Artesunate

目录号：S2265 批次号：S226504

化学数据

	别名	WR-256283	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₁₉H₂₈O₈
	分子量	384.42	CAS号	88495-63-0
Solubility (25°C)*	体外


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Artesunate是一种抗疟类药，作用于小细胞肺癌细胞系H69，IC50为< 5 μM。它是一种潜在的STAT3抑制剂，在体外对癌细胞有选择性细胞毒性作用；是有效的EXP1抑制剂。

靶点

EXP1(a membrane glutathione S-transferase) ^[4]

STAT3 ^[7]

参考文献

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Artesunate在文献中得到引用

Artesunate disrupts ribosome RNA biogenesis and inhibits ovarian cancer growth by targeting FANCA [ Phytomedicine, 2024, 136:156333]	PubMed: 39731835
In vitro assessment of the anti-adenoviral activity of artemisinin and its derivatives [ Virus Res, 2024, 349:199448]	PubMed: 39127240
Artesunate ameliorates irinotecan-induced intestinal injury by suppressing cellular senescence and significantly enhances anti-tumor activity [ Int Immunopharmacol, 2023, 119:110205]	PubMed: 37104917
The Antimalarial Drug Artesunate Mediates Selective Cytotoxicity by Upregulating HO-1 in Melanoma Cells [ Biomedicines, 2023, 11(9)2393]	PubMed: 37760834
Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity [ Discov Oncol, 2023, 14(1):139]	PubMed: 37498338
Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity [ Discov Oncol, 2023, 14(1):139]	PubMed: 37498338
Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation [ Biomed Pharmacother, 2022, 155:113705]	PubMed: 36271541
Involvement of Bid in the crosstalk between ferroptotic agent-induced ER stress and TRAIL-induced apoptosis [ J Cell Physiol, 2022, 10.1002/jcp.30863]	PubMed: 35994698
Artesunate Regulates Neurite Outgrowth Inhibitor Protein B Receptor to Overcome Resistance to Sorafenib in Hepatocellular Carcinoma Cells [ Front Pharmacol, 2021, 12:615889]	PubMed: 33716742
In vitro efficacy of artemisinin-based treatments against SARS-CoV-2 [ Sci Rep, 2021, 11(1):14571]	PubMed: 34272426

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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