A-83-01

目录号：S7692 批次号：S769204

打印

化学数据

别名

N/A

储存条件
(自收到货起)

3年-20°C 粉状

化学式

C₂₅H₁₉N₅S

分子量

421.52

CAS号

909910-43-6

Solubility (25°C)*

体外

DMSO

21 mg/mL (49.81 mM)

Water

Insoluble

Ethanol

Insoluble

体内（现配现用）

澄清溶液

5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O

1.05mg/ml (2.49mM)

以 1 mL 工作液为例，取50μL21mg/ml的澄清DMSO储备液加到 400μL PEG300中，混合均匀使其澄清；向上述体系中加入50μLTween80，混合均匀使其澄清；然后继续加入500μL ddH2O定容至 1 mL。工作液请现配现用！

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

A-83-01 是一种有效的 TGF-β type I receptor (ALK5-TD) 的抑制剂，其IC50值为12 nM。A-83-01 还抑制由 activin/nodal type I receptor (ALK4-TD) 和 nodal type I receptor (ALK7-TD) 诱导的转录，对应的IC50值分别为45 nM和7.5 nM。在溶液中不稳定，请现配现用！

靶点

ALK7 ^[1] (Cell-free assay)	ALK5 ^[1] (Cell-free assay)	ALK4 ^[1] (Cell-free assay)
7.5 nM	12 nM	45 nM

参考文献

A-83-01在文献中得到引用

Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A-menin to bivalent promoters [ Nat Genet, 2025, 57(1):165-179]	PubMed: 39806204
Microbial metabolites control self-renewal and precancerous progression of human cervical stem cells [ Nat Commun, 2025, 16(1):2327]	PubMed: 40057497
RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosus [ Cell Rep Med, 2025, S2666-3791(25)00047-3]	PubMed: 39983716
A pancreatic cancer organoid incorporating macrophages reveals the correlation between the diversity of tumor-associated macrophages and cancer cell survival [ Biomaterials, 2025, 314:122838]	PubMed: 39348736
NLRP7 maintains the genomic stability during early human embryogenesis via mediating alternative splicing [ Commun Biol, 2025, 8(1):125]	PubMed: 39865169
Generation and characterization of induced pluripotent stem cells of small apes [ Front Cell Dev Biol, 2025, 13:1536947]	PubMed: 40177132
Establishing Pancreatic Cancer Organoids from EUS-Guided Fine-Needle Biopsy Specimens [ Cancers (Basel), 2025, 17(4)692]	PubMed: 40002285
Human induced pluripotent stem cells derived neutrophils display strong anti-microbial potencies [ Cell Regen, 2025, 14(1):8]	PubMed: 40113653
Protocol for generating a pancreatic cancer organoid associated with heterogeneous tumor microenvironment [ STAR Protoc, 2025, 6(1):103539]	PubMed: 39772386
Restoring sweat gland function in mice using regenerative sweat gland cells derived from chemically reprogrammed human epidermal keratinocytes [ Sci Bull (Beijing), 2024, S2095-9273(24)00799-0]	PubMed: 39550273

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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