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别名 | NSC 27640, Deoxyfluorouridine | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C9H11FN2O5 |
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分子量 | 246.19 | CAS号 | 50-91-9 | |
Solubility (25°C)* | 体外 | DMSO | 49 mg/mL (199.03 mM) | |
Water | 49 mg/mL (199.03 mM) | |||
Ethanol | 10 mg/mL (40.61 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Floxuridine (FUDR)是一种前体药物,在体内可迅速分解为5-fluorouracil。Floxuridine 可用于治疗各种癌症,特别是转移到肝脏的癌症。Floxuridine 可抑制 Poly(ADP-Ribose) polymerase、诱导DNA损伤和凋亡。Floxuridine 对HSV和CMV具有抗病毒作用。 |
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体外研究 | Floxuridine呈现对PEPT1比相应的5'-O-单氨基酸酯前药更高的亲和力。[1] Floxuridine和Leucovorin联用导致人T淋巴细胞白血病细胞生长的协同抑制作用。[2] Floxuridine显著抑制[(3)H]-inosine和[(3)H]腺苷的的摄取(对照的60-70%),而它的氨基酸酯前体,包括缬氨酸,苯丙氨酸,Asp和赖氨酸酯,显著下降抑制效力(对照的10-30%)。[3] Floxuridine在36天抑制细胞增值超过对照细胞的50%,细胞数量和初始细胞密度相比增加了4倍。Floxuridine导致对体外培养的人眼球筋膜囊成纤维细胞增殖长时间延长。[4] Floxuridine是一种理想的肝动脉灌注(HAI)药物,由于其半衰期短,陡峭的剂量反应曲线,高总清除率和高肝提取。[5] |
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258] | PubMed: 35207746 |
Establishment and characterization of NCC-UPS4-C1: a novel cell line of undifferentiated pleomorphic sarcoma from a patient with Li-Fraumeni syndrome [ Hum Cell, 2022, 10.1007/s13577-022-00671-y] | PubMed: 35118583 |
CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity [ Cell Chem Biol, 2021, S2451-9456(21)00306-8] | PubMed: 34265272 |
Establishment and characterization of the NCC-GCTB4-C1 cell line: a novel patient-derived cell line from giant cell tumor of bone [ Hum Cell, 2021, 10.1007/s13577-021-00639-4] | PubMed: 34731453 |
Establishment and characterization of NCC-MFS4-C1: a novel patient-derived cell line of myxofibrosarcoma [ Hum Cell, 2021, 34(6):1911-1918] | PubMed: 34383271 |
Establishment and characterization of novel patient-derived cell lines from giant cell tumor of bone [ Hum Cell, 2021, 10.1007/s13577-021-00579-z] | PubMed: 34304386 |
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors. [ Cancer Cell Int, 2020, 19;20:58] | PubMed: 32099531 |
Establishment and characterization of a novel cell line, NCC-TGCT1-C1, derived from a patient with tenosynovial giant cell tumor [ Hum Cell, 2020, 10.1007/s13577-020-00425-8] | PubMed: 32886306 |
Establishment and characterization of NCC-MFS2-C1: a novel patient-derived cancer cell line of myxofibrosarcoma [ Hum Cell, 2020, 10.1007/s13577-020-00420-z] | PubMed: 32870449 |
Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers. [ Cell Chem Biol, 2018, 25(6):705-717] | PubMed: 29628435 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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