Oridonin

目录号：S2335 批次号：S233504

化学数据

	别名	NSC-250682, Isodonol, Rubescenin	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₀H₂₈O₆
	分子量	364.43	CAS号	28957-04-2
Solubility (25°C)*	体外	DMSO	72 mg/mL (197.56 mM)
		Ethanol	34 mg/mL (93.29 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Oridonin是从Rabdosia rubescens中分离的对映贝壳杉烷二萜,是一种具有抗肿瘤、抗细菌和抗感染效果的传统中药。Oridonin 抑制AKT1 和 AKT2的激酶活性，对应的IC50值分别为8.4 μM 和 8.9 μM。

靶点

Akt1 ^[5] (Cell-free assay)	Akt2 ^[5] (Cell-free assay)
8.4 μM	8.9 μM

体外研究

Oridonin有效抑制各种癌细胞的增殖，包括来自前列腺癌 (LNCaP, DU145, PC3)，乳腺癌(MCF-7, MDA-MB231)，非小细胞肺癌 (NSCL) (NCI-H520, NCI-H460, NCI-H1299)，急性早幼粒细胞白血病(NB4)，以及胶质母细胞瘤(U118, U138)的细胞增殖，ED50s的范围为1.8 to 7.5 μ克/毫升。^[1] Oridonin的抗肿瘤活性可能是由于它对NF-κB和MAPKs信号通路的抑制作用。^[2] ^[3]

体内研究

LD50:小鼠35-40毫克/千克。^[4]

参考文献

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客户使用selleck产品的实验数据

: 数据来源于[Data independently produced by , , Int J Mol Sci, 2018, 19(8)]

Oridonin在文献中得到引用

Oridonin attenuates the progression of atherosclerosis by inhibiting NLRP3 and activating Nrf2 in apolipoprotein E-deficient mice [ Inflammopharmacology, 2023, 31(4):1993-2005]	PubMed: 37155118
Network-Based Method to Investigate the Promoted Cell Apoptosis Mechanisms of Oridonin in OSCC through the RNA-Transcriptome [ J Immunol Res, 2023, 2023:5293677]	PubMed: 36969496
FBW7-mediated ubiquitination and destruction of PD-1 protein primes sensitivity to anti-PD-1 immunotherapy in non-small cell lung cancer [ J Immunother Cancer, 2022, 10(9)e005116]	PubMed: 36104103
Oridonin alleviates hyperbilirubinemia through activating LXRα-UGT1A1 axis [ Pharmacol Res, 2022, 178:106188]	PubMed: 35338002
Effect of oridonin on oxylipins in the livers of mice with acute liver injury induced by D-galactosamine and lipopolysaccharide [ Int Immunopharmacol, 2022, 102:108387]	PubMed: 34838489
Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway [ BMC Complement Med Ther, 2022, 22(1):180]	PubMed: 35799227
Oridonin Relieves Angiotensin II-Induced Cardiac Remodeling via Inhibiting GSDMD-Mediated Inflammation [ Cardiovasc Ther, 2022, 2022:3167959]	PubMed: 35360548
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation [ J Exp Med, 2021, 218(9)e20202637]	PubMed: 34342641
Eryptosis and Malaria: New Experimental Guidelines and Re-Evaluation of the Antimalarial Potential of Eryptosis Inducers [ Front Cell Infect Microbiol, 2021, 11:630812]	PubMed: 33777843
Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin [ J Nat Prod, 2021, 10.1021/acs.jnatprod.0c01231]	PubMed: 33890470

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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