Fenofibrate

目录号：S1794 批次号：S179403

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化学数据

化学结构式 别名 NSC-281319 储存条件
(自收到货起)		 3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C20H21ClO4
分子量 360.83 CAS号 49562-28-9
Solubility (25°C)* 体外 DMSO 72 mg/mL (199.53 mM)
Ethanol 72 mg/mL (199.53 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Fenofibrate是一种Fibrate类化合物，是纤维酸衍生物。Fenofibrate 是 PPARα 的选择性激动剂，EC50为30μM。Fenofibrate 可结合并抑制 cytochrome P450 epoxygenase (CYP)2C ，对于CYP2C19、CYP2B6和CYP2C9的IC50分别为0.2 μM、0.7 μM和9.7 μM。Fenofibrate 可诱导自噬。
靶点
PPARα [1] CYP2C19 [3]
(Cell-free assay)		 CYP2B6 [3]
(Cell-free assay)		 CYP2C9 [3]
(Cell-free assay)
0.2 μM 0.7 μM 9.7 μM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

客户使用selleck产品的实验数据

数据来源于[Data independently produced by , , Diabetes, 2017, 66(9):2387-2399]

数据来源于[Data independently produced by , , Food Funct, 2018, 9(12):6608-6617]

Fenofibrate在文献中得到引用

EDARADD promotes colon cancer progression by suppressing E3 ligase Trim21-mediated ubiquitination and degradation of Snail [ Cancer Lett, 2023, 10.1016/j.canlet.2023.216427] PubMed: 37838280
Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis [ Cell Metab, 2022, 34(2):299-316.e6] PubMed: 35108516
Repositioning Fenofibrate to Reactivate p53 and Reprogram the Tumor-Immune Microenvironment in HPV+ Head and Neck Squamous Cell Carcinoma [ Cancers (Basel), 2022, 14(2)282] PubMed: 35053444
Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis [ Redox Biol, 2021, 46:102082] PubMed: 34343908
The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR(-/-) Mice by Improving Hyperlipidemia [ Front Mol Biosci, 2021, 8:783807] PubMed: 34966782
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies [ Cancer Discov, 2020, CD-20-0160] PubMed: 32703768
The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα [ J Cell Mol Med, 2020, 24(6):3384-3398] PubMed: 31981312
The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα. [ J Cell Mol Med, 2020, 24(6):3384-3398] PubMed: 31981312
Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis [ Evid Based Complement Alternat Med, 2020, 2020:8888040] PubMed: 33178326
The fucoidan A3 from the seaweed Ascophyllum nodosum enhances RCT-related genes expression in hyperlipidemic C57BL/6J mice. [ Int J Biol Macromol, 2019, 134:759-769] PubMed: 31100394

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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