Daunorubicin (RP 13057) HCl

For research use only. Not for use in humans.

目录号:S3035 别名: Daunomycin HCl, Rubidomycin HCl 中文名称:道诺霉素

Daunorubicin (RP 13057) HCl Chemical Structure

CAS No. 23541-50-6

Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin)抑制DNA和RNA合成,无细胞试验中抑制DNA合成的Ki为0.02 μM。Daunorubicin 是 topoisomerase II 的抑制剂并可诱导凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 727.52 现货
RMB 579.56 现货
RMB 2188.15 现货
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客户使用Selleck生产的Daunorubicin (RP 13057) HCl发表文献45篇:

产品安全说明书

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

生物活性

产品描述 Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin)抑制DNA和RNA合成,无细胞试验中抑制DNA合成的Ki为0.02 μM。Daunorubicin 是 topoisomerase II 的抑制剂并可诱导凋亡。
靶点
DNA synthesis [1]
(Cell-free assay)
20 nM(Ki)
体外研究

Daunorubicin给药后达到峰值血药浓度时的药物浓度表明,药物作用的主要机制可能是与拓扑异构酶II相互作用,至少在白血病细胞和胸腺细胞中,这可能是导致细胞凋亡的信号通路激发了生长阻滞和/或细胞杀伤。在氧化还原酶,包括细胞色素P450还原酶,NADH脱氢酶,和黄嘌呤氧化酶介导的反应中,醌结构允许daunorubicin以电子受体发挥作用。Daunorubicin浓度超过大约2–4 μM时,自由基介导的毒性和DNA交联可能变得明显。Daunorubicin在0.2 到2 μM浓度范围内抑制HeLa 细胞中DNA 和RNA合成。Daunorubicin在超过4 μM浓度范围时抑制埃利希腹水瘤细胞中DNA合成。HL-60或U-937人白血病细胞中,Daunorubic在0.5和1 μM浓度下引起细胞凋亡。[1]在P388和U937细胞中,通过激活神经酰胺合酶从头合成,Daunorubicin刺激神经酰胺增加和细胞凋亡。[2]人脐静脉内皮细胞中,Daunorubicin剂量依赖性增加磷脂酰丝氨酸的暴露和随后促凝血酶的活性。Daunorubicin (0.2 mM)显著增强内皮微粒的释放,其在人脐静脉内皮细胞中具有高的促凝血作用。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA MB 361(mammary carcinoma cell line) MkT4R5l1d3SxeHnjxsBie3OjeR?= M3HVOXRp\SClb33wc5Vv\CC5YYOgeIV{fGWmIH\vdkBqdnS{YXPlcIx2dGG{IHP5eI91d3irY3n0fUBi\2GrboP0JG1FSSCPQjCzOlEpdWGvbXHyfUBk[XKlaX7vcYEh[2WubDDsbY5mMSCneIDy[ZN{cW6pIFzhZ3ohMGKndHGt[4Ft[WO2b4Pp[IF{\SluIFnDOVA:OTdibl2= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODN7NUS5NEc,OTB|OUW0PVA9N2F-
P388 leukemia cell line M2T6O2N6fG:2b4jpZ:Kh[XO|YYm= Mo[4R49ueG:3bnSge4F{KGW4YXz1ZZRm\CCob4KgZ5l1d3SxeHnjbZR6KGGpYXnud5QhWDN6ODDs[ZVs\W2rYTDj[YxtKGyrbnWsJGlEPTB;MzDuUS=> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODR5OUK5O{c,OTB2N{myPVc9N2F-
Dx5 w/PSC cell lines MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlTIWIhmKGOxbYDveY5lKHejczDleoFtfWG2ZXSg[o9zKHSqZTDndo94fGhiaX7obYJqfGmxbjDv[kBFgDVidz;QV2Mh[2WubDDsbY5meyC3c3nu[{BOXFRiYYPzZZktKEmFNUC9NVQhdk1? NHnqUWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zME[5PFQ1QSd-MUC2PVg1PDl:L3G+
MES-SA uterine tumor cell lines MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGHGcI1VcGViY3;tdI92dmRid3HzJIV3[Wy3YYTl[EBnd3JidHjlJIdzd3e2aDDpcohq[mm2aX;uJI9nKE2HUz3TRUB2fGW{aX7lJJR2dW:{IHPlcIwhdGmwZYOgeZNqdmdiTWTUJIF{e2G7LDDJR|UxRTBwMEKxJO69VQ>? M1:2dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNkm4OFQ6Lz5zME[5PFQ1QTxxYU6=
Dx5 cell lines NVzucWZpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXvyXnpNXGinIHPvcZBwfW6mIIfhd{BmfmGudXH0[YQh\m:{IITo[UBoem:5dHigbY5pcWKrdHnvckBw\iCGeEWgZ4VtdCCuaX7ld{B2e2mwZzDNWHQh[XO|YYmsJIlkPTB;MjFOwG0> MorYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB4OUi0OFkoRjFyNkm4OFQ6RC:jPh?=
human epidermoid carcinoma cell line KB-3-1 MmriR5l1d3SxeHnjxsBie3OjeR?= NHzTR3FKdiC4aYTyc{BkgXSxdH;4bYMh[WO2aY\peJkhf2G|IHX2ZYx2[XSnZDD1d4lv\yC2aHWgbJVu[W5iZYDp[IVzdW:rZDDjZZJkcW6xbXGgZ4VtdCCuaX7lJGtDNTNvMTygTWM2OD15IH7N NXLLS4wzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK0OFM4PjNpPkGyOFQ{PzZ|PD;hQi=>
