Barasertib (AZD1152-HQPA)

目录号：S1147 批次号：S114707

化学数据

	别名	AZD2811, INH-34, Barasertib-HQPA , Defosbarasertib	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₆H₃₀FN₇O₃
	分子量	507.56	CAS号	722544-51-6
Solubility (25°C)*	体外	DMSO	100 mg/mL (197.02 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) 是一种高度选择性的Aurora B抑制剂，无细胞试验中IC50为0.37 nM，作用于Aurora B比作用于Aurora A选择性高3700倍左右。

靶点

Aurora B ^[1]
(Cell-free assay)

0.37 nM

参考文献

客户使用selleck产品的实验数据

: 数据来源于[Data independently produced by Nature, 2014, 508(7494), 118-22]

: 数据来源于[Data independently produced by J Exp Med, 2014, 10.1084/jem.20141123]

: 数据来源于[, 33, 3550-60]

: 数据来源于[, 31, 1217–1227]

Barasertib (AZD1152-HQPA)在文献中得到引用

High-throughput screening identifies Aurora kinase B as a critical therapeutic target for Merkel cell carcinoma [ Nat Commun, 2025, 16(1):1583]	PubMed: 39939315
Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies [ Cell Rep Med, 2025, 6(2):101964]	PubMed: 39933527
Identification of chemical inhibitors targeting long noncoding RNA through gene signature-based high throughput screening [ Int J Biol Macromol, 2025, 292:139119]	PubMed: 39722392
Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis [ Elife, 2025, 14e75393]	PubMed: 39791360
Proteomic profiling identifies upregulation of aurora kinases causing resistance to taxane-type chemotherapy in triple negative breast cancer [ Sci Rep, 2025, 15(1):3211]	PubMed: 39863788
Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs [ Gastroenterology, 2024, S0016-5085(24)00062-3]	PubMed: 38262581
Detection of senescence using machine learning algorithms based on nuclear features [ Nat Commun, 2024, 15(1):1041]	PubMed: 38310113
Repurposed AT9283 triggers anti-tumoral effects by targeting MKK3 oncogenic functions in Colorectal Cancer [ J Exp Clin Cancer Res, 2024, 43(1):234]	PubMed: 39164711
WEE1 confers resistance to KRASG12C inhibitors in non-small cell lung cancer [ Cancer Lett, 2024, 611:217414]	PubMed: 39725152
Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells [ Br J Cancer, 2024, 10.1038/s41416-024-02584-z]	PubMed: 38287178

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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