1[W62IF3YSlchf2m2aDDJR|UxKG:oIEGuNVczKM7:TR?= MmjkPFk3ODV3OB?=
WiDr NIi0eoxEgXSxdH;4bYMhSXO|YYm= MUPBZ5Rqfmm2eTDh[4FqdnO2IIPlcpNqfGm4ZTDXbWRzKGOnbHyge4l1cCCLQ{WwJI9nKDBwMEWzJO69VQ>? MYC4PVYxPTV6
MCF NGfoZW5HfW6ldHnvckBCe3OjeR?= NVrWdVByWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SCjc4Pld5Nm\CCjczDlcohidmOnbXXueEBqdiCleYTveI95cWOrdImgc4Yh[WS{aXHtfYNqdg>? NIfCUXo5QTh2MUWx
C6 NE[zc3NEgXSxdH;4bYMhSXO|YYm= M3XQRlIvPSCvZz;tUC=> NXnUTXZ2PzJiaB?= M12zRWROW09? NWqxNo9jS3m2b4TvfIlkcXS7IHHnZYlve3RicnH0JGM3KGOnbHzzJIF1KDVyIIXnM41NKHSxIEKuOUBu\y:vTB?= MoHHPFk5QDZyNB?=
C6 NV;jSmtOTnWwY4Tpc44hSXO|YYm= NVrXbIs1Oi53IH3nM41N MVu0JIg> MnewSG1UVw>? MV7Jcohq[mm2aX;uJI9nKHS3YoXsbY4heG:ueX3ldol7[XSrb36= MlnkPFk5QDZyNB?=
C6 NV3zdY51S3m2b4TvfIlkKEG|c3H5 M2\iflIvPSCvZz;tUC=> NWfiOmNWPSCq Mn\rSG1UVw>? MkT4R5l1d3SxeHnjbZR6KGG|c3Xzd4VlKGG|IHPlcIwhemWuZXHz[S=> NYTnSooyQDl6OE[wOC=>
SKVLB MluwR5l1d3SxeHnjJGF{e2G7 Mkm0O|IhcA>? NH\3eXdKSzVyPU[uOVQh|ryP M{XsZlkxODN3MkC=
MCF7/VP16 NUnzfZBMS3m2b4TvfIlkKEG|c3H5 NFWzfGI2OCEQvHevcWw> M3ryV|czKGh? NGDPZ|JKSzVyPUG0MlIh|ryP MYK5NFIzPzl{
CA755 NXTSZ|E2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHr6T4wyOCEQvF2= NUPnco5mPiCm NWr4epZ5UUN3ME2wMlAyPCEQvF2= M4DVclk2OjZ3N{C=
CHO NV\CUJBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[0NVAh|ryP M4jzO|Yh\A>? MlywTWM2OD1yLkC2JO69VQ>? MX:5OVI3PTdy
Panc02 M2fGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPKbmE3OTBizszN M{P5VFYh\A>? M3Ts[mlEPTB;MD6wOlUh|ryP NEDVOok6PTJ4NUew
PC14 NHHxdYhEgXSxdH;4bYMhSXO|YYm= NVfHcVBpPCCm MYLEUXNQ MoftTWM2OD1yLkK5JO69VQ>? NEHj[YI6QDJ{NUSy
HOP62 MWLDfZRwfG:6aXOgRZN{[Xl? NW\OR|ZmPzJiaB?= M1jHSGlEPTB;MD6wNFQh|ryP NHPoTms6QDd|Nk[x
SF-295 MX3DfZRwfG:6aXOgRZN{[Xl? M{CzNVczKGh? M{[zWGlEPTB;MD6wN|Uh|ryP MlLXPVg4OzZ4MR?=
MDA-MB-361 Mmi3R5l1d3SxeHnjJGF{e2G7 MVGxJIg> MmXvSG1UVw>? NUnjVXdCS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTBMW1DNTN4MTDlfJBz\XO|aX7nJGxi[1pid3n0bEBKSzVyIH;mJFAvODF{IN88US=> MoTaNVA{QTV2OUC=
MDA-MB-361 NWDsR3p7S3m2b4TvfIlkKEG|c3H5 NFziZZEyKGh? NVnyU|BqTE2VTx?= NVjLRoJ[S3m2b4TvfIlkcXS7IHHnZYlve3RiTVTBJG1DKDN4MTDlfJBz\XO|aX7nJINiemKxeInw[ZB1cWSjc3Wgd5REWEd{IIfpeIghUUN3MDDv[kAxNjBzODFOwG0> M4fpd|ExOzl3NEmw
CCRF-SB NGixVnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\FTIc1KGR? NH\0[|JFVVOR NV7jcHlYUUN3ME2wMlAyKM7:TR?= NFz5eY4yODRzMUS3Oi=>
CHO-K1 M3i5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;BZotuPCCm MkjYSG1UVw>? MonLTWM2OD1yLkSg{txO MnnNNVA1OTF2N{[=
KB MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr2OWFOPCCm MYLEUXNQ NE\rUY5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIRzfWdvcnXzbZN1[W62IFvCO2Qhf2m2aDDJR|UxKG:oIECuOlUh|ryP M37aclExPDFzNEe2
KB MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLNfHQ1KGR? NFLOcnpFVVOR MnSyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDkdpVoNXKnc3nzeIFvfCCNQlPhcZB4cXSqIFnDOVAhd2ZiMD6wOkDPxE1? MXSxNFQyOTR5Nh?=
KB NEC2PVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\PU|Qh\A>? NEnnRXNFVVOR M2HHV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4Sg[JJ2\y2{ZYPpd5RidnRiS1LNSHIhf2m2aDDJR|UxKG:oIECuOUDPxE1? MkDaNVA1OTF2N{[=
KB NXzXco9{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPNPWE1KGR? MVrEUXNQ NYLIdWVVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpLYLld4l{fGGwdDDLRnYzOENid3n0bEBKSzVyIH;mJFAvPCEQvF2= Ml\XNVA1OTF2N{[=
HTB-54 M1TR[GN6fG:2b4jpZ{BCe3OjeR?= MmXHNVAxKM7:TR?= NYDVSXpjUUN3ME2xMlEh|ryP M4LVblExPDd4OE[x