human uterine sarcoma cell line MES-SA M37DW2N6fG:2b4jpZ:Kh[XO|YYm= NWrKSYV5UW5idnn0do8h[3m2b4TvfIlkKGGldHn2bZR6KHejczDleoFtfWG2ZXSgeZNqdmdidHjlJIh2dWGwIIX0[ZJqdmVic3HyZ49u[SClZXzsJIxqdmViTVXTMXNCNCCLQ{WwQVAvODdizszN MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjR2M{e2N{c,OTJ2NEO3OlM9N2F-
Jurkat T lymphocytes NEn3UGVEgXSxdH;4bYPDqGG|c3H5 MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBLfXKtYYSgWEBtgW2yaH;jfZRmeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6wPFI3KM7:TR?= M17uVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4M{[2OlAzLz5zNkO2OlYxOjxxYU6=
human HeLa3 cell line MkmyR5l1d3SxeHnjxsBie3OjeR?= NVi4OWtPS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYUOgZ4VtdCCuaX7lJIJ6KE2WVDDhd5NigSxiSVO1NF0zNjl4IN88US=> M4jFdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUSyNFM4Lz5zNkm0NlA{PzxxYU6=
NCI-H69 cell line MljjVJJwdGmoZYLheIlwdiCjc4PhfS=> NWXZbI1sSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBlenWpIIPlcpNqfGm4ZTDOR2kuUDZ7IHPlcIwhdGmwZTDifUBCdGGvYYKgRox2\SCjc4PhfUwhUUN3ME2wMlEh|ryP NX:4VZFCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyPFY{QTNpPkG3Nlg3Ozl|PD;hQi=>
L1210 NYmw[odXTnWwY4Tpc44h[XO|YYm= NEK2[WVKdmirYnn0bY9vKG:oIGLORUB{gW62aHXzbZMhcW5ibX;1d4UhVDF{MUCgZ4VtdHNuIFXEOVAhRSByLkOg{txONg>? NVe0XGZ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxNEKzNVgyLz52MkOxPFE9N2F-
L1210 MYjGeY5kfGmxbjDhd5NigQ>? MnPxTY5pcWKrdHnvckBw\iCGTlGgd5lvfGinc3nzJIlvKG2xdYPlJGwyOjFyIHPlcIx{NCCHREWwJF0hOSEQvF2u M37xbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzR{M{G4NUc,PDJ|MUixQE9iRg>?
L1210 NWj1[GtzTnWwY4Tpc44h[XO|YYm= M2TxNWlvcGmkaYTpc44hd2ZiUl7BJJN6dnSqZYPpd{BqdiCvb4Xz[UBNOTJzMDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFt|SG31dollcW6nIHnuZ49zeG:{YYTpc44tKEWGNUCgQUAxNjNizszNMi=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek81QTB3M{enQlQ6ODV|N{yvZV4>
L1210 MkDnSpVv[3Srb36gZZN{[Xl? NYLXdYQxUW6qaXLpeIlwdiCxZjDEUmEhe3mwdHjld4l{KGmwIH3veZNmKExzMkGwJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiW{PIYZRpgW2rZHnu[UBqdmOxcoDvdoF1cW:wLDDFSFUxKD1iMD60JO69VS5? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek81QTB3M{enQlQ6ODV|N{yvZV4>
L1210 MUXGeY5kfGmxbjDhd5NigQ>? NHHDRVdKdmirYnn0bY9vKG:oIGuzTH12emmmaX7lJIlv[2:{cH;yZZRqd25iaX70c{Bxem:uaX\ldoF1cW6pIFyxNlExKGOnbHzzMEBGTDVyIE2gNE4{OyEQvF2u M3vSNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzZ5MU[0NFEoRjZ5MU[0NFE9N2F-
L1210 NGTYO4tHfW6ldHnvckBie3OjeR?= NYWzdmE5UW6qaXLpeIlwdiCxZjDbN2hefGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gbY51dyCycn;sbYZmemG2aX7nJGwyOjFyIHPlcIx{NCCHREWwJF0hOC54NjFOwG0v MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek83PzF4NECxK|43PzF4NECxQE9iRg>?
L1210 NXHZOZY6TnWwY4Tpc44h[XO|YYm= MnTPSI9{\SC{ZYH1bZJm\CC2bzDpcohq[mm2IITo[UBTVkFic4nueIhme2m|IHnuJIxmfWunbXnhJGwyOjFyIHPlcIx{NCCHREWwJF0hOC5|IN88UU4> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84OjV{OUe2K|44OjV{OUe2QE9iRg>?
L1210 M4WwN2Z2dmO2aX;uJIF{e2G7 MXnEc5NmKHKncYXpdoVlKHSxIHnubIljcXRidHjlJGRPSSC|eX70bIV{cXNiaX6gcIV2c2WvaXGgUFEzOTBiY3XscJMtKEWGNUCgQUAyKM7:TT6= NWrrV|YxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{K1Nlk4Pid-N{K1Nlk4PjxxYU6=
MCF7 M1PJO2N6fG:2b4jpZ4l1gSCjc4PhfS=> NIPiTIc1QCCqcoO= M2HN[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOjJizszNMi=> NUXPbHpxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPVA1PDdpPkG3NVkxPDR5PD;hQi=>
