Glycyrrhizin (NSC 167409)

目录号：S2302 批次号：S230205

打印

化学数据

化学结构式 别名 N/A 储存条件
(自收到货起)		 3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C42H62O16
分子量 822.93 CAS号 1405-86-3
Solubility (25°C)* 体外 DMSO 100 mg/mL (121.51 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Glycyrrhizin (NSC 167409, Glycyrrhizic Acid)是一种直接的高迁移率族蛋白1(HMGB1)的抑制剂，抑制依赖于HMGB1的炎症分子表达和氧化应激反应。调节p38和p-JNK信号通路，而不影响p-ERK信号通路。同时也能抑制11 beta-hydroxysteroid dehydrogenase。
靶点
11 beta-hydroxysteroid dehydrogenase [1] HMGB1 [2] MAO [4]
(Cell-free)
0.16 μM
体外研究

Glycyrrhizin抑制单胺氧化酶（MAO），IC50为0.16 μM[4]。
体内研究

Glycyrrhizin在小鼠的大脑中增加单胺类如epinephrine和dopamine的水平[3]。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

客户使用selleck产品的实验数据

数据来源于[Data independently produced by , , DNA Cell Biol, 2017, 36(1):67-76]

Glycyrrhizin (NSC 167409)在文献中得到引用

Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis [ Ecotoxicol Environ Saf, 2024, 272:116068] PubMed: 38330871
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 14:1024706] PubMed: 36761729
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 10.3389/fimmu.2023.1024706] PubMed: 36761729
Glycyrrhizin mitigates acute lung injury by inhibiting the NLRP3 inflammasome in vitro and in vivo [ J Ethnopharmacol, 2023, 303:115948] PubMed: 36423713
Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors [ Transl Oncol, 2023, 35:101712] PubMed: 37354638
Effects of HMGB1/RAGE/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic-ischemic brain damage [ J Neurochem, 2023, 167(3):410-426] PubMed: 37753942
Glycyrrhizin Attenuates Hypoxic-Ischemic Brain Damage by Inhibiting Ferroptosis and Neuroinflammation in Neonatal Rats via the HMGB1/GPX4 Pathway [ Oxid Med Cell Longev, 2022, 2022:8438528] PubMed: 35432719
Inhibition of HMGB1/TLR4 Signaling Pathway by Digitoflavone: A Potential Therapeutic Role in Alcohol-Associated Liver Disease [ J Agric Food Chem, 2022, 70(9):2968-2983] PubMed: 35212223
Glycyrrhizin alleviates sepsis-induced acute respiratory distress syndrome via suppressing of HMGB1/TLR9 pathways and neutrophils extracellular traps formation [ Int Immunopharmacol, 2022, 108:108730] PubMed: 35354111
HMGB1 mediates cognitive impairment caused by the NLRP3 inflammasome in the late stage of traumatic brain injury [ J Neuroinflammation, 2021, 18(1):241] PubMed: 34666797

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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