Icariin

目录号:S2312 批次号:S231204

打印

化学数据

化学结构式 别名 N/A 储存条件
(自收到货起)
3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C33H40O15

分子量 676.66 CAS号 489-32-7
Solubility (25°C)* 体外 DMSO 100 mg/mL (147.78 mM)
Water Insoluble
Ethanol Insoluble
体内
(现配现用)
均匀悬浊液
CMC-NA
≥5mg/ml 以 1 mL 工作液为例,取 5 mg该产品加到 1 ml CMC-NA 溶液中,混合均匀,即可得工作液浓度为 5 mg/ml的均匀悬浊液。
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 Icariin是一种cGMP特异性的PDE5抑制剂,IC50为0.432 μM,作用于PDE5比作用于PDE4选择性高167倍。
靶点
PDE5
0.432 μM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Icariin在文献中得到引用

Combined protective effects of icariin and selenomethionine on novel chronic tubulointerstitial nephropathy models in vivo and in vitro [ British Journal of Nutrition, March 05, 2021, 12-22] PubMed: 33663624
Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1 [ Journal of Orthopaedic Surgery and Research, July 15, 2023, 500] PubMed: 37454090
Icariin mediates autophagy and apoptosis of hepatocellular carcinoma cells induced by the β-catenin signaling pathway through lncRNA LOXL1-AS1 [ Naunyn-Schmiedebergs Archives of Pharmacology, January 15, 2025, 8455-8468] PubMed: 39812768
Icariin mediates autophagy and apoptosis of hepatocellular carcinoma cells induced by the β-catenin signaling pathway through lncRNA LOXL1-AS1 [ Naunyn-Schmiedebergs Archives of Pharmacology, 2025, 8455-8468] PubMed: 39812768
Icariin mediates autophagy and apoptosis of hepatocellular carcinoma cells induced by the β-catenin signaling pathway through lncRNA LOXL1-AS1 [ Naunyn Schmiedebergs Arch Pharmacol, 2025, none] PubMed: 39812768
Matrine and icariin can inhibit bovine viral diarrhoea virus replication by promoting type I interferon response in vitro [ J Vet Res, 2024, 68(1):35-44] PubMed: 38525227
Matrine and icariin can inhibit bovine viral diarrhoea virus replication by promoting type I interferon response in vitro [ Journal of Veterinary Research, 2024, 35-44] PubMed: 38525227
Icariin regulates acidic microenvironment to alleviate pain caused by postmenopausal osteoporosis in the elderly [ Chinese Journal of Tissue Engineering Research, 2024, (28): 4461-4468.] PubMed: none
Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors [ Transl Oncol, 2023, 35:101712] PubMed: 37354638
Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1 [ Journal of Orthopaedic Surgery and Research, 2023, 500] PubMed: 37454090

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!

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