MDA-MB-231 MVvDfZRwfG:6aXPpeJkh[XO|YYm= NXe2e2M2PDhiaILz M1TFfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNlUh|ryPLh?= M13QeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUmwOFQ4Lz5zN{G5NFQ1PzxxYU6=
HeLa MX7DfZRwfG:6aXPpeJkh[XO|YYm= MXm0PEBpenN? Mn3NR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4{OiEQvF2u NGTHPXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G5NFQ1Pyd-MUexPVA1PDd:L3G+
PC-3 NGWwPYNEgXSxdH;4bYNqfHliYYPzZZk> MX[0PEBpenN? MlTwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGMuOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE41PCEQvF2u NFLrboQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G5NFQ1Pyd-MUexPVA1PDd:L3G+
Yoshida sarcoma tumor cells NX\URWNMTnWwY4Tpc44h[XO|YYm= NI\IR3BEd26lZX70doF1cW:wIHnubIljcXSrbnegX|NJZVSmUjDpcoNwenCxcnH0bY9vKGmwIGnvd4hq\GFic3HyZ49u[SC2dX3vdkBk\WyuczDpckB3cXS{bzDpckBz[XS|LDDJR|UxKD1iMD6wNkDPxE1w NFzENXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zM{KyPVg3Lz5zM{KyPVg3RC:jPh?=
HL60 MWjBdI9xfG:|aYOgZZN{[Xl? MlW4TY4hfmm2cn:gZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDpcoR2[2ViYYDvdJRwe2m|IHnuJGhNPjBiY3XscJMtKEGFNUCgQUAxNjB2IN88UU4> NYrsco9mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4O|c2QTNpPkGyPFc4PTl|PD;hQi=>
HL60R MVHBdI9xfG:|aYOgZZN{[Xl? NHvK[ZlKdiC4aYTyc{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJIlv\HWlZTDhdI9xfG:|aYOgbY4hUEx4MGKgZ4VtdHNuIFHDOVAhRSBzMDFOwG0v NILJWlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMki3O|U6Oyd-MUK4O|c2QTN:L3G+
HL60 NFfaZ4pEgXSxdH;4bYNqfHliYYPzZZk> NEPFWoxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJVDZyIHPlcIx{KGGodHXyJFQ5KGi{czDifUB1enmyYX6gZox2\SCneHPseZNqd25ibXX0bI9lNCCDQ{WwJF0hOC5zIN88UU4> NWXybIRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizN|k1PTVpPkG4N|M6PDV3PD;hQi=>
HL60 MYjBdI9xfG:|aYOgZZN{[Xl? NWX1TmNiUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBufWy2aXTyeYchemW|aYP0ZY51KGi3bXHuJGhNPjBiY3XscJMh[W[2ZYKgOFghcHK|LDDBR|UxKD1iM{ig{txONg>? MnuyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|M{m0OVUoRjF6M{O5OFU2RC:jPh?=
HTB-81 NWTZTWZ5S3m2b4TvfIlkcXS7IHHzd4F6 NFfvOGVEgXSxdH;4bYNqfHlidHjheEBk[XW|ZXSgZUA2OCVicnXkeYN1cW:wIHnuJIFje2:{YnHuZ4Uh[XRiNEmwJI5uKGmwIHj1cYFvKHC{b4P0ZZRmKGOjbnPldkBJXEJvOEGgZ4VtdHNidYPpcochVVSVIHHzd4F6NCCHQ{WwJF0hOC5yNUig{txONg>? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4OUc,OTFyMkCyPFU9N2F-
B16 M1z0N2N6fG:2b4jpZ4l1gSCjc4PhfS=> NWLQNnFDS3m2b4TvfIlkcXS7IIToZZQh[2G3c3XkJIEhPTBnIILl[JVkfGmxbjDpckBi[nOxcnLhcoNmKGG2IES5NEBvdSCrbjDCNVYhdW:3c3WgcYVt[W6xbXGgZ4VtdHNidYPpcochVVSVIHHzd4F6NCCHQ{WwJF0hOC5zNjFOwG0v NVHhOmhoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGwNlAzQDVpPkGxNFIxOjh3PD;hQi=>
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Rh41 NHHJe5NyUFSVIHHzd4F6 M3vFTpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCUaESxJINmdGy| M3nvUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
P388 M3fVdWFvfGm2dX3vdkBie3OjeR?= MVewMlI2KHSxIEGwJI1oN2up M4W2WWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIGCzPFgh[2WubIOgZYxtd2e{YX\0[YQhcW5ibX;1d4Uh[XO|ZYPz[YQh[XNidIXtc5Ih\3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6yOUB1dyBzMDDt[{9s\w>? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjV3Nk[xK|4yOjV3Nk[xQE9iRg>?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-Chk1 / Chk1 / p-ATR / ATR ; 

