Laduviglusib (CHIR-99021)

目录号：S1263 批次号：S126308

化学数据

	别名	CT99021	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₂H₁₈Cl₂N₈
	分子量	465.34	CAS号	252917-06-9
Solubility (25°C)*	体外	DMSO	93 mg/mL (199.85 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Laduviglusib (CHIR-99021, CT99021)是一种GSK-3α和GSK-3β抑制剂， IC50分别为10 nM and 6.7 nM。CHIR99201对CDKs没有交叉反应性，对GSK-3β的选择性是对CDKs选择性的350倍。CHIR-99021 可作为Wnt/β-catenin的激活剂并诱导自噬。

靶点

GSK-3β ^[1] (Cell-free assay)	GSK-3α ^[1] (Cell-free assay)
6.7 nM	10 nM

参考文献

[1] Ring DB, et al. Diabetes. 2003, 52(3):588-595.

客户使用selleck产品的实验数据

: , Dr. Yong-Weon Yi from Georgetown University Medical Center

: 数据来源于[Data independently produced by , , Med Oncol, 2017, 35(1):7]

Laduviglusib (CHIR-99021)在文献中得到引用

Structure-guided discovery of highly efficient cytidine deaminases with sequence-context independence [ Nat Biomed Eng, 2025, 9(1):93-108]	PubMed: 38831042
AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models [ Nat Commun, 2025, 16(1):2196]	PubMed: 40038304
Highly efficient construction of monkey blastoid capsules from aged somatic cells [ Nat Commun, 2025, 16(1):1130]	PubMed: 39875393
Intelligent in-cell electrophysiology: Reconstructing intracellular action potentials using a physics-informed deep learning model trained on nanoelectrode array recordings [ Nat Commun, 2025, 16(1):657]	PubMed: 39809732
STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration [ Nat Commun, 2025, 16(1):138]	PubMed: 39746933
Microbial metabolites control self-renewal and precancerous progression of human cervical stem cells [ Nat Commun, 2025, 16(1):2327]	PubMed: 40057497
Heparan sulfate regulates myofibroblast heterogeneity and function to mediate niche homeostasis during alveolar morphogenesis [ Nat Commun, 2025, 16(1):1834]	PubMed: 39979343
An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models [ J Clin Invest, 2025, 135(4)e174081]	PubMed: 39959972
c-JUN: a chromatin repressor that limits mesoderm differentiation in human pluripotent stem cells [ Nucleic Acids Res, 2025, 53(3)gkaf001]	PubMed: 39876710
Construction of human pluripotent stem cell-derived testicular organoids and their use as humanized testis models for evaluating the effects of semaglutide [ Theranostics, 2025, 15(6):2597-2623]	PubMed: 39990223

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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