MEL-AC NV;R[FI2S3m2b4TvfIlkKEG|c3H5 MlvWNVAxKM7:TR?= MlfDTWM2OD1zLkKg{txO NULaTmtQOTB2N{[4OlE>
DU145 NX7jNG1yS3m2b4TvfIlkKEG|c3H5 NVHO[FF{PzJiaB?= MULJR|UxRTBwMEWyPEDPxE1? MVixNFQ4QTJ6Mh?=
K562R MVfDfZRwfG:6aXOgRZN{[Xl? MWm3NkBp MkD3TWM2OD1yLkCxOVYh|ryP MYqxNFQ4QTJ6Mh?=
PACA-2 M1XBO2N6fG:2b4jpZ{BCe3OjeR?= MWW2JIQ> NED5cZpGTDVyPUCuNFA3OyEQvF2= NFXscVgyODR7OEKxOC=>
3Y1 M1myUGN6fG:2b4jpZ{BCe3OjeR?= MYC3NkBp MUjHTVUxRTBwMECzPEDPxE1? NFLvb|IyODZ7MUexNC=>
P388 MknTR5l1d3SxeHnjJGF{e2G7 M{\G[FczKGh? M3y3cWdKPTB;MD6wNVIh|ryP MV6xNFY6OTdzMB?=
HMV-1 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HBN2lEPTB;MD6yPEDPxE1? Ml:yNVA3QTh2M{[=
MKN-1 NVjqWJY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwNkSg{txO MXKxNFY6QDR|Nh?=
PC14 M4\3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3PTWM2OD1zLkmg{txO NVnJWnRLOTB4OUi0N|Y>
T24 MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjZdnRKSzVyPUCuOlQh|ryP NEnNUZoyODZ7OESzOi=>
U937 NIC0XlVHfW6ldHnvckBCe3OjeR?= M{XnZ|I1KGh? MYPEUXNQ M2K4bWlvcGmkaYTzJIlv[2:{cH;yZZRqd25ib3[gX|NJZXSqeX3p[Ilv\SC5aYToJGlEPTBib3[gNE4yKM7:TR?= MljPNVA4QDB7MUG=
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NCI-H2052 NV;HTXpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfzcXZKSzVyPUG2NE41PyCwTR?= MVPTRW5ITVJ?
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RPMI-8866 NG\XPVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF7Mj6xN{BvVQ>? NETjNoVUSU6JRWK=
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OE19 M1\PTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfyTWM2OD1{MECuNVghdk1? MW\TRW5ITVJ?
NCI-H1694 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rEPGlEPTB;MkCwMlI3KG6P NHv2NIRUSU6JRWK=
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NCI-H1882 NVnkNJFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[0TWM2OD1{MUWgcm0> M3zrc3NCVkeHUh?=
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MHH-NB-11 M2Sz[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknQTWM2OD1{MkCuNlIhdk1? MXTTRW5ITVJ?
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KYSE-70 M1zUfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Cz[GlEPTB;MkK0MlY3KG6P M1TGOHNCVkeHUh?=
NCI-H838 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHjcopKSzVyPUKyOE44OyCwTR?= NGTafpdUSU6JRWK=
NY NWXjZmp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrCWo9KSzVyPUKyPE41QSCwTR?= M{\ZcHNCVkeHUh?=
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MHH-PREB-1 MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJ{OT64NkBvVQ>? M{fRXXNCVkeHUh?=
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Detroit562 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fWdmlEPTB;MkOwMlczKG6P Ml;BV2FPT0WU
NCI-H2405 NWjyfoxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LYTWlEPTB;MkO0MlEhdk1? NHHpTndUSU6JRWK=
NCI-H2081 MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XaUGlEPTB;MkO0MlI4KG6P NX;XS4FSW0GQR1XS
LB2241-RCC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7tTWM2OD1{M{WuNVEhdk1? NGnJRZVUSU6JRWK=
SNU-387 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJ|Nj6wPEBvVQ>? M1jlbXNCVkeHUh?=
PC-14 NXLI[phbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nDfmlEPTB;MkO2MlEzKG6P NHXtPFNUSU6JRWK=
CAS-1 NF7ZSGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnaTWM2OD1{M{iuN|Ehdk1? NVvlZYFOW0GQR1XS
TE-11 Mn;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vaTGlEPTB;MkSwMlg5KG6P NGXIenpUSU6JRWK=
LC4-1 MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj0TWM2OD1{NECuPFkhdk1? MXfTRW5ITVJ?
