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别名 | N/A | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C42H62O16 |
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分子量 | 822.93 | CAS号 | 1405-86-3 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (121.51 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Glycyrrhizin (NSC 167409, Glycyrrhizic Acid)是一种直接的高迁移率族蛋白1(HMGB1)的抑制剂,抑制依赖于HMGB1的炎症分子表达和氧化应激反应。调节p38和p-JNK信号通路,而不影响p-ERK信号通路。同时也能抑制11 beta-hydroxysteroid dehydrogenase。 | ||||||
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靶点 |
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体外研究 | Glycyrrhizin抑制单胺氧化酶(MAO),IC50为0.16 μM[4]。 |
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体内研究 | Glycyrrhizin在小鼠的大脑中增加单胺类如epinephrine和dopamine的水平[3]。 |
数据来源于[Data independently produced by , , DNA Cell Biol, 2017, 36(1):67-76]
Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis [ Ecotoxicol Environ Saf, 2024, 272:116068] | PubMed: 38330871 |
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 14:1024706] | PubMed: 36761729 |
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 10.3389/fimmu.2023.1024706] | PubMed: 36761729 |
Glycyrrhizin mitigates acute lung injury by inhibiting the NLRP3 inflammasome in vitro and in vivo [ J Ethnopharmacol, 2023, 303:115948] | PubMed: 36423713 |
Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors [ Transl Oncol, 2023, 35:101712] | PubMed: 37354638 |
Effects of HMGB1/RAGE/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic-ischemic brain damage [ J Neurochem, 2023, 167(3):410-426] | PubMed: 37753942 |
Glycyrrhizin Attenuates Hypoxic-Ischemic Brain Damage by Inhibiting Ferroptosis and Neuroinflammation in Neonatal Rats via the HMGB1/GPX4 Pathway [ Oxid Med Cell Longev, 2022, 2022:8438528] | PubMed: 35432719 |
Inhibition of HMGB1/TLR4 Signaling Pathway by Digitoflavone: A Potential Therapeutic Role in Alcohol-Associated Liver Disease [ J Agric Food Chem, 2022, 70(9):2968-2983] | PubMed: 35212223 |
Glycyrrhizin alleviates sepsis-induced acute respiratory distress syndrome via suppressing of HMGB1/TLR9 pathways and neutrophils extracellular traps formation [ Int Immunopharmacol, 2022, 108:108730] | PubMed: 35354111 |
HMGB1 mediates cognitive impairment caused by the NLRP3 inflammasome in the late stage of traumatic brain injury [ J Neuroinflammation, 2021, 18(1):241] | PubMed: 34666797 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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