A-83-01

目录号:S7692 批次号:S769204

打印

化学数据

化学结构式 别名 N/A 储存条件
(自收到货起)
3年-20°C 粉状
化学式

C25H19N5S

分子量 421.52 CAS号 909910-43-6
Solubility (25°C)* 体外 DMSO 21 mg/mL (49.81 mM)
Water Insoluble
Ethanol Insoluble
体内(现配现用)
澄清溶液
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
1.05mg/ml (2.49mM) 以 1 mL 工作液为例,取50μL21mg/ml的澄清DMSO储备液加到 400μL PEG300中,混合均匀使其澄清;向上述体系中加入50μLTween80,混合均匀使其澄清;然后继续加入500μL ddH2O定容至 1 mL。工作液请现配现用!
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 A-83-01 是一种有效的 TGF-β type I receptor (ALK5-TD) 的抑制剂,其IC50值为12 nM。A-83-01 还抑制由 activin/nodal type I receptor (ALK4-TD)nodal type I receptor (ALK7-TD) 诱导的转录,对应的IC50值分别为45 nM和7.5 nM。在溶液中不稳定,请现配现用!
靶点
ALK7 [1]
(Cell-free assay)
ALK5 [1]
(Cell-free assay)
ALK4 [1]
(Cell-free assay)
7.5 nM 12 nM 45 nM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

A-83-01在文献中得到引用

Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously [ Nat Commun, 2024, 15(1):668] PubMed: 38253551
VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification [ Nat Commun, 2024, 15(1):583] PubMed: 38233381
Autophagy is essential for human myelopoiesis [ Stem Cell Reports, 2024, 19(2):196-210] PubMed: 38215759
Single-nucleus RNA sequencing reveals heterogenous microenvironments and specific drug response between cervical squamous cell carcinoma and adenocarcinoma [ EBioMedicine, 2023, 97:104846] PubMed: 37879219
Single-nucleus RNA sequencing reveals heterogenous microenvironments and specific drug response between cervical squamous cell carcinoma and adenocarcinoma [ EBioMedicine, 2023, 97:104846] PubMed: 37879219
Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells [ Cell Rep, 2023, 42(10):113308] PubMed: 37858462
Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems [ Cell Rep, 2023, 42(6):112566] PubMed: 37235474
Incorporation of human iPSC-derived stromal cells creates a pancreatic cancer organoid with heterogeneous cancer-associated fibroblasts [ Cell Rep, 2023, 10.1016/j.celrep.2023.113420] PubMed: 37955987
Feedback activation of EGFR/wild-type RAS signaling axis limits KRASG12D inhibitor efficacy in KRASG12D-mutated colorectal cancer [ Oncogene, 2023, 10.1038/s41388-023-02676-9 10.3322/caac.21660 10.1001/jama.2021.6021 10.1038/nrdp.2015.65 10.1038/s41575-019-0189-8 10.1038/nature11252 10.1038/s41392] PubMed: 37020035
SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition [ NPJ Precis Oncol, 2023, 7(1):136] PubMed: 38102334

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!

退换货政策

Selleck提供宽松的退换货承诺,努力为您营造最优的购物体验。每个订单Selleck只提供一次退换货服务,为了确保您的权益,请您仔细阅读以下内容:

1. 请在返还样品之前事先与我们取得联系,以确保产品是直接向我们或者当地代理商购买的;

2. 自收到货物起七天内,如因运输过程有问题或其他任何问题,您可以提出退换货要求;自收到货物起365天内,如因产品质量有问题,您可以提出退换货要求。

3. 请使用我们的快递账号进行退换货,您无需为此承担任何费用。

4. 如您已收到由Selleck开具的发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck。请您妥善保管发票,如发票丢失,将无法办理退换货手续。

5. 对于合理的退换货要求,我们会在5个工作日内处理完成您的款项退还和新换货物的运输等,请耐心等待。