HH Mm\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVznc4Q2UUN3ME2yOFEvPDZibl2= NYDtO3Q2W0GQR1XS
JVM-2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr2So1TUUN3ME2yOFIvOTdibl2= NVSwfVVDW0GQR1XS
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T-24 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGL1O4JKSzVyPUK0OU41QCCwTR?= M3roOnNCVkeHUh?=
D-392MG NHTScHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\xUWhKSzVyPUK0PE42KG6P NHfVfWRUSU6JRWK=
KOSC-2 M{flO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPHTWM2OD1{NEiuO|Ehdk1? M2O1R3NCVkeHUh?=
D-283MED NF7XO|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTJ3MD6xN{BvVQ>? Mnm2V2FPT0WU
BV-173 M{\yZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfmTWM2OD1{NUCuO|chdk1? M1Thd3NCVkeHUh?=
EW-18 NG\HWWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTJ3MD65JI5O M2nre3NCVkeHUh?=
MS-1 M3\QNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJ3Mj61N{BvVQ>? MX;TRW5ITVJ?
Calu-6 M3jlZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJ3Mz61OUBvVQ>? NIjVXnlUSU6JRWK=
GR-ST M2L2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJ3NT60NkBvVQ>? MWfTRW5ITVJ?
GAK MoDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7EUJhXUUN3ME2yOVYvQTFibl2= MYPTRW5ITVJ?
TE-9 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T3OWlEPTB;MkW3MlQ4KG6P NVjEe4V{W0GQR1XS
HuH-7 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPBSZVKSzVyPUK1PE41PCCwTR?= NUn0UodUW0GQR1XS
KYSE-520 M33zOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\YOXlKSzVyPUK2NE44PyCwTR?= NHq2WndUSU6JRWK=
NCI-H520 MmPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDOUI1KSzVyPUK2Ok43OSCwTR?= M2P2b3NCVkeHUh?=
HD-MY-Z Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzNTWM2OD1{N{KuO|khdk1? MmLNV2FPT0WU
SW756 NGDFU49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjiTWM2OD1{N{SuO|ghdk1? MXXTRW5ITVJ?
NB12 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjuTWM2OD1{N{euNVIhdk1? M1XFTHNCVkeHUh?=
EW-3 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTIUpJQUUN3ME2yO|kvQDlibl2= NF7KbHZUSU6JRWK=
AM-38 NV3vbmZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFv0SYVKSzVyPUK4NU42OiCwTR?= MnfQV2FPT0WU
NCI-H23 MmDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK5TWM2OD1{OEOuPVIhdk1? NFHvdnNUSU6JRWK=
GOTO M3G3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJ6NT61OkBvVQ>? NYPE[XZoW0GQR1XS
NCI-H1693 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\6ZZFKSzVyPUK5NE4{OiCwTR?= MnzvV2FPT0WU
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MDA-MB-361 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHaUmNKSzVyPUK5Nk43PSCwTR?= NIroVYNUSU6JRWK=
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CAL-54 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;NTWM2OD1|MECuO|Mhdk1? NGmwSYdUSU6JRWK=
D-263MG MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD2[I1KSzVyPUOwOU42OiCwTR?= M3PCcHNCVkeHUh?=
SKG-IIIa MmjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTNzMT6xOEBvVQ>? Ml3mV2FPT0WU
HAL-01 NIHRc|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHvTnNKSzVyPUOxN{41PCCwTR?= Mli2V2FPT0WU
LAN-6 NXPZXZBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjYN2hRUUN3ME2zNVUvOTFibl2= NEXB[29USU6JRWK=
NCI-H1304 NWTZWnNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTHSYZmUUN3ME2zNlEvOTdibl2= NH3YSWpUSU6JRWK=
no-11 M3zDcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\jfZJMUUN3ME2zNlEvPjRibl2= MXXTRW5ITVJ?
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L-363 NX:y[pdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTN{ND60N{BvVQ>? M1:xW3NCVkeHUh?=
EM-2 MkXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInte5lKSzVyPUOyOU41OSCwTR?= MnTDV2FPT0WU
DV-90 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqwTWM2OD1|MkmuOFUhdk1? NIjYRpBUSU6JRWK=
Saos-2 NF3SW|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTN{OT65OEBvVQ>? NWHhfoFrW0GQR1XS
UMC-11 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTWWnR7UUN3ME2zN|EvOjhibl2= NGDKU4pUSU6JRWK=
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