Nystatin

目录号：S1934 批次号：S193401

化学数据

	别名	Fungicidin	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₄₇H₇₅NO₁₇
	分子量	926.09	CAS号	1400-61-9
Solubility (25°C)*	体外	DMSO	19 mg/mL (20.51 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述	Nystatin (Fungicidin) 是一种多烯类抗真菌剂，常常被用作oropharyngeal candidosis的局部治疗剂。
体外研究	Nystatin导致所有六个念珠菌属种类的颊上皮细胞粘附的显著减少。^[1] Nystatin是抗生素，增加血浆膜对小的一价离子的渗透性，包括氯离子。Nystatin增加心尖氯离子渗透，跨上皮氯离子的运输是由运输横跨气管上皮细胞的基底膜，这主要反映了共转运子的活性。Nystatin（400 unit/mL）增加了跨上皮36Cl流量基础水平约1.5倍，并消除了UTP对流量的刺激作用。Nystatin治疗还消除UTP刺激的可饱和的基底外侧的结合的发挥作用的Na-K-CL共转运子，isoproterenol刺激的结合仅被 Nystatin轻度抑制。^[2] 通过调控endostatin内化介导网格蛋白，Nystatin显著增强内皮细胞摄取endostatin。Nystatin增强endostatin内化，也增加了其对内皮细胞管形成和迁移的抑制作用。^[3]
体内研究	Nystatin combined with endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues but not in normal tissues of tumor-bearing mice, ultimately resulting in elevated antiangiogenic and antitumor efficacies of endostatin in vivo. ^[3] Liposomal Nystatin, at doses as low as 2 mg/kg of body weight/day, protects neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group. ^[4]

参考文献

[4] Wallace TL, et al. Antimicrob Agents Chemother,?997, 41(10), 2238-2243.

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Nystatin在文献中得到引用

Porcine deltacoronavirus enters ST cells by clathrin-mediated endocytosis and does not require Rab5, Rab7, or Rab11 [ Microbiol Spectr, 2023, 10.1128/spectrum.02553-23]	PubMed: 37962380
Low-dose metformin targets the lysosomal AMPK pathway through PEN2 [ Nature, 2022, 603(7899):159-165]	PubMed: 35197629
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK [ Nat Metab, 2022, 4-10:1369-1401]	PubMed: 36217034
The internalization mechanisms and trafficking of the pea albumin in Caco-2 cells [ Int J Biol Macromol, 2022, 217:111-119]	PubMed: 35764167
Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids [ PLoS Pathog, 2022, 18(6):e1010620]	PubMed: 35696443
Hsp90 Regulates GCRV-II Proliferation by Interacting with VP35 as Its Receptor and Chaperone [ J Virol, 2022, 96(19):e0117522]	PubMed: 36102647
Hsp90 Regulates GCRV-II Proliferation by Interacting with VP35 as Its Receptor and Chaperone [ Journal of Virology, 2022, Vol. 96, No. 19]	PubMed: None
Channel catfish virus entry into host cells via clathrin-mediated endocytosis [ Virus Res, 2022, 315:198794]	PubMed: 35504448
Porcine Deltacoronavirus (PDCoV) Entry into PK-15 Cells by Caveolae-Mediated Endocytosis [ Viruses, 2022, 14(3)496]	PubMed: 35336903
Modification of Metal-Organic Framework Nanoparticles Using Dental Pulp Mesenchymal Stem Cell Membranes to Target Oral Squamous Cell Carcinoma [ J Colloid Interface Sci, 2021, 601:650-660]	PubMed: 34091312

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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