PubMed: 26727128     


After Caco-2 cells were treated with or without 1 μ M daunorubicin, whole cell extracts were collected at 1, 3, 6, 12, 24, and 48 h and immunoblotted for Chk1, p-Chk1, ATR, and p-ATR. β-actin served as the loading control.

26727128
Immunofluorescence
p-Chk1; 

PubMed: 26727128     


Caco-2 cells were treated with or without 1 μ M daunorubicin for 48 h, and then fixed and stained with anti-p-Chk1 antibody and DAPI. Images were collected under a fluorescence microscope. Scale bar = 10 μm. 

26727128
Growth inhibition assay
Cell viability; 

PubMed: 30745844     


(A) Viability of AML cell lines under different concentrations of Dnr according to the CCK-8 assay. (B) IC50 of AML cell lines calculated according to the result of the CCK-8 assay.

30745844

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 100 mg/mL (177.31 mM)
Water 100 mg/mL (177.31 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 563.98
化学式

C27H29NO10 . HCl

CAS号 23541-50-6
储存条件 粉状
溶于溶剂
别名 Daunomycin HCl, Rubidomycin HCl

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04562792 Recruiting Drug: Daunorubicin Relapsed Pediatric ALL|Relapsed Pediatric AML|Refractory Acute Myeloid Leukemia|Refractory Acute Lymphoblastic Leukemia Children''s Mercy Hospital Kansas City May 8 2020 Phase 2
NCT03878927 Recruiting Drug: CPX-351|Drug: Gemtuzumab Ozogamicin Acute Myeloid Leukemia Weill Medical College of Cornell University|Jazz Pharmaceuticals|Pfizer August 23 2019 Phase 1
NCT03896269 Recruiting Drug: Liposome-encapsulated Daunorubicin-Cytarabine Blasts 10-19 Percent of Bone Marrow Nucleated Cells|Blasts More Than 5 Percent of Bone Marrow Nucleated Cells|High Risk Chronic Myelomonocytic Leukemia|Recurrent Chronic Myelomonocytic Leukemia|Recurrent High Risk Myelodysplastic Syndrome|Refractory Chronic Myelomonocytic Leukemia|Refractory High Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|National Cancer Institute (NCI) May 14 2019 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID