Abemaciclib

目录号：S5716 批次号：S571603

化学数据

	别名	LY2835219	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₇H₃₂F₂N₈
	分子量	506.59	CAS号	1231929-97-7
Solubility (25°C)*	体外	Ethanol	10 mg/mL (19.73 mM)
		DMSO	3 mg/mL (5.92 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Abemaciclib是一种对 CDK4/6 有选择性的细胞周期抑制剂，在无细胞试验中的IC50值分别为2 nM和10 nM。

靶点

CDK4 ^[1] (Cell-free assay)	CDK6 ^[1] (Cell-free assay)
2 nM	10 nM

参考文献

Abemaciclib在文献中得到引用

Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment [ Cancer Cell, 2024, S1535-6108(24)00037-0]	PubMed: 38402610
Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma [ Clin Cancer Res, 2024, 30(4):703-718]	PubMed: 37695642
Intracellular calcium links milk stasis to lysosome-dependent cell death during early mammary gland involution [ Cell Mol Life Sci, 2024, 81(1):29]	PubMed: 38212474
Cyclin-dependent kinase inhibitors enhance programmed cell death protein 1 immune checkpoint blockade efficacy in triple-negative breast cancer by affecting the immune microenvironment [ Cancer, 2024, 130(S8):1449-1463]	PubMed: 38482921
Modulation of autophagy and apoptosis can contribute to the anticancer effect of Abemaciclib/Celecoxib combination in colon cancer cells [ Med Oncol, 2024, 41(2):43]	PubMed: 38170401
p21 Prevents the Exhaustion of Cluster of Differentiation 4-Positive T Cells Within the Antitumor Immune Response Against Colorectal Cancer [ Gastroenterology, 2023, S0016-5085(23)05008-4]	PubMed: 37734420
Single-cell morphological and topological atlas reveals the ecosystem diversity of human breast cancer [ Nat Commun, 2023, 14(1):6796]	PubMed: 37880211
Single-cell morphological and topological atlas reveals the ecosystem diversity of human breast cancer [ Nat Commun, 2023, 10.1038/s41467-023-42504-y]	PubMed: 37880211
Molecular mechanisms of tubulogenesis revealed in the sea star hydro-vascular organ [ Nat Commun, 2023, 14(1):2402]	PubMed: 37160908
Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer [ Cell Rep Med, 2023, 4(8):101120]	PubMed: 37451269

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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