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别名 | Benzenebutyric acid | 储存条件 (自收到货起) |
3年 -20°C 粉状 | |
化学式 | C10H12O2 |
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分子量 | 164.20 | CAS号 | 1821-12-1 | |
Solubility (25°C)* | 体外 | DMSO | 33 mg/mL (200.97 mM) | |
Ethanol | 33 mg/mL (200.97 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | 4-PBA (4-Phenylbutyric acid)是 histone deacetylase (HDAC) 抑制剂,是抗 HCV 的肝铁调素的主要表观遗传诱导剂。4-Phenylbutyric acid 通过调节急性肺损伤模型中的内质网压力 endoplasmic-reticulum (ER) stress 和自噬来抑制LPS诱导的炎症。 | |
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靶点 |
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A novel CSN5/CRT O-GlcNAc/ER stress regulatory axis in platinum resistance of epithelial ovarian cancer [ Int J Biol Sci, 2024, 20(4):1279-1296] | PubMed: 38385070 |
Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke [ J Transl Med, 2024, 22(1):248] | PubMed: 38454480 |
IRE1α arm of unfolded protein response in muscle-specific TGF-β signaling-mediated regulation of muscle cell immunological properties [ Cell Mol Biol Lett, 2023, 28(1):15] | PubMed: 36849929 |
Porcine reproductive and respiratory syndrome virus infection triggers autophagy via ER stress-induced calcium signaling to facilitate virus replication [ PLoS Pathog, 2023, 19(3):e1011295] | PubMed: 36972295 |
Routes of Albumin Overload Toxicity in Renal Tubular Epithelial Cells [ Int J Mol Sci, 2023, 24(11)9640] | PubMed: 37298591 |
Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression [ Int J Mol Sci, 2023, 10.3390/ijms241813825] | PubMed: 37762128 |
Endoplasmic reticulum stress mediates environmental particle-induced inflammatory response in bronchial epithelium [ J Immunotoxicol, 2023, 10.1080/1547691X.2023.2229428] | PubMed: 37417782 |
Effects of endoplasmic reticulum stress on erectile function in rats with cavernous nerve injury [ Sex Med, 2023, 11(4):qfad050] | PubMed: 37674767 |
ASK1-ER stress pathway-mediated fibrotic-EV release contributes to the interaction of alveolar epithelial cells and lung fibroblasts to promote mechanical ventilation-induced pulmonary fibrosis [ Exp Mol Med, 2022, 1-13.] | PubMed: 36473935 |
A heterozygous p.S143P mutation in LMNA associates with proteasome dysfunction and enhanced autophagy-mediated degradation of mutant lamins A and C [ Front Cell Dev Biol, 2022, 10:932983] | PubMed: 36111332 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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