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别名 | NSC-26386, Medroxyprogesterone 17-acetate, Farlutin | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C24H34O4 |
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分子量 | 386.52 | CAS号 | 71-58-9 | |
Solubility (25°C)* | 体外 | DMSO | 12 mg/mL (31.04 mM) | |
Ethanol | 12 mg/mL (31.04 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | MPA (Medroxyprogesterone acetate)是一种孕激素,是一种人体孕激素的人工合成的变体,是有效的孕激素受体激动剂。 | |
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体外研究 | Medroxyprogesterone acetate(MPA)抑制酶3- hydroxyste-固醇脱氢酶,参与(THP)5alpha-dihydroprogesterone(DHP)和3α,5alpha-tetrahydroprogesterone之间的可逆转换,因此,可能会影响到大脑中DHP和THP的作用。[1] Medroxyprogesterone acetate(MPA)减少人乳腺癌细胞中IL-6和PTHrP的分泌。 在KTC-2细胞中,MPA剂量依赖性减少IL-6和PTHrP的分泌和表达。[2] 在M-1个细胞中,Medroxyprogesterone acetate(MPA)和dexamethasone剂量依赖性增加α-ENaC的启动子驱动的萤光素酶活性,这是不通过Org31710抑制,这表明MPA调节的α-ENaC与PR无关。在M-1和Madin-Darby狗肾-C7细胞中,MPA和地塞米松,但不是黄体酮,剂量依赖性增加α-ENaC的和SGK1的mRNA。[3] Medroxyprogesterone acetate(MPA)(0.1 nM)显著增强体外产生特异性免疫球蛋白G(IgG)的抗体,这似乎涉及与PRG受体的孕激素的相互作用的效果。[4] |
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体内研究 | 在老年卵巢切除(OVX)大鼠中,Medroxyprogesterone acetate(MPA)损害水面上旋臂迷宫(WRAM)延迟记忆保留,并加剧Morris水迷宫(MM)的隔夜遗忘。MPA显著和progesterone减少海马中GAD水平,MPA和progesterone显著增加内嗅皮质的GAD水平。[5] |
数据来源于[Data independently produced by , , Molecular Pain, 2015, 11:46.]
The role of non-genomic actions of progesterone and its membrane receptor agonist in ovarian cancer cell death [ Cancer Rep (Hoboken), 2024, 7(1):e1934] | PubMed: 38013666 |
Genome-wide CRISPR screening reveals ADCK3 as a key regulator in sensitizing endometrial carcinoma cells to MPA therapy [ Br J Cancer, 2023, 129(4):601-611] | PubMed: 37402867 |
Genome-wide CRISPR screening reveals ADCK3 as a key regulator in sensitizing endometrial carcinoma cells to MPA therapy [ Br J Cancer, 2023, 129(4):601-611] | PubMed: 37402867 |
Elevated high-mannose N-glycans hamper endometrial decidualization [ iScience, 2023, 10.1016/j.isci.2023.108170] | PubMed: 37915610 |
RNA-seq and ATAC-seq analysis of CD163+ macrophage-induced progestin-insensitive endometrial cancer cells [ Cancer Med, 2023, 12(5):5964-5978] | PubMed: 36373483 |
ABX-1431 inhibits the development of endometrial adenocarcinoma and reverses progesterone resistance by targeting MGLL [ Cell Death Dis, 2022, 13(12):1067] | PubMed: 36550099 |
Chlorpromazine Sensitizes Progestin-Resistant Endometrial Cancer Cells to MPA by Upregulating PRB [ Front Oncol, 2021, 11:665832] | PubMed: 33937078 |
Characteristics of Circular RNA Expression in Ishikawa Human Endometrial Carcinoma Cells with Progesterone Treatment [ Research Square, 2020, 10.21203/rs.3.rs-30247/v1] | PubMed: None |
poFUT1 promotes endometrial decidualization by enhancing the O-fucosylation of Notch1 [ EBioMedicine, 2019, 44:563-573] | PubMed: 31201143 |
poFUT1 promotes uterine angiogenesis and vascular remodeling via enhancing the O-fucosylation on uPA [ Cell Death Dis, 2019, 10(10):775] | PubMed: 31601791